Conserved Protein Domain Family
Pat_TGL3-4-5_SDP1

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cd07206: Pat_TGL3-4-5_SDP1 
Triacylglycerol lipase 3, 4, and 5 and Sugar-Dependent 1 lipase
Triacylglycerol lipases are involved in triacylglycerol mobilization and degradation; they are found in lipid particles. TGL4 is 30% homologus to TGL3, whereas TGL5 is 26% homologus to TGL3. Sugar-Dependent 1 (SDP1) lipase has a patatin-like acyl-hydrolase domain that initiates the breakdown of storage oil in germinating Arabidopsis seeds. This family includes subfamilies of proteins: TGL3, TGL4, TGL5, and SDP1.
Statistics
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PSSM-Id: 132845
View PSSM: cd07206
Aligned: 24 rows
Threshold Bit Score: 398.123
Threshold Setting Gi: 74626314
Created: 7-Nov-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active sitenucleophile
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the crystal structure of semet patatin (1OXW)
  • Comment:catalytic dyad is formed by Ser and Asp
  • Comment:oxyanion hole is formed by two Gly and one Arg

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                    ## #
Q12043       114 IRTKWVRNLGNMNNvnLYRHSHTGTKQIIhdyleesqavlt--alihqsnmndhyLLGILQQTrrnIGRTALVLSGGSTF 191 baker's yeast
P0C584       330 IEACVKNNFVGIENprLYSQTYYGTKNLVqnyvdeversik--flidtkqltkeqKRVMFKGIcanYGRTALCLSGGATF 407 Neurospora cras...
NP_196024    162 MRADLVRNLGNMCNseLHKGRLQVPRHIKeyidevstqlrmv-cnsdseelsleeKLSFMHETrhaFGRTALLLSGGASL 240 thale cress
Q9Y7P3       113 LRSSLLRNFGNIGNssLYTENYSGTKILIeeyvrevnncle--flyhtkrlsydvKCDFFSAArisFGTTCLYFNGGTAF 190 fission yeast
XP_001031401 115 IRSHPFKNIANILNpsLYQQCYFGTKQVIhdfineldlsik--yiaqsqhldlseKLEFFAEVrhaLGRTAMIFSGGAFL 192 Tetrahymena the...
XP_976660    114 LRSHAFRNIGNILDplLYKECFNGTKDLIedfqneidlciq--yiastsqlsvrkKMEFFIEMrhaVGRTALVLSGGGLM 191 Tetrahymena the...
YP_958859     76 LREGLHHDLGNMGNpaLYTRSRVGTKHLIeeyitqvcesldylcdhpvpgfpvydKLQFFRDTltsYGRPTLLLSGGASL 155 Marinobacter aq...
YP_433865     78 LREGLHHDLGNMGNalLYQHSYIGTKHLIeeyvnqvcdalnyvcdndipelpprqKLEFFKDTsisFGRPSLLLSGGATL 157 Hahella chejuen...
YP_046026     86 LQEGLTHDIANIGHpmLFAATYVGTKQIIedyieevslslafiaasqcqtltvaeKLKFFKNCqktYGQPALMFSGGATL 165 Acinetobacter s...
YP_001706756  86 LKEGLTYDIANIGHpmLFAATHVGTKKLIedyieevsqslayiassecitfqrkeKIEFFENCekaYGQPALMFSGGATL 165 Acinetobacter b...
Feature 1                                #                                                       
Q12043       192 GlFHIGVLAALFEsdLMPKVISGSSAGAIVASIFCVHTTQEIpslltnvlnmefnifnddnskspnenllikisrfcqng 271 baker's yeast
P0C584       408 AyYHFGVVKALLEvdYLPDIITGTSGGALVAALVATRTNDELkellnpalahkitacresftvwf-------wrwwktga 480 Neurospora cras...
NP_196024    241 GaFHVGVVRTLVEhkLLPRIIAGSSVGSIICAVVASRSWPELqsffenslhslqffdqlggvfsi-------vkrvmtqg 313 thale cress
Q9Y7P3       191 GlYHFGVAKTLWKrnLLPQILAGCASGALIASLLSVYRDEELnglfdtfpselwkicqqtsdysl--------skvveyg 262 fission yeast
XP_001031401 193 GlYHAGVAKSLFEqnLLPRILAGSSAGSITAAFIGTTKYEDLgnyfdreqrkinysaflqrdprnsaf--rkiirflkeg 270 Tetrahymena the...
