Conserved Protein Domain Family
2DBD_NR_DBD2

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cd07179: 2DBD_NR_DBD2 
The second DNA-binding domain (DBD) of the 2DBD nuclear receptor is composed of two C4-type zinc fingers
The second DNA-binding domain (DBD) of the 2DBD nuclear receptor (NR) is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which co-ordinates a single zinc atom. NRs interact with specific DNA sites upstream of the target gene and modulate the rate of transcriptional initiation. The proteins contain two DBDs in tandem, probably resulting from an ancient recombination event. The 2DBD-NRs are found only in flatworm species, mollusks and arthropods. Their biological function is unknown.
Statistics
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PSSM-Id: 143548
View PSSM: cd07179
Aligned: 6 rows
Threshold Bit Score: 102.581
Threshold Setting Gi: 219466968
Created: 5-Feb-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
zinc bindingputative DNA
Feature 1:zinc binding site [ion binding site]
Evidence:
  • Comment:Zinc finger, C4-type: The domain contains two groups of four Cys residues. Each group is involved in the co-ordination of a single zinc atom.
  • Comment:contacts derived from related proteins

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         #  #             #  #                      #      #         #  #                
AAR29356      567 CRVCGGRSSGFHFGALTCEGCKGFFRRTEGSSn-------SLVCVGGQnaCTITPRSRNACKSCRFRRCLAAGMSKKGSR 639  Schistosoma m...
AAW88534      174 CRVCSGPSSGFHFGALTCEGCKGFFRRTVLSNv-------RLECPGNNd-CPITPANRNMCKSCRFQRCLAVGMSKTGSR 245  Schistosoma m...
AAW88550      479 CRVCGAKSSGFHFGAITCEGCKGFFRRTINERes-----qRYTCRNGGn-CAVTGATRNNCKSCRYRRCLAVGMSKHAVV 552  Schistosoma m...
XP_002231112    1 CKVCGAESSGFHFGVDTCEGCKGFFRRSQLKTkngtyeyeSYRCSKSKd-CAINVVTRNLCRYCRYAKCLAVGMSKEGQY 79   Florida lancelet
XP_783869     110 CWVCGEKSNTFHYGILSCEGCKSFFARASSNHi-------SYNCPTKQ--CVINKETRNRCMYCRWKKCVAVGMSKTASK 180  purple urchin
AAR32910      567 CRVCGGRSSGFHFGALTCEGCKGFFRRTEGSSn-------SLVCVGGQnaCTITPRSRNACKSCRFRRCLAAGMSKKGSR 639  Schistosoma m...
Feature 1           
AAR29356      640 IG 641  Schistosoma mansoni
AAW88534      246 IG 247  Schistosoma mansoni
AAW88550      553 SA 554  Schistosoma mansoni
XP_002231112   80 NL 81   Florida lancelet
XP_783869     181 LG 182  purple urchin
AAR32910      640 IG 641  Schistosoma mansoni

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