Conserved Protein Domain Family
ALDH_AldH-CAJ73105

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cd07131: ALDH_AldH-CAJ73105 
Uncharacterized Candidatus kuenenia aldehyde dehydrogenase AldH (CAJ73105)-like
Uncharacterized aldehyde dehydrogenase of Candidatus kuenenia AldH (locus CAJ73105) and similar sequences with similarity to alpha-aminoadipic semialdehyde dehydrogenase (AASADH, human ALDH7A1, EC=1.2.1.31), Arabidopsis ALDH7B4, and Streptomyces clavuligerus delta-1-piperideine-6-carboxylate dehydrogenase (P6CDH) are included in this CD.
Statistics
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PSSM-Id: 143449
View PSSM: cd07131
Aligned: 10 rows
Threshold Bit Score: 700.255
Threshold Setting Gi: 108805710
Created: 2-Jan-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
NAD bindingcatalytic
Feature 1:NAD binding site [chemical binding site]
Evidence:
  • Comment:based on similarity to structure 2JG7, Seabream antiquitin (alpha-aminoadipic semialdehyde dehydrogenase) in complex with cofactor NAD+.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
CAJ73105       5 NYINGAFVDSassEVFESRNPAYCDEVLGTFPLssadDVNNAVLAAKTAYDTWRkISRIRRGEYLDELAQLLKKDREAIS 84  Candidatus Kuen...
NP_487811      9 NYINGQWLNAateTTLNSHNPADKSEIVATFPRsqadDVDRAVAAARQAYGSWRkVPAPARAEYIFRVGELLLQHKEELA 88  Nostoc sp. PCC ...
YP_445899     41 NYIGGRWTGAasqATFDNRNPADPDDHIGDFPDsapaDVDAAVQAAQDAFSDWGsTPAPDRGKILKASGDLLAERKDEIA 120 Salinibacter ru...
YP_001635373   9 NLIGGEFVPAqsgKTFERRNPADTRDVVGIFADsderDVHAAVEAAKAAFPQWSkVPAPKRGEILLRAAELLQARKEQYS 88  Chloroflexus au...
YP_590535     16 NLIDGEWVESksgQTFENLNPADTREVVGIFQRsgkeDVEHAIDAASEAYKKWRlVPAPRRAELLFKAAAILEQRKEKYS 95  Acidobacteria b...
YP_356912      6 NFIGGQWVPPstgEYGQSVNPAHDMEVVARYPLsaksDVDRAVQAAVDAFPGWRaMPAPRRAEILFRAAEILCRRKDELG 85  Pelobacter carb...
YP_645647     19 SRIGGRPAEEapgGRLTSANPARLEEAVAEVLLgdasTFVEACRAAREAQGEWAaVPAPIRAQVVKRIGRLVEKNKEALA 98  Rubrobacter xyl...
NP_617759     18 LHIGGESRDSatgETFDNINPATLENLATVQVAgs-eDVDRAVEAAEEGFRVWSeVPAPRRAEVLFRTARILQERKEDLA 96  Methanosarcina ...
NP_279763      5 HYINGEWVDGdgtETFDSRNPANGETLGTFQRGtt-tDVEAAIAAADDAEDEWQsLSRIDRAEYLWDIYHELKDRHQELG 83  Halobacterium s...
ZP_02732781   11 SFIGGDWHAR---EDFTSLNPANLSEVVGTFPAatpaEVSAAVEAARAAFPGWRrTSRILRAEAFDRLAQLIKRDTDALA 87  Gemmata obscuri...
Feature 1                                                                       ####             
CAJ73105      85 QLVSKECGKgIAEGRADVTEGIHMVQYIFGTTRM-PHGDIIDSEIVEKDSFMRRRPKGVVAAITPWNFPFAIPLWLICPS 163 Candidatus Kuen...
NP_487811     89 QLISREMGKpLTEARGDVQEGVDCAFYSAGEGRR-LFGQTTPSEMPNKFAMTMRMPIGVCALITPWNFPVAIPCWKAMPA 167 Nostoc sp. PCC ...
YP_445899    121 RSMTREMGKpFFETKGDVQEAIDTAYYAASETRR-LFGTTVPSELPDKMNMAIRRPLGVCGIITAWNFPVAVPSWKIFPA 199 Salinibacter ru...
