Conserved Protein Domain Family
Pat_hypo_Ecoli_Z1214_like

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cd07209: Pat_hypo_Ecoli_Z1214_like 
Hypothetical patatin similar to Z1214 protein of Escherichia coli
Patatin-like phospholipase similar to Z1214 protein of Escherichia coli. This family predominantly consists of bacterial patatin glycoproteins and some representatives from eukaryotes and archaea. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have also been found in vertebrates.
Statistics
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PSSM-Id: 132848
View PSSM: cd07209
Aligned: 51 rows
Threshold Bit Score: 145.127
Threshold Setting Gi: 118469544
Created: 2-Jan-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active sitenucleophile
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the crystal structure of semet patatin (1OXW)
  • Comment:catalytic dyad is formed by Ser and Asp
  • Comment:oxyanion hole is formed by two Gly and one Arg

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             ## #                                #                                      
NP_286749      9 LVLSGGGAVGAYQAGVVKALAECGt--------qISMVSGTSIGAFNGAIIAASpdls--eaaVRLEALWEHLGNNQVLs 78  Escherichia col...
YP_701867      5 FVLSGGASLGALEVGMLQTLIGRGi--------rPDLVVGTSVGALNGAWLAGGssd---adlRELADLWRGLTRSAVFp 73  Rhodococcus sp....
ZP_03210588    5 VVFGGGAAHGAYQAGVWSVLGPRLa---------PAFVIGSSIGAINAAATAHMa-------pQQLAHWWQSLTSLKTRg 68  Lactobacillus r...
NP_518342      9 FVFAGGGSLGAIEAGMLRELVARGv--------mPDMVVGASAGAINAAFFACHphm---dgaARLEALWRGVRRAEVMp 77  Ralstonia solan...
CAJ89425      39 VVVGAGGVLGAAHVGVGHALEQRGf--------rPDMIIGTSVGALNGAIAAAHpdr----aaPWLEHVWTELRRRDVYq 106 Streptomyces am...
6689533       12 LVLCGGGARGAMQVGFYQAIIELGl--------sFDLVVGSSVGALNGTLIAAGms------pAELSELWQGLRKPDVVs 77  Xanthomonas cam...
YP_889976      3 FVLGGGGVLGAAEAGMALALLESGv--------rPDLVCGTSVGAINGAALAADptp---egaRALVKFWDALGGDGVFg 71  Mycobacterium s...
YP_001547619   4 IVFSGGANRGSLQAGAALALLEAGi--------iPDLVVGSSVGSINGAVLACHpnl---agiQRIAQRWKSVKREDIFp 72  Herpetosiphon a...
YP_001108440   5 WVLPGGSTFGAIQAGLVTSLFEAGe--------aPDAVIGTSVGSLNAAWLAGDpta---rgaEKLREVWLSMRRSDVFa 73  Saccharopolyspo...
XP_001011026  28 LVIAGGADLGSYEAGVIQGLVQAYnelgqvsevyWDVISGVSVGAITAVGLGQFpkeqtvemaNWVVNLWENISKSDVYs 107 Tetrahymena the...
Feature 1                                                                                        
NP_286749     79 vnrlvyfsllkklfqamnlcqipgragallttllrhistingfdnlmaqpllsdepltalmdhyldtdalADGLPLYVSL 158 Escherichia col...
YP_701867     74 tglltgftgfv------------------------------------------------glrnhlvsnraIRRLLEQNLR 105 Rhodococcus sp....
ZP_03210588   69 pifar------------------------------------------------------------rnfvpLLEQMLRLPK 88  Lactobacillus r...
NP_518342     78 wswrvmlgm----------------------------------------------------lgrrsthlvDAGGLQRLLN 105 Ralstonia solan...
CAJ89425     107 lgfpssr-------------------------------------------------------asiftdrgLRRLIARAGL 131 Streptomyces am...
6689533       78 wnwrgllge----------------------------------------------------tggfysfapLRRLLHEALP 105 Xanthomonas cam...
YP_889976     72 gslirraaevl------------------------------------------------rrptslhdnseLRRLLRERLP 103 Mycobacterium s...
YP_001547619  73 ggslrsawrvv------------------------------------------------rgrgslhhnhgLRRFILSLLP 104 Herpetosiphon a...
YP_001108440  74 iqpmrilagklgltnh--------------------------------------lmsnrglarwlyqtlpYRRLEDARIP 115 Saccharopolyspo...
