Conserved Protein Domain Family
ALDH_VaniDH_like

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cd07150: ALDH_VaniDH_like 
Pseudomonas putida vanillin dehydrogenase-like
Vanillin dehydrogenase (Vdh, VaniDH) involved in the metabolism of ferulic acid and other related sequences are included in this CD. The E. coli vanillin dehydrogenase (LigV) preferred NAD+ to NADP+ and exhibited a broad substrate preference, including vanillin, benzaldehyde, protocatechualdehyde, m-anisaldehyde, and p-hydroxybenzaldehyde.
Statistics
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PSSM-Id: 143468
View PSSM: cd07150
Aligned: 11 rows
Threshold Bit Score: 670.577
Threshold Setting Gi: 118468557
Created: 2-Jan-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:catalytic residues [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
EDZ41734      24 FDDTNPNDGSLWAripdatcqDARRAIDAAQAAFPAWAaLKFQDRANIMLKVAQIIEKRAGDYIPAAQFEgGGWYGKGVY 103 Rhodobacterales...
YP_256456     22 KVKTSPIDNSPLAeiavgdreDAKRAIDSAYEAFKGWSsLTAMKRSEYLLKLEETIRANEGDLINTLIVEgGGTYKKAWG 101 Sulfolobus acid...
YP_663449     21 DTSYNPATSEPYAvvqlasvqDATDAIASAHQAFQTWKdVLPSVREKILLDIADAFERRADEFKDLLIDEaGSSMLKAGY 100 Pseudoalteromon...
ZP_02037901   35 MEDRNPADGSVMAmvhmggrqDAEKALAAAYAARGKWAaTAPDVRERILLRAANEMEARAEGLTQLMIAEsGSARYKAWG 114 Bacteroides cap...
ZP_02085683   20 AEDKNPADDSVFArvhfaggaEVEEAIAAAQRAWRPWAdTPAAQKEQILLKAADWMQEHIDEVADVLMGEsGSAFGKAYF 99  Clostridium bol...
NP_560043     19 RPKHSPIDGSVIAetpvskreDAKAAIDAAYDALKAWSqLPAIKRAEYLYKLYEIIKSREEELINILMVEgGGIYKKAWG 98  Pyrobaculum aer...
NP_049221     21 FDDLNPVDDSVYSrvpagtaeDVNRAVENAHQAYLQHRdLPAAVREGWIAKAAEIMERDTAKFADVLVDEiGSPIAKAGF 100 Novosphingobium...
EDZ44270      27 FEVLNPLDDSPYAyaakgsgnDVRQAVAAAKAAFTSFKeTTPTERERWLLRVAEIMEVRQKDLVDCLIDEiGSPVQKAMF 106 Rhodobacterales...
YP_001951155  22 FDDFNPYTGEILTtvangsqqDALLAVNAAADAFPDWAaVAPSQKRLLFLKAADLLEKRKDELIDLLAREtGAARPFAAY 101 Geobacter lovle...
YP_888324     34 FDDADPWSGEVYArvarcgrqEAAAAVQAAADAYPAWSqTTPREKARLFRAAAAVVARRRDDLAVTLAREtGTTKVNADF 113 Mycobacterium s...
YP_160079     21 LDDLNPATSEVWGrvhqasaaDLERAIAAAYRARESWGnTLANEREAILLRAADALQKRIPDVAAVLIDEaGSTYGKAMF 100 Azoarcus sp. EbN1
Feature 1                                                         #                              
EDZ41734     104 ETKVMPEMLKAAAAVCYapiGEVLPSl-nGKVSNAVRFPMGVISVISPWNMPGILATRPFSVPMAMGNTIVLKPSEEtPY 182 Rhodobacterales...
YP_256456    102 EVVFTERLVRNAAEMARhfkGETIPSdseGIISMTFRKPKGVVGAITPWNYPLSISMKKVAHSLAIGNTVVLKLSSE-TP 180 Sulfolobus acid...
YP_663449    101 ETHHAPSFLRGMAGECRrvkGETYQSdypGLKSYSIRRPLGVVLSIAPFNFPLLLAIRKIGWALAAGNTVVLKPSEV-TP 179 Pseudoalteromon...
