Conserved Protein Domain Family
ALDH_LactADH_F420-Bios

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cd07145: ALDH_LactADH_F420-Bios 
Methanocaldococcus jannaschii NAD+-dependent lactaldehyde dehydrogenase-like
NAD+-dependent, lactaldehyde dehydrogenase (EC=1.2.1.22) involved the biosynthesis of coenzyme F(420) in Methanocaldococcus jannaschii through the oxidation of lactaldehyde to lactate and generation of NAPH, and similar sequences are included in this CD.
Statistics
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PSSM-Id: 143463
View PSSM: cd07145
Aligned: 10 rows
Threshold Bit Score: 665.203
Threshold Setting Gi: 41033583
Created: 2-Jan-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:catalytic residues [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
Q58806        13 MDVINPYSLEVIKkipalsrEEAKEAIDTAEKYKEVMKnlPITKRYNILMNIAKQIKeKKEELAKILAIDAGKPIKQARV 92  Methanocaldococ...
YP_001191853  17 ITVMDPGKGKPLNevsvagrEETRHAIELADQAFDHFSrlALKERTKILERAAEIMEkRSEELARTLTAESGKPIRDARV 96  Metallosphaera ...
NP_343053      7 IEVRSPSNLNVIGtvkrmhkDEVRGEIEEAYKGFEIISkmPLYKRTAILRKVSEILErEQERLAKLLAMEAGKPIRDSRV 86  Sulfolobus solf...
CAF18458       9 VVVVNPATEEVLAvlpsasrEEVRRAIDEAEDAFYRWSelPLRERAKLLRRAADLIE-ADDTLINTLVAESGKPIRDARA 87  Thermoproteus t...
YP_001539917   5 IPVYEPATGEVLAyvpdmsiNEVRDAISKAYDALPRIQsiPAYERAKLLMKVAQAIRaRKEELARLLTREIGRPIKSTRL 84  Caldivirga maqu...
YP_823352     18 FAVRNPANGEIIDtvpqagpPDVHAAIEVARLGKAVMAalPAHARCEILKRASQTIErRAEELSQLLTSENGKPINQCRF 97  Solibacter usit...
YP_001191206  16 ISVRNPATMETVDtvpllsrEQVKEAIESAWTALDALNslLIAKRSRLLLQVSQLIReNLQELAITMTRETGRPIKSSKG 95  Metallosphaera ...
A4FW36        13 IDVFDPYTLENIEkitaldrEETKSAIEVAEKNKEIMKnlSPSKRYSILMKIAEQISlKKDLFAKTISIDVGKPIKQSKI 92  Methanococcus m...
A6UVT6        13 IEVKNPYNNEIIGyipslsrNETKEAIKIAEEHKSTMKnlSPTIRYNILMKIASELSkNKRELAKLITIDVGKPIKQSII 92  Methanococcus a...
YP_001273040  16 AEVKNPYNGEVIDtvpvshlNNVDLAIDAAVNAKDSIQemSAFKISNKLYAVYEKLKdNKDELAELLTKEVGKPINESVV 95  Methanobrevibac...
Feature 1                                                                 #                      
Q58806        93 EVERSIGTFKLAAFYVk-eHRDEVIPSDd---------RLIFTRREPVGIVGAITPFNFPLNLSAHKIAPAIATGNVIVH 162 Methanocaldococ...
YP_001191853  97 EVTRAIHLFRSAAQEVrlvLEGATFRVDgyeyppgnerRMVMSVREPLGVVGAILPFNFPANSFAHKVAPNLAVGNTVVV 176 Metallosphaera ...
NP_343053     87 EVLRASRLFRHAAEEVgmvLEGKNYRVDayeyppgnenRIVVSTREPIGVVTAILPFNFPINSFAHKVAPALAVGNSVVV 166 Sulfolobus solf...
CAF18458      88 ELRRAIEIFRASAEEAkyiLEGKIPRVDaydyplanenRIAMEVREPMGVVAGALSYNNPASTFAHKIAPVIAAGNTVIA 167 Thermoproteus t...
YP_001539917  85 ILERTARIYELAAQELphvLTGEFIPLEaydypagnekRIAFIRREPVGVVGAITPFNFPPDSMAHKVAPALAIGNTVVL 164 Caldivirga maqu...
YP_823352     98 EIGVTARLFSDFAEEAk-rIRGQYLPMDnvpg---lerMVAYTLRHPIGIVVGIIPFNYPAELFAHKIPGALAAGNSVIV 173 Solibacter usit...
YP_001191206  96 EIERTAQIFELASSEVrrvFEGKYIPLQeyefpagnerRMALITREPIGVVGAITPFNFPAASFAHKVAPSLAVGNSVVF 175 Metallosphaera ...
A4FW36        93 EVDRTLTALKLSAFYAk-eLRGETINSEn---------GLIFTKKEPLGVVGAITPFNFPLNLITHKIGPAIATGNSVVL 162 Methanococcus m...
