Conserved Protein Domain Family
Pat_hypo_W_succinogenes_WS1459_like

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cd07210: Pat_hypo_W_succinogenes_WS1459_like 
Hypothetical patatin similar to WS1459 of Wolinella succinogenes
Patatin-like phospholipase. This family predominantly consists of bacterial patatin glycoproteins. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have also been found in vertebrates.
Statistics
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PSSM-Id: 132849
View PSSM: cd07210
Aligned: 11 rows
Threshold Bit Score: 223.377
Threshold Setting Gi: 149195004
Created: 4-Jan-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
nucleophileactive site
Feature 1:nucleophile elbow
Evidence:
  • Comment:The nucleophile elbow is identified by a consensus sequence Sm-X-Nu-X-Sm (Sm = small residue, X = any residue and Nu = nucleophile)
  • Comment:characteristic of alpha/beta hydrolases
  • Citation:PMID 9379946
  • Citation:PMID 8154368

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                          #####                                         
NP_907618     31 INLVLSGGGTRA-IGHLAIISALLErGFEIRAISGSSGGAIVGSLLASGKSPKECYDLLlktnfvrl------------- 96  Wolinella succi...
EDY87408      14 FTLCLSSGFFSF-YAHLGLWAALEEsGLKPAKLSGSSAGALVAAAWASGMSCDEMRALFfslkred-------------- 78  gamma proteobac...
EDX89214      11 FTLAMSSGFFGF-FAHFGTLRALLEhGLAPARFCGSSAGALVGACVASGASINAIEDMLlgldrsq-------------- 75  Alcanivorax sp....
ZP_01912963   18 FTLVLSAGFFGF-FAHTGVLAALEEaGLAPRRVVGTSAGAIAGGMWASGVPTRELIERLvalrlpdfwdpvwr-wparra 95  Plesiocystis pa...
ZP_02931069   15 LAVALGSSFFGF-YSHTAFMRALHDqGIFPSHMSGTSAGAVAAALCGVGLQGADLEAFVmrrglrrafldwaa--plrfp 91  Verrucomicrobiu...
ZP_03127774   13 VALCLNSSFLGY-FAHAGFLRALLNlGVRPVAVSGASAGALVAGLFAAGISPDEMLQIFaspelrkvfrepga-plrgfa 90  Chthoniobacter ...
ZP_01451704    7 TGLVLSAGGVRGvYAHSGFMQALAGmDIQLSAVAGCSAGALVGGIHASGTPLEQWLEALahmerkhfwrpgswrralmel 86  Mariprofundus f...
YP_000574     10 TALTFNSAFFGF-YAHAGFAKGLSEiGFRPSKITGCSSGALIGSLVAAGIPIDTMTDLIlnlkkkdfwegnlv-tnfvkp 87  Leptospira inte...
XP_001702804  20 CDLVLSSGFLAF-AGHAGFLQAVEEmGVPVGGVMGTSAGALVGSLYCAGYSPLEVAKHLsdqtpasll------------ 86  Chlamydomonas r...
ZP_01872097    3 LSIALSGGAARG-VFHLGFLDVLLKeGVEIKEISGSSAGAIVAGAIACKIPLKDIFEIVkskefks-------------- 67  Caminibacter me...
EDZ38953      27 FVLVLSGGVIRG-AGHLGFLAACQQaNLPVRGIVATSAGAIAGAVFQSGKSTTEEAQKRlktlrtwe------------- 92  Leptospirillum ...
Feature 1                                                                                        
NP_907618     97 -fafkmsqGGLFHLKRGEAYLEk--ILGIKEFSELSLPLYVCVVDlkeg-rpfFLSEGNIAKAVIASSSISPFMRPVEME 172 Wolinella succi...
EDY87408      79 -fwdpalgLGLLKGDRFRALLRe--HFPVARMEQTAYPLAVSVYDwrrr-qtlSFSKGLLAELVSASCAVPGLFQPVSYR 154 gamma proteobac...
EDX89214      76 -fwdpspgLGLLSGQAFRRMLAg--LLPTQRVEDARTPLAVSAWQaksr-rtqVLQQGNLVEAVYASCAVPLLFQPARIG 151 Alcanivorax sp....
ZP_01912963   96 adpdpgtpLGLLRGRKFDAILGeilDGRPDTIEACPTPFAAVTHDlgrn-attVHERGPLRPVIRASAALPVMFGPVRID 174 Plesiocystis pa...
ZP_02931069   92 gvvstlvcSGILSGHNFVQFLRk--HLPKQRLEECTHPRVQLAVTnltrrecvLVEEGDIAQWVMASCAVPGLFCNQVID 169 Verrucomicrobiu...
