1EYY


Conserved Protein Domain Family
ALDH_KGSADH

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cd07129: ALDH_KGSADH 
Click on image for an interactive view with Cn3D
Alpha-Ketoglutaric Semialdehyde Dehydrogenase
Alpha-Ketoglutaric Semialdehyde (KGSA) Dehydrogenase (KGSADH, EC 1.2.1.26) catalyzes the NAD(P)+-dependent conversion of KGSA to alpha-ketoglutarate. This CD contains such sequences as those seen in Azospirillum brasilense, KGSADH-II (D-glucarate/D-galactarate-inducible) and KGSADH-III (hydroxy-L-proline-inducible). Both show similar high substrate specificity for KGSA and different coenzyme specificity; KGSADH-II is NAD+-dependent and KGSADH-III is NADP+-dependent. Also included in this CD is the NADP(+)-dependent aldehyde dehydrogenase from Vibrio harveyi which catalyzes the oxidation of long-chain aliphatic aldehydes to acids.
Statistics
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PSSM-Id: 143447
View PSSM: cd07129
Aligned: 56 rows
Threshold Bit Score: 506.309
Threshold Setting Gi: 78048299
Created: 29-Oct-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:NADP binding site [chemical binding site]
Evidence:
  • Structure:1EYY; Aldehyde dehydrogenase from Vibrio harveyi with NADP+ bound, defined using 3.5 A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
1EYY_A        32 VNQAATAAAKVARdfrRLNNSKRASLLRTIASELEARSDDIIARAHLETALpe--vrLTGEIARTANQLRLFADVVNSGS 109 Vibrio harveyi
NP_864635     30 DAACERAADAALEl-rELSPEQLSEFLSAVAAEVRSRRSEIVARCELETGYin--arVEGEFDRATGQLDLFARLAVERP 106 Rhodopirellula ...
NP_868633     73 CDEALDAAVEAAAelrKLGPAKIADFMEAYADKIDAAKDQLVETAFAETGLarsprlADVELPRTSNQLRAAAKACRTGN 152 Rhodopirellula ...
ZP_01092234   45 CDAALDAADEAFQtlsQLPPERIAAFLTRYAELIDANADELCAIANAESGLpvsprlKDVELPRTSNQLRTAAAAAVERS 124 Blastopirellula...
ZP_01855737   45 ESALEAAADAAKAm-rGWSGQRFAAFLEAYANEIEKRTDELVATAHAETGYpesprlRDGELPRTTNQLRQAAAHAREGT 123 Planctomyces ma...
EDY81838      44 LEALVDAGHAAAEglaDIPAATVADFLETYAAKIEASTDKLAEIANLETGLpltprlAGVEIPRTVNQIRQAAAAARAGD 123 Verrucomicrobia...
YP_921274     53 VDRAVEAAVDAFAsfrDWDDARRADLLDAIAAALVHDGSAILSAVEAETALpr--arAEGELVRTAEQFRAFARVLRQGW 130 Nocardioides sp...
YP_001545270  42 LELALSAGVAASRelaQSSPEQRAKFLEGYADLIEAKRQELSAIAHSETGLpieprlNSVELPRTVNQLRQAAQAVRNHT 121 Herpetosiphon a...
YP_587224     34 IDQHATRAHEASAawaHSSPTVRSGVLRALADALDARANELAVMADEETGLgi--prLTGEIARTSFQLRGFADEVVAGV 111 Ralstonia metal...
YP_549119     27 VNAAAVAAQATFAswsASTGTTRGALLRALAAALEADRDELVAVADEETALgp--vrLNGELDRTAFQLRRFADIAERGV 104 Polaromonas sp....
Feature 1                                              #                          # ##           
1EYY_A       110 YhqAILDTPnptra-plpkPDIRRQQIAL-GPVAVFGASNFPLAF-SAAGGDTASALAAGCPVIVKGHTaHPGTSQIVAE 186 Vibrio harveyi
NP_864635    107 WdrVTSEPAdpark-pfpkPRMTRRFVPV-GPIAVFGACNFPLAI-SVVGNDFVSAIATGNPVIVKSHPsHPGTCELLGD 183 Rhodopirellula ...
