Conserved Protein Domain Family
Pat_PNPLA8

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cd07211: Pat_PNPLA8 
Patatin-like phospholipase domain containing protein 8
PNPLA8 is a Ca-independent myocardial phospholipase which maintains mitochondrial integrity. PNPLA8 is also known as iPLA2-gamma. In humans, it is predominantly expressed in heart tissue. iPLA2-gamma can catalyze both phospholipase A1 and A2 reactions (PLA1 and PLA2 respectively). This family includes PNPLA8 (iPLA2-gamma) from Homo sapiens and iPLA2-2 from Mus musculus.
Statistics
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PSSM-Id: 132850
View PSSM: cd07211
Aligned: 20 rows
Threshold Bit Score: 373.129
Threshold Setting Gi: 211965692
Created: 10-Feb-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active sitenucleophile
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the crystal structure of semet patatin (1OXW)
  • Comment:catalytic dyad is formed by Ser and Asp
  • Comment:oxyanion hole is formed by two Gly and one Arg

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                        ## #                             #                               
Q9NP80        435 DPVKGRGIRILSIDGGGTRGVVALQTLRKLVELTQKPVhQLFDYICGVSTGAILAFMLGLfh-mPLDECEELYRKLGSDV 513  human
BAD30421      593 RPVAKKGLRILSMDGGGMKGLATVQILKQIEQGTGKRIhEMFDLICGTSTGGMLAMALGVkq-mTLDQCEEIYTKLGECL 671  Japanese rice
EEB00888     2023 RAGRRRGLRILCFDGGGTRGVLSLALLKQIMACVGQEVhETFDIICGTSTGGVIAALLGLek-aTVSEAERLYDLLIREI 2101 Toxoplasma go...
XP_001611186  873 NRFKNRGLRVLSIDGGGSKGVIVLEILLDLEKRLGRPLyEVFDVIVGNSCGGIIGAFLALek-sRVTDVQRYFDAMLGDV 951  Babesia bovis...
XP_955468     782 KTFENRGVRILSIDGGGSKGVVALEILDYLNKQLEKPLhECFDIICGTSTGGLLASLVALek-mEISEIQKLYDSMIKSI 860  Theileria ann...
XP_001764573  500 RPISKRGLRILSMDGGGMRGMATVQMLRNIEKGTGRRIhEIFDLICGTSTGGMLAVALGIkr-mDLDQCENIYKSLGKLV 578  Physcomitrell...
NP_500969     200 PSPKGKGVHVLSIDGGGTRGMMGLEVLEKIEKLSGKKIcELFDMICGVSTGSIIAALLTAkg-ySVKECREVYMDVSKRL 278  nematode
EEB14558      179 NPLPSQGIRILAIDGGGIRGLLVMEMLAKFEELTGKKInELFDYICGVSTGSVIACTVGAsg-kSIDEISALYRELGNKI 257  human body louse
XP_001702734  506 PPIRGRGLRVLALDGGGMRGLALVQILRHIEKRTGRPLhGLFDLVVGTSTGAIVAVGLGVfh-fSLDQCEAIYTGLGHKV 584  Chlamydomonas...
XP_001656129  116 PPLPGPGIRILSVDGGGIRGLIVAELLRRIEKMTGKKIfELFDMVCGVSTGAILLCALTSeknlTLDESIILYKKMSHKM 195  yellow fever ...
Feature 1                                                                                         
Q9NP80        514 FSQnv------------------------------------------ivGTVKMSWSHAFYDSQTWENILKdrmgsalmi 551  human
BAD30421      672 LALtfhiflivlpsellvspgklvfaepapkdeaatwkekidqlfksssQSFRVVVHGSKHSADQFERLLKemcadedgd 751  Japanese rice
EEB00888     2102 FVRdsa-----------------------------------------avTGARLVLRQALYNEKGWEGILErawgrrrmi 2140 Toxoplasma go...
XP_001611186  952 FKKegy-----------------------------------------gsKGKRLFTHLAYYNEQTLYDALTaafgnleli 990  Babesia bovis...
XP_955468     861 FVRdyy-----------------------------------------piTGTRLLFRHAIYDDTTLKDILKtsleeieli 899  Theileria ann...
XP_001764573  579 FAEpipkdneaatwr-----------------------ekidqvyksssQNFRVVVHGSKHNAEQFEHLLKemcadeegd 635  Physcomitrell...
NP_500969     279 FSQgk------------------------------------------fqGSMGLILKHSYYNTNLWISILKqmigeditm 316  nematode
EEB14558      258 FSQnv------------------------------------------ffGARSLIWNHGYYDTALWEKILKehvgetpli 295  human body louse
XP_001702734  585 FNQggwrdslf-------------------------------rvvrgtsTSLRVAVYGFKHDASTFEELLRqmc------ 627  Chlamydomonas...
