Conserved Protein Domain Family
Pat_PNPLA6_PNPLA7_NTE1_like

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cd07205: Pat_PNPLA6_PNPLA7_NTE1_like 
Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1
Patatin-like phospholipase domain containing protein 6 (PNPLA6) and protein 7 (PNPLA7) are included in this family. PNPLA6 is commonly known as Neuropathy Target Esterase (NTE). NTE has at least two functional domains: the N-terminal domain putatively regulatory domain and the C-terminal catalytic domain which shows esterase activity. NTE shows phospholipase activity for lysophosphatidylcholine (LPC) and phosphatidylcholine (PC). Exposure of NTE to organophosphates leads to organophosphate-induced delayed neurotoxicity (OPIDN). OPIDN is a progressive neurological condition that is characterized by weakness, paralysis, pain, and paresthesia. PNPLA7 is an insulin-regulated phospholipase that is homologus to Neuropathy Target Esterase (NTE or PNPLA6) and is also known as NTE-related esterase (NRE). Human NRE is predominantly expressed in prostate, white adipose, and pancreatic tissue. NRE hydrolyzes sn-1 esters in lysophosphatidylcholine and lysophosphatidic acid, but shows no lipase activity with substrates like triacylglycerols (TG), cholesteryl esters, retinyl esters (RE), phosphatidylcholine (PC), or monoacylglycerol (MG). This family includes subfamily of PNPLA6 (NTE) and PNPLA7 (NRE)-like phospholipases.
Statistics
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PSSM-Id: 132844
View PSSM: cd07205
Aligned: 32 rows
Threshold Bit Score: 171.19
Threshold Setting Gi: 115374448
Created: 2-Jan-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active sitenucleophile
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the crystal structure of semet patatin (1OXW)
  • Comment:catalytic dyad is formed by Ser and Asp
  • Comment:oxyanion hole is formed by two Gly and one Arg