NP_868633    153 WamPTIDTQ----------TGIRSCLGPL-GPVCVFGPNNFPFAFgSVSGGDFAAAIAAGNPVIGKANSsHPDTTRLFAE 221 Rhodopirellula ...
ZP_01092234  125 WkqATIDTK----------SNIRAYFAPL-GPVCVFGPNNFPFAFgGASGGDFAAAIASGNPVIAKANPsCPGTTLALAK 193 Blastopirellula...
ZP_01855737  124 WtqPTIDTA----------AGISSMFGPI-GPVAVFGPNNFPFAFnSIAGGDFAAAVAAGNPVIAKGHSsHPKTTQIFAE 192 Planctomyces ma...
EDY81838     124 WarPTIDTA----------TNIRSMHGALgGPVIVFGPNNFPFAYnGIAGGDFASAIAAGNPVIAKAHPaHPYTTQLLAE 193 Verrucomicrobia...
YP_921274    131 HrdALVDPPdpgav-pvprPDVRRINVPV-GPVAVFGASNFPLAF-STPGGDTAAALAAGCPVVVKGHPsHPATSELCGR 207 Nocardioides sp...
YP_001545270 122 WelATIDSK----------ANIRSLYGSLaAPVAIFGPNNFPFAYnAIAGSDFASAIAAGNAVIAKGHPsHPATTELLAE 191 Herpetosiphon a...
YP_587224    112 Py-VQVDDEaipgpppsgrPRLTRVMVPI-GPVAVFAASNFPFAF-SVLGGDTASALAAGCPVIVKPHGgHPRLSIEVAK 188 Ralstonia metal...
YP_549119    105 Pf-ATTDDPavagpppaghPAMVRLRVPL-GPVAMFSASNFPFAF-SVLGGDTASALAAGCPVVVKAHSgHLVLSNRAFG 181 Polaromonas sp....
Feature 1                                    #            #  #  #                                
1EYY_A       187 CIEQALkqeqlPQAIFTLLQGNqr-alGQALVSHPeIKAVGFTGSVGGGRALFNLAherpePIPFYGELGAINPTFIFPS 265 Vibrio harveyi
NP_864635    184 TVKEVVkrmgfPAGTFDLFHGRsp-etSIRLISHPaISAVGFTGSPQGGRALAKAVlerenPIPIFAELGSTNPVFIGRD 262 Rhodopirellula ...
NP_868633    222 LALEALtetglPAATVQLIYRTsh-adGEKLVSDPrNGATGYTGSRGAGLTLKSAAdk--aGKPIYLELSSVNPVVITPA 298 Rhodopirellula ...
ZP_01092234  194 LAFQAVqetdlPPATIQLFYHCny-ddGAKLVADPrIGATAYTGSRRAGLVLKEAAdk--hGKPIYLELSSVNPVVILPG 270 Blastopirellula...
ZP_01855737  193 AADAAAkatdmPAGFVQLIYRTsh-adGCRLVSHPlMGAIGYTGGRSAGLTIKEAAdk--aGKPAYLELSSINPVFILPG 269 Planctomyces ma...
EDY81838     194 LAQAAAeehqlPAGTVQLFYNTpp-elGLNLVAHPkVAAIAFTGSRPGGLALKAAAdk--aGKPIYLEMSSVNPVFIMPG 270 Verrucomicrobia...
YP_921274    208 AIVRALrehdaPAGTFSLLQSTrn-evGAALVQHPqVAAVGFTGSEAGGRALFDLAsrrptPIPVYAEMGSLNPVLVTVA 286 Nocardioides sp...
YP_001545270 192 LAHQAVlaaglPAASVQLLYGLpd-elGLALVSHPlIGAIGFTGSRRAGLTLKAAAdq--aGKAIYLEMSSINPVVMLAG 268 Herpetosiphon a...
YP_587224    189 IAAEVLraqgvEEGVFSMLDCDmsrdaNIHLVKHPlIAGVAFTGSYQGGVALWRAAnereiPIPFFGELGSINPVVVLPA 268 Ralstonia metal...
YP_549119    182 LVQQVLkaqnlPAGLIGMIQGGgs-dvGVRLVRHPaMAAGAFTGSTRGGAALQAEAnarprPIPFYGELGSTNPVVALPG 260 Polaromonas sp....