YP_001635373  89 RDLTREMGKpLFEAGGDIVEAIGMAQYAGSEGRR-MHGVTTPSELPNKFQMSIRQPIGVVGLITPWNFPMAIASWKMLPA 167 Chloroflexus au...
YP_590535     96 QEMTREMGKvIKETRGDVQEAIDAGYYNAGEGRR-MFGPTTPSELPNKFAMAVRQPLGVCAMITPWNFPMAIPSWKLFPA 174 Acidobacteria b...
YP_356912     86 QLVTREMGKvLSEGLGDVQEAIDMAYFMAGEGRR-LQGETVPCELPNKDAKSFRVPWGVFALITPWNFPIAIPSWKIFAS 164 Pelobacter carb...
YP_645647     99 RLVTREVGKpYAESLGEVQEIIDTCDFFTGEGRR-LYGHTVPSEMPDKQLFTFRVPVGVAAVITAGNFPVAVPSWYLVPA 177 Rubrobacter xyl...
NP_617759     97 RLMTEEMGKvLPETRGDVQEAIDIAIYAAGEGRR-MFGETTTSELKDKFCMTVLRPIGVVGMITPWNFPLAIPGWKIMPA 175 Methanosarcina ...
NP_279763     84 EVVTKECGKeISEGKADVTEAWQMVEWAAGDARH-PKGDVVPSEIPEKDAYMRRQPRGVVGCITPWNFPVAIPFWHMAVA 162 Halobacterium s...
ZP_02732781   88 TLMARECGKnVTECRAEVVEGLHMVQYVFGTGRTgVYGEVVASEIAEKDAFTRRKPWGVVAVVTPWNFPFAVPLWMLGPS 167 Gemmata obscuri...
Feature 1                 # ##                                  ##              ####  #  #       
CAJ73105     164 VVEGNTVVLKPSReTPCVANKIAEYVHAAGFPPGVINVIHGGC---GDALVRHSD---TQVILFTGSCEVGEGIKKIAAe 237 Candidatus Kuen...
NP_487811    168 LVCGNTVILKPAEdTPACATKLIEIFAAAGLPPGVINLVHGVGeevGKALVEHPN---IDLVSFTGSSATGAYVGETCGr 244 Nostoc sp. PCC ...
YP_445899    200 LAAGNTIVFKPSEdAPHSGLRFVQTLIDAGIPDGVINVVHGADe-aGQALVEHPE---VDAIGFTGSYEVGTAIAETCGr 275 Salinibacter ru...
YP_001635373 168 IVCGNTVVIKPGEdASVSTYNLVQCLMEAGLPPGVVNIVTGYGpraGQPLVEHPD---VPVISFTGSTETGRLVYELGAr 244 Chloroflexus au...
YP_590535    175 LVCGNTAVIKPAQdTPLSTFNFVQALNDAGVPKGVINIVTGYGgevGTPMTEHPE---VKAVSLTGSTAVGRIVGQAAAk 251 Acidobacteria b...
YP_356912    165 LICGNTVVFKPSSdSPLCATRLVEVLEEAGMPPGVVNMITGAGetvGETLAMHPD---VQGVSFTGSCSVGEALACSVAq 241 Pelobacter carb...
YP_645647    178 ILCGNAVVWKPAEyAAAAGDALAQLFFHGGLPEGVLNVVQARGeatFEGLERALGeglVDKVGFTGSTEVGSRIGELCGr 257 Rubrobacter xyl...
NP_617759    176 LIAGNAIVFKPASdTPLLAIKLVEILMEAGLPPGVVNLVTGPGgstGKAIVQHPR---IKAISFTGSLETGKWIMEECAk 252 Methanosarcina ...
NP_279763    163 LVEGNTVVWKPAEqTPWCGQIIAEMFADAGIPDGVFNMVQGFGd-aGARIVDHDD---IDTVLFTGSAEVGEEVARTVAd 238 Halobacterium s...
ZP_02732781  168 LLEGNTCVFKPSEeTPAIALKLVELFAEAGFPAGTVNLIHGRGd-vGEALVKNPA---VNVVCFTGSYAVGERIQQASAt 243 Gemmata obscuri...
