Conserved Protein Domain Family
ALDH_F21_RNP123

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cd07147: ALDH_F21_RNP123 
Aldehyde dehydrogenase family 21A1-like
Aldehyde dehydrogenase ALDH21A1 (gene name RNP123) was first described in the moss Tortula ruralis and is believed to play an important role in the detoxification of aldehydes generated in response to desiccation- and salinity-stress, and ALDH21A1 expression represents a unique stress tolerance mechanism. So far, of plants, only the bryophyte sequence has been observed, but similar protein sequences from bacteria and archaea are also present in this CD.
Statistics
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PSSM-Id: 143465
View PSSM: cd07147
Aligned: 18 rows
Threshold Bit Score: 673.189
Threshold Setting Gi: 21224028
Created: 1-Jan-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:catalytic residues [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
Q8RYB8        24 LDVTNKYTGEVGAkvqlathdDVDKAIDAAVAAAPAMAaLGAFERKAILEKTVAELKKRAEEIAQILTMESGKPIkDARG 103 Tortula ruralis
YP_501949     19 IPISNPYSLVTFAevcaagpdEIEEAIRIAEQGAVRMAaLPAHKRSELLFHLVRLMEEEADILTDIIVREGGKVRkFAAA 98  Methanospirillu...
YP_590607     27 VEIHSPFDHKVIGqvfygssaHVEAAIRASVEAFQITRkLGSYERERILSAISQKLSEQREDFAHTIALEAGKPIkTARQ 106 Acidobacteria b...
YP_001277798  23 YTVACPYDGSPVAvvhraapaDLEQAIQAAVEAFRTTRrSPLHRRAAALRAIAAGIEARAEELARTIALEAGKPIkQARI 102 Roseiflexus sp....
YP_864754     17 LKVYNPYNDQLVDtvaqcgphEIDRALDGAVDALEQTSrMQPYERAACLAKIRDGIAARGAEFARVLSLENGKTLaESTL 96  Magnetococcus s...
YP_001046474  20 LDVRFPYTGEVVGrvclagsdDVEDALRCAERGFSLTRrLPAHRRSEILYNLADLIRERSAELTGTIMLEAGKTRaLAES 99  Methanoculleus ...
XP_646482     31 LEVIDKFTNEIASkipmadkeMIEQSIVIAQKACEPMRqLSAATKKQILLNIANDLEKRADEFAKAIVVEVGKPLvDANA 110 Dictyostelium d...
ZP_01877079   19 TESTCVYSQKKFAevslanpeHIEQAIEIGHKAKNSMKnLSAHQKRKVLLECRDLFEVNFEDLAETITLESGKTInESRA 98  Lentisphaera ar...
CAC10513      19 IDVQYPYDGRTVAsvfvpsaeQVEEAVAAMHAARDVVGaTSAHRRASALSHVADRLEQRSEEAAQVIVLESGKPIkWARV 98  Pseudonocardia ...
NP_629807     20 FDVTSPWDGTTVGtvslptdaQVEEAVAAAYAVRDEFAaTPAHVRAAALDHVGRRLAERTEEIARLISAENGKPVkWARG 99  Streptomyces co...
Feature 1                                                              #                         
Q8RYB8       104 EVARTIDTFQVAAEESvr-iYGEHMPLdisarnkGPQGIVKKFPIGPVSMVSPWNFPLNLVAHKVAPALAVGCPFVLKPA 182 Tortula ruralis
YP_501949     99 EVARAIGTIRISAEEAvr-iHDQMVPMdgypageGRIAMIMRVPVGIVLAITPFNLPLNQICHKAGPALAAGNSCIIKPP 177 Methanospirillu...
YP_590607    107 EVERAIYTFKVAAEEStr-iEGEYLHLdtieatkGRWGIVRRFPIGPIFAITPFNFPLNLVAHKLAPAIAAGCPVILKPA 185 Acidobacteria b...
YP_001277798 103 EVARSIVTFSTAADEAtr-sNDEALRLdaapggeGRQAIVRRFPVGPVAAITPFNFPLNLVAHKVAPAIAAGCSVVLKPA 181 Roseiflexus sp....
YP_864754     97 EVARAVATFDIAVGEAtr-iYGEAYDLginpmgsGRRALVRKYPIGVVSAIAPFNFPINLAVHKIAPALAVGCPVVLKPA 175 Magnetococcus s...
YP_001046474 100 EVVRARETIEVSAEEArr-iDGTILPLdwnaageGRVGCLRRFPLGPVLAITPFNFPLNLACHKLGPAIGAGDSVVLKPA 178 Methanoculleus ...
XP_646482    111 EVGRAIDTFTCAAEESir-qYGEQIPLdissrnlGFQGITKRFPVGPISMIAPFNFPLNLCAHKIAPSIAAGCPFVLKPS 189 Dictyostelium d...
ZP_01877079   99 EMQRVISTFDYASIEVmk-mDGEVLAMdthanseEFECLIKRFPKGLCTFITPFNFPINLIAHKVAPAIAAGCPFIIKPS 177 Lentisphaera ar...