XP_001656129  196 FHRpspl--------------------------------------dkitGASRMVLSHAYYDIELWESLLKqylgyrrii 237  yellow fever ...
Feature 1                                                                                         
Q9NP80        552 -------------------etarnptcPKVAAVSTIVNRg---iTPKAFVFRNYGHFPGIn------------------- 590  human
BAD30421      752 lliesavkgipkyppgtvevssvmtesPSIGSAGTPVSGap--vGIKPINTVGTAVSGAPvgi----------------- 812  Japanese rice
EEB00888     2141 -------------------dfaadpacPKVFCVSTVASPn----PTQVMVWRNYNFPVRLvpkaaaqprgretppngdsg 2197 Toxoplasma go...
XP_001611186  991 -------------------dysvdpdaPKFCCLSVQLDIy----PFKPVLWRSYNYPPNAeskk---------------- 1031 Babesia bovis...
XP_955468     900 -------------------dysvdstcPKFFCVSTQMDVt----PLRPIIWRNYNYHKDIyslgskdlt----------- 945  Theileria ann...
XP_001764573  636 l-----------------liesavkgvPKVFVVSALVSVt----PAQPFVFRNYQYPPGTpetapstndgpaasvsg--- 691  Physcomitrell...
NP_500969     317 ------------------intsrklhtPRLAIVSSIVNLp----TIQPYIFRNYDHPAGRd------------------- 355  nematode
EEB14558      296 -------------------ktsrnhpyPKIGVISTVTNHd----QIVPYIFRNYELPYRVk------------------- 333  human body louse
XP_001702734  628 -------------------------evKKLGCVGNQMIDaaalgGPKVAAVATLVSVCPV-------------------- 662  Chlamydomonas...
XP_001656129  238 -------------------dtsklpnvPKFCCVSTTICDe----HIEAHVFRNYTFPLNAh------------------- 275  yellow fever ...
Feature 1                                                                                         
Q9NP80            --------------------------------------------------------------------------------      human
BAD30421          --------------------------------------------------------------------------------      Japanese rice
EEB00888     2198 daseptakpeagresqrearrlgfvdwwrklgtkesgapqpeaagreardqdnsrlcrgsaqyspsqsvfsrfayffrpp 2277 Toxoplasma go...
XP_001611186      --------------------------------------------------------------------------------      Babesia bovis...
XP_955468         --------------------------------------------------------------------------------      Theileria ann...
XP_001764573      --------------------------------------------------------------------------------      Physcomitrell...
NP_500969         --------------------------------------------------------------------------------      nematode
EEB14558          --------------------------------------------------------------------------------      human body louse
XP_001702734      --------------------------------------------------------------------------------      Chlamydomonas...
XP_001656129      --------------------------------------------------------------------------------      yellow fever ...
Feature 1                                                                                     #   
Q9NP80        591 ----------------------------------------SHYLGGCQYKMWQAIRASSAAPGYFAEYALGNDLHQDGGL 630  human
BAD30421      813 --------------------------------------krGAFMGSCKHRIWEAIRASSAAPYYLDDFSDDVNRWQDGAI 854  Japanese rice
EEB00888     2278 htasgspsrqgrpdsfspyscsspcalpspssfllvpsrgSRHAGSSRILVKDALRATTAAPGFFSGIFWEGQAFSDGAL 2357 Toxoplasma go...
XP_001611186 1032 -------------------------------------nspRIIDGTFAVKTPDALRATSAAPTYFPMMEINGALYADGAL 1074 Babesia bovis...
XP_955468     946 --------------------------------iedlnkliEIIGGSCTIRLRDAIKATTSALGYFPLFERNGHLYGDGAL 993  Theileria ann...
XP_001764573  692 ------------------------tpatatplttqvgprrSAFIGSCKHRIWEAIRASSAAPYYLDDFSQESNRWQDGAI 747  Physcomitrell...
NP_500969     356 ----------------------------------------SHYRGGADHCLWTAIQASAAAPLYFSEVKLDNLLLQDGGV 395  nematode
EEB14558      334 ----------------------------------------SKYLGSYKHQLWEATRASAAAPTYFEEFSLGDFLHQDGGV 373  human body louse
XP_001702734  663 ----------------------------------------TPFLFTTYELPPEAVRASSAAPYYLDDFLCGEDRFQDGAA 702  Chlamydomonas...
XP_001656129  276 ----------------------------------------SVYSGSHTARMWEVVRASSAAPAYFGDFQLDGQLHQDGGI 315  yellow fever ...