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                ## #                        #                                            
Q6ZV29        926 IALVLGGGGARGCAQVGVLKALAECGIPVDmVGGTSIGAFVGALYSEErnysqmrirakqw------------------- 986  human
ZP_02425963    24 VGVVMSGGGAKGLYHIGVLQALEESGIPIDyVSGTSMGSIIAGMYAAGyspeemrrivasgvvkqwvsgridpsylpyyr 103  Alistipes put...
YP_635354     351 VGLALSGGGVWGFYHVHILRWLVSQGVPIDiVSGASMGSLVGAYFCGSaldghdglegl--------------------- 409  Myxococcus xa...
YP_001931779    3 IGIALSGGAVRGLAHIGVLKALEELDIKPDiVSGVSAGSIIGSFYCAGyspkemeeia---------------------- 60   Sulfurihydrog...
NP_809687      15 IGYALSGGFIKGFAHLGVMQALLEHDIKPDiISGVSAGALAGVFYADGnephqvieyf---------------------- 72   Bacteroides t...
NP_905141      13 IGLALSGGAAKGFAHSGVLHALEDNGIRPDiIAGTSAGALVAALYADGyrpeeipqlf---------------------- 70   Porphyromonas...
NP_809809       9 VGLVLSGGGAKGLTHIGIIRALEENNIPIDyITGTSMGAIIGSLYAMGyspddmeellksedfkrwysgqieekyv--yh 86   Bacteroides t...
YP_593142      37 VGVALEGGAALGLAHIGVLQWMEEHHIPIYyVAGTSMGGLVGGMYATGnspeemkafiskinwddvlagqtey------- 109  Acidobacteria...
EDZ62757       22 IALVLSGGGARGGAHVGVLKVLEENKIPVDiIVGTSMGSFVGGLYASGrsaddieqmlvssdwknyirtdfdra------ 95   Campylobacter...
ZP_01894728    29 VGLVLSGGGAKGMAHVGVLRVLEELQVPVDiVVGTSAGSAVGALYASGmevqeieerfiemdwvssfrddpgr------- 101  Marinobacter ...
Feature 1                                                                                         
Q6ZV29        987 -------------aegmtslmkaalDLTYPITSMFSGagfnssif-----svfkdqqIEDLWIPYFAITTDITASamrvh 1048 human
ZP_02425963   104 rntgtpiflsirlnmkdhpddpnasRFRLPSYLISSNqidlaladlfgpattasrrdFDSLMVPFLCVASDMNTRrpvvl 183  Alistipes put...
YP_635354     410 ---------------rrleeramsrQLTLAATAAIVTtyslerfv----eqdlgrlcLEELAIRFLPVTTDLTSGdcval 470  Myxococcus xa...
YP_001931779   61 ----------------lktnlnsfiLPSISKKALFSLdklesfle-----kyigkinIEDLKIPLIIAATNLNKAtieyf 119  Sulfurihydrog...
NP_809687      73 ----------------sghkfqdltKLVIPKKGLFDLcefidflh-----tnlkaknLEELQIPLIITATDLDHGrmvhf 131  Bacteroides t...
NP_905141      71 ----------------rgknfrfltEWQIPQRGVFSIqrfksflr-----stlrhknIEDLPLPIRIVATDLDRGvvkvf 129  Porphyromonas...
NP_809809      87 fkknvptpeffnirfsfkdslknfkPQFLPTSVVNPIqmnlvfvdlyaratasckgdFDKLFVPFRCIASDVYNKkqlvm 166  Bacteroides t...
YP_593142     110 -qnltyrrkedatqypnrlefgirdGVRFPEGFNSGHqvglildqi--alpysemksFDDLPIPFACVATDLVSKkqhvf 186  Acidobacteria...
EDZ62757       96 dtpmrvkeveyiyqgrlglgidsknSIVLPTGVLKRQplllkfmae--tqhaqniidFDDLAIPFRAVATNIANGdpvvl 173  Campylobacter...
ZP_01894728   102 aykpvrrkrqdwrypvspgigvrldGLHLGGGIIAGQnlgfilnel--trdaalvedFDELAIPFRAVATDLETGeevvi 179  Marinobacter ...
Feature 1                                         #                          
Q6ZV29       1049 tdGSLWRYVRASMSLSGYMPPLcdpkdghlLMDGGYINNLPADvar-smGAKVVIAIDV 1106 human
ZP_02425963   184 rkGDMGEAIRSSMSIPLAFKPMkid--tmlLYDGGIYDNFPWEpldkefHPDFLIGSKC 240  Alistipes putredinis DSM 17216
YP_635354     471 eqGPVALAVRASGSAPGIWGPTvvp--parYVDGAFTSMVPAHvll-naGADVIFSSNI 526  Myxococcus xanthus DK 1622
YP_001931779  120 qsGSLIKTVKASCSIPVMFKPVkid--kyfYVDGGVMNNLPVEsl--reKVDFAIGVEV 174  Sulfurihydrogenibium sp. YO3AOP1
NP_809687     132 hrGSIAERVAASCCMPVMFAPVnid--gtnYVDGGLMMNLPVStl--rrICDKVVAVNV 186  Bacteroides thetaiotaomicron VPI-5482
NP_905141     130 sqGSLVETVTASCSIPILFNPVeid--gttYVDGGLFKDLPASvi--reDCRYLIGVHL 184  Porphyromonas gingivalis W83
NP_809809     167 rnGDLGDAVRASMSFPFMFKPIeid--nvlAYDGGIYNNFPTDvmrddfHPDIIIGSVV 223  Bacteroides thetaiotaomicron VPI-5482
YP_593142     187 reGSLGQALRSTMSMPGVFNPVrtd--sqvLVDGALLENLPVDitk-qlGADIVIAVHL 242  Acidobacteria bacterium Ellin345
EDZ62757      174 ksGSLAKAIYASSSIPGGLQPInid--gidLVDGGVSDNLPVQlak-dmGADIIIAVDV 229  Campylobacterales bacterium GD 1
ZP_01894728   180 gsGNLSEAIRASMSVPGVYAPVtln--grlLVDGGVANNLPVSvah-elGADIVIAVDI 235  Marinobacter algicola DG893

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