1AD3


Conserved Protein Domain Family
ALDH_F3AB

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cd07132: ALDH_F3AB 
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Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins
NAD(P)+-dependent, aldehyde dehydrogenase, family 3 members A1 and B1 (ALDH3A1, ALDH3B1, EC=1.2.1.5) and fatty aldehyde dehydrogenase, family 3 member A2 (ALDH3A2, EC=1.2.1.3), and similar sequences are included in this CD. Human ALDH3A1 is a homodimer with a critical role in cellular defense against oxidative stress; it catalyzes the oxidation of various cellular membrane lipid-derived aldehydes. Corneal crystalline ALDH3A1 protects the cornea and underlying lens against UV-induced oxidative stress. Human ALDH3A2, a microsomal homodimer, catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Human ALDH3B1 is highly expressed in the kidney and liver and catalyzes the oxidation of various medium- and long-chain saturated and unsaturated aliphatic aldehydes.
Statistics
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PSSM-Id: 143450
View PSSM: cd07132
Aligned: 25 rows
Threshold Bit Score: 776.399
Threshold Setting Gi: 91088891
Created: 1-Jan-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
NAD(P) bindinghomodimericcatalytic
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:NAD(P) binding site [chemical binding site]
Evidence:
  • Structure:1AD3; ALDH3A1, class 3 rat liver aldehyde dehydrogenase complex with nicotinamide-adenine-dinucleotide, defined using 3.5 A.
    View structure with Cn3D
  • Citation:PMID 9095201

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
1AD3_A         4 SDTVKRAREAFNSGktRSLQFRIQQLEALQRMINENLKSISGALASDLGKneWTSYYEEVAHVLEELDTTIKELPDWaED 83  Norway rat
AAK49121       5 KQVLERLRGAFRSGvtLPVHFRLTQLEAMMSLFEDNETQILEALHEDLAKpkFETVLSEIDIVVNDICYNISNLQTWmQP 84  zebrafish
BAC30840       8 EKALIKAREAFARNvtRSVDFRIRQLKQLRACIDDNYDQFLGALREDFRKpkFESVITELEFVKNDIKYQLDHIHQYvKP 87  house mouse
XP_002124149   6 ISAIVAAKEAFSSGktKDVKFRKQQLQKLFKCVRDNEVRWCEALKKDLNKskTEAVSAEIILVNNEIVTAIKNLDQWvKN 85  Ciona intestinalis
CAM15184       2 SEVLRRARAAFSAGrtAQDTFRLAQLEALLRMLMDHECDFVDALGRDVHKprFETVMSELLVVKNEALHAISNLKKWmEP 81  zebrafish
XP_972598     39 QEVLNTARTAFSCGksKPINFRKKQLKALEKFLIECEDEICEAVHKDLGKhrQEASMGEIDLVKRDLRHTLFELSDWaKP 118 red flour beetle
XP_001629556   9 AAIVKQARDEFRSGktREYEFRRQQLKNMVQLLDKHEDEIVAALKKDLCKprQETVIAEILLAKNDAILALEKLSEWmKP 88  starlet sea ane...
P43353         5 GDTLRRLREAFHAGrtRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKsaFESEVSEVAISQGEVTLALRNLRAWmKD 84  human
XP_426371     32 AGLVSRLRAAWLSRrtRPLEYRVAQLEALGRFLEEKKQDILEATALDMRKppFEAEFSEVLLCKNELNEALNNLSRWmKD 111 chicken
NP_001087173  37 EDALRKCREAFSCGktRPYSFRLLQLEAILNMLDKHEEEIVGALEQDMHRprFETVLSEITSVKNEALYAVNNLEKWmQP 116 African clawed ...
Feature 1                                    ###                         #                       
1AD3_A        84 EPVAktrQTQQDDLYIHSEPLGVVLVIGAWNYPfNLTIQPMVGAVAAGNAVILKPSEvSGHMADLLATLIPqYMDQNLYL 163 Norway rat
AAK49121      85 SYVGtnlATKLDDCFVRREPLGVVLIIGAWNYPiQLILSPLIGAIAAGNCAILKPSEiSKATEKLLAELIPkYLSQECYA 164 zebrafish
BAC30840      88 QRVArpaANILDDAYIKWDPLGVVLIFSAWNYPvQLMLAPLAGAIAAGNCVVIKPSEvAGSTANVMASLLPkYLDKECYP 167 house mouse
XP_002124149  86 EPKKkelATITADIYTRKEPFGTCLIMSAWNYPfLLMLAPMIGAIAAGNCVVIKPSEcAAHTAKLLQELLPqYIDPTCYP 165 Ciona intestinalis
CAM15184      82 QRIErdwATAFDECVLVNEPLGLVLIIGNWTSPlQLCLVPLVGAIAAGNCAIISPSEtCTHTAGLLHRLIPaYLDNECFH 161 zebrafish
XP_972598    119 VAPDrsiLNLLDGVYIYHDPYGVVLIMSAWNYPfMLLLGPLIGAIAGGNCVILKPSElAVESAKLIAKFLPrYLDKDCYQ 198 red flour beetle
XP_001629556  89 QPVEtgiVNKMDTCYIKNEPLGVALIISAWNYPvQLIFLPLVGAIAGGNCAVLKPSEvASATAQLVADLVPkYLDPDCYP 168 starlet sea ane...
