Conserved Protein Domain Family
ALDH_ALD2-YMR170C

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cd07144: ALDH_ALD2-YMR170C 
Saccharomyces cerevisiae aldehyde dehydrogenase 2 (YMR170c)-like
NAD(P)+-dependent Saccharomyces cerevisiae aldehyde dehydrogenase 2 (YMR170c, ALD5, EC=1.2.1.5) and other similar sequences, are present in this CD.
Statistics
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PSSM-Id: 143462
View PSSM: cd07144
Aligned: 9 rows
Threshold Bit Score: 859.403
Threshold Setting Gi: 45198320
Created: 2-Jan-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
NAD(P) bindingcatalytic
Feature 1:NAD(P) binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
XP_001386665  14 GNTFTQPTGLFINNEFVKSVSGKTldSINPSTSEVNGTVYCaeeeDVDIAVKAARAAFKDwk--kvTGVDRGILLNKVAD 91  Pichia stipitis...
NP_985349     14 GFTYLQPLGLFIDNEFVAPMGGSQlqTTNPANGELIATFYAagaaDVDAAVAAARRAYEErwr-htSAQERGALLARLAE 92  Ashbya gossypii...
XP_001645397  14 SVEYNQPLGLFINNEFVKSSDQEKikTFNPSNGEYIVSFYAasekDTNLAIDVAERAYCSsws-ntTPNERSELLDKLYH 92  Vanderwaltozyma...
EDP50237      61 GRKYSQPIGLFINNEFVPSKSGEKfaTINPSDESEIASVYAageeDIDIAVKAARKALKDpswkmlPATDRGNLMLKLAD 140 Aspergillus fum...
XP_502555      8 GKSYDQPTKLFINNEWVDGHGGSIe-SVNPATEQVICSVEAadesDVDKAVQAARNCYENvwr-kvTGAERAQLMRKLAD 85  Yarrowia lipoly...
P47771        14 KISLKQPLGLFINNEFCPSSDGKTieTVNPATGEPITSFQAanekDVDKAVKAARAAFDNvws-ktSSEQRGIYLSNLLK 92  baker's yeast
Q9URW9        14 GKSVKQPIGLYINGEWHKSAETWE--TVDPSIEEVIAKVYLagekEIDYAVKSAKEAFKTwk--kvPGSEKGELLMKLAE 89  fission yeast
XP_382336     12 GKKYDQPTGLFINNEFIAATGDEFv-VTNPHTEEEVIKLKGaskeDVDKAVQAARKAFEGews-elAAVDRGAFLYKIAD 89  Gibberella zeae...
XP_504993     29 GNKYEQPTGIFINNEWSEASDKGTipVYNPSTGDEVVQVAAataeDVDRAVVAARKAFQSwr--dvPGEERAKLLDNFIN 106 Yarrowia lipoly...
Feature 1                                                                                ## ##   
XP_001386665  92 AFEAQRDLIGAIEAWDSGKTkeqNAVYDIDECISCFRYFAGWADKi-qGKVIQndpkKLAYTIHEPLGVCGQIIPWNYPL 170 Pichia stipitis...
NP_985349     93 LVDEEREVLAGIETLDSGKPyhtNALADLDQVAYVTRYYAGGADKmhqGDAFAlshtKQAYTLEVPYGVVAQIVPWNYPL 172 Ashbya gossypii...
XP_001645397  93 LTKKNRELLGTIETLDTGKPfhsNSLNDIDQILEVIRYYSGSCDKlttGETFItennYHRYTVKQPYGVVGLIVPWNYPL 172 Vanderwaltozyma...
EDP50237     141 LVEQHRETLATIETWDNGKPysvAFNDDLGEVINTIRYCAGWADKv-hGQTISttsaKFAYTLRQPIGVVGQIIPWNFPL 219 Aspergillus fum...
XP_502555     86 LVEKNKDLLTSIEAADSGKPkygNCDGDVDELIYVLRYYSGLAEKagnGVTIStsneKFAYTIHEPYGVCGQIIPWNYPI 165 Yarrowia lipoly...
P47771        93 LIEEEQDTLAALETLDAGKPyhsNAKGDLAQILQLTRYFAGSADKfdkGATIPltfnKFAYTLKVPFGVVAQIVPWNYPL 172 baker's yeast
Q9URW9        90 LTEKHADTLAAIEAMDSGKPlvsNARGDVDGTIALLRYCAGWADKi-yGQVIPtgpeKLAYAKRTPIGVCGQIVPWNYPL 168 fission yeast
XP_382336     90 LIDRDRELIAAIDAFDNGKPfsaCLAGDLDESYNVFRYYAGAADKi-sGKTIEtspaKLAYVLQEPLGVCGQIIPWNFPF 168 Gibberella zeae...
