2HQS,2AIZ,3CYQ,3CYP,1R1M,2ZF8,2K1S


Conserved Protein Domain Family
OmpA_C-like

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cd07185: OmpA_C-like 
Click on image for an interactive view with Cn3D
Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA
OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.
Statistics
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PSSM-Id: 143586
View PSSM: cd07185
Aligned: 1046 rows
Threshold Bit Score: 67.5782
Threshold Setting Gi: 52842529
Created: 30-Sep-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
ligand binding
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:1AIZ; Haemophilus influenzae Pal with bound biosynthetic peptidoglycan precursor, UDP-N-acetylmuramyl-L-Ala-alpha-d-Glu-m-Dap-D-Ala-d-Ala, 4.5A distance
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                  ##                                ##      #   ##  #                   
2HQS_H         5 NNIVY---FDLDKYDIRsdFAQMLDAHANFLRSNpsykVTVEGHADEr----GTPEYNISLGERRANAVKMYLQGKGVSa 77  Escherichia coli
2AIZ_P        29 YNTVY---FGFDKYDITgeYVQILDAHAAYLNATpaakVLVEGNTDEr----GTPEYNIALGQRRADAVKGYLAGKGVDa 101 Haemophilus inf...
YP_845279     74 NCGVL---FPDDSTELKpdAPARIAPVAEVLAKYpatsIKVDGFTDRt----GSEKYDHEITESRATAVRDVLVGKGIDp 146 Syntrophobacter...
NP_713865    546 SIQINnlfFESKSFQIApeSAPELDRLAEIVKENpdieIQIEGHTDNi----GKKKDNLILSEKRAAAVAEYLFQKHSIs 621 Leptospira inte...
ZP_01689572  398 DGAFR---FKLGSDELDekSKALLDSVAQKMMEFpeaeIEVSGHTCNi----GTKAGNLRLSKKRAEAVRKYLMEYDGId 470 Microscilla mar...
YP_002137132  60 KGPIK---FKTGKAEIDpsCDKTMTAIAAIMTDYpgfhVQVDGHTDNv----GKPEANQKLSQDRADAVVKYLVDKKAVd 132 Geobacter bemid...
YP_002429487 272 LTGLE---FKTNKADIAkkYYPIMDKAICVLKKYpdlkVLIGGHTDSr----GPDKFNQELSQDRAQAVMDYMVKKGVAp 344 Desulfatibacill...
A3M8K2       229 ELRVF---FDTNKSNIKdqYKPEIAKVAEKLSEYpnatARIEGHTDNt----GPRKLNERLSLARANSVKSALVNEYNVd 301 Acinetobacter b...
YP_579863     84 EYRAF---FAKGSSELSkeYQLELDTVALKLQEYytatMRIEGHASVde-msDTKLRPNSLARNRALIVKNYLVLKHKId 159 Psychrobacter c...
YP_001280857  87 EFRAF---YDTNSSEIKskYREELDRWAKKMDEYpdayMLIEAHISEpearlEENASHQTLALSRVEGIKNYLIQKHNId 163 Psychrobacter s...
Feature 1                               #   #      
2HQS_H        78 d-qISIVSyGKEKPAvlghdeaaYSKNRRAVLVY 110 Escherichia coli
2AIZ_P       102 g-kLGTVSyGEEKPAvlghdeaaYSKNRRAVLAX 134 Haemophilus influenzae
YP_845279    147 a-rIRARGfGDSKPLttnatdegRRTNRRVTITI 179 Syntrophobacter fumaroxidans MPOB
NP_713865    622 ktrIQTKGfGDSVPLskndseeaRKKNRRVNFTI 655 Leptospira interrogans serovar Lai str. 56601
ZP_01689572  471 pkrIKTAGyADNRPLvpnvnepnRKKNRRVAFKM 504 Microscilla marina ATCC 23134
YP_002137132 133 akrLSAKGfGDSKPIadnktkagQAKNRRVDFTV 166 Geobacter bemidjiensis Bem
YP_002429487 345 e-rLSVRGfGAAKPIaandskegRAQNRRVTLTP 377 Desulfatibacillum alkenivorans AK-01
A3M8K2       302 asrLSTQGfAWDQPIadnktkegRAMNRRVFATI 335 Acinetobacter baumannii ATCC 17978
YP_579863    160 perLNTFNyDAEQPItssdteegKSMNRRVYGVA 193 Psychrobacter cryohalolentis K5
YP_001280857 164 pnrIRTYTySAERPIapnddaegIKLNQRVYAVI 197 Psychrobacter sp. PRwf-1

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