A6UVT6        93 EVDRTITTFKFSAFYSr-eLRGETIPFDd---------GMVITKREPVGLVGAITPFNFPLNLFAHKIAPAIAMGNSIVA 162 Methanococcus a...
YP_001273040  96 EVNRSIETLKLSAEEAk-rIYGETVPLDggin---gkgFFAFTQRVPLGVVAAITPFNYPLNLSIHKIAPAIACKNTVII 171 Methanobrevibac...
Feature 1                                                                                       #
Q58806       163 HPSSkaPLVCIELAKIIENalkkyNVPLGVYNLLTGAGEvVGDEIVVNEkVNMISFTGSSKVGELITKKAg--FKKIALE 240 Methanocaldococ...
YP_001191853 177 KPSTstPITGVLLGEILYEa----GLPKGVLSVLPGGGDtVGAEIVENRrVKGITFTGSTPVGTSIASKAvttGKRVMME 252 Metallosphaera ...
NP_343053    167 KPSIntPLAAIEMKKILVEa----GLPDSAVRVVTGYSSeIGDEIITHPlVGLITLTGSTQTGLKIASKAvslGKRIIME 242 Sulfolobus solf...
CAF18458     168 KPSShtPLTALKMAQILQKa----GVPQGVVQVVVGSGEeIFNEFVDNPkVVGISFTGSTAVGLQVAAKAagrGKKFMIA 243 Thermoproteus t...
YP_001539917 165 KPSRnsPLTETEIAKIITEv----GFPEGSINVVTGDSSmIGDEFVNNPkVSLITFTGSSKVGLNLASRAilmGKRVIME 240 Caldivirga maqu...
YP_823352    174 KLPEqcPLTVLMLGEILLDa----GLPPEGMQMLTGYPQeMGDELLTHPdVGMISFTGSASAAKLIACKAagtLKRLAFE 249 Solibacter usit...
YP_001191206 176 KPSSltPLTQLKLGELVSR-----VFPPGAINVVTGDSSmIGDEFVTNPkVSVITFTGSASVGLGLASRAireGKRVIME 250 Metallosphaera ...
A4FW36       163 HPSSkaPIVAIYLTKIIEHvlkqmDVPRGIFNLATGNGDiVGDEISKNDnINMVSFTGSVEVGESISKNAk--MKKVALE 240 Methanococcus m...
A6UVT6       163 HPSSkaPMITIELTKIIEKvlkskKIPLGVFNLLTGEGHiVGDEIVKNNkINKLSFTGSVEVGESITKKAg--FKKITLE 240 Methanococcus a...
YP_001273040 172 KPPInaPLTVMKFAELVNE-----EFPDGVINTVTGYGSeVGDALVTSPkVDKISFTGSVATGLLIASRAg--MKKVTLE 244 Methanobrevibac...
Feature 1                                       #  #                                             
Q58806       241 LGGVNPNIVLKDADLNKAVNALIKGSFIY-AGQVCISVGMILVDesIADKFIEMFVNKAKVLNVGNPLDEkTDVGPLISV 319 Methanocaldococ...
YP_001191853 253 MGGSDPIVVFKDADLERAVSISVRARFEY-AGQNCNAGKRILVQeeIYEKFLKEYVNRVKSLRVGDPMDEsTEMGPVISA 331 Metallosphaera ...
NP_343053    243 LGGSDPIIILEDANIERASSIAVRARFEY-AGQNCNAGKRIIVReeIYDKFVKAFNDKARALKVGDPLDEtTDVGPVINK 321 Sulfolobus solf...
CAF18458     244 PGGSDPAIVFADADLEAAASIIARARFEN-AGQNCNATKRVFVErkVYDKFLDILRRKIAAIKVGDPMDEsTEMGPVISD 322 Thermoproteus t...
YP_001539917 241 LGGSDAMIILEDADLNKAVQAATVGRFDY-AGQFCNATKRLIVRdeVYDEFIKRLTESVSKLKIGDPLREdTDVGPLISR 319 Caldivirga maqu...
YP_823352    250 LGGTDAMIVLEDANLEAAADAVVHGRLTNgAGQICCAAKRILVQesVYSRFLDLLIERVGKINMGDPLLDeTNLGPMISP 329 Solibacter usit...
YP_001191206 251 LGGSDAMIVLEDADLKRAVKSALLGRYDF-AGQFCNATKRVIVRkeIEDKFSALLREEVSKLRIGDPLDEnTDLSPLISG 329 Metallosphaera ...
A4FW36       241 LGGNNPMIVLKDSDIKLAAKSAVKSKFLN-AGQVCISVGQVLVEeeVLETFTKHVIEETKKLILGNPLDTkTDIGPLISP 319 Methanococcus m...
A6UVT6       241 LGGNNPMIILKDANINKAVESCMSGKFLN-SGQVCISVGRVLIEqeVADEFINKIVEKVKKLKIGNPLDEdTNISSLISL 319 Methanococcus a...