XP_976660    192 GmYHVGVVKTLYEqkLLPRIISGSSAGSIIAAFICTRKYEELpslfltdginwqafqkrdpkgqmir----klkrffkeg 267 Tetrahymena the...
YP_958859    156 GmFHFGVIKALWEkgLLPQVIAGSSIGAIIAGILGIHTDAEIpemlvpeshnlkawkwrglls------------amrgt 223 Marinobacter aq...
YP_433865    158 GlFHLGVIKALWErgLLPQVIAGSSVGSVIAAMLGTHTDAEIpemlepsrhnlkawrwtglfn------------glrgr 225 Hahella chejuen...
YP_046026    166 GlFHSGVCKTLIQqdLMPRVLSGSSAGAIMAGMLGTSTASEFqkillgenffseafhfrgvrd-----------llkgng 234 Acinetobacter s...
YP_001706756 166 GlFHTGVCKALIEqdLMPKVLSGSSAGAIMTGMLGISASEDIqnllngeqffsdafhfrklre-----------likgng 234 Acinetobacter b...
Feature 1                                                                                        
Q12043       272 twfnnqplintmlsfLGNLTFREAYNKTGKILNITVspasiyeqPKLLNNLTAPNVLIWSAVCASCSLPGVFpSTPLFEK 351 baker's yeast
P0C584       481 rfdsvdwakqcawwcHGSLTFREAYERTGRILNVSCvpsdphspTILCNYLTSPDCVIWSAVLASAAVPGILnPVVLMMK 560 Neurospora cras...
NP_196024    314 alhdirqlqcmlrnlTSNLTFQEAYDMTGRILGITVcsprkhepPRCLNYLTSPHVVIWSAVTASCAFPGLFeAQELMAK 393 thale cress
Q9Y7P3       263 nmldismiasfvrqrLGTITFQEAFERTGRIVNIVAppsavsgsPQVLNYFTAPNVLIWSAVCSSNSWAAIYrSSPLLAK 342 fission yeast
XP_001031401 271 yfmdmniykkflrdnLGDKTFQEAFDDTGFILNITVtgagrhtqDRVLNYLTAPNVVIWSAVCCSCSLPFVFpPSDLYFK 350 Tetrahymena the...
XP_976660    268 vlldvkvlyeftrqnIGDITFQEAYDRTGFILNITVtgqgthdnDRVLNYLSAPNVIIWSAVCCSCGIPYIYgPSDLLCK 347 Tetrahymena the...
YP_958859    224 glmdqdtlrrclrenIGDYTFEEAYQRTGRSINISVspvqahqkARLLCGYTSPYLLVWSAALASAAVPGIFpPVTLMKK 303 Marinobacter aq...
YP_433865    226 gfmdvrqlekclrsnIGEYSFLEAYQRTGRSINISVspvhhhqkERLLSGYTSPYLLVWSAALASSAVPAVFpPVRLMRK 305 Hahella chejuen...
YP_046026    235 gfadvkylkkflienLGDLTFSEAYERSGLHINVAVapydgsqnARILNAYTAPNLLVWSAVLASCAVPVLFpPVRLTSK 314 Acinetobacter s...
YP_001706756 235 giadvhylkkflienLGDLTFEEAFKKSGLNINVAVapydatenPRIMNAIMTPNVLVWSAVLASCAVPVLFpPVRLTSK 314 Acinetobacter b...
Feature 1                                      #                                                 
Q12043       352 Dphtgkikewg-------atnlhlsnmkFMDGSVDNDMPisRLSEMFNVDHIIACQVNIHVFPLLkfsntcvggeiekei 424 baker's yeast
P0C584       561 Nrdgslep--------------ysfghkWKDGSLRTDIPikSLNLHFNVNFSIVSQVNPHINLFFfssrgsvgqpvthrk 626 Neurospora cras...
NP_196024    394 DrsgeivpyhppfnldpevgtksssgrrWRDGSLEVDLPmmQLKELFNVNHFIVSQANPHIAPLLrlkdlvrayggrfaa 473 thale cress
Q9Y7P3       343 Lpdgstevct----------pknfiwpyAGLPNTGRSNPyaRISEIFNVNHFVITQSRPSLFPTFydelhhhrvsgyslk 412 fission yeast
XP_001031401 351 Nrngqlik--------------yiedskFIDGSIAFDIPhnQLSEQFNVSTTIVSQVNPHVVPLLnhtekiryknklivk 416 Tetrahymena the...
