Conserved Protein Domain Family
ALDH_F14-YMR110C

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cd07135: ALDH_F14-YMR110C 
Saccharomyces cerevisiae aldehyde dehydrogenase family 14 and related proteins
Aldehyde dehydrogenase family 14 (ALDH14), isolated mainly from the mitochondrial outer membrane of Saccharomyces cerevisiae (YMR110C) and most closely related to the plant and animal ALDHs and fatty ALDHs family 3 members, and similar fungal sequences, are present in this CD.
Statistics
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PSSM-Id: 143453
View PSSM: cd07135
Aligned: 22 rows
Threshold Bit Score: 617.695
Threshold Setting Gi: 2494079
Created: 1-Jan-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
NAD(P) bindingcatalytic
Feature 1:NAD(P) binding site [chemical binding site]
Evidence:
  • Comment:based on similarity to structure 1AD3, class 3 rat liver aldehyde dehydrogenase (ALDH3A1)
  • Citation:PMID 9095201

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
Q04458        11 YTPVSKIDEIVEISRNFFFEKQlklshennprkkDLEFRQLQLKKLYYAVKDHEEELIDAMYKDFHRnkiESVLNETTKL 90  baker's yeast
CAG90422      60 YTPLDEIPVRVARLTESFHKTRkt---------hSIQYRLNQLRNLYFAVKDNVDPLCDALYKDFYRsasETKNLEITGG 130 Debaryomyces ha...
XP_500179      9 PTPIDTFDSNLQRLRDSFETGKl----------dSVDYRLEQLRTLWFKFYDNLDNIYEAVTKDLHRprfETELTEVLFV 78  Yarrowia lipoly...
XP_001730031   3 TTPADTIPALVGRLRATFLTGKt----------rCVEYRKNQLKQLYFLVKDNEEAFVDAIGQDLGRpgmETTFAEVIGI 72  Malassezia glob...
XP_001642608   8 YTPLDEIDRKIQRSVDYYHNRQrnlaqvrnpskhDLQFRELQLKKLYYAVKDNEQEIVKALQADFHRsplETIGLEYCKL 87  Vanderwaltozyma...
XP_762570    117 YTPIDDIPSIVSDLRAAFLTGKt----------rSVEYRKNQLKQLAYMIKDNQEAFVESLRKDLGRsrfESIFAELMGT 186 Ustilago maydis...
XP_505802     12 ATPLDQIPGDIQRLRKGFRSGKt----------lDLNYRLDQIRNLHYVLRDNVEAIKDAVYKDLGRpkhETDLCEVGFL 81  Yarrowia lipoly...
XP_568438      8 STSLSQIDQLYDTVNKRFNSGVt----------lPLAYRLYNLKQLAYLIKDNETLIQAAIEKDNGKgpfDATLGDIWPT 77  Cryptococcus ne...
XP_448377      7 YTELSEIDAKISISRNYFQQNRkelanqknvrsaDNKQRQFWLKKLYWSVKDHEEQILEALEKDFHRsrqESISLEYVKL 86  Candida glabrat...
XP_452089      6 FTDLKSIPGKIELAKQFYRSRQarlaqskspratDINERIRSLQKLYWAVKDNEERLIAAASKDFHRarsETLTIELVPL 85  Kluyveromyces l...
Feature 1                                                       ###                         #    
Q04458        91 MNDILHLIEILPKLiKPRRVSdssp-pfmfGKTIVEKISRGSVLIIAPFNFPLLLAFAPLAAALAAGNTIVLKPSELTPH 169 baker's yeast
CAG90422     131 LSELLHVMSSLHKWiQPEKVTdlpv-smsaTPVYIERVPLGTVLVISPFNYPFLLSLSSIVAALAGGNVVVFKPSESTPH 209 Debaryomyces ha...
XP_500179     79 RDEFSTVIKNLRKWvKEEKVEnpgg-pfqfANPRIRPVPLGVVLVITPWNYPVMLNISPVIAAIAAGCPIVLKMSELSPH 157 Yarrowia lipoly...
XP_001730031  73 ENDLATSISQLSKWsKDECVGagpp--fmlHGTKIRKDPKGTVLVLGAWNYPITVQLGPMVGAIAAGNTVILKPSELSPH 150 Malassezia glob...
XP_001642608  88 VGDILNMLKGLKKWvKPEKVAdnsp-pfmfGKIVIEKASLGSVLVISPFNFPVMLGLTPVAGAIAGGNSVILKPSELTPC 166 Vanderwaltozyma...
XP_762570    187 TNEIVEAVTKIDKWaKPAKPWagaa--wamHGATIRSEPKGTVLVLGAWNYPITVQIGPVIGAIAAGNTVILKPSEVASH 264 Ustilago maydis...
XP_505802     82 WGEFNNVVANLKKWaADEDVKtnlq--ysiSSPKIRKRPLGNVLIISPWNYPFMLTVSPLIGALAAGNTVAVKFSEMAPH 159 Yarrowia lipoly...