YP_001273040 245 LGGNDPLVVLKDADIDRAVNGVMNGAYLN-AGQVCMGVKRIIVDesIADEFTQKLVRETKKIKMGDPMDKnTVLGTLIDE 323 Methanobrevibac...
Feature 1                                                                                        
Q58806       320 EHAEWVEKVVEKaideGGKLLLGGKRd---kALFYPTILEVDr---dNILCKTETFAPVIPIIRTN-EEEMIDIANSTEY 392 Methanocaldococ...
YP_001191853 332 SVVKDLENAVLDsetkGGVIHRGMAGtg--gYYFAPTVVENAnl--dMVIMKREIFGPVAPIAKFSdWKEAVELANSTEY 407 Metallosphaera ...
NP_343053    322 ESVENLNSVLADakakGGKVEILNKGpe-sgSFFPLTMVTNPsl--dMLVLKSEVFGPIVPIVSVKsDEEAIRIANSTEY 398 Sulfolobus solf...
CAF18458     323 KMVKAMEGIVADavekGGKLLYGGRRmqrkgYFFEPTLVAFDgrppeAKAFREEVFGPVLPVAPFEdEREAVELANWTQY 402 Thermoproteus t...
YP_001539917 320 EAVETMEFFVNDalskGGRIIYRVSGvpergFYYPPTILEAPf---nSAVWIEEVFGPVLPVARVKdDDEAVELANRTEY 396 Caldivirga maqu...
YP_823352    330 QAVDKAHDQVRQslemGARCLTGGERid--gCFYQPTVVVDVtp--eMPVMRDEVFGPVAPIYTFKdAESAVRIANDSPY 405 Solibacter usit...
YP_001191206 330 EARERMKLFLDDavskGGEIIYKGEVqe-rgNYFPPVILRLRpf-sdLKVLKEEVFGPILPIVSVDsDDEAVDVANSTEY 407 Metallosphaera ...
A4FW36       320 ESALRIENLIKKsvneGGEVLIGGNRq---nSLISPAVINIDe---nNILSKIETFGPVLPILKVKdSEEAVSIANNSKY 393 Methanococcus m...
A6UVT6       320 DSAERVEKLINKsigqGGKLICGGKRe---nSIIYPTILEITa---dNILANIEIFAPVLPIIRVNdMNEALNQANNSNY 393 Methanococcus a...
YP_001273040 324 DAARMVEETVNNavkaGAKILTGGKRd---gAFYEATVLDNVtp--dMDVVVNETFGPVAPIIKVKsTDEAIKVANDTEY 398 Methanobrevibac...
Feature 1                                                                                
Q58806       393 GLHSAIFTNdINKSLKFAEnLEFGGVVINDSslFRQDNMPFGGVKKSG---LGREGVKYAMEEMSNIKTIII 461 Methanocaldococcus jann...
YP_001191853 408 GLQASIFTSdLKLALKMSReIRAGAVIVNDStrLRWDSLPFGGVGLSGi--GSREGVRSTMLAMTEEKLISL 477 Metallosphaera sedula D...
NP_343053    399 GLQSAIFTNdVNRALKLSReLKFGAVIINDStrLRWDSLAFGGFKKSS---IGREGVRETMLEMTENKLIAI 467 Sulfolobus solfataricus P2
CAF18458     403 GLQSAVFTSdYKRAFRVARaIKAGAVMINDStrVRFDALPYGGVKMSGlsaGWREGVRSTMLLFTEIKYYVL 474 Thermoproteus tenax
YP_001539917 397 GLDASIFSRnFSRAYKLATrIKAGTIFINDTtrLRFDNLPFGGFKKSG---IGRESVRDTMIEMSEVKVISY 465 Caldivirga maquilingens...
YP_823352    406 GLQASVFSEnISNALKVAHkLEVGGVVINGSgaFRPGNIPFGGFKQSG---IGRESIVETVLDMTEETTIVI 474 Solibacter usitatus Ell...
YP_001191206 408 GLDASIFTKdFGRALRIASrLKVGTVVINDTtrLRWDNLPFGGTKKSG---IGRESVLDTMLEMTETKLIVY 476 Metallosphaera sedula D...
A4FW36       394 GLQAGVFTNdINKAMKIADsLEYGGIMINSSptFRKDNMPFGGVKKSG---LGREGIKYTVEEMCETKTIVI 462 Methanococcus maripalud...
A6UVT6       394 GLHSGVFTQdINKALYFADnLEYGGVLINNSptFRIDNMPFGGIKHSG---LGREGIKYAIDEMSEIKTIIV 462 Methanococcus aeolicus ...
YP_001273040 399 GLQAGVFTEnFRDGLRCANeIEAGTVFVNKQstFRTDNMPFGGFKNSG---TGKEGVKYAVEEMTKEKLIGL 467 Methanobrevibacter smit...

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