Conserved Protein Domain Family
Patatin

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cd07198: Patatin 
Patatin-like phospholipase
Patatin is a storage protein of the potato tuber that shows Phospholipase A2 activity (PLA2; EC 3.1.1.4). Patatin catalyzes the nonspecific hydrolysis of phospholipids, glycolipids, sulfolipids, and mono- and diacylglycerols, thereby showing lipid acyl hydrolase activity. The active site includes an oxyanion hole with a conserved GGxR motif; it is found in almost all the members of this family. The catalytic dyad is formed by a serine and an aspartate. Patatin belongs to the alpha-beta hydrolase family which is identified by a characteristic nucleophile elbow with a consensus sequence of Sm-X-Nu-Sm (Sm = small residue, X = any residue and Nu = nucleophile). Members of this family have been found also in vertebrates. This family includes PNPLA (1-9), TGL (3-5), ExoU-like, and SDP1-like subfamilies. There are some additional hypothetical proteins included in this family.
Statistics
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PSSM-Id: 132837
View PSSM: cd07198
Aligned: 19 rows
Threshold Bit Score: 93.1748
Threshold Setting Gi: 15800735
Created: 2-Jan-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active sitenucleophile
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the crystal structure of semet patatin (1OXW)
  • Comment:catalytic dyad is formed by Ser and Asp
  • Comment:oxyanion hole is formed by two Gly and one Arg