XP_568438     78 LNEIDLAVKNVKKWmKDESRTgdailamksMPSRVKKQPKGVALILATWNYPWQLALCPLVGAISAGCTAVIKGSEHAPT 157 Cryptococcus ne...
XP_448377     87 LGDILHLIEGIPKWnKPKKVRdnsa-pfmfGNINIEKISRGNVLVISPFNFPVLLALAPVACALSAGNTVILKPSEMTPH 165 Candida glabrat...
XP_452089     86 YNNILYLIKNMKKEiEPKKIKvsll-ahwfGTTFVEKIALGTVLVISPFNFPILLALDPLAGAIAGGNSVVFKPSELTPA 164 Kluyveromyces l...
Feature 1                                 #                  #                                   
Q04458       170 TAVVMENLLTtagFPDGLIQVVQGAIDeTTRLLDCgkFDLIFYTGSPRVGSIVAEKAAksLTPCVLELGGKSPTFITENf 249 baker's yeast
CAG90422     210 FSKLFCEIVSn-aLDDDIFYAINGAIPeTTKALEQk-YDKIMYTGSTMVGTIIAKKAAetLTPVLLELGGKSPCFVLDDv 287 Debaryomyces ha...
XP_500179    158 TSAVLGRIFKe-aLDPGIIQVVYGGVPeTTALLTQh-WDKIMYTGNGAVGRIIAQAAVknLTPLALELGGKSPVFITSNc 235 Yarrowia lipoly...
XP_001730031 151 TAQLIADLWSk-yMDTETTAVVNGGIPeATALLDQr-FEHIFYTGNGRVGRIVAEKAArwLCPVSLELGGKSPVIVDASa 228 Malassezia glob...
XP_001642608 167 SARICEKIIReanLDENLVQIVQGAVPeTTRLLECgkFSKIFYTGSPAVGSIVAEKAAksLTPCVLELGGKSPVYITENf 246 Vanderwaltozyma...
XP_762570    265 TAKLIAELWNk-yLDPECFRVVNGGIPeTTALLDQr-FEHIFYTGNGTVGRIIAEKAAkwLCPTTLELGGKSPVYVDKSa 342 Ustilago maydis...
XP_505802    160 TSKIVGDLCTk-aLDPDVFQAIQGGVPvVTKTLEQk-FDKIMYTGNHTVGKIIATAANkyLTPVILELGGKSPVFVTKNc 237 Yarrowia lipoly...
XP_568438    158 SSALLADLLPk-yLDPEGYAVVLGEVEqAQALLAKp-WGHILYTGSAVVGKIVAEAAAktLTPTTLELGGKSPVIVASDa 235 Cryptococcus ne...
XP_448377    166 CALVLEDIVKscqLPEGVLQIVQGGVEqTTKLINSesLDMIFYTGSPRVGSIVAQAAAknLVPCVLELGGKSPTFITGSl 245 Candida glabrat...
XP_452089    165 CAEVMEEICNe-aFEKGQVETVQGGAEeTSALVESgkFDKIFYTGSTTVGTIIAEKAAksLTPCVLELGGKSPVFISPNl 243 Kluyveromyces l...
Feature 1                                                                                # ##  # 
Q04458       250 kasNIKIALKRIFFGAFGNsGQICVSPDYLLVHksiYPKVIKECESVLNEFYpsf-------deqTDFTRMIHEPAYKKA 322 baker's yeast
CAG90422     288 kgkDLPTIARRIVWGRFTNcGQTCVAVDYVLAHasiKDKLVKAMVKVVEEEFygsl-----nkddRNYTHLIHDRAFANL 362 Debaryomyces ha...
XP_500179    236 --kSVMTAARRIVWGKFVNaGQICVAPDYILVApekEAELVACIKEVLQERYgskr-----dahhPDLSHIISKPHWKRI 308 Yarrowia lipoly...
XP_001730031 229 ---DLKIAAHRTLWAKAFNaGQTCVAPDYCLVDrrvQDKFAHELLQAQREFWpsrd------hqeRDFGRIVSDNHWKRI 299 Malassezia glob...
XP_001642608 247 snmKIETALKRIYFGKFGNaGQICVAPDYMLVHeskYEVVLQVAKKLLEEFWpgf-------nqnTDYTHMVNFKAYSNT 319 Vanderwaltozyma...
XP_762570    343 ---DLSIAAHRILWGKSFNcGQTCIAPDYVLIQpdlQDKFVQELKKAYQRFYpelqg---gvnnsESYARIINPGHWKRL 416 Ustilago maydis...
XP_505802    238 --kNIKLAAKRALWGKVVNaGQTCVAPDYVIVEpevEQEFIDACKYWINEFYsgki-----dqynPDFAKIATPNHWNRL 310 Yarrowia lipoly...
XP_568438    236 ---DLKIAARRMFSIKQMTgGQICVAPDYVLCVkdkVDEFISICKTTLDEFFppspspqsllnnqSASSFLRSPADFSRQ 312 Cryptococcus ne...