Feature 1                ###                               #                                     
CAJ73105     238 sYNKMCACEMGGKNAIIVLDGANMEIAVNASILSAFKTsGQRCTSAGRLILHvnMLEEFEKRFVELAKRIKIGNPLDEeV 317 Candidatus Kuen...
NP_487811    245 -THKRVCLEMGGKNAQVVMEDADLELALDGALWGAFGTtGQRCTATSRLILHrdIKEKFTTMLRERTSQLRLGAGTEPeT 323 Nostoc sp. PCC ...
YP_445899    276 -LNTPVSLEMGGKNPMIVMDDADLDLALEGAIWGAYGTtGQRCTATSRLICHesVHDELVAMIRDEAEALVLGDGNDAdT 354 Salinibacter ru...
YP_001635373 245 -RIKRVSLEMGGKNPLIVMPDADLDLALDGVLWAAFGTtGQRCTATSRLIVHraVAKELVERIVARAQSLRVGNGLDPaT 323 Chloroflexus au...
YP_590535    252 -SFKHCSLELGGKNPMIVLDDANLDLALEGALWGSFGTtGQRCTATSRIILQkgIYKKFADELVARARKLKVGNGLDEtV 330 Acidobacteria b...
YP_356912    242 -LHRPIAMEMGGKNAILIMDDADLDLALEGVLWGAFGTtGQRCTAASRIIVHekVYDEFLDRLVRAANAMRLGDGLEKdT 320 Pelobacter carb...
YP_645647    258 -HRQSPCLELGGKNPLVVMPDANLDLAVEGALFSGFGTaGQRCTSLGTAIVHesVYGEFLSRFDRAVREAPVGDPMRE-V 335 Rubrobacter xyl...
NP_617759    253 -TMKRVSLELGGKNPVIIMDDADLELALEGVLWGAFGTtGQRCTATSRLILHekIKDEFTARLLAKTKLLRVGNGLLPeT 331 Methanosarcina ...
NP_279763    239 dPGKLAACEMGGKNGIVVTEKADLDIAVHAAVMSSFKTtGQRCVSSERLIVHedLYDEFKQRFVEIAESVAVDDPLDEeT 318 Halobacterium s...
ZP_02732781  244 iPNRIVAAEMGGKNAVIVCDDARFDLAVNAGILSAFKTtGQRCVSASRIIVHesLVERYAKAFVDTAKRLQFGDPLDAkN 323 Gemmata obscuri...
Feature 1                                                                                      # 
CAJ73105     318 FMGPVINQAATEKILRYNDFak------neGAEVLLDGSRLtggg--------ydkGYFMSPFVYRMKnnpksRVLHEEV 383 Candidatus Kuen...
NP_487811    324 DIGPIINNRQLQRVHEYMNIar------eeGAKILIGGEIAtegq--------lqqGYFFQPTILDNVtp-qmRVAREEI 388 Nostoc sp. PCC ...
YP_445899    355 DVGPLINQAAAETVHRYVEIgq------eeGATLEMGGAPAsvd---------gldGHFYEPTLFTDVtp-dmTIAQEEI 418 Salinibacter ru...
YP_001635373 324 EMGPLVNEKQLQRVLNYIDIgk------qeGATLLCGGYRLtggd--------ydyGYFIAPTVFTNVts-qmRIAREEI 388 Chloroflexus au...
YP_590535    331 DMGPAVNENQMNTDLKYIEIgk------geGAKLAHGGHRLdkgd--------yahGWFLEPTIFTDVnh-kmRIAQEEI 395 Acidobacteria b...
YP_356912    321 DVGPLINRRALNKVLNYIRIgk------deGARLCCGGNQAkhng--------lteGYFVEPTVFSNVtp-smRIAQEEI 385 Pelobacter carb...
YP_645647    336 LYGPMISEKFYERFVGWLELvqd-----hhTLHGSTGTGRItrdnprenflgdpeaGLYCHPTIVAGVtg-edELYRTET 409 Rubrobacter xyl...
NP_617759    332 DIGPIINKAQLEKIERYVRIgm------eeGATLLLGGKAIdpg----------lpGYFFEPTVFTDVrp-dmRIAQEEI 394 Methanosarcina ...