CAC10513      99 EVARAASTFRWAAEEArr-wSGTLQRLdtdaggaGRLALVRRFPRGSLLAITPFNFPLNLVAHKVAPAIAVGVPVIIKPA 177 Pseudonocardia ...
NP_629807    100 EVGRAVSVFRFAAEEArrfnGGEAQRLdtdaggqGRLALTRRFPKGVVLGIAPFNFPLNLCAHKIAPAIAAGAPLILKPA 179 Streptomyces co...
Feature 1                                                                               #        
Q8RYB8       183 SrTPLSALILGDILVPd-rGAAKGAFSVLPVSRAdADMFTVDERFKLLTFTGSGPVGWDMKARaGKKKVVMELGGNAPCI 261 Tortula ruralis
YP_501949    178 SaTPLTGLKFGELLIRa--GFPKEAVSVIPCRSDiAERLATDKRISCLSFTGSPSVGWHLRSItPARHVTLELGGNAAVI 255 Methanospirillu...
YP_590607    186 PqTPITALKLARVIHEs--GWPAGALTVMPLSNEdASLLVTDERIKLLTFTGSSIGWDLKSKA-GKKRVLLELGGNAAII 262 Acidobacteria b...
YP_001277798 182 SqTPIVALKLAEIIASs--GWLPEALSVLPLASRdAAPLVEDERFGLLTFTGSPVVGWEMKRRaGRKRVTLELGGNAGVI 259 Roseiflexus sp....
YP_864754    176 SlTPLTALMMAEVVEAs--GWPKQAFSVVPCNRSaGQMLVEDERIKLLSFTGSPEVGWKMKSEaGKKKVVLELGGNAGLI 253 Magnetococcus s...
YP_001046474 179 SaTPISSLMLGEMALDa--GIPPEAVSVVPCHTDlAERMVRDDRVACVSFTGSPAVGWHLREIaGRKRVGLELGGNAAVV 256 Methanoculleus ...
XP_646482    190 DrTPISAMLLGELLAKqtpLLPEGAFSILPTTHQdASILSKDERFKLCSFTGSPAIGWKIKNEaGKKKVVLELGGDAACI 269 Dictyostelium d...
ZP_01877079  178 DkTPICALKFAEILKQt--SLPKEAFSVLPCSNEdSLKLVKDERISFLSFTGSEKVGWMLKGLaGKKSVCLELGGIASCA 255 Lentisphaera ar...
CAC10513     178 PsTPLSSLFLGQLLAEt--DLHQGSWSVLPVPNSqMEHLILDPRLPIISFTGSGPVGWDIKSLvPRKHVTLELGGNAAAV 255 Pseudonocardia ...
NP_629807    180 PaTPLSGLILGELLAEt--DLPAGSWSILPVPNDkMPALVQDERLPVISFTGSETVGYAIMDSvPRKHCTLELGGNGAAV 257 Streptomyces co...
Feature 1                                  #  #                                                  
Q8RYB8       262 VDDYv---pDLDYTIQRLINGGFYQgGQSCIHMQRLYVHerLYDEVKAEFLAQVKKLK--VGNPFEDdTFIGPMISEKDA 336 Tortula ruralis
YP_501949    256 VHDDa----DQTLAASRIIEGAYSHtGQVCISVQRVFIQrtIAYRFIYELVSRCNALV--TGDPEDPaTDVGPMITPDKA 329 Methanospirillu...
YP_590607    263 IHSDa----DLRFAAERCAHGAFGYaGQSCISVQRILVEksVYSEFRQMLVNAAGKLK--TGDPLDEaTDVGPLIRESDA 336 Acidobacteria b...
YP_001277798 260 IHSDa----DLAFAAARCVVGGFSYaGQSCISVQRIFVHasVYDAFMELFVPQVQALK--VGHPLDEaSDLSALINPSEA 333 Roseiflexus sp....
YP_864754    254 IDHNv---kDWDHLIQRAILGAFYQcGQVCISVQRIFVHqdVMGEFRARFAKAAQALV--IGDPLDAkTTLGPVIDRANV 328 Magnetococcus s...
YP_001046474 257 VHEDa----DIPFAAGRIVAGAFSNaGQTCIAVQRVYLHrpIYEEALALLVERARALT--TGDPREPgTDVGPMISAPAA 330 Methanoculleus ...
XP_646482    270 VDSAtq-qsRLPSIAQRILFGGFYSqGQSCISVQRVFIHdsLYDQMKQLLIDGAKPLIqrMGDPMDPtTFVGPMITEHDA 348 Dictyostelium d...
ZP_01877079  256 VYPDt----DLANASKNILTAAFGQaGQSCISLQKLYIHneVKESLIKLLVDGCKDIV--LGDPSDQkTKLGPLINEDSL 329 Lentisphaera ar...