ZP_02037901  115 EVMGSAGILRVAAGECRrlhGEVLQPggaGQMSMAVRSPLGVVLGITPFNYPMILAIKKLAYALAAGNTFILKPSPL-TP 193 Bacteroides cap...
ZP_02085683  100 EAGFAVDILRTAAGECRrvfGQVQQQe-aGEISMIRRLPLGVVAGIAPFNFPLLLALKKVAFALAAGNTFVLKPASA-TP 177 Clostridium bol...
NP_560043     99 EVVFTERLVRNAAELARhygGKTLQSdaeGVVSMVFKRPKGVVGVITPWNYPLSISMKKIAHALATGNTIVYKPASE-TP 177 Pyrobaculum aer...
NP_049221    101 ETRFAVSFLRAAIGVPRrirGETIPSdtpGRFSMSLRQPVGVVAGITPFNVPLIKGIKQSAMALATGNAFVLLPSEA-AP 179 Novosphingobium...
EDZ44270     107 EFTKGLTMIRAAAGMCRnvrGETIPSdrpGTFSMSIREPLGVVAVITPFNVPLIKTTRLVANALAVGNTVVHLPSEM-AP 185 Rhodobacterales...
YP_001951155 102 QAAAGPNYLREAGSQAHrvtGTILPSe-tTKVSMVMRHPVGVVAGISPWNCPVVLSLRAVCFAMAYGNTVVLKPSEEsPV 180 Geobacter lovle...
YP_888324    114 QITLTIELIEQAAGWVYlpaGEVLRSdfaDTSQTVVRRPLGVVASFTPWNGATILSWRAALSPIAAGNTVVVKPSELaPV 193 Mycobacterium s...
YP_160079    101 EASFVVNLLRSAAGECRritGETMPSdspGVFSMSVRRPLGVIAGIAPFNFPFLLATKKVALALAAGNTFILKPASY-TP 179 Azoarcus sp. EbN1
Feature 1                                                                               #        
EDZ41734     183 QGGLFFAEVMEEAGVPPGVFNVITCSRdnvaeVGDEMVDNPkVKGVAFTGSAAVGRRIAAKCGaHLKKACIELGGKDSLI 262 Rhodobacterales...
YP_256456    181 IIGVKIAELVQRAGLPKGVVNVVTGPGs---aVGDEIVTNKrVSHVTFTGETNTGREIASKAGhSLKTVTLELGGSDPLI 257 Sulfolobus acid...
YP_663449    180 VIALKLAEVMTEGGLPKGVLNVIPANGa---eLGDVLIADErVRKVTFTGSTRVGKSIALACAkYHKPITLEMGGKNPFI 256 Pseudoalteromon...
ZP_02037901  194 ATGLAIAGVFEAAGLPSGVLNVVPGRSe---vIGDMLVDDPrVRMVTFTGSSAVGRSIAVRAArDLKKVAMELGGKNPLI 270 Bacteroides cap...
ZP_02085683  178 VSGVMIAKALDGAGIPKGVFNLVPGSGe---eVGNKLIEDErIRMVAFTGSTAVGRGIASKASvLFKKYSLEMGGKNPLI 254 Clostridium bol...
NP_560043    178 VTGFKIAEMIHQAGFPKGVFNLVVGPGs---tVGDEIVVNKkVSHVTFTGESATGREIASKAGgALKTVTLELGGSDPLI 254 Pyrobaculum aer...
NP_049221    180 MIADLLAKLWKEAGVPDGLFNVVYGNGa---eIGDVLTGHPkVASITFTGSSRVGKHIAEIAArNLKKYTLELGGKSPLV 256 Novosphingobium...
EDZ44270     186 HLSLIFAEIVAEAGIPEGVYNVVTGMGa---eIGDDLTSHKdIDFVTFTGSTVVGQHINEICAkNKTPNTLELGGKSPTI 262 Rhodobacterales...
YP_001951155 181 SGGILLAELFEEAGFPKGVFNIVTHGYgrsseVGDLFIQDRrVKRISFTGSTRVGRELAEKCGrHLKRIALELGGNDPLI 260 Geobacter lovle...