Feature 1                                                                                         
Q9NP80        631 LLNNPSALAMHECK-CLWPDVPLECIVSLGTGRYESdvr----------------------------------------- 668  human
BAD30421      855 VANNPTIFAIREAQ-LLWPDTRIDCLVSIGCGSVPTksr----------------------------------------- 892  Japanese rice
EEB00888     2358 LANNPTAVALAEARgLYGEDVPIDLVVSIGTGKFPSsfsspsrgdslhhreeaat------------------paesdkg 2419 Toxoplasma go...
XP_001611186 1075 YANNPSAIAVIESK-LLYPDVPIDLLVSISNGDWNDmfsldaataaaagidiapsdteskdnnttervppldkiyndivl 1153 Babesia bovis...
XP_955468     994 YCNNPSVVALIESK-LLYPDTPVELLVSVGNGLSQFnpngsndpgncqsd---------------------------dvt 1045 Theileria ann...
XP_001764573  748 VANNPTIIALREAQ-LIWPDTQVDCLVSVGCGNVPTkar----------------------------------------- 785  Physcomitrell...
NP_500969     396 YANNPTAIAYHEAK-LLWPDENVNCVVSVGNGRTVTsvep---------------------------------------- 434  nematode
EEB14558      374 LVNNPTALAVHEAK-QLWPNNEIQCVVSFGTGRLDPlsiesvk------------------------------------- 415  human body louse
XP_001702734  703 TANNPGILALQQAR-LLWPNTPVEALVSVGCGAAPSvrr----------------------------------------- 740  Chlamydomonas...
XP_001656129  316 LYNNPTAVAIHEAK-CLWPNEPIQCVVSFGTGRTRTrdwkdgqkii---------------------------------- 360  yellow fever ...
Feature 1                                                                                         
Q9NP80        669 --------ntvTYTSLKTKLs----------nVINSATDTEEVHIMLDGl---LPPDTYFRFNPVMcen-ipLDESRNEK 726  human
BAD30421      893 ---------rgGWRYLDTGQv-----------LIESSCSVERVEETLDTlipmLPEMQYFRFNPVDercgmeLDETDPAV 952  Japanese rice
EEB00888     2420 dtlpagwssllGLGGWETLLa----------qLANCATNTEAVHDLLSDl---LPQSVYFRFNPDIsgd-wpIDETRTQR 2485 Toxoplasma go...
XP_001611186 1154 rsgmtcpratqKTVGLDKLLk----------hIIFSATNTEMVHLSLHA----VMGDHYVRINPSMpl--veLDVVVPEV 1217 Babesia bovis...
XP_955468    1046 nlvklyenfmdHGTSNIKKEnknlsidqlithLSYAVTTSEMTHSALEFt---MPRDVYYRLTPIIln--akIDETNPEV 1120 Theileria ann...
XP_001764573  786 --------gkgGWRYLDTGQv-----------LIESACSVERAEEALDTllpmLPNLQYFRFNPIDdrcdmeLDETDAAV 846  Physcomitrell...
NP_500969     435 -------tptvFSTSFQDKLl----------rIIDSATDTEGVHMNVHDm---LPESVYYRFNPYMtya-ygLDEIDQER 493  nematode
EEB14558      416 -----tkksaaKQTSWKEKFy----------nILVSATDTEAVHMILNDl---LPPSVYFRFNPFVtql-lsMDECQPEK 476  human body louse
XP_001702734  741 --------ekgAHAMLDTGAv-----------LVDAATSPDRADEALSTllplVPGCRYFRFQPVHercameLDDVDPAH 801  Chlamydomonas...
XP_001656129  361 --skniieqtsLSSSWKTKFl----------rILDSATDTEATHTMLSDl---LPPGRYFRFNPYLtef-lsMVETRPEK 424  yellow fever ...
Feature 1                        
Q9NP80        727 LDQLQLEGLKYIERN 741  human
BAD30421      953 WLKLEAATDEYIQKN 967  Japanese rice
EEB00888     2486 LDVLKCLAERFFLDN 2500 Toxoplasma gondii ME49
XP_001611186 1218 LQDLKDRTKEFLKQE 1232 Babesia bovis T2Bo
XP_955468    1121 LNKIKDQTKQYLKLS 1135 Theileria annulata strain Ankara
XP_001764573  847 WSKLETATQEYVDAN 861  Physcomitrella patens subsp. patens
NP_500969     494 LEQMASDAEFYVRRN 508  nematode
EEB14558      477 LDLLKQDALMYIRRN 491  human body louse
XP_001702734  802 WAALQPSSLFEYFFG 816  Chlamydomonas reinhardtii
XP_001656129  425 IAQLERDTTEYFHRN 439  yellow fever mosquito

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