CAC10513     256 VCSDwsseqDLEWAAQRIALFANYQaGQSCISVQRVYVPreLYEVFTVLLSRHIGALR--QGNPNDDaTDVGPVINEASA 333 Pseudonocardia ...
NP_629807    258 VLADwasdeDLDRAATRIATFSNYQgGQSCISVQRVIADaaVYDRLLPRIVAAVEAQV--TGDPNDDaTDVGPLVSEAAA 335 Streptomyces co...
Feature 1                                                                                        
Q8RYB8       337 TRVEDWVKEAVekGGKLLCGGSRk----GAVMQPTVLEDVpmdAMARKEEIFGPVVLFYKYSdFKEAVKECNNTHYGLQS 412 Tortula ruralis
YP_501949    330 KEALQRIEEAVsqGARVLCGGRLs----GHLLLPTIIADTtpdMAVNCEEVFAPILTVTPYEsFEDAIAMVNDSRFGLQA 405 Methanospirillu...
YP_590607    337 LRAESWVKEAVaqGATLLCGGTRk----GSLLEPTVLTNTrpeMLVNCREIFAPVVTVEAYDdFNEALRQVNNSPFGLQA 412 Acidobacteria b...
YP_001277798 334 VRVSAWLNEARsaGAEFVTGGMVe----GGVVAPTIVARAapeLRVNCQEIFAPVVTVQPYTtFEEALAAVNNSEFGLQA 409 Roseiflexus sp....
YP_864754    329 ERLQGWIQEALdqGAALVTGNTIadvgaGNSMTATILEEVdagCRINADEAFGPVVTLTPVQsMDEAFHLVNNSRFGLQC 408 Magnetococcus s...
YP_001046474 331 ETAFAKVEDAIagGAKVLVGGTRd----GPLFKPTILVDTtpdMAVNRTEVFAPVVTVAPYEtFEEAIAFANDTEYGLQA 406 Methanoculleus ...
XP_646482    349 KRVESWVNNAVskGANVLVGGKRn----DHFMQPTILENLpldTEISCKEVFGPVFFIERFNdFKQVVQRVNSSEFGLQA 424 Dictyostelium d...
ZP_01877079  330 QRVQKLINQSVktGTEIITGGKRr----NNSFEPTILTKLdinDPISTQEVFAPLFIVEEFNnSDELFQIINKSPYGIHV 405 Lentisphaera ar...
CAC10513     334 IRIEQWIDDAVhaGAKILVGGRRn----GTSLEPTLLADVplaARILRDEAFGPVVSITPFDsLDSAFAAVNDSDFGLQT 409 Pseudonocardia ...
NP_629807    336 ERVEAWVREAVdaGAKLLTGGKRd----GASYAPTVLTELpadTTLAHEEVFGPVLSVQRVTgEAEAFAAVNDSKYGLQA 411 Streptomyces co...
Feature 1                                                                         
Q8RYB8       413 GIFTKDLNKAFYAFEhMEVGGVILNDSPaLRVDSQPYGGLKDSGIQREGVKYAMEDYLETKVLVM 477 Tortula ruralis
YP_501949    406 GIFTKDLGLAIHASKtIQCGAVLINDIPtFRIDSMPYGGVKESGIGREGPYYAIREMTEERLVII 470 Methanospirillum hungatei JF-1
YP_590607    413 GILTRDAQRIFTAFNgLDVGGVVAGDVPtFRIDHMPYGGIKDSGLGREGVRYTIEEMTEPKLLVM 477 Acidobacteria bacterium Ellin345
YP_001277798 410 GVFTRDVGRIFQAYEeLEVGGVIINDVPtWRIDPMPYGGVKQSGFGREGLRYAIEEMTERKLLVV 474 Roseiflexus sp. RS-1
YP_864754    409 GLFTQDFATVMRALDqLEVGGVIHNDVPsFRVDSMPYGGVKDSGLGREGVKYAMEDMLEPRVLVY 473 Magnetococcus sp. MC-1
YP_001046474 407 GIFTHDSRRIAQAFEeLRVGGLVVNDIStFRMDHAPYGGVRGSGIGREGPKYAIEEMTEERMMIF 471 Methanoculleus marisnigri JR1
XP_646482    425 GVFTDDIHKAYYAFNnIEAGAVVINDIPsVRVDAQPYGGVKESGFGREGIRHTIEEYTELKLMIL 489 Dictyostelium discoideum AX4
ZP_01877079  406 GIYSSNIKLAMRAWNeLECTSVVFGHVPtWRSDKMPYGGIKNSGCGREGLKYAIEEMTELKSLVI 470 Lentisphaera araneosa HTCC2155
CAC10513     410 GVFTRDIRTAFRAHRdLEVGGVIIGDVPsYRADQMPYGGMKDSGIGREGVRSAMDDFTVEKVLVL 474 Pseudonocardia tetrahydrofuran...
NP_629807    412 GVFTHDLQAAFRAHRaLEVGGVVIGDIPsYRADQMPYGGAKQSGVGREGVKFAMDDYTYERVLVL 476 Streptomyces coelicolor A3(2)

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