2A66,2FF0


Conserved Protein Domain Family
NR_DBD_Lrh-1_like

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cd07167: NR_DBD_Lrh-1_like 
Click on image for an interactive view with Cn3D
The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which co-ordinates a single zinc atom. This domain interacts with specific DNA sites upstream of the target gene and modulates the rate of transcriptional initiation. This nuclear receptor family includes at least three subgroups of receptors that function in embryo development and differentiation, and other processes. FTZ-F1 interacts with the cis-acting DNA motif of ftz gene, which is required at several stages of development. Particularly, FTZ-F1 regulated genes are strongly linked to steroid biosynthesis and sex-determination; LRH-1 is a regulator of bile-acid homeostasis, steroidogenesis, reverse cholesterol transport and the initial stages of embryonic development; SF-1 is an essential regulator of endocrine development and function and is considered a master regulator of reproduction; SF-1 functions cooperatively with other transcription factors to modulate gene expression. Phospholipids have been identified as potential ligand for LRH-1 and steroidogenic factor-1 (SF-1). However, the ligand for FTZ-F1 has not yet been identified. Most nuclear receptors function as homodimer or heterodimers. However, LRH-1 and SF-1 bind to DNA as monomers. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, receptors in this family have a central well conserved DNA-binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD).
Statistics
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PSSM-Id: 143541
View PSSM: cd07167
Aligned: 16 rows
Threshold Bit Score: 178.032
Threshold Setting Gi: 99032236
Created: 2-Feb-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
zinc bindingDNA binding
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:zinc binding site [ion binding site]
Evidence:
  • Structure:1A66_A; zinc binding site of Human Liver Receptor, contacts at 4A
    View structure with Cn3D
  • Comment:Zinc finger, C4-type: The domain contains two groups of four Cys residues. Each group is involved in the co-ordination of a single zinc atom.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         #  #             #  #               #     #         #  #                        
2A66_A         12 CPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIenqnCQIDKTQRKRCPYCRFQKCLSVGMKLEAVRaDRMRGGR 91   human
AAV80237      109 CPICGDKVSGYHYGLPTCESCKGFFKRTVQNKKEYHCNeqgnCVVDRLHRKRCAYCRFQKCLIVGMRVEAVReDRMRGGR 188  Schistosoma m...
NP_476932     376 CPICGDKISGFHYGIFSCESCKGFFKRTVQNRKNYVCVrggpCQVSISTRKKCPACRFEKCLQKGMKLEAIReDRTRGGR 455  fruit fly
NP_001071721    9 CPVCGDKVSGYHYGLLTCESCKGFFKRTVQNGKKYTCVhtskCHINKDQRKGCQACRFQKCLRVGMKLEAVRrDRVRGGR 88   Ciona intesti...
XP_002247805    1 CPVCGDKISGFHYGIFSCESCKGFFKRTIQNKKNYKCLaaakCDVSLKTRKRCPACRFSKCLSKGMKLEAIReDRTRGGR 80   Florida lancelet
NP_001024550   18 CPVCGDRVSGYHYGLLTCESCKGFFKRTVQNKKQYQCSaeanCHVDRTCRKRCPSCRFQKCLTMGMKMEAVRaDRMRGGR 97   nematode
AAI63909       51 CPVCGDRVSGYHYGLLTCESCKGFFKRSVQNNKRYTCAeaqnCPMDLAQRKRCPYCRFQKCVAVGMKKEAVRaDRMRGGR 130  zebrafish
XP_791919      46 CPVCGDKVSGYHYGLLTCESCKGFFKRTVQNKKVYTCIenrnCAIDKTQRKRCPYCRFQKCLKVGMKLEAVRpDRMRGGR 125  purple urchin
XP_001122182  412 CPVCGDKVSGYHYGLLTCESCKGFFKRTVQNKKVYTCVaersCHIDKTQRKRCPYCRFQKCLEVGMKLEAVRaDRMRGGR 491  honey bee
NP_524143     508 CPVCGDKVSGYHYGLLTCESCKGFFKRTVQNKKVYTCVaersCHIDKTQRKRCPYCRFQKCLEVGMKLEAVRaDRMRGGR 587  fruit fly
Feature 1                       
2A66_A         92 NKf-GPMYKRDRAL 104  human
AAV80237      189 SRrgRSSYCVVTTP 202  Schistosoma mansoni
NP_476932     456 STy-QCSYTLPNSM 468  fruit fly
NP_001071721   89 NKf-GPLYKQDRAR 101  Ciona intestinalis
XP_002247805   81 STy-EGALHTAKLK 93   Florida lancelet
NP_001024550   98 NKf-GSFYKKDRAH 110  nematode
AAI63909      131 NKf-GPLYRRDRQL 143  zebrafish
XP_791919     126 NKf-GPMYKRDRAL 138  purple urchin
XP_001122182  492 NKf-GPMYKRDRAR 504  honey bee
NP_524143     588 NKf-GPMYKRDRAR 600  fruit fly

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