3B4W


Conserved Protein Domain Family
ALDH_AldA-Rv0768

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cd07139: ALDH_AldA-Rv0768 
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Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like
The Mycobacterium tuberculosis NAD+-dependent, aldehyde dehydrogenase PDB structure, 3B4W, and the Mycobacterium tuberculosis H37Rv aldehyde dehydrogenase AldA (locus Rv0768) sequence, as well as the Rhodococcus rhodochrous ALDH involved in haloalkane catabolism, and other similar sequences, are included in this CD.
Statistics
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PSSM-Id: 143457
View PSSM: cd07139
Aligned: 33 rows
Threshold Bit Score: 586.464
Threshold Setting Gi: 111027004
Created: 2-Jan-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
NAD bindingcatalytic
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:NAD binding site [chemical binding site]
Evidence:
  • Structure:3B4W; Mycobacterium tuberculosis aldehyde dehydrogenase complexed with NAD+, defined using 3.5 A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
3B4W_A        11 LFIGGKWTkpstsdvieVRCPATGEYVGKVPMaaaaDVDAAVAAARAAFDNgpwpstPPHERAAVIAAAVKMLAERKDLF 90  Mycobacterium t...
YP_700367     21 IFLGGRWVdstgdewvdVVDSFTEEKVARVRTatveDVTKAVAAARESFDRgewasrTMADRADVLDAIADRLEQRVDEL 100 Rhodococcus sp....
YP_001261505  16 FLIDGTWIepgdrrrfdIVTPSDESLYASVPCatadDVARAVAAARRAFDEgpwpglAPAERGAVLDRLADAIDARSDLF 95  Sphingomonas wi...
YP_366966     14 FYIGGQWVapstpdtfdVLDCATEEVVATVAKaasaDMQRAIDAARDAFDNgpwprmTPQERAGYLEKFAERLEALNDEF 93  Burkholderia sp...
YP_001262046  11 LFIGGAWVepldgqpisVVSPDTEEVVYTVAGagprDMDRAVEAARRAFDGsgwsdaQPEERIAAVERLADALDRRSAEI 90  Sphingomonas wi...
YP_498071     14 LYIAGRWVpahsgrmieLVSPNTELVVGRVAEadetDMDAAVAAARDAFDHgpwpttPPAERIAAFRRMVAHLETRVPEL 93  Novosphingobium...
YP_001859404  20 FYIGGHWVlpnsketasLVSPTTEKSFLSVPLadrrDVDDAVRAARKAFDTgpwplmSAAERSDYLRRLSGAVASRMQLL 99  Burkholderia ph...
NP_641234     19 LFIDGQWRastgdrtvdVIAPHTEERLLRYTEpspsDTEAAIAAARSAFDNgpwpqlSPQERSVVLKRVADHLRARMPEL 98  Xanthomonas axo...
YP_001262477  20 LFIGGEWRapadgtfldVVSPATGAVGARVAAggpkDIEAAVRAARDAFDNgpwprmPIAERAAIVRRIGALLRERLTET 99  Sphingomonas wi...
YP_001260890  14 LFIGGDWAassddggieIVSPSTEEVVGRVGKagraDMDRVVAVARHAFDHgpwprmTGAERAAVLRRIAGEMGKRADDF 93  Sphingomonas wi...
Feature 1                                                                        #####           
3B4W_A        91 TKLLAAETGQPptiIETMHWMGSMGAMNYFAGAadkvtwTETRTgs--yGQSIVSREPVGVVGAIVAWNVPLFLAVNKIA 168 Mycobacterium t...
YP_700367    101 TPIGVIEVGVPv-sVSRPTQQMTGGLFRAVAAVarefevSEERSra-dgGISRIVKEPTGVVAAIIPWNGPIGTIAFKLA 178 Rhodococcus sp....
YP_001261505  96 ATIWTHEVGGVl-tHGGHMVAASTAVIRDYARLgrdfpfIERQAptaggAVGMLVHEPVGVVGAIIPWNGPILMLASKIA 174 Sphingomonas wi...
YP_366966     94 ARIWTIETGIVykvAQPRIGLFISGAFRQYAAMaatfpfVEEQRsv-tgNLGYRVYEPVGVVGEIIPWNGPAGLMAYKTA 172 Burkholderia sp...
YP_001262046  91 AEVWSRQMGALs-vIAPIFTGIGTQNLRDAIAAgrrfpfETRVEsq-aaADARVVHEPVGVVAAITPWNVPYMLMTAKIG 168 Sphingomonas wi...
YP_498071     94 AKAWTAQMGGLa-sFAGPMHGGSVMALGQIAGFaekfefVERRPsm-aaDTALIAYEPVGVVAAIAPWNGPFGIMANKVA 171 Novosphingobium...
YP_001859404 100 SRLWTAEVGAPv-wFADLFTPTATAMLEYYAELslsfpfKEHRQtr--gGHARVLRQPVGVTALIAPWNAQLPILAYKLS 176 Burkholderia ph...
NP_641234     99 AEAWTGQVGATl-gFSKRASQQAPDLFDYYADLiathafVQPRVrp-sgGRVHVVQEPVGVVAAITPWNAPLVLLCYKVA 176 Xanthomonas axo...
