Conserved Protein Domain Family
Pat_hypo_Ecoli_yjju_like

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cd07208: Pat_hypo_Ecoli_yjju_like 
Hypothetical patatin similar to yjju protein of Escherichia coli
Patatin-like phospholipase similar to yjju protein of Escherichia coli. This family predominantly consists of bacterial patatin glycoproteins, and some representatives from eukaryotes and archaea. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have also been found in vertebrates.
Statistics
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PSSM-Id: 132847
View PSSM: cd07208
Aligned: 49 rows
Threshold Bit Score: 172.794
Threshold Setting Gi: 149926816
Created: 14-Nov-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active sitenucleophile
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the crystal structure of semet patatin (1OXW)
  • Comment:catalytic dyad is formed by Ser and Asp
  • Comment:oxyanion hole is formed by two Gly and one Arg

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             ## #                              #                                        
732119        27 LVCEGGGQRGI-FTAGVLDEFMRAQFn----pFDLYLGTSAGAQNLSAFICNQPGyarkvi------------------- 82  Escherichia coli
XP_001694925  54 LVVEGGGMRGC-ISGAMLMALHDLGIsq---vFDVVYGASAGAINATYFLTGQRNglriyh------------------- 110 Chlamydomonas r...
ZP_01915075   12 LALAGGGPLGAiYEIGALVALSEAIDgldlndMSVYVGVSAGGIVATGLAHDLTPhqiyklfiegepee----------- 80  Limnobacter sp....
YP_958100     15 LALGGGGPLGGiYEIGALRALDEALDgldfnnIDVYVGVNAGSFVAANLANQMTTaqlcrifvrneaevh--------pf 86  Marinobacter aq...
YP_117197     22 LVIEGGGSRGV-YSSGMVQGLEELGLsa---vFDAVYGTSAGAINGAWLLCGRAVpgmrsw------------------- 78  Nocardia farcin...
NP_761139      4 LVVEGGAMRGV-FASGVLDAFLQKNYq----pFDLAIGVSAGASNLVGYLANAQGrsfnvi------------------- 59  Vibrio vulnific...
YP_002126181   5 LVVEGGAMRGI-FAAGVLDKFMEHDYy----aFDFTLGVSAGATNLSTYVSKMPGlsktii------------------- 60  Alteromonas mac...
YP_001636863   8 LVLAGGGVAGAaYEIGALCAIDQVLEhlsvneFDVYVGTSAGALISACLANNMSPrtlisvlessllgidqlephhlyql 87  Chloroflexus au...
YP_001862729 104 LAISGGGDNGA-FAAGLLNAWTETGTrp---eFKLVTGISTGALIAPFAFLGEKYdat---------------------- 157 Burkholderia ph...
ZP_02736657   99 LVVTGGGSYGA-YPAGVLVGWTATGTrp---eFDVVTGISTGALLGAFAFLGPGE------------------------- 149 Gemmata obscuri...
Feature 1                                                                                        
732119        83 --------mryttKREFFDPLRFVRGGNLIDLDWLVeatas------------------------------qmplQMDTA 124 Escherichia coli
XP_001694925 111 --------edltqGTAFLDFRNLFSSSGAPVMNVDFlidqv------------------------------mntsKPLDW 152 Chlamydomonas r...
ZP_01915075   81 lafdpsillrpawKEYWMRLRKVPSLLGTAVSDYFLrddatwvscierlgaaiptglfngdelhewmadliakggGTNDF 160 Limnobacter sp....
YP_958100     87 hpevfyrpalreiGRRLLAVPGLLSTAVSRFVNNPYdqslleamtilaqaapagl--fdneglheylkraftmlgRTNDF 164 Marinobacter aq...
YP_117197     79 --------snpdiMRAVIDPARLLRGGAAFDVRYLVhrvy--------------------------------dgvEPMDF 118 Nocardia farcin...
NP_761139     60 --------tklatSQRFYNPKRFIKGGDLVDVKWLVdes---------------------------------mrrYPIEA 98  Vibrio vulnific...
YP_002126181  61 --------tqyatKREFFSPLRFIKGGHMTDVHWLWhh-----------------------------------skQSMNI 97  Alteromonas mac...
YP_001636863  88 nitdllyraahlpGALVQAIQRWVREGGEVSLLDLIetvavglptglyd-------------srsleqylraaleQPGRS 154 Chloroflexus au...
YP_001862729 158 ----------lkqVYTTISPNDVLEKRSLLGGVLSDamadnrpll----------------------altrkfvtEDLLK 205 Burkholderia ph...
ZP_02736657  150 -------------DAELQRCYTTLRDRDIYKRNRIIpsllseslad--------------------sgplaqvieRTAND 196 Gemmata obscuri...
Feature 1                                                                                        
732119       125 ARLFDSgk------sFYMCACRQDDYAPNYFlptk----------qnwlDVIRASSAIPGFYRSg-------VSLEGINY 181 Escherichia coli