XP_976660    348 Nekdeivl-------------yldkkkkFVDGSIGADLPmhRLSEFFNVNSFIVSQTNPWVVPFMdrgekhpivylpfvk 414 Tetrahymena the...
YP_958859    304 Dlngnslp--------------ymprlkFVDGSVVSDLPieRLMHLYDVNFTIVSQTNPHVVPFLtdrgqdeklsltnlp 369 Marinobacter aq...
YP_433865    306 Denggivp--------------ympklrWVDGSVVSDLPieRLKHLYDINFSIVSQTNPHIVPFMnakkrdqkislvslp 371 Hahella chejuen...
YP_046026    315 Krdgshtp--------------ymantkWVDGSVRSDFPqeKMARLYNLNYTIASQVNPHVVPFMqsdasryrkdilswp 380 Acinetobacter s...
YP_001706756 315 Rydgehtp--------------ymantkWVDGSVRSDFPqeRMARLYNLNYTIASQVNPHVVPFMqddarrfrkdvlswp 380 Acinetobacter b...
Feature 1                                                                                        
Q12043       425 tarfrnqvtkifkff---sdetihfldilkelefhpylmtklkhlflQQYSGNVTILPdlsmvgQFHEVLKNPsqlfll- 500 baker's yeast
P0C584       627 grgwrggylgsateqyikldltkwlrvlrqlellprplgqdwsqlwlQTFGGTVTIWPksi-psDFLKILSDPdpprla- 704 Neurospora cras...
NP_196024    474 klahlveme---------------vkhrcnqvlelgfplgglaklfaQEWEGDVTVVMpat-laQYSKIIQNPthvelq- 536 thale cress
Q9Y7P3       413 mirlvglem--------------ayrfrqldilgllpprlrrffvddYVPSAYITLTPtfs-fsDIKHAFTKPslsdiq- 476 fission yeast
XP_001031401 417 ilkilef-------------------ikmlisqevrlslvtavrvmdQNYEGDITVWPipk-ltDYLNLLKNPtsqefie 476 Tetrahymena the...
XP_976660    415 lfniirkll---------------nselkhrvqqlsdfdllpgalskWTYVGHITIAPvpr-wsDYANVLEVPkssddfe 478 Tetrahymena the...
YP_958859    370 shllksevqfhgq-------gvfdylrkrvrpeilrqlsgqmytimaQRYSGDVTIAPnys-lrHFRRMLANPspeyvr- 440 Marinobacter aq...
YP_433865    372 friaraemqfhgm-------gafdylrkqaepellrqlcgqaytilaQRYYGDVTIAPrys-fwHFRRMLSNPspdvve- 442 Hahella chejuen...
YP_046026    381 qrilrrqgkvisl------gimdftrerlgnvppvrrlldhgygivgQRYYGDVNIIApfn-lrQYAYMLQNPrphlfk- 452 Acinetobacter s...
YP_001706756 381 erilrrqgkvlsm------glmdftrqrlgaispvrrlldhgygvvgQRYYGDVNIIAkys-lkHYAYTLQNPrphlfk- 452 Acinetobacter b...
Feature 1                                     
Q12043       501 hqttlGARATWPKISMIQnNCGQEFALDK 529 baker's yeast
P0C584       705 rmiheGQQSAFPKVKFIAnRLKIERLVER 733 Neurospora crassa OR74A
NP_196024    537 kaanqGRRCTWEKLSAIKsNCGIELALDD 565 thale cress
Q9Y7P3       477 ywilvGERATWQAIPLLQvRCKTEISLRH 505 fission yeast
XP_001031401 477 pytaaGARMTYGKIPHIEiLTKFERVIEE 505 Tetrahymena thermophila SB210
XP_976660    479 hfmlgGARKTFSKIPYIKaYMRYENSLTR 507 Tetrahymena thermophila SB210
YP_958859    441 emileGERATWPKISMIRsHARISKTLER 469 Marinobacter aquaeolei VT8
YP_433865    443 rlaleGERATWPKISMIRtHSKISLTLEK 471 Hahella chejuensis KCTC 2396
YP_046026    453 llqqqGERATWPKISAIEtHARIGKTIQH 481 Acinetobacter sp. ADP1
YP_001706756 453 rlqreGERATWPKISSIEtHARIGKTIQH 481 Acinetobacter baumannii SDF

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