NP_279763    319 FMGPAIEPAHVEKIQTYNDIareeaenvlvDRTELGDDEIPdgh----------edGNWVGPFVYEVDydpdlRSITEEV 388 Halobacterium s...
ZP_02732781  324 FAGPLVNRKGVEKVLNYNALak------seGVEVLLAPNGPpd-----------akGCFLTPFVYRTEakpslRVTHEEV 386 Gemmata obscuri...
Feature 1                                                                           #            
CAJ73105     384 FGPHVAIIPVEs-IDEAINVYNDTEYGLSCAVITEdfRKARRIRD-DCEYGLGYVNLPtIGAEVHLPFGGLKKSGTGLPS 461 Candidatus Kuen...
NP_487811    389 FGPVVALIEVSt-FEEAIAILNDTKYGLSSSVYTRdiNRAFVAMR-DIEAGITYINGPtIGAEVHLPFGGVKQTGNGHRE 466 Nostoc sp. PCC ...
YP_445899    419 FGPVLATFEVGs-YDEAVTVANDTQYGLSSSIYTQdvNKSFRAMR-DLEAGITYVNGPtIGAEAHMPFGGVKDTGNGQRD 496 Salinibacter ru...
YP_001635373 389 FGPVLSVIEVDs-LDEAVAIANDVAYGLSSAIYTRdiNAAFRAMQ-ALQAGIVYINAPtIGAEIHLPFGGVKATGNGHRE 466 Chloroflexus au...
YP_590535    396 FGPVVALIPCDd-LDEAIEIANGIEYGLSSAIYTRdvNKSFRAMR-DLHAGITYVNAPtIGAEVHMPFGGVKATGNGHRE 473 Acidobacteria b...
YP_356912    386 FGPVVCLIKCDs-YEQGIAIVNQSRFGLSTAIYTRdvNISARAEG-DLDSGLVYINAStIGAEIQLPFGGFKHSGSGHPE 463 Pelobacter carb...
YP_645647    410 FGPIVGVAKFSt-FEEAVELANGHGYGLSAAIYTEsaREALRFRE-RVSAGMLSVNNStSGAEAHLPFGGNGKSGNGSRL 487 Rubrobacter xyl...
NP_617759    395 FGPVLSIITVSg-LEEAIEVANNTRYGLSSAIYTEnvGKAFRAVK-KIEAGITYVNAPtIGAEVHLPFGGVKGTGNGFRE 472 Methanosarcina ...
NP_279763    389 FGPHVALIEYSgdIERAVEIHNDTPYGLAGAVISEdyRQINYYRD-NAEVGLAYGNLPcIGAEVQLPFGGMKKSGNGYPS 467 Halobacterium s...
ZP_02732781  387 FGPHVALIPFKt-DEQAAAIYNDTEYGLSMAVITEs-YRRMRFFRdECEYGMGYVNLPsIGAEVHLPFGGVKKSGNGHPS 464 Gemmata obscuri...
Feature 1                              
CAJ73105     462 A---STLIDAVTHRTAWTVNHD 480 Candidatus Kuenenia stuttgartiensis
NP_487811    467 Ag--TTALDVFTEWKSVYVDFS 486 Nostoc sp. PCC 7120
YP_445899    497 Gg--YAAFEFWTEHKTLYVDYS 516 Salinibacter ruber DSM 13855
YP_001635373 467 Ag--PTMLDVFSEWKSVYIDYS 486 Chloroflexus aurantiacus J-10-fl
YP_590535    474 Gg--IGALDFYTEWKAIYVDYS 493 Acidobacteria bacterium Ellin345
YP_356912    464 AggrMGALDFFSRIKVVYRDFS 485 Pelobacter carbinolicus DSM 2380
YP_645647    488 Sg--VWVLEQFTRWQAMNWDFS 507 Rubrobacter xylanophilus DSM 9941
NP_617759    473 Ag--TEAIKEFTEIKAVYIDYS 492 Methanosarcina acetivorans C2A
NP_279763    468 A---REVIEAVTERTAWTLNNS 486 Halobacterium sp. NRC-1
ZP_02732781  465 A---AALVEAVTHKTAWTVNHG 483 Gemmata obscuriglobus UQM 2246

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