3C3D,3C3D


Conserved Protein Domain Family
CofD_like

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cd07186: CofD_like 
Click on image for an interactive view with Cn3D
LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis
CofD is a 2-phospho-L-lactate transferase that catalyzes the last step in the biosynthesis of coenzyme F(420)-0 (F(420) without polyglutamate) by transferring the lactyl phosphate moiety of lactyl(2)diphospho-(5')guanosine (LPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin ribitol (F0). F420 is a hydride carrier, important for energy metabolism of methanogenic archaea, as well as for the biosynthesis of other natural products, like tetracycline in Streptomyces. F420 and some of its precursors are also utilized as cofactors for enzymes, like DNA photolyase in Mycobacterium tuberculosis.
Statistics
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PSSM-Id: 132872
View PSSM: cd07186
Aligned: 26 rows
Threshold Bit Score: 358.448
Threshold Setting Gi: 119504590
Created: 6-Jan-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:substrate binding site [chemical binding site]
Evidence:
  • Structure:3C3D; Methanosarcina 2-Phospho-(S)-lactate transferase with bound 7,8-didemethyl-8-hydroxy-5-deazariboflavin ribitol (Fo),contacts at 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                    #                  #                
3C3D_A         1 XIIFSGGTGTPKLLDGLKEIlpeeELTVVVNTAEDLWVSGNLISPDLDTVLYLFSdqiDRKRWWGIENDTFGTYERXKel 80  Methanosarcina ...
YP_001260920   2 ILALAGGVGGARLARGLAAIlppgKLTIAVNTGDDFEHLGLLVCPDIDTVCYTLAginNAAQGWGLEGESWAFMDALGkl 81  Sphingomonas wi...
ZP_01301747    4 VVVLTGGVGGAKLVLGLSRIvageGLTAIVNTGDDFRHMGLHISPDIDTLLYTLSgkaNGAQGWGREGESWGFMAALRel 83  Sphingomonas sp...
ZP_01616788   10 YLALSGGVGGAKLALGLSKIldpeQLTIVANTGDDFEHLGLSISPDLDTVMYTLAeinNKELGWGLAGESWDTMDALArl 89  marine gamma pr...
YP_195718      2 ILALAGGVGGARLARGLAAAlapeALTIIVNTGDDFEHLGLHVSPDIDTVMYTLAglnNRQQGWGLAGESWAFMSALRrl 81  Azoarcus sp. EbN1
EEA96752       9 VTLIAGGVGGAKMAEGLYHLen-vELSIIGNIADDDAFHGLWVSPDIDTLTYTLAdviDRKQGWGVADESHRALETLSkl 87  Pseudovibrio sp...
YP_001633846   2 IVVLSGGVGAARFIEGLAAVvapeRIAAVVNTGDDMVLHGLYISPDLDIVTCTLAdviDRNQGWGIAGDTDACMQWLArl 81  Chloroflexus au...
ZP_02038156    3 TVVFSGGVGGSRFLSGLCRVmdqkDITVISNIGDDTEFYGLYVCPDIDIVLYTLAgriNPKTGWGLEGDTFQVLDALKkl 82  Bacteroides cap...
YP_270704      3 ILLLSGGVGGAKMAEGLYHSeygnELSVIGNVADDMLFHGLWVSPDIDTLTYTLAdliDTKKGWGLKDETTNTLEALErl 82  Colwellia psych...
ZP_01626669    7 TVLLAGGGGGARLARGFYGLvqhaETLVLTNPGDDFEHLGLLVCPDTDSVLYAVSdaiDAQRGWGRESESWSVLAEVErl 86  marine gamma pr...
Feature 1             ##    #                                                            #       
3C3D_A        81 GIEEGLKLGDRDRATHIIRSNIIRdgasltdsTVKLSSLFg-iKANILPXsddPVSTYIETaeGIXHFQDFWIGkr-geP 158 Methanosarcina ...
YP_001260920  82 GGESWFNLGDRDLATHVLRTGMIGrqsl-seiTALLAGRMg-iAHRIVPMsddRVRTMVDTdeGELPFQQYFVRrr-aeP 158 Sphingomonas wi...
ZP_01301747   84 DGEDWFQLGDGDLALHVARTHALTqgqslsqiTARFAAQWg-iATRILPMsdqALATILVTdqGRLEFQRYFVEqr-caP 161 Sphingomonas sp...
ZP_01616788   90 GGETWFRLGDRDLATHLQRSTLLAsgvnlsgvTQSLCQQLg-iIHPIIPMsddPVRTCVKTdkGDLAFQQYFVReq-ctP 167 marine gamma pr...
YP_195718     82 GGATWFQLGDQDLATHVERTWRLKtqpl-savTAEFCARLn-vRHRVVPMtddPVRTLVDTdeGRLAFQDYFVRrq-saP 158 Azoarcus sp. EbN1