P43353        85 ERVPknlATQLDSAFIRKEPFGLVLIIAPWNYPlNLTLVPLVGALAAGNCVVLKPSEiSKNVEKILAEVLPqYVDQSCFA 164 human
XP_426371    112 KHVDknlATQLDSAFIRKDPYGVVLIIGPWNYPiYLLLVPLIGAIAAGNCVIIKPSElTKNSEKLMEEVLPkYLDKDCFA 191 chicken
NP_001087173 117 LPGQksmSNLLDSCFIQMEPVGVVLIIGGWSFPvQLSLIPLVGAVAAGNCVVLQPSGtCTHAANLLQKLIPlYLDNSCFH 196 African clawed ...
Feature 1             #                  #                                                       
1AD3_A       164 VVKGGVPe-TTELLKERFDHIMYTGSTAVGKIVMAAAAkhLTPVTLELGGKSPCYVDKDc--DLDVACRRIAWGKFMNsG 240 Norway rat
AAK49121     165 VVCGGAEe-TKTLLENRFDHIFYTGSQSVARCVLQAAAvhLTPVTLELGGKCPCLIYGRl--DMKAAAKRLVWAKFFNsG 241 zebrafish
BAC30840     168 VVTGGADv-ANQLLQERFDLVFFTGSPNIGKLVYQAASkhMTPVVLELGGKSPLYIDDSvegQLEVAAKRVLWGKLTNsG 246 house mouse
XP_002124149 166 VIVLDAKdsADLVTNNRFDFIFFTGGTAIGRIVMKAAAeyLTPVVLELGGKNPCFVDDSc--DIRNTARRICWGRFLNtG 243 Ciona intestinalis
CAM15184     162 SVIAAAHe-IPEIVDLTFDYVFFSGDKEDGIKVAQAAArtLARVTLVLRVKNPCYVDSQc--DINTTARRITWARFHNaG 238 zebrafish
XP_972598    199 VVLGGIEd-TTELLKHKFDYIFFTGSSSVGKIIHQAAArhLTPTTLELGGKSPIYLDESa--DILTATRRIIWGRTMNaG 275 red flour beetle
XP_001629556 169 VVNGGVPe-TQQLLNQKFDKIFYTGGSAVGKLVMAAAAknLTRVTLELGGKSPCYIDEDc--DMKTVARRICWGKFTNsG 245 starlet sea ane...
P43353       165 VVLGGPQe-TGQLLEHRFDYIFFTGSPRVGKIVMTAAAkhLTPVTLELGGKNPCYVDDNc--DPQTVANRVAWFRYFNaG 241 human
XP_426371    192 VVTAGVEe-TTRLLENKFDYIFFTGSPSVGRIIMTAAAkhLTPVTLELGGKNPCYVSDTc--DVQNVARRVVWGRFFNaG 268 chicken
NP_001087173 197 VVSGGQNd-LMKLLENKFDHILYTGDRVTGRAVMLAAAryITPVSLVLGGKNPCYVDQSc--DIKMASHRIAWARFVNaG 273 African clawed ...
Feature 1                                                      # ##  #                           
1AD3_A       241 QTCVAPDYILCDpsiQNQIVEKLKKSLKDFYGeda-kqsRDYGRIINDRHFQRVKGLIDNq--KVAHGGTWdqssRYIAP 317 Norway rat
AAK49121     242 QSCVAPDYVLCTdevKEMLLPFMKEALESFYGsep-qesPDYGRIVTDRHWNRLIELMKKsegKIVIGGESvketRYIAP 320 zebrafish
BAC30840     247 QTCVAPDYVLCSpsvQDRFVEASKKVLKDFYGdpa--ksDSFARIVNDRNFDRLEKLLSAtkgKVVVGGQTakgeRYIAP 324 house mouse
XP_002124149 244 QLCLCPDYVLCSqgvRDKFVEEIKLALKEFYGsdp-khsPDYGRIINERQTLRLKKVIESgagKIVVGGEVdvkeRYVAP 322 Ciona intestinalis
CAM15184     239 QSAVAPDYILCHaevKENLLQALRCSLQQFYGtdp-resRSFGRIVNEENFSKAKEQLWGs-gKVIIGGQVneieRYIAP 316 zebrafish
XP_972598    276 QTCISPDYLLCSkevEEKFLAAARTVLEEFYGdgdvklsPYLSKIVLDRHYNRLMNFIKGs--NVAIGGSGdprtRIIAP 353 red flour beetle
XP_001629556 246 QTCVAPDYVLCNpgiQSKFIKSMKETLYEFYGedp-hdsADYGRIVNDKHYNRLKALLTRg--TIVLGGDTddkeRYISP 322 starlet sea ane...
