Conserved Protein Domain Family
NR_DBD_PNR_like

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cd07154: NR_DBD_PNR_like 
The DNA-binding domain of the photoreceptor cell-specific nuclear receptor (PNR) nuclear receptor-like family
The DNA-binding domain of the photoreceptor cell-specific nuclear receptor (PNR) nuclear receptor-like family is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which coordinates a single zinc atom. PNR interacts with specific DNA sites upstream of the target gene and modulates the rate of transcriptional initiation. This family includes nuclear receptor Tailless (TLX), photoreceptor cell-specific nuclear receptor (PNR) and related receptors. TLX is an orphan receptor that plays a key role in neural development by regulating cell cycle progression and exit of neural stem cells in the developing brain. PNR is expressed only in the outer layer of retinal photoreceptor cells. It may be involved in the signaling pathway regulating photoreceptor differentiation and/or maintenance. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, PNR-like receptors have a central well-conserved DNA-binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD).
Statistics
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PSSM-Id: 143529
View PSSM: cd07154
Aligned: 5 rows
Threshold Bit Score: 150.413
Threshold Setting Gi: 156376474
Created: 6-Feb-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
zinc bindingputative DNA
Feature 1:zinc binding site [ion binding site]
Evidence:
  • Comment:Zinc finger, C4-type: The domain contains two groups of four Cys residues. Each group is involved in the co-ordination of a single zinc atom.
  • Comment:Residues identified by homology to related proteins

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         #  #             #  #               #       #         #  #                
NP_990501      16 CKVCGDRSSGKHYGVYACDGCSGFFKRSIRRnrTYVCKsGNqGGCPVDKTHRNQCRACRLKKCLEVNMNKDAVQ 89   chicken
XP_001607668   11 CKVCGDRSYGKHYGVYCCDGCSCFFKRSIRRgvLYTCIaGN-GSCVIDKARRNWCPHCRLKKCFAVSMNTAAVQ 83   jewel wasp
NP_989925      35 CKVCGDTSSGKHYGIYACNGCSGFFKRSVRRklIYRCQaGT-GLCPVDKAHRNQCQACRLKKCLQAGMNKDAVQ 107  chicken
XP_002236522    3 CRICGDRSSGKHYGVYSCDGCRGFFKRSIRRnlAYICK-EN-GSCVVDVARRNQCQACRFKKCLDAQMNKDGFR 74   Florida lancelet
XP_001630385    9 CKVCGDISSGRHYGVYTCDGCSGFFMRSVRRdmVYTCK-GN-GGCTVDKKRRNQCQACRFKKCLEVKMNRFAVQ 80   starlet sea anemone

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