Conserved Protein Domain Family
NR_DBD_DmE78_like

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cd07165: NR_DBD_DmE78_like 
DNA-binding domain of Drosophila ecdysone-induced protein 78 (E78) like is composed of two C4-type zinc fingers
DNA-binding domain of proteins similar to Drosophila ecdysone-induced protein 78 (E78) is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which coordinates a single zinc atom. E78 interacts with specific DNA sites upstream of the target gene and modulates the rate of transcriptional initiation. Drosophila ecdysone-induced protein 78 (E78) is a transcription factor belonging to the nuclear receptor superfamily. E78 is a product of the ecdysone-inducible gene found in an early late puff locus at position 78C during the onset of Drosophila metamorphosis. An E78 orthologue from the Platyhelminth Schistosoma mansoni (SmE78) has also been identified. It is the first E78 orthologue known outside of the molting animals--the Ecdysozoa. The SmE78 may be involved in transduction of an ecdysone signal in S. mansoni, consistent with its function in Drosophila. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, E78-like receptors have a central well conserved DNA-binding domain (DBD), a variable N-terminal domain, a non-conserved hinge and a C-terminal ligand binding domain (LBD).
Statistics
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PSSM-Id: 143539
View PSSM: cd07165
Aligned: 5 rows
Threshold Bit Score: 158.872
Threshold Setting Gi: 115727676
Created: 2-Feb-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:zinc binding site [ion binding site]
Evidence:
  • Comment:Zinc finger, C4-type: The domain contains two groups of four Cys residues. Each group is involved in the co-ordination of a single zinc atom.
  • Comment:contacts derived from related proteins

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1      #  #             #  #               #     #         #  #                        
P45447     367 CKVCGDKASGYHYGVTSCEGCKGFFRRSIQKqIEYRCLRdgKCLVIRLNRNRCQYCRFKKCLSAGMSRDSVRYGRVPKRS 446  fruit fly
AAR30507   289 CKVCGDKASGYHYGVISCEGCKGFFRRSIQKqIEYKCLRdgKCLVIRLNRNRCQYCRFRKCLAAGMSKDSVRYGRMPRRT 368  Schistosoma mansoni
AAK54127   163 CKVCGDKSSGFHYGVTACEGCKGFFRRSIQKqMEYRCLRdgKCHIHRLNRNRCQFCRFRKCLAVGMSRDSVRYGRTPRRK 242  dog heartworm ne...
AAC77795   151 CKVCGDKASGYHYGVTSCEGCKGFFRRSIQRkIDYRCLKqqVCEIKRESRNRCQYCRFKKCLDSGMSKDSVRQMKFRNAM 230  nematode
XP_781794   24 CKICGDRSSGVHYGIISCEGCKGFFRRCLRRqKEYVCVRggKCEISRQHRNRCPACRYKKCLELGMSKDAVRIGRIPNKQ 103  purple urchin
Feature 1       
P45447     447 R 447  fruit fly
AAR30507   369 R 369  Schistosoma mansoni
AAK54127   243 G 243  dog heartworm nematode
AAC77795   231 R 231  nematode
XP_781794  104 K 104  purple urchin

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