XP_504993    107 LVSKNLDTVAAIEALDSGKPlqlNARGDIAGGLAVYKYYAGWADKv-fGKTIVnttkKLAYTLHEPHGVCGQIIPWNYPF 185 Yarrowia lipoly...
Feature 1                           #  #                            ##   ##            ####  #  #
XP_001386665 171 AMAAWKLAPALAAGNVVVLKTSEiTPLSLLYVARLFKdAGFPAGVVNIISGFGavaGKALSSHLdVDKIAFTGSTATGKL 250 Pichia stipitis...
NP_985349    173 AMASWKAQGCLAAGNCVVIKPSEnTSLSLLYFASLVRrAGFPPGVFNVLPGLGpevGQRLAEHKgVDKIAFTGSTAVGQK 252 Ashbya gossypii...
XP_001645397 173 AMAAWKLFGCLAAGNTVVIKPSEhTSLSLLYYGKLLVeAGLPPGVVNIIPGYGeitGRAIAMSDkLQKLSFTGSTRVGKL 252 Vanderwaltozyma...
EDP50237     220 AMAAWKLGPALACGNTVVMKPAEqTPLSILYLATLIKeAGFPPGVVNILNGFGrvaGSALVNHPdVDKVAFTGSTATGRE 299 Aspergillus fum...
XP_502555    166 AMAAWKLGPCLAAGNVLVMKLSEyTPLSMLVICNLVKeAGFPPGVVNVVNGYGakaGNRLAEHPdVDKIAFTGSTATGRS 245 Yarrowia lipoly...
P47771       173 AMACWKLQGALAAGNTVIIKPAEnTSLSLLYFATLIKkAGFPPGVVNIVPGYGslvGQALASHMdIDKISFTGSTKVGGF 252 baker's yeast
Q9URW9       169 NMAGWKIAPALAAGNCIIIKSAEtTPLSLLYFATLVEeAGFPKGVVNIISGLGtvaGSYMAKHPgIDKIAFTGSTKVGVI 248 fission yeast
XP_382336    169 MMLAWKVAPALACGNTVILKPAEqTPLSALYFGNLVKeAGLPAGVVNVLPGLGpstGKAIAGHMdIDKVAFTGSTNTGRA 248 Gibberella zeae...
XP_504993    186 LMAAWKIAPAIAAGNVVVMKLAEnTPLSMLYLCNLFKeAGFPPGVINIFTGHGakaGSRLAEHPdVDKIAFTGSTATGRI 265 Yarrowia lipoly...
Feature 1        #              ###                               #                              
XP_001386665 251 IQQAAAs-nLKAVTLECGGKSPLIIREDaDLEQAVKWAAIGIMSNqGQICTSTSRVYVHesVYDKFLEEYTAHVKEAykq 329 Pichia stipitis...
NP_985349    253 VMAAAAmsnLKDVTLECGGKSPAVIFADaDLDSAVNYVAAGIFYNsGQNCTANSRIYVQeaVYDAFLDKFRAHVRSTysf 332 Ashbya gossypii...
XP_001645397 253 MMEMSGqsnMKDVTLECGGKSPAVVFRDaNLDNAASWIATGICYNsGQNCTATSRVYADknIYNELISKIVEEIKQNwki 332 Vanderwaltozyma...
EDP50237     300 IMKMAAg-tMKNITLETGGKSPLLVFDDaDLEQSAKWAHIGIMYNqGQVCTATSRILVHesVYDRFVTLFKEAVATTskv 378 Aspergillus fum...
XP_502555    246 VMKAATg-nMKAVTMELGGKSPLLIFDDcDLAKAIEWAHIGIMYNmGQVCSATSRILVQegIADKFVEGFIKQCNEAsil 324 Yarrowia lipoly...
P47771       253 VLEASGqsnLKDVTLECGGKSPALVFEDaDLDKAIDWIAAGIFYNsGQNCTANSRVYVQssIYDKFVEKFKETAKKEwdv 332 baker's yeast
Q9URW9       249 VQQLAAs-nLKAVTLECGGKSPFLVFEDaDLDQAVKWAALGIMYNsGQICTSNSRIYVQdsVYDKFIELFKKHVIQDyiv 327 fission yeast
XP_382336    249 IMKDAAn-nLKNITLECGGKSPSIVFADaELEQAVKWCHFGIMDNkGEVCTSTSRIYVHedIYDKFLEKFVEVTKENdkl 327 Gibberella zeae...
XP_504993    266 IMKLAAt-nLKAITLECGGKSPMIVLGDaDLDQATKWAHAGIMTNqGQICCGVSRVLVHesIYDQFVDKYVEVVKQRsrv 344 Yarrowia lipoly...
Feature 1                                                                                  # #   
XP_001386665 330 gsm---fdseaVVGPQVSKVQRDKVLSYIEIGkkeGARLLLGGEKnsegelsKGFYIKPTIFADIkpeMRIVNEEIFGPV 406 Pichia stipitis...