YP_888324    194 SAGLQLAEIMEEAGFPAGVVNVVTHGPgeagpIADEFFDNPlVRCINFIGSVPTGRMLAERAGaTLKRSVMELGGYNPLI 273 Mycobacterium s...
YP_160079    180 VTGLKIAEIFEAAGLPKGVLNVVPVQGs---vLGNTFVADPrVRMITFTGSTEVGRELSAEAGrHFKRITLELGGKSPMI 256 Azoarcus sp. EbN1
Feature 1                              #  #                                                      
EDZ41734     263 VLEDaDMERATSSASFGAFMHQGQICMSVEKVLVQeqVFDEFLKGFVARAAKLkTGNTADkaNVIGPLINDRQAARVKHQ 342 Rhodobacterales...
YP_256456    258 VLDDaDVNLAVKIAVFGAFFHQGQICTSSKRIIVSekVYEAFVKKFVERVSQLkVGDPRDrtIEQGPLISKRQVESMIEF 337 Sulfolobus acid...
YP_663449    257 VLADaDVDYAVDAATFSNFMHQGQVCMTGSRVIVEdaVYDEFVRKFTAKVSALgYGNPRDpgVIVGPLIRPTQTEFIKKQ 336 Pseudoalteromon...
ZP_02037901  271 VLKDfDPVQAADIAAYGAFCHQGQVCMATSRIIVEgdGYQPFCDALVCRAEGLkVGDPREedTIIGPLIQPEKWKFIDGQ 350 Bacteroides cap...
ZP_02085683  255 LLKDfDVEQAVRIAGFGAFFHQGEICMCTSRLIVEepVYDPFCEAFAAYARTMkVGDPHQkdTIIGPLIKQEQCQIIDSQ 334 Clostridium bol...
NP_560043    255 ILDDaDLNLAVRIAVFGAFFHQGQICTSSKRIIVHerVYDVFVKKFVERVSQLkVGDPRDrtVEQGPLISPRQADEMERF 334 Pyrobaculum aer...
NP_049221    257 ICADaDLDKAVNAALFSIFMYQGQVCMGASRIYVErsIFDQFTKAFAAATGRAnSGDLRDptTMLGPIISERQRDRVRRH 336 Novosphingobium...
EDZ44270     263 VLADaDLDKVMPLAARSVFMFAGQACIASSRFYVErpLYDEFVKQFSFIIGKLgMGDLRDpnTVIAPAISPRQRERIKSH 342 Rhodobacterales...
YP_001951155 261 VLNDaDMDHAVNAAIFGRFLHQGQVCMNAKRLIIEktVAQEFTARFVARTSALkVGNPLDaaTVIGPLINHKQYETLEGQ 340 Geobacter lovle...
YP_888324    274 ILEDvDLDYAVRVAAFSAFFHQGQICLNARKILVHrdIYDEFVARLVAKAESLtSGDPLHadTFIGPLITPAAVELVHAR 353 Mycobacterium s...
YP_160079    257 VLKDaDVDYAVNAAAFGIFLHQGQVCMANSRLIVEapIFDVFCDKLATKIAGFkVGDPRDpqTVIGPLIDRKQCAVLDRH 336 Azoarcus sp. EbN1
Feature 1                                                                                        
EDZ41734     343 LEDAVAKGAKIAIGGGVnGRFVEPTIVTNVTsdMDIWRDETFGPVAVVVPFKdDFEAVAMNNDTEYGLSAGIISRNeHRA 422 Rhodobacterales...
YP_256456    338 YEDSVKRGGKIMTGGKWdGNYFYPTVVTDVDrnFRIMKEEVFGPIRPVLRVKdDEEAIEVANDTEYGLSAAVVTRNvTRA 417 Sulfolobus acid...
YP_663449    337 VEKAVEQGAKINVGGHYeGNVFQPTVISDVTsdMSIFHTECFGPVASVIKASdYLHALALANDSEYGLTSAVITNDlQMS 416 Pseudoalteromon...
