Conserved Protein Domain Family
NR_DBD_PXR

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cd07162: NR_DBD_PXR 
DNA-binding domain of pregnane X receptor (PXRs) is composed of two C4-type zinc fingers
DNA-binding domain (DBD)of pregnane X receptor (PXR) is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which co-ordinates a single zinc atom. PXR DBD interacts with the PXR response element, a perfect repeat of two AGTTCA motifs with a 4 bp spacer upstream of the target gene, and modulates the rate of transcriptional initiation. The pregnane X receptor (PXR) is a ligand-regulated transcription factor that responds to a diverse array of chemically distinct ligands, including many endogenous compounds and clinical drugs. PXR functions as a heterodimer with retinoic X receptor-alpha (RXRa) and binds to a variety of promoter regions of a diverse set of target genes involved in the metabolism, transport, and ultimately, elimination of these molecules from the body. Like other nuclear receptors, PXR has a central well conserved DNA-binding domain, a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain.
Statistics
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PSSM-Id: 143536
View PSSM: cd07162
Aligned: 4 rows
Threshold Bit Score: 169.336
Threshold Setting Gi: 11863132
Created: 2-Feb-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
zinc bindingputative DNA
Feature 1:zinc binding site [ion binding site]
Evidence:
  • Comment:Zinc finger, C4-type: The domain contains two groups of four Cys residues. Each group is involved in the coordination of a single zinc atom
  • Comment:coodianting residues determined by comparison to related proteins

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         #  #             #  #               #      #         #  #                      
NP_001079364  36 ICRACGDRATGYHFNAMTCEGCKGFFRRAMKRnLRLSCPFQNs-CVINKSNRRHCQACRLKKCLDIGMRKELIMSDAAVE 114 African clawed ...
NP_001092087  45 ICQVCGDKSTGYHFNAMTCEGCKGFFRRAMKRpAQLCCPFQSa-CVITKSNRRQCQSCRLQKCLSIGMKRELIMSDEAVE 123 zebrafish
NP_071285     79 ICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRnARLRCPFRKgaCEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVE 158 human
NP_001118144  30 VCQVCGDRATGYHFNAMTCEGCKGFFRRAMKHpTKFCCPRQGv-CVITKNNRRQCQACRLHKCQSIGMLKELIMSKEAVE 108 rainbow trout
Feature 1                
NP_001079364 115 QRRALIKR 122 African clawed frog
NP_001092087 124 KRRLQIRR 131 zebrafish
NP_071285    159 ERRALIKR 166 human
NP_001118144 109 KRRSQIRR 116 rainbow trout

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