XP_001694925 153 DGVLTSpa------pLKVVASCLDSLQPVIIsdfad--------raelaEALKATAAVPQIAGPp-------RQLRGRQL 211 Chlamydomonas r...
ZP_01915075  161 RSLRNR---------LILVATDLDSGDSIPFgmpgfd-------dvpisKAVQASASLPGLFPP--------TRIANRHY 216 Limnobacter sp....
YP_958100    165 RQLKRS---------LYVVAADVESTEAVCFgapgyd-------hvpisRAVQASTSSPGLYVP--------VEIDGRFY 220 Marinobacter aq...
YP_117197    119 DAILNHat------tFHPIATDARTGNAVDLrphiyd-------krslmRALRASANLPILAGGp-------ILLDGVPY 178 Nocardia farcin...
NP_761139     99 ERLFTNt-------rLLATTTDIATGLPHYQqltk----------qnvnQLLEASCALPIAYRQp-------PCFAGSCF 154 Vibrio vulnific...
YP_002126181  98 PEPGEKsc-----mpLFVGITNADSGECEYIqatk----------dnvdDLMVASCALPTAYRDe-------ITINGTRY 155 Alteromonas mac...
YP_001636863 155 NRFADLdh------eLMIVATDLDTGERAIFglppld-------nvpisLAVCASAAIPIFYRP--------VRIGDHDY 213 Chloroflexus au...
YP_001862729 206 EIAAEYakg----rmLLVGTTDLDSRRGVIWdmgkiatyggpaaldlfvKVLIASTSIPGAFPPmmidvevgGKRYQEMH 281 Burkholderia ph...
ZP_02736657  197 ERIARFaaehakgrrYYVGTTDLDARRAVVWdmgaiaarntpesrelfrKVLLASAAIPGFFPPvripmtvdGRRYVERH 276 Gemmata obscuri...
Feature 1         #                                                                              
732119       182 LDGGISDAIPVk-----------eAARQGAKTLVVIRTVPSQMYYtpqwfkrmerwlgdsSLQPLVNLVQHhe------- 243 Escherichia coli
XP_001694925 212 VDAAVFEPVPVp-----------sAIRDGCTHVLVLCTRPAPTQRspw---------aqrMRSTIEAMAKStvlnapymr 271 Chlamydomonas r...
ZP_01915075  217 VDGALKKTLHAs-----------tALKEGVELLICLNPLVPYDDRlnpknhr--rrakgkAFQPGSRLYEGglplvlsqt 283 Limnobacter sp....
YP_958100    221 VDGTLRKGLHAs-----------iAFEDGADLVLAVNPQVPIDASaavragt--mkpgelTRSGMPNLLSQmfrtm---- 283 Marinobacter aq...
YP_117197    179 FDGGIAEPIPIh-----------aAVRGGGTHFLVLRTRRADESRppasrvh-rlvgggyLRRRAPGAYRAwla------ 240 Nocardia farcin...
NP_761139    155 TDGGVSDSIPVk-----------eAYRQGARDITVVLSHPLSYEMpesrht----wltntLLSRQPAIAKAlrqr----- 214 Vibrio vulnific...
YP_002126181 156 LDGGVADAIPAi-----------qAYKMGARDITVILSQPVGFTKpevksp----wlmqkMYKNQPALLEKmlqr----- 215 Alteromonas mac...
YP_001636863 214 IDGGLRGTASLd-----------vAIERGAELIVCINPMVPFDNRrhppga---aisdqgIQRIGNQVFRTfiha----- 274 Chloroflexus au...
YP_001862729 282 VDGGVVAQVFAypa--------tlRVAEEASALGVIRERKLYIIRnarldsd-wmqvqraTMRIASRAVESmiqsq---- 348 Burkholderia ph...
ZP_02736657  277 IDGGTTSSMFFappyappghepppGWLHGSNLYILVAGKLYPDPSpvk----------prTFAIASNAVSTviydq---- 342 Gemmata obscuri...
Feature 1                                                                                   
732119       244 ------------------tsYRDIQQFIEKPPGKLRIFEIYPPkpl------hsiALGSRIPALREDYKLGRLCG 294 Escherichia coli
XP_001694925 272 eawrtarspdivswdqqlvaTLHGCPHEVQRSMGAYVLPLYPEhta------gchPLCLDPNTLLAACDVGRQAL 340 Chlamydomonas reinha...
ZP_01915075  284 ------------frsiihsrMDIGMERYGHLYPNADIVLFEPQhgdgeffftnpfSYASRRRLCEHAYQRTREEL 346 Limnobacter sp. MED105
YP_958100    284 ----------------vysrMQSGIAQYTRDYPDKDILLFEPTrddaklffsnvfSFQSRRMVCEHAYQMTRRDL 342 Marinobacter aquaeol...
YP_117197    241 ------------------rpDQERAEDRLLADLGEKVWQIHPPpgsp-----tvdGTARDTGLLSRALELGRRAV 292 Nocardia farcinica I...
NP_761139    215 -----------------aqnYNAALAFIRFPPADATIRVIAPEegf------kvkRLTMNQSKLHQGYQMGITQG 266 Vibrio vulnificus CMCP6
YP_002126181 216 -----------------asiYNDTLAFLNSPPSDCTIRVIAPDeaf------cvkRLTMDKKKLLKGYGQGRRMA 267 Alteromonas macleodi...
YP_001636863 275 -----------------glhYHIKQVRRRHPEVDIILIEPSRQdrt------mfaENTMRFHTRMTIARHGFESV 326 Chloroflexus auranti...
YP_001862729 349 ---------------gvgdlYRIYATANRDGVDFNLAFIPSSFqa--------phEEEFDTEYMRALYYTAYNMA 400 Burkholderia phymatu...
ZP_02736657  343 ----------------trsdLHKLFLLTAMTGMTYNVSVIPPEins------pleSTKFDPKEMSRLFCAGAQWA 395 Gemmata obscuriglobu...

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