1HLZ


Conserved Protein Domain Family
NR_DBD_REV_ERB

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cd07166: NR_DBD_REV_ERB 
Click on image for an interactive view with Cn3D
DNA-binding domain of REV-ERB receptor-like is composed of two C4-type zinc fingers
DNA-binding domain of REV-ERB receptor- like is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which coordinates a single zinc atom. This domain interacts with specific DNA sites upstream of the target gene and modulates the rate of transcriptional initiation. REV-ERB receptors are transcriptional regulators belonging to the nuclear receptor superfamily. They regulate a number of physiological functions including the circadian rhythm, lipid metabolism, and cellular differentiation. REV-ERB receptors bind as a monomer to a (A/G)GGTCA half-site with a 5' AT-rich extension or as a homodimer to a direct repeat 2 element (AGGTCA sequence with a 2-bp spacer), indicating functional diversity. When bound to the DNA, they recruit corepressors (NcoR/histone deacetylase 3) to the promoter, resulting in repression of the target genes. The porphyrin heme has been demonstrated to function as a ligand for REV-ERB receptor. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, REV-ERB receptors have a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a non-conserved hinge and a C-terminal ligand binding domain (LBD).
Statistics
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PSSM-Id: 143540
View PSSM: cd07166
Aligned: 10 rows
Threshold Bit Score: 144.232
Threshold Setting Gi: 17942647
Created: 2-Feb-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:zinc binding site [ion binding site]
Evidence:
  • Structure:1HLZ_A; zinc binding site of human Orphan Nuclear Receptor Rev- Erb, contacts determined at 4A
    View structure with Cn3D
  • Comment:Zinc finger, C4-type: The domain contains two groups of four Cys residues. Each group is involved in the coordination of a single zinc atom.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              #  #             #  #                #     #         #  #                  
1HLZ_A          5 GMVLLCKVCGDVASGFHYGVLACEGCKGFFRRSIQQnIQYKRCLKNenCSIVRINRNRCQQCRFKKCLSVGMSRDAVRFG 84   human
NP_001085940  110 GMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQnIQYKKCLKNetCSIVRINRNRCQQCRFRKCLSVGMSRDAVRFG 189  African clawe...
NP_991292     123 GMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQnIQYKKCLKNetCTIMRINRNRCQQCRFKKCLSVGMSRDAVRFG 202  zebrafish
NP_990536      73 GMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQnIQYKKCLKNnnCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFG 152  chicken
O01639         42 GTTVLCRVCGDKASGFHYGVHSCEGCKGFFRRSIQQkIQYRPCTKNqqCSILRINRNRCQYCRLKKCIAVGMSRDAVRFG 121  spruce budworm
EEC02510       34 GTTVLCRVCGDKASGFHYGVHSCEGCKGFFRRSIQQkIQYRPCTKNqqCSILRINRNRCQYCRLKKCIAVGMSRDAVRFG 113  black-legged ...
ACD81870      240 GTTVLCRVCGDKASGFHYGVHSCEGCKGFFRRSIQQkIQYRPCTKNqqCSILRINRNRCQYCRLKKCIAVGMSRDAVRFG 319  fruit fly
XP_785820       8 GYAVLCRVCGDKASGFHYGVHACEGCKGFFRRSIQHnVKYRVCSKGdeCLIMRINRNRCQYCRLKKCLAVGMSKDAVRLG 87   purple urchin
XP_002204584   13 GMMILCKVCGDKASGFHYGVHACEGCKGFFRRSIQQkIQYKQCTKNekCSIMRVNRNRCQHCRLKKCLAVGMSRDAVRFG 92   Florida lancelet
NP_001071962   42 LLDMPCKVCGDKSSGVHYGVYSCEGCKGFFRRTIHQkIKYRSCILDrtCSITKINRNRCQTCRFMKCLYVGMSKDAVKYG 121  Ciona intesti...
Feature 1                  
1HLZ_A         85 RIPKREKQR 93   human
NP_001085940  190 RIPKREKQR 198  African clawed frog
NP_991292     203 RIPKREKQR 211  zebrafish
NP_990536     153 RIPKREKQR 161  chicken
O01639        122 RVPKREKAR 130  spruce budworm
EEC02510      114 RVPKREKAK 122  black-legged tick
ACD81870      320 RVPKREKAR 328  fruit fly
XP_785820      88 RCPKKCKPQ 96   purple urchin
XP_002204584   93 RVPKREKAR 101  Florida lancelet
NP_001071962  122 RIPKKQKAR 130  Ciona intestinalis

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