Conserved Protein Domain Family
NR_DBD_LXR

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cd07160: NR_DBD_LXR 
DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which co-ordinates a single zinc atom. LXR interacts with specific DNA sites upstream of the target gene and modulates the rate of transcriptional initiation. LXR operates as cholesterol sensor which protects cells from cholesterol overload by stimulating reverse cholesterol transport from peripheral tissues to the liver and its excretion in the bile. Oxidized cholesterol derivatives or oxysterols were identified as specific ligands for LXRs. LXR functions as a heterodimer with the retinoid X receptor (RXR) which may be activated by either LXR agonist or 9-cis retinoic acid, a specific RXR ligand. The LXR/RXR complex binds to a liver X receptor response element (LXRE) in the promoter region of target genes. The ideal LXRE sequence is a direct repeat-4 (DR-4) DNA fragment consisting of two AGGTCA hexameric half-sites separated by a 4-nucleotide spacer. LXR has typical NR modular structure with a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and the ligand binding domain (LBD) at the C-terminal.
Statistics
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PSSM-Id: 143534
View PSSM: cd07160
Aligned: 6 rows
Threshold Bit Score: 197.413
Threshold Setting Gi: 116242681
Created: 2-Feb-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:zinc binding site [ion binding site]
Evidence:
  • Comment:Zinc finger, C4-type: The domain contains two groups of four Cys residues. Each group is involved in the co-ordination of a single zinc atom.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                            #  #             #  #                 #     #         #  #  
NP_001086083  69 EEPERKRKKGPAPKMLGNEVCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKn--AQYSCKNNGKCQMDMYMRRKCQECRL 146 African clawed ...
BAE06541     189 APVREKRKKGPAPKLDGNEVCLICGDKASGYHYGVLSCEGCKGFFRRCIIKt--PNFKCKNNGQCQMDTYMRRKCQKCRL 266 Ciona intestinalis
NP_001017545  45 EGQPVKRKKGPAPKMLGNEVCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKg--AQYSCKNSGRCEMDMYMRRKCQQCRL 122 zebrafish
CAD45182      40 ENPPLKRKKGPAPKMLGNEVCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKg--AQYVCKNGGKCEMDMYMRRKCQECRL 117 chicken
Q9Z0Y9        76 ELRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKg--ARYVCHSGGHCPMDTYMRRKCQECRL 153 house mouse
Q5BIS6        62 EEPERKRKKGPAPKMLGDELCQVCGDTASGFHYNVLSCEGCKGFFRRSVIRggaGRYACRGGGTCQMDAFMRRKCQQCRL 141 cattle
Feature 1                               
NP_001086083 147 RKCREAGMREQCVLSEEQIRSKK 169 African clawed frog
BAE06541     267 DKCRAAGMKDETVLTEVQSKAKR 289 Ciona intestinalis
NP_001017545 123 RKCREAGMLEQCVLSEEQIRLKK 145 zebrafish
CAD45182     118 RKCQEAGMREQYVLSEEQIRLKK 140 chicken
Q9Z0Y9       154 RKCRQAGMREECVLSEEQIRLKK 176 house mouse
Q5BIS6       142 RKCKEAGMREQCVLSKEQIRKKK 164 cattle

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