XP_001011026 108 nyl----------------------------------------------------------------ggvVQGFLFEESL 123 Tetrahymena the...
Feature 1                                                                               #        
NP_286749    159 YPTeggmqdiid------ciraelgvgTTKNAVFQHIQslpr-gqqkEALLASAALPLLFRPreVQGTMFGDGGMGGWRN 231 Escherichia col...
YP_701867    106 FERmedapip-----------lhviaaDVLTGKDVRLStgp----avDAVTASAALPGILPPvvIDGRALMDGGVVDNTP 170 Rhodococcus sp....
ZP_03210588   89 RDQravla--------------vttrlPDLRAHVTRIDelsv-adarEWLLASSAMPGIFTPidRHGTSFVDGGVVNDLP 153 Lactobacillus r...
NP_518342    106 RHFaqarleaap-------lplhvvatDMQTGAEVVLStgs----ivQAVLASAAIPGVFPPvrVDGRLLIDGGVANNTP 174 Ralstonia solan...
CAJ89425     132 PSRieelavp-----------ftavamDLVTGAPALLDhgd----leSALLASAAIPGILPPvdREGRTLVDGGMTAYVP 196 Streptomyces am...
6689533      106 VKRfeelkhp-----------lvitttNLQSGQPCYHErhg---vliEPMIASMSLPGVFPPvwIAGDQHVDGGVTDNVP 171 Xanthomonas cam...
YP_889976    104 VHTfeelavp-----------fecvaaSIERAREHWFDsgd----lvEPVLASCALPGVLPPvrIGDEHFFDGGLVNSIP 168 Mycobacterium s...
YP_001547619 105 PNIrrfsdlai---------pffvtatNYRTGDMHLFGddpr-erlvDALMASAAVPPYLPAyhYRGETYLDGGFVSNLP 174 Herpetosiphon a...
YP_001108440 116 LTVta---------------------tDIDSGEAVYFDrgp----alPALVASCSIPGMFPPikVGDRWLVDGGPAAFMP 170 Saccharopolyspo...
XP_001011026 124 FKTdplraflkknvtrkqtrklvigvtNANTGEYERYNeslsdadliEAVMCSSAVPAFFPYqiFKGNTYFDGGVVRAAD 203 Tetrahymena the...
Feature 1                                                                                        
NP_286749    232 MQGNTpvtp------lvdaGCNMVIVTHLSDGSlwdr------qafPDTTILEIRPRKrlkyagdggnsggllsftsaht 299 Escherichia col...
YP_701867    171 ISHAIelgattvwvlptgyACTLSKVPGSALGMgll-------gvtLAINQRLALDIEryesva--------------di 229 Rhodococcus sp....
ZP_03210588  154 VDIARd------------iGADFVVAISGAGIGrigs-----dhgdVYLKPSRPLPRLfnfrp----------------- 199 Lactobacillus r...
NP_518342    175 ISTAIr------------lGATRVVVLPAGFACadrreprsaiehaLNALSLLVARQLaqdlehwag---------tipi 233 Ralstonia solan...
CAJ89425     197 VLAAMr------------aGAASVVVVPTGPESsp----------lPATTPPRRAGAIaarvglv-------------lm 241 Streptomyces am...
6689533      172 FDKALd------------rGAHEILMISCTCCPrd---------stALASPLKILLRS---------------------- 208 Xanthomonas cam...
YP_889976    169 LDRAVs------------rGADTIWVLHVGRLEeelrvp--rflweVGFAAFEIARRHr--------------------- 213 Mycobacterium s...
YP_001547619 175 IGVALq------------qGASEIWALEIGLDAaa---------tvPPFGVRGSLTRTfdalmrr-------------qm 220 Herpetosiphon a...
YP_001108440 171 ISRAVe------------qGAERVYVLPCGGSEp-----------fEFDRRRRGVGTVatwpppqsppks---itgvnga 224 Saccharopolyspo...
XP_001011026 204 VFGAIdrckelv-ddvsqiTVDVILVTSKTFEQd-----------vPDDLKPIKVGTLsqkvk----------------d 255 Tetrahymena the...
Feature 1                        
NP_286749    300 dawrQQGYEDTMLAME 315 Escherichia coli O157:H7 EDL933
YP_701867    230 rvvpPLCPLDTSPADF 245 Rhodococcus sp. RHA1
ZP_03210588  200 aaitEMMALGKKDAEM 215 Lactobacillus rhamnosus HN001
NP_518342    234 svvpPLCPLEVSPYDY 249 Ralstonia solanacearum GMI1000
CAJ89425     242 hrqiERDLREVSRRLP 257 Streptomyces ambofaciens ATCC 23877
6689533      209 ----FMIALDTKYLCS 220 Xanthomonas campestris
YP_889976    214 ----FHGDLERVRSDV 225 Mycobacterium smegmatis str. MC2 155
YP_001547619 221 aherELVRLAAKAGVK 236 Herpetosiphon aurantiacus ATCC 23779
YP_001108440 225 amgaAMVAAARLDMQV 240 Saccharopolyspora erythraea NRRL 2338
XP_001011026 256 hhnaRRSLLEAYEAFP 271 Tetrahymena thermophila SB210

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