YP_001262477 100 TWATTLEMGAPl-pMARAVAERAAALFDEYADIgeayliEDVRAra-ngEHAVVVSEPVGVVAAIVPWNGPSLLAALKVA 177 Sphingomonas wi...
YP_001260890  94 ARAWSLQVGMPy-aQSSMTAPYMAAYLTYFADLaek-gfEEVRQpm-mgGHCIVVHEPVGVVAAVVPWNAPLATLLLKVA 170 Sphingomonas wi...
Feature 1                   #                                       #             ####  #  #     
3B4W_A       169 PALLAGCTIVLKPAAetPLTANALAEVFAe----vGLPEGVLSVVPGGIetGQALTSNPdIDMFTFTGSSAVGREVGRRA 244 Mycobacterium t...
YP_700367    179 PALAAGCSVVLKTAPeaPISPSVFADIIAelvaegRIPEGVVSVLCADRevSESLVTNPdVDHVTFTGSTAAGRRIMSLA 258 Rhodococcus sp....
YP_001261505 175 PALVAGCTLVVKTSPeaPLEAVLLGEIVEe----lGLPPGVVNILMADReeSELLVRNPdVDKISFTGSSAVGQHVASIC 250 Sphingomonas wi...
YP_366966    173 PALLAGCTLVIKSSPeaPCSAYLFAEICDe----iGLPPGVVNVVTADRdvSEELVRHPgVDKITFTGSTGAGRRIASIA 248 Burkholderia sp...
YP_001262046 169 PALVAGCTIVMKPSPetPLEAYIIAECAEe----aGLPPGVVNLVPSDReaADHLMRNPaVDKVAFTGSTAVGRQIAQVC 244 Sphingomonas wi...
YP_498071    172 YALLTGCTVIMKPSPetPLEAYIIAEAAEa----aGIPAGVVNLVTGHReaSDHLVCNEgVDKVSFTGSTVAGKRIASVC 247 Novosphingobium...
YP_001859404 177 AALAAGCTVVVKAPPetPLDALVLAECAHe----vDLPPGVLNVITADAdrGAHLVANVaVDKVSFTGSTATGKVIAKTC 252 Burkholderia ph...
NP_641234    177 AALAAGCTVVAKPSPetPIDAYILAECISa----aGVPDGVFNLLPAGRevGEQLIRHPhVDKISFTGSTQAGRSIGIAC 252 Xanthomonas axo...
YP_001262477 178 PALVAGCAVVLKPAPetPLDAYILAECIEa----aGVPAGVFNLVPADReaSDHLIRHHdVDKISFTGSTMVGKHILRTT 253 Sphingomonas wi...
YP_001260890 171 PALAAGCAVIAKPSPetPLEALILAECIAa----aGVPEGVFSVLTADRevSDHLIRNPgIDKVSFTGSTAAGLHIASVC 246 Sphingomonas wi...
Feature 1                 ###                                #                                   
3B4W_A       245 AemLKPCTLELGGKSAAIILEDv-DLAAAIPMMVFSGVMNaGQGCVNQTRILAPrsrYDEIVAAVTNFVTALpvGPPSDP 323 Mycobacterium t...
YP_700367    259 GerIARVSLELGGKSAAIILDDa-DINHVLQTLPMGGCMQsGQACIALTRVLVSrkrHDEVVEALKAAYGSLpmGNPWEP 337 Rhodococcus sp....
YP_001261505 251 GgrMARATLELGGKSAAVVLDDs-PLDVVVGAIAPQVGMLaMQFCSALSRVIVPahrHDDLLDGLAAALRQVkvGDPFDA 329 Sphingomonas wi...
YP_366966    249 GdrIARVTLELGGKSPAVILDDydIETAANVLGPSYFGYNtGQICHSLTRVIVPrakHDAMVEALSAIAKQIvvGDPFAP 328 Burkholderia sp...
YP_001262046 245 AeqVRRCTLELGGKSAAIMLDDm-SDAEAAKILTEAITTLsGQVCAMLSRALVPrhrHDGVAAAIVEEMKRVriGHSDDP 323 Sphingomonas wi...
YP_498071    248 GsrMARCTLELGGKSAAIVRDDf-PIDAAAKMLAGTITMMsGQVCAMLSRVIVPrrrHDELAEAIAAEMKKVriGNSDDP 326 Novosphingobium...
YP_001859404 253 AdrLARVTLELGGKSAAIILEDa-ELEPTLASLSPYTMPFsGQICFAQTRILVPrnrEQEIVEAYSAVIGGLnvGDPWDE 331 Burkholderia ph...
NP_641234    253 AerLARVGLELGGKSAAIVLEDa-DLAKMLPTLVPYSMPIaGQVCFSLTRVLVPtqrREEILQAYCTALSAVklGDPFAA 331 Xanthomonas axo...
YP_001262477 254 AdrVARVSLELGGKSAAIVLDDa-DPELVVSRMATEVTMNtGQICAALMRVIVPraqAKMYGEMLADAVAKIrvGNPFEQ 332 Sphingomonas wi...
