Conserved Protein Domain Family
2DBD_NR_DBD1
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cd07157: 2DBD_NR_DBD1 
The first DNA-binding domain (DBD) of the 2DBD nuclear receptors is composed of two C4-type zinc fingers
The first DNA-binding domain (DBD) of the 2DBD nuclear receptors(NRs) is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which co-ordinates a single zinc atom. NRs interact with specific DNA sites upstream of the target gene and modulate the rate of transcriptional initiation. Theses proteins contain two DBDs in tandem, probably resulted from an ancient recombination event. The 2DBD-NRs are found only in flatworm species, mollusks and arthropods. Their biological function is unknown.
Links
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Statistics
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PSSM-Id: 143532
Aligned: 4 rows
Threshold Bit Score: 149.169
Created: 9-Feb-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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zinc bindingputative DNA
Feature 1:zinc binding site [ion binding site]
Evidence:
  • Comment:Zinc finger, C4-type: The domain contains two groups of four Cys residues. Each group is involved in the co-ordination of a single zinc atom.
  • Comment:contacts derived from related proteins
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #  #             #  #                         #     #         #  #            
AAW88534    79 QACQICGQPAVGFHHRAYVCEACKKFFMRHTAArlrnseigstvsESICPmGGRCRVEGPGRGKCPHCRYRKCLELGMTL 158  Schistosoma mansoni
AAR29356   480 QKCQVCGELAAGFHHGAYVCEACKKFFMRHSMAdt--------kpTNVCPtGGNCIVAKGSRGKCQICRYRKCLLVGMKM 551  Schistosoma mansoni
Q24753       3 QTCKVCGEPAAGFHFGAFTCEGCKSFFGRSYNNis---------tISECKnDGKCIIDKKNRTTCKACRLRKCYNVGMSK 73   Drosophila virilis
AAW88550   392 KPCDICGDVAAGFHCNAYVCEACKKFFIRSSKGen--------ftKYTCTkSNTCEINKDTRTHCQRCRYQKCIRLGMVL 463  Schistosoma mansoni

Feature 1                    
AAW88534   159 TPPGGEAGCDISQI 172  Schistosoma mansoni
AAR29356   552 KDPETQSEIDISNI 565  Schistosoma mansoni
Q24753      74 GGSRYGRRSNWFKI 87   Drosophila virilis
AAW88550   464 PGAAVFPVTDISEI 477  Schistosoma mansoni

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