P43353       242 QTCVAPDYVLCSpemQERLLPALQSTITRFYGddp-qssPNLGRIINQKQFQRLRALLGCg--RVAIGGQSdesdRYIAP 318 human
XP_426371    269 QTCIAPEYVLCSvemQEKLIPALREAITEFYGsep-rnsPDFGRIVGDKQFRRVQALLSSg--RVAIGGQTdekeRYIAP 345 chicken
NP_001087173 274 QSSLAPDYILCQpeiRNALIHELKTCVEEFYGknp-resPNYGRLACMEQYIRVKDLLSCg--QVAFGGETddteRYIAP 350 African clawed ...
Feature 1                       # #                                                              
1AD3_A       318 TILVDVdpqSPVMQEEIFGPVMPIVCVRsLEEAIQFINQREKPLALYVFSNneKVIKKMIAeTSSGGVTANDVIVHITVP 397 Norway rat
AAK49121     321 TVIVDVkgtDALMQEEIFGPILPILTIKsLDEGINFINEKEKALALYAFSDesQVVTTVLErTSSGGFCSNDGIVHMTLP 400 zebrafish
BAC30840     325 TLVANVtgnDSLMSEELFGPILPIVPVKsEEEAIQFINRGEKPLAMYIFSNkqPTVNKFLDqTSCGSVCVNDTLMQMVLH 404 house mouse
XP_002124149 323 TVVTDIpadSAYMQQEMFGPILLVVTVKdMDEAIAVVNSREKPLAMYIFAKnkKLVNKILSnTSSGGVTVNDVVMHYVPH 402 Ciona intestinalis
CAM15184     317 TVLMDVmesDPIMHQDVFGPILPILTVQdADEAVAFINSREKPLCVYAYSSnnKVISKIMNeTSSGSFCSNDSVLQSVMV 396 zebrafish
XP_972598    354 TVLIDVkpdDPVMLEEIFGPILPIVTVNsPLEAINFINERDKPLALYVFTNrkDVKELFLNnTSSGAVTVNDVIMHIWAD 433 red flour beetle
XP_001629556 323 TILTGVkpsDPVMENEIFGPILPIVSVDsLDDAIDFINDRDKPLALYIFSNkqESIKRIQEnTSSGGFCANDVVIHAALE 402 starlet sea ane...
P43353       319 TVLVDVqemEPVMQEEIFGPILPIVNVQsLDEAIEFINRREKPLALYAFSNssQVVKRVLTqTSSGGFCGNDGFMHMTLA 398 human
XP_426371    346 TVLVDVkpsDPAMQEEIFGPILIIITVAnIDEAIDFINSRERPLVVYAFSSnsKEVNQVLErTSSGGFCGNDTLMHVTLT 425 chicken
NP_001087173 351 TVLTDVqeaDPIMQTEILGPVLPILTVPnLDEAIQLINRKDRPLAVYVYSEneQVISDILSrTSSGSFCSNDSMIQSIYT 430 African clawed ...
Feature 1                                                           
1AD3_A       398 tLPFGGVGNSGMGAYHGKKSFETFSHRRSCLVKSLl--nEEAHKARYPPSP 446 Norway rat
AAK49121     401 gLPFGGVGASGMGNYHGRWGFETFSHKRGCMLRGWg--lERVNVLRYPPYT 449 zebrafish
BAC30840     405 sLPFGGIGNSGIGKYHGTYSFETFSHSKSVLAKDYnpliEYFASSRYPPYT 455 house mouse
XP_002124149 403 sLPFGGVGESGMGAYHGKHTFDTFSHRRSCLVDGNp---EFFNSLRYPPHS 450 Ciona intestinalis
CAM15184     397 gLPFGGVGASGMGSYHGRYSFDAFSHKKSCLLRSTr--iECMTVLRYPPYE 445 zebrafish
XP_972598    434 nLPFGGVGASGMGAYHGKFGFDTFTHKKGVLERGLgkiaELTQFARYPPYT 484 red flour beetle
XP_001629556 403 tLPFGGVGGSGMGAYHGKHSFEAFTHKKGCMVKKLs--mEAMNSIRYPPYK 451 starlet sea anemone
P43353       399 sLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSPg--mEKLNALRYPPQS 447 human
XP_426371    426 sLPFGGIGSSGLGMYHGQFTFDTFTHHRGCLQRSTg--lEPINTLRYPPYS 474 chicken
NP_001087173 431 sMPCGSIGNSGVGIYRGKHSFDAFSQGRACLLRNTa--vECVTYLRYPPYA 479 African clawed frog

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