YP_001260890 247 GgrMARVTTELGGKSAAIVLDDa-TIETVVAGIMPNLVGLcGQQCAAFSRILVPaarKAEVTEAMAAAMQAVtvGDPFDQ 325 Sphingomonas wi...
Feature 1                                                                       # #              
3B4W_A       324 aaQIGPLISEKQRTRVEGYIAKGieeGARLVCGGGRpegldnGFFIQPTVFADVDnkmTIAQEEIFGPVLAIIPYDtEED 403 Mycobacterium t...
YP_700367    338 tnFLGPLASKRQQDRVLGYIDIAkedGAKVVLGGGRpegldtGFFVAATLIDDVQpdsRIAQEEVFGPVISVITYEdEED 417 Rhodococcus sp....
YP_001261505 330 atQMGPMAMKRQLDRARSFIDSGkadGFTLAAGGGRpagldrGYYLEPTLFGHVRndaRIAQEEIFGPVIAVIPARdEEE 409 Sphingomonas wi...
YP_366966    329 etTSGPLASARQRETVERFVATGiaeGATLATGGKRpaglarGFFFEPTVFGNVDnrsTIAQDEIFGPVLSVIPADdEAS 408 Burkholderia sp...
YP_001262046 324 stQMGPLATRRQLDRVERYVEIGvseGAQVLTGGKRpaqpnrGVFFEPTLFVGVTndmTIAREEIFGPVLCLIPYDgVDD 403 Sphingomonas wi...
YP_498071    327 etQLGPVAMKRQLERIEMYIEEGr-kTADLVTGGGRpahlnrGYFIEPTLFANVRnesRIAQEEIFGPVLSLIPVEdEED 405 Novosphingobium...
YP_001859404 332 ttQIGPLANRRQFDRVLRYIDVGrseGARLATGGKScerferGYFVEPTIFSGVTpdmTIAREEIFGPVVTVTAYDdVDH 411 Burkholderia ph...
NP_641234    332 dtGMGPLALGRQLERVQSYIAKGkaeGARLVMGGSRpahlsrGFFVEPTVFAEVMpdmAIAREEIFGPVVSFIDYHdEAD 411 Xanthomonas axo...
YP_001262477 333 gtQVGPLAMKRQLERVQGYIEKGreeGATLMCGGGRpsdlgdGFYIQPTVFANVDhrmTIAREEIFGPVASVIAHDgPDD 412 Sphingomonas wi...
YP_001260890 326 atQMGPLVTRNQHGRVFGYIEKGkaeGARLVTGGGRpahlpkGWFVEPTLFADASndmAIAREEIFGPVGTIIAYDdEEQ 405 Sphingomonas wi...
Feature 1                                                        #                            
3B4W_A       404 AIAIANDSVYGLAGSVWTTdVPKGIKISQQIRTGTYGINWYaFDPGSPFGGYKNSGIGRENGPEGVEHFTQQKSVLL 480 Mycobacterium tube...
YP_700367    418 AIAIANNSVYGLSGAVYTEdLDHGFEVARRIRTGTISVNTAtMDFTLPFGGYKQSGVGREGGIEGLEEFFETKTVHL 494 Rhodococcus sp. RHA1
YP_001261505 410 AIRLANQSDFGLNSSVFTRdAERAMAVARRLRAGTVGHNAFrSDFGIAFGGFKKSGIGREGGRPGLMPYLEAKTVIM 486 Sphingomonas witti...
YP_366966    409 AIRMANDTPFGLNAAVFTNdRARALHVARQIRSGTVGHNGPrTDFSIGFGGFKQSGIGREGGVEGLTAFMESKTIVM 485 Burkholderia sp. 383
YP_001262046 404 AVRIANDSIYGLNASVLTHdAAAAAAIGRRLRAGMFAQNGLrSDFSLPMGGFKQSGIGREGGEQGLRGYLETKTMLL 480 Sphingomonas witti...
YP_498071    406 AIRTANASAYGLNGSVLTNdAEAAYRIARRVRTGGFGQNGLrMDFGLPFGGFKQSGIGREGGPEGLFPYLEMKTILI 482 Novosphingobium ar...
YP_001859404 412 AIALANDSDFGLSGTVFTTdVERGYDVARQLKTGNVSVNGLeMSPNVPFGGFKQSGVGREGGPEGLSAFLEDQAIYL 488 Burkholderia phyma...
NP_641234    412 LIAKANASDYGLHGTIYSEdAERAYRIARRVRSGSHAINGMwVDISMPFGGFKHSGIGREGGIEGLHAFLETRTLYL 488 Xanthomonas axonop...
YP_001262477 413 AVRIANDSDYGLHGGVFTRdVDTAYAVARRMRTGNVGHNIRtIDWQMPFGGFKQSGLSREGGVEGFRNFLEIKTVYV 489 Sphingomonas witti...
YP_001260890 406 AIAIANDSNYGLSGGVFTEsPDRAYAVARRIRTGNFGHNGRvIDFTMPYGGFKQSGIGREGGIEGLYAFTETKAVFM 482 Sphingomonas witti...

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