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           ## #                            #                                          
P41247       6 LSFAACGFLGiYHLGAASALCRhgkklvkdvkaFAGASAGSLVASVLLTapekieecnqft------------------- 66   human
Q6ZV29     928 LVLGGGGARGcAQVGVLKALAEcgip----vdmVGGTSIGAFVGALYSEernysqmrirakqw----------------- 986  human
Q04958    1373 LVLGGGGARGiSHLGVIQAIEEqgip----vdvIGGTSIGSFVGGLYAKdydlvpiygrvkkf----------------- 1431 baker's yeast
EDY37539     6 LALGSGGARGwAHIGVIRALQEegig----isgIAGASIGALVGAMYCAgelddledfvrd------------------- 62   Cyanobium sp. PC...
P0A642     309 LVMAGGGARGlAHFGVYQELTEagvv----idrFGGTSSGAIASAAFALgmdagdaiaaar------------------- 365  Mycobacterium tu...
P0C584     399 LCLSGGATFAyYHFGVVKALLEvdyl----pdiITGTSGGALVAALVATrtndelkellnpalahkitacresftvwfwr 474  Neurospora crass...
NP_196024  232 LLLSGGASLGaFHVGVVRTLVEhkll----priIAGSSVGSIICAVVASrswpelqsffenslhslqffdqlggvfsivk 307  thale cress
Q9Y7P3     182 LYFNGGTAFGlYHFGVAKTLWKrnll----pqiLAGCASGALIASLLSVyrdeelnglfdtfpselwkicqqtsdysl-s 256  fission yeast
732119      27 LVCEGGGQRGiFTAGVLDEFMRaqfn---pfdlYLGTSAGAQNLSAFICnqpgyarkvim-------------------- 83   Escherichia coli
NP_286749    9 LVLSGGGAVGaYQAGVVKALAEcgtq----ismVSGTSIGAFNGAIIAAspdlsea------------------------ 60   Escherichia coli...
Feature 1                                                                                      
P41247      67 ----------------ykfaeeirrqsfGAVTPGYDFMarlrsgmesilp------------------------------ 100  human
Q6ZV29     987 ---------------aegmtslmkaaldLTYPITSMFSgagfnssifsvf------------------------------ 1021 human
Q04958    1432 ---------------agrissiwrmltdLTWPVTSYTTghefnrgiwktf------------------------------ 1466 baker's yeast
EDY37539    63 -----------------lrwrdlltyfdMVFPTSGLLDgnrvyellsehm------------------------------ 95   Cyanobium sp. PC...
P0A642     366 -----------------efiagsdplgdYTIPISALTRggrvdrlvqgff------------------------------ 398  Mycobacterium tu...
P0C584     475 wwktgarfdsvdwakqcawwchgsltfrEAYERTGRILnvscvp------------------------------------ 518  Neurospora crass...
NP_196024  308 rvmtqgalhdirqlqcmlrnltsnltfqEAYDMTGRILgitvcs------------------------------------ 351  thale cress
Q9Y7P3     257 kvveygnmldismiasfvrqrlgtitfqEAFERTGRIVnivapp------------------------------------ 300  fission yeast
732119      84 -----------------ryttkreffdpLRFVRGGNLIdldwlveatasqmpl--------------------------- 119  Escherichia coli
NP_286749   61 ---------------------avrlealWEHLGNNQVLsvnrlvyfsllkklfqamnlcqipgragallttllrhistin 119  Escherichia coli...
Feature 1                                                                                      
P41247     101 -------------------------------------------------psahelaqnrlHVSITNAKTrenhlvstfss 131  human
Q6ZV29    1022 ------------------------------------------------kdqqiedlwipyFAITTDITAsamrvh----t 1049 human
Q04958    1467 ------------------------------------------------gdtriedfwiqyYCNSTNITDsvqeih----s 1494 baker's yeast
EDY37539    96 ------------------------------------------------qamriedaaipfCCVATDLIRgkevql----r 123  Cyanobium sp. PC...
P0A642     399 ------------------------------------------------gntliehlprgfFSVSADMITgdqiih----r 426  Mycobacterium tu...
P0C584     519 ------------------------------------------------------sdphspTILCNYLTSpdc-------- 536  Neurospora crass...
NP_196024  352 ------------------------------------------------------prkhepPRCLNYLTSphv-------- 369  thale cress
Q9Y7P3     301 ------------------------------------------------------savsgsPQVLNYFTApnv-------- 318  fission yeast
732119     120 ----------------------------------------------qmdtaarlfdsgksFYMCACRQDdyapnyfl-pt 152  Escherichia coli
NP_286749  120 gfdnlmaqpllsdepltalmdhyldtdaladglplyvslypteggmqdiidciraelgvgTTKNAVFQHiqslp------ 193  Escherichia coli...
Feature 1                                                              #                       
P41247     132 redliKVLLASSFVPIYAglklve-------------------------ykgqkWVDGGLTNALPilp----------vg 176  human
Q6ZV29    1050 dgslwRYVRASMSLSGYMpplcdp-------------------------kdghlLMDGGYINNLPadvar-------smg 1097 human
Q04958    1495 fgyawRYIRASMSLAGLLpplee---------------------------ngsmLLDGGYVDNLPvtemr-------arg 1540 baker's yeast
EDY37539   124 sgcmvDAVRASISVPGIFtpfcd---------------------------gdrfLGDGGIVNPVPvdvar-------dlg 169  Cyanobium sp. PC...
P0A642     427 rgsvsGAVRASISIPGLIppvhn---------------------------geqlLVDGGLLNNLPanvmc-------adt 472  Mycobacterium tu...
P0C584     537 --viwSAVLASAAVPGILnpvvlmmknrd--------------gslepysfghkWKDGSLRTDIPiks----------ln 590  Neurospora crass...
NP_196024  370 --viwSAVTASCAFPGLFeaqelmakdrsgeivpyhppfnldpevgtksssgrrWRDGSLEVDLPmmq----------lk 437  thale cress
Q9Y7P3     319 --liwSAVCSSNSWAAIYrsspllaklpdgs----------tevctpknfiwpyAGLPNTGRSNPyar----------is 376  fission yeast
732119     153 kqnwlDVIRASSAIPGFYrsgvs--------------------------leginYLDGGISDAIPvk------------e 194  Escherichia coli
NP_286749  194 rgqqkEALLASAALPLLFrprev---------------------------qgtmFGDGGMGGWRNmqgntpvtplvdagc 246  Escherichia coli...
Feature 1             
P41247     177 rTVTISP 183  human
Q6ZV29    1098 aKVVIAI 1104 human
Q04958    1541 cQTIFAV 1547 baker's yeast
EDY37539   170 aELVIAV 176  Cyanobium sp. PCC 7001
P0A642     473 dGEVICV 479  Mycobacterium tuberculosis H37Ra
P0C584     591 lHFNVNF 597  Neurospora crassa OR74A
NP_196024  438 eLFNVNH 444  thale cress
Q9Y7P3     377 eIFNVNH 383  fission yeast
732119     195 aARQGAK 201  Escherichia coli
NP_286749  247 nMVIVTH 253  Escherichia coli O157:H7 EDL933

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