ZP_02037901  351 IEDALSKGAKLLTGGRHeGPWYWPTVLADVTpeMRIFHEETFGPVTSVMRAKdPEEALALCNDNEYGLSAALLTHNlELA 430 Bacteroides cap...
ZP_02085683  335 IQDAVSKGAVLMTGGTHeGNFYQPTVLKDVTpdMRIFYEESFGPVTSIIKAVdAQDAVRLCNDNQYGLSSSLLTNDlSKA 414 Clostridium bol...
NP_560043    335 YQDAVSRGGRALTGGKRaGAYFWPTVFVDVDrnFRIMREEVFGPIRPVVPVKnDDEAVEVANDTEYGLSAAVVTTNiNRA 414 Pyrobaculum aer...
NP_049221    337 IDDARSKGAAVLAGGEWsGNSCAATILSGVTaeMTVFEEETFGPVTSLFPFDtLEEALELANNTEYGLSASIFTRDlDKA 416 Novosphingobium...
EDZ44270     343 IDDARAKGANVIGGEWE-GNRCQPTLLTDVSedMAVCRTETFGPVTAIYPIDsYEEGLEKANDTEYGLSSAIFTKDiDKA 421 Rhodobacterales...
YP_001951155 341 VNRAVAEGAELLCGGYGnGLCYHPTVLGNVRedMSIFHEETFGPVAPIIVAEdADDALRLANSSAYGLSAGILTNNmQQG 420 Geobacter lovle...
YP_888324    354 VNDAVAKGARLLTGGTYdGPVYAPTVLVDVPddAVVSSEETFGPVVVVHPVDtAEEAIEIANRPLYGLSSAILSGDtHRA 433 Mycobacterium s...
YP_160079    337 VADAVAKGAKLLHGGKSdGAFYQPTILAGVTpdMVVFREESFGPAVSVIRAAdSEDALRLANDSCYGLSSGLITNDlQKA 416 Azoarcus sp. EbN1
Feature 1                                                               
EDZ41734     423 MQMATlLETGMCHINCSpINDEAHAPFGGAKASGMGRYGgRWSQESFSETRWITL 477 Rhodobacterales bacterium HTCC2083
YP_256456    418 FKFVEqIESGMVHINDVtMLEESHIPFGGIKASGIGREGgEYSFRETTYERWTTI 472 Sulfolobus acidocaldarius DSM 639
YP_663449    417 IFFSEnLESGMVHINGPsIRDEAVVPFGGVKNSGMGREGgTFAMDEFTELKWITV 471 Pseudoalteromonas atlantica T6c
ZP_02037901  431 WSMGLrMEAGMVHINDTtFLSGTTAPSGGVKFSGFGREGgRYSMEDFTELKWLTM 485 Bacteroides capillosus ATCC 29799
ZP_02085683  415 MSLSLdMEAGMVHINNAtVSDNSTVAFGGVKNSGVGREGgSYSIDEFTELKWITV 469 Clostridium bolteae ATCC BAA-613
NP_560043    415 FKIAEaIESGMVHINDVtMLEESHVPFGGIKASGFGREGgEWSFHETTYDRWLTI 469 Pyrobaculum aerophilum str. IM2
NP_049221    417 LAFAQrAEAGMVHINAPtLHDEPHVPFGGTKASGFGREGtEADLEIMTEWKWVTI 471 Novosphingobium aromaticivorans
EDZ44270     422 FHFARnSNAGMCHINGPtIHDEAHVPFGGNGESGVGREGtDADMEAMTELKWVTV 476 Rhodobacterales bacterium HTCC2083
YP_001951155 421 LALARrIESGACHVNDSpLYGETHAPLGGVNNSGWGKFG-IEAMHEFTEQQWVTL 474 Geobacter lovleyi SZ
YP_888324    434 TKLAEsLRSGVVRVNLPtIDDEIQAPIGGVRDSGWGRSG-PWALQDFTDLVAIAV 487 Mycobacterium smegmatis str. MC2 155
YP_160079    417 FDLSLrLEAGMVHINDSsIMDEPHVPFGGVKDSGFGREGgHHSMDEMTELKWITV 471 Azoarcus sp. EbN1

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