NP_985349    333 gsg--lfskdcNMGPVISKTQYDRVMGYINHGi--NEKLAYEQFGsv---peKGYYIPPTIFLDVpqsSRLCREEIFGPV 405 Ashbya gossypii...
XP_001645397 333 sstfdpfdddgTLGPIINNTQYDRVTDFIHVGs-hIEKLNRIDIFkel-gecKGNYINPVIFTDVpqtSVLIQNEIFGPV 410 Vanderwaltozyma...
EDP50237     379 gdp---faddtFQGPQVTKAQYERVLSYIEAGkseGATLVAGGEPyknvkdgKGFFIAPTIFTNVkddMRIYREEVFGPF 455 Aspergillus fum...
XP_502555    325 gcp---ldqktSHGPQVNKIQYEKVLGYIEKGkaeGAKCILGGEAapq--ngKGYFIKPTAFTNVnkdMTIWKEEIFGPV 399 Yarrowia lipoly...
P47771       333 agkfdpfdekcIVGPVISSTQYDRIKSYIERGk-rEEKLDMFQTSefpiggaKGYFIPPTIFTDVpqtSKLLQDEIFGPV 411 baker's yeast
Q9URW9       328 gmp---fddntVVGPVVNKTQYNRIKNYIEQGkkeGAKLVLGDEPlp---lkQGYFISPTIFADCsenMTIVKEEIFGPV 401 fission yeast
XP_382336    328 gap---fdestVQGPQVSKTQYDRVLSYIEEGrksGAKLLYGGSKhg----gKGYFLQPTVFADTtedMKIMKEEIFGPV 400 Gibberella zeae...
XP_504993    345 gdm---fqdkiLQGPQVSKVQQEKVLGYIEKGkeeGAKLVYSGAVaae-aleKGYFVPPTVFADVrddMVISREEIFGPV 420 Yarrowia lipoly...
Feature 1                              #                                     #                   
XP_001386665 407 VVVGKFSsDEEVITYANQTQYGLGAAIFTKDITVAHTMAAeIQAGMVWINSSnDSDVHIPFGGVKMSGVGRELGEYGLSI 486 Pichia stipitis...
NP_985349    406 AVVAKFKdYDEAIRYANDTNYGLASCVFTENIRVAHRFVRdVQSGTVWVNSSnDEEVGVPFGGFKMSGIGRELGKAGLQT 485 Ashbya gossypii...
XP_001645397 411 LTISKFTtYDEVVKLVNDSRYGLAAAAFTEDYRLAHQFTKeVEAGTVWINSSnDECIGMPFGGFKMSGIGRELGATGVES 490 Vanderwaltozyma...
EDP50237     456 VVISSFKtEEEAITRANDTTYGLGAAVFTKDIERAHRVASeIEAGMVWINSSnDSDFRVPFGGVKQSGIGRELGEAGLEA 535 Aspergillus fum...
XP_502555    400 VVIDTFKtEEEAIAKANDTPYGLAAALFTENIRRAHRVVKeLRAGQVWVNSDnDSDPRVPFGGVKQSGIGRELGEYGLSI 479 Yarrowia lipoly...
P47771       412 VVVSKFTnYDDALKLANDTCYGLASAVFTKDVKKAHMFARdIKAGTVWINSSnDEDVTVPFGGFKMSGIGRELGQSGVDT 491 baker's yeast
Q9URW9       402 VAISKFKtEDEAIEKANNTTYGLAAMCFTKDLERAHRVSDeLEAGMVFINSTeNSDIQAPFGGIKMSGIGNELGSNGIEM 481 fission yeast
XP_382336    401 VSIAKFStDEEAIKKANDTSYGLAAALFTEKIARAHKVARkLQAGMVWINSSgDSHFGIPFGGYKSSGIGRELGQYALDA 480 Gibberella zeae...
XP_504993    421 VAIAKFSdVEDAINRANDSEYGLAASVYTKDLTEAHRISRrLESGQVFINMAhMGDYRMPFGGYKQSGIGRELGEYGLDT 500 Yarrowia lipoly...
Feature 1                   
XP_001386665 487 YTQAKAIHVNL 497 Pichia stipitis CBS 6054
NP_985349    486 YLQTKAVHLNF 496 Ashbya gossypii ATCC 10895
XP_001645397 491 YLQTKSVHFNL 501 Vanderwaltozyma polyspora DSM 70294
EDP50237     536 YTQIKAVHVNL 546 Aspergillus fumigatus A1163
XP_502555    480 YTQAKAVHINL 490 Yarrowia lipolytica CLIB122
P47771       492 YLQTKAVHINL 502 baker's yeast
Q9URW9       482 YTQIKAVHINF 492 fission yeast
XP_382336    481 YTQPKAVHVNL 491 Gibberella zeae PH-1
XP_504993    501 YTQCKAVHINM 511 Yarrowia lipolytica CLIB122

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