XP_448377    246 qkkNLETALKRIFFGAFGNaGQICVSPDYLLVHesiYDDVVKESGKVMKELYpdl-------nehTEYTHMIHKASYDKT 318 Candida glabrat...
XP_452089    244 pksQWETAIRRIYYSSMGNaGQICVAADYVLCPdsiYDEFVDSCKKVLNEFYpsv-------tsdTEYTHMIHERAYNRI 316 Kluyveromyces l...
Feature 1                                                             # #                        
Q04458       323 VASINStngskivpSKISINSDTed----lCLVPPTIVYNIgw---dDPLMKQENFAPVLPIIEYEd-LDETINKIIEEH 394 baker's yeast
CAG90422     363 SRVLDDt------kGDVVVGGLRde---ssRFFSPTIIDNCsw---dDSTMKAELFGPLLPILTYTdlSVATAEVVQNHD 430 Debaryomyces ha...
XP_500179    309 HNMIAQt------kGDIQVGGLEnad-edqKFIQPTIVSNVpd---dDILMQDEIFGPIIPIIKPRtlGQQVDYVTRNHD 378 Yarrowia lipoly...
XP_001730031 300 HSLVSSs------kAELVVGGTAgad-qakRFIPLTILKNVda---sDSVMTDEIFGPVLPIVPFDt-IRDAVDFVNERD 368 Malassezia glob...
XP_001642608 320 VQKLKTt------kGQVYTPNFAepd-eisLCIPPSVISNVdw---aDPLMMEENFGPVLPLIKYSnlDDALDNVIKYHD 389 Vanderwaltozyma...
XP_762570    417 NAMLSGt------kGKVVLGGEGee---atKFLPPTVIADVkp---dDAIMSGEIFGPLLPIVPVRd-VEAAVDLINSRD 483 Ustilago maydis...
XP_505802    311 TSMLSKs------kGEIITGGNTde---ktRFIAPTVVAKVpd---nDSLMEDEIFGPLLPILTARsvEEGIKYVHENHD 378 Yarrowia lipoly...
XP_568438    313 LSYIQTae----kaGKLVYKGEMdeq--tkRMGISLIRLNEngegeeGGVMVDEIFGPVLTIIPVDs-IEAAIAYVNARP 385 Cryptococcus ne...
XP_448377    319 LEKLQKtk-----gRKVSAADVKidntsgkLMIPPTIVFDSdw---dDALMEEENFAPVLPVIKYTdiDATIDKILSKHD 390 Candida glabrat...
XP_452089    317 QTVIETtk-----gQKTVAQHSDnl---ppLCIPPTIISDVsw---dDPSMTGENFGPILPIMRYTdlDETIDTLIKRFD 385 Kluyveromyces l...
Feature 1                                                                                    
Q04458       395 DTPLVQYIFSds----qTEINRILTrLRSGDCVVGDTVIHVGITDAPFGGIGTSGYGNYGGYYGFNTFSHERTIFK 466 baker's yeast
CAG90422     431 FPLAQYIFTSgstsrknPQVDQILTsIRSGGAVVNDVLMHFSLTNAPIGGVGASGQGAYHGYYSFRAFTHERTTME 506 Debaryomyces hansenii
XP_500179    379 TPLAMYIFSDd-----pKEVDWLQTrIRAGSVNINEVIEQVGLASLPLSGVGASGTGAYHGKFSFDVFTHKQAVMG 449 Yarrowia lipolytica...
XP_001730031 369 QPLALYVFTSc-----nETRDYILAyTRSGGVVRGDCLLHYAIDSLPFGGTGPSGYGSYHGKAGFDCFTHERAVVD 439 Malassezia globosa ...
XP_001642608 390 TPLVQYIFSDs-----kADIDHILTrVRSGDCLIGDTMMHVGINNAPFGGIGNSGYGSYGGVFSFKAFTHERIVFK 460 Vanderwaltozyma pol...
XP_762570    484 QPLALYLFAGd-----nRVKNFFFDnTRSGACVQGDTLLHFAVDVLPFGGTGPSGYGNYHGKASFDQFSHQRASLD 554 Ustilago maydis 521
XP_505802    379 TPLAMYVFTDk-----aSEGDYIQSqINSGGLIFNDTLIHVGCVQAPFGGVGMSGYGAYHGEDSFLAFTHRQTYLN 449 Yarrowia lipolytica...
XP_568438    386 KPLSLYVCSSk-----rSVFEDIITkTTSGSATWNDFGIATLSRNIPFGGVGESGWGSYHGKDGFNTFTHHKAVLE 456 Cryptococcus neofor...
XP_448377    391 TPLVQYIFSEk-----qKEIDHILArLRSGDCIICDTTIHVGIKDAPFGGIGQSGYGNYGGVYGFDAFSHERIVLK 461 Candida glabrata CB...
XP_452089    386 TPLVQYIFTNs-----kDEIDHILTrIRSGACVVNDTLLHVGIEEAPFGGIGTSGYGNYHGPYTFKTFTHERTIFK 456 Kluyveromyces lacti...

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