EEA96752      88 GDDTWMSLGDRDVGLHIYRTHRRRqgdrptliAQDIARSFg-lTCDLILPtddVVQTRVKTdaGWLSFQEYFVKer-caP 165 Pseudovibrio sp...
YP_001633846  82 GAPTWFKLGDRDLALHIYRTARLQagatlsqvADEIRQALg-vAVSIIPMsddPAPTHVLTdqGELHFEEYFVRer-cqP 159 Chloroflexus au...
ZP_02038156   83 GHPCWFNLGDQDLATHLHRTMRLKegwplskvTAELARLNg-lELTVLPStdqRVETRFDTpmGDMPFQEYMVKhr-wqV 160 Bacteroides cap...
YP_270704     83 GCDTWMYLGDKDFATHIYRTQQKQsgirpsviAKHIAKQLg-vTANILLPtdqVIQNRIHTeqGWLDFQSYFVKkg-cqP 160 Colwellia psych...
ZP_01626669   87 GGPSWFQLGDRDIAMHLLRREGLDagqsltciTGNLAERLgirGLQIVPAseqSVRTVLTTaeGDLDFQSYFVGrrcepK 166 marine gamma pr...
Feature 1                                                                                        
3C3D_A       159 DVRGVDIRGvseasISPKVLEAFEKEEn--ILIGPSNPITSIGPIISLPGXRELLKKk--KVVAVSPIIgnapVSGPAGK 234 Methanosarcina ...
YP_001260920 159 RFRAIRFDGietarPSAGLLDAVADPAleaVILCPSNPVLSITPILALSGVRAALAArgvPIVAVSPFIggqaVKGPAAK 238 Sphingomonas wi...
ZP_01301747  162 AVRHIMFEGathavPAPGVIEAIQSADa--VLLAPSNPFLSIDPLLAVPGIGSAIKQtkaPVIAVSPLVggtaVKGPTAK 239 Sphingomonas sp...
ZP_01616788  168 EVEGFYFDGiesakPQPQMMDLLAGDElaaIIICPSNPFVSVDPILGLANVKDAMRNnsaPVIAISPIVagmaIKGPAAK 247 marine gamma pr...
YP_195718    159 RFRAISLAGieaarPHSALAAALADPAlaaIVICPSNPVLSIRPILALPGITELLRRrraPVVAVSPFIggqaIKGPAAK 238 Azoarcus sp. EbN1
EEA96752     166 EVRELHYDHieeahATEEALKVLAEADl--IVIAPSNPLVSILPILKVPGILEAVKAakaPKIGVSPIInggvVKGPADR 243 Pseudovibrio sp...
YP_001633846 160 VVHGVRLHAagpvrPAPALLPLLMSAEv--IIIAPSNPVVSVGPILAIPEVRTTLTTtntPVVAVSPIVggaaIKGPAVP 237 Chloroflexus au...
ZP_02038156  161 DIEKIRFVGaetasPAPGVLEALESAEr--IILAPSNPYISIGAILAVPGIREALERakcPVIAVSPIVggkaIKGPAAR 238 Bacteroides cap...
YP_270704    161 EILDIFVSGiedaqPTPESLKAINEADl--IIIAPSNPIVSINPIVNVPGIRAALKSskaPVVAVSPMIngktVKGPADR 238 Colwellia psych...
ZP_01626669  167 VESLEYQGAieaapAPDLLAFLQAGCDc--VILGPSNPYLSLAPMLAISGIVEALTRa-aQVVAVAPIVdgaaIKGPLAK 243 marine gamma pr...
Feature 1                                                                                
3C3D_A       235 LXPACGIevSSXGVAEYYqdFLDVFVFDErdradef-----aferlgcHASRADTLXTstEKSKELAEIVVQ 301 Methanosarcina mazei Go1
YP_001260920 239 IMGEIGLatTPAGLAAYYdgLLDGIVIDRvdtga---------dagtaALHVTATLMRdlDDQRRLADETIA 301 Sphingomonas wittichii RW1
ZP_01301747  240 LMQELSMavDNDSIARHYagLIDAILIDNgdrce----------apdiVVGRCATLMTtpDDKIRVAQAALD 301 Sphingomonas sp. SKA58
ZP_01616788  248 MMSELGIpaTAAEVARFYgnLIDGFVLDEsdyglks-----eieqcgiHVHCTNTIMKtlDDRIDLAKDVLS 314 marine gamma proteobact...
YP_195718    239 IMHELGLpvSPAGLASFYgdLLDGLVIDRadaala-------eglagpAIMATNTLMRddADQERLARETLH 303 Azoarcus sp. EbN1
EEA96752     244 MLASLGFesTAFGVAQIYadFLDCFVIDHadeqhis-----ainglglSTSQDAILMKtrEDKVRLAAELLT 310 Pseudovibrio sp. JE062
YP_001633846 238 LMKAVGLtpTALGVAETYadLIDGIVIDTidaelap-----aiqsrgiATLVTDTIMRgmPEKMALARATLE 304 Chloroflexus aurantiacu...
ZP_02038156  239 LLEQFGQpvSPVGVARVYqgLVSHMVIDNadrelag-----qleamgiVCGVTDTMMDsfPRKEALARFVLE 305 Bacteroides capillosus ...
YP_270704    239 MMAAMNFssDVLGVANCYqgLIDGFVIDIedqqfts-----vleasglKVMVAQTLMKnrIDKVSLAENVVA 305 Colwellia psychrerythra...
ZP_01626669  244 MMADRGLepTALSWVDEMk-TLHPGLVDLwvldrrdqdaaevlrlrgeRVFTCDTMMTdtTQKIALAGQLIE 314 marine gamma proteobact...

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