ZP_03127774   91 tilnlpghTGALRGERAAALLRe--KLGTRRIEECQAPKLALSVTnlsagrseAVTSGPLAELILASGAFPGVFATRPVE 168 Chthoniobacter ...
ZP_01451704   87 mlhrgrtfTGIATTDDALDFCRr--NIAVDSFEACRIPFHTIATSlttg-ekqMFSAGDLALGIAASSTVPLLYQPVEIE 163 Mariprofundus f...
YP_000574     88 irkglknySGILSGKNVKELLKp--HLGHKKIEELSIPMGISVSNitkq-ireLKTKGDLIDQILASMTFPFLFEIQKLG 164 Leptospira inte...
XP_001702804  87 rpsaapwrGGALSLDGVISRLR---DLLPPRFEDLQREFAVGVVTaeg--ehlLIDSGPLPEAVAASAAIPIIFQAVDVP 161 Chlamydomonas r...
ZP_01872097   68 -ifkfslkTGLFKIDLNSTILDk--FFLYDDLSKSDIPLFICVTDfqee-kalYLNAGDPKKIIPASCAIYPFFEPIVYK 143 Caminibacter me...
EDZ38953      93 mfrfrprrGGFLDAGRTAELVGe-mIGPETTFSDLRGPLAVAAVSlasr-nlaLLKEGSVPLAVAASSALPPFFQPVEIG 170 Leptospirillum ...
Feature 1                                                                                        
NP_907618    173 Gr-----mGADGGIMNNLPIepfl--eenlPIIGINVNPNrpfhsh----------smvsiaKRALFLQFYSNILersk- 234 Wolinella succi...
EDY87408     155 Gy-----sLLDGGIKDRPGLlgva---pdeRVFYHHIASRspwr---------------rkgDPALKVPERHNMAslqid 211 gamma proteobac...
EDX89214     152 Gr-----yYWDGGIADRHGLaaty---pgeRVLYHHLQSRspwr---------------gpySKALHHPYRPNLItla-- 206 Alcanivorax sp....
ZP_01912963  175 Gr-----lHADGGIRDRPGFrala---pgeRCLYHHLPHStpwprah---------gqageeLERMDTPTRTVLAi---- 233 Plesiocystis pa...
ZP_02931069  170 Gm-----rWCDGGVALEIPFdhwledpeihTIVLHRIEHVrgtecvprwpsvatgfaashdtINGTLHQMRMRQAresgk 244 Verrucomicrobiu...
ZP_03127774  169 Dh-----wFWDGGVANALPFdhwvddpeidTILVHIVANPee------------------laVRQGGRPRRMSHAvnlsh 225 Chthoniobacter ...
ZP_01451704  164 Gi-----fYCDGGVIDLGPTdaiccrheldVLIVHHVATRtrgfrgidate-qdgwpileiiDTLLFRNRPWYLSdlplt 237 Mariprofundus f...
YP_000574    165 Ee-----eFIDGGVADQEPIkelildksihKIVIHSIRTKkg------------------hsEKAMIRAFHSSVQii--- 218 Leptospira inte...
XP_001702804 162 GhvsrhgpFKDGGVVDRVGLkawr--drrrAQISKQLAAGd---------------------GNAPLRPPTCLVHvidrs 218 Chlamydomonas r...
ZP_01872097  144 Dk-----iLVDGGYKDNLPSspl-----ngNILGINVVPNckieklth-------kniiikiSQMLIRNTINYEKik--- 203 Caminibacter me...
EDZ38953     171 Gv-----pYVDGGLLSVLPVmaartlyphtPIVAVNVNDRegrqgrpgl-----sswledgtSRHPGGPVSWNMLl---- 236 Leptospirillum ...
Feature 1                                
NP_907618    235 ---------lcslYLEPSGIDAYT 249 Wolinella succinogenes DSM 1740
EDY87408     212 g------lvrsgpRRMALGPIAYQ 229 gamma proteobacterium HTCC5015
EDX89214     207 -----------idGLVRSGPGKLE 219 Alcanivorax sp. DG881
ZP_01912963  234 ------------dTLPRVGPMALD 245 Plesiocystis pacifica SIR-1
ZP_02931069  245 --------rvievVTETPHPGLLP 260 Verrucomicrobium spinosum DSM 4136
ZP_03127774  226 --------qiicdELFRLKSDLAR 241 Chthoniobacter flavus Ellin428
ZP_01451704  238 frrcpcgckalivVLEPSLPELPW 261 Mariprofundus ferrooxydans PV-1
YP_000574    219 -----------enETRELKELLAK 231 Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130
XP_001702804 219 spf---sgfddmtATGESHILVVK 239 Chlamydomonas reinhardtii
ZP_01872097  204 ------------yLIEPQEICKIR 215 Caminibacter mediatlanticus TB-2
EDZ38953     237 ------------hPLSSLGLEIVW 248 Leptospirillum sp. Group II '5-way CG'

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