Feature 1                                                                                        
1EYY_A       266 am-rAKADLADQFVASMTMGCGQFCTKPGVVFALntpeTQAFIETAQSLIRQQSPsTLLTPGIRDSYQSQVVSRGSdd-g 343 Vibrio harveyi
NP_864635    263 amaaRVGTIAEGFAASLRFGNGHMCTKPGVVIVHea-dADAFVEATCKTFAKQPNlPMLSGPVADAFDRGIEQLQSaadv 341 Rhodopirellula ...
NP_868633    299 aleeRGDAIVDEFITSVLMGTGQFCTNPGMVMLVkgeaTDKFIAAVKERFTAAPAgTLLSPAVASSLGKSIEQLVGf--g 376 Rhodopirellula ...
ZP_01092234  271 alkeRGDKLVDEFTGSCLMGAGQFCTNPGLVLVIdnaeSQAFVSDTAAKFAAAPVgTLLTKAVETGLTVALQTLKEa--g 348 Blastopirellula...
ZP_01855737  270 alteRGADIAEEFKGSCLMGTGQFCTNPGLVAIKagetADAFIEAVKQKFEESPAgILLGEGVQRGFQSGITAIQSa--g 347 Planctomyces ma...
EDY81838     271 alqeRGADIATELHGSCTLGAGQFCTKPGLVVVQkspqSDELLASLTQNFASSPAgILLTAGGVEAVSKSVTQLAAa--g 348 Verrucomicrobia...
YP_921274    287 aleaRADAIAQGLSGSFLFCAGQYCTKPGLVLVPegpaGDRFVGLLATTVREQEAlPVLAANIGSAFDTSVGALEAal-g 365 Nocardioides sp...
YP_001545270 269 avteRAEALAAEFAGSCTLGAGQFCTNPGLLILEhsaaSADFIEATKAHFNQHPSlTLLNHGVLAGLEQGIEHLQDa--g 346 Herpetosiphon a...
YP_587224    269 alhdDPVAPAKVLAASMLQGCGQFCTSPGVIVVVddqrGREFVSALGDSLAGQAThRMLSEGIRNGFEDAVARIKAna-n 347 Ralstonia metal...
YP_549119    261 ilaaRGAELAGVLAGSISLGCGQFCTSPGVIVLLkdpaSDAFVQQLTSALATQKPhAMLTPGMRSAFDAGVAHMASag-a 339 Polaromonas sp....
Feature 1                                                                                        
1EYY_A       344 IDVTFSQae----sPCVASALFVTSsenw-rkhpAWEEEIFGPQSLIVVCEnVADMLSLSEMLAGSLTATIHATEe--dY 416 Vibrio harveyi
NP_864635    342 EQLFVAEgldgegpWHRGAHWFAMSaeta-irdgWLHSETFGPVSVLVRCPdEETMLRVAGEFHGSLTTTLHTETs--dN 418 Rhodopirellula ...
NP_868633    377 AELLAGGgeaesdrCAMANTLLKTSgtdflgnpeGFQTEAFGNASLIVVADnLDQLCESIRHLEGNLTGCVYTSTnggdE 456 Rhodopirellula ...
ZP_01092234  349 AEELAGGaagagtgYSHANTLLKVDaakfltdplVFQTEAFGNGSLIVVAQdLSEVIAVIDSLEGNLTGCVYSDTqgsdD 428 Blastopirellula...
ZP_01855737  348 ATLVTGGlqtdgpgFSCANTLLKVSgsqflenpeALQSEAFGNSSLIVVADsDEQLVQIAEYLEGNLTGCIYSHTggedE 427 Planctomyces ma...
EDY81838     349 AQILAGGniadtphYGYQPTLLSVSgdaflakpdKLQSEAFGAVCLVVVANdFEQALAIASLLEGNLTGSIYSDTagsdD 428 Verrucomicrobia...
YP_921274    366 DDAVVHGqar-rrgLEREAALVVVDaarv-reapDLLVEHFGPLSVVVRYAsPTDVLDVIAQVPGSLTATVHGEPd--dH 441 Nocardioides sp...
YP_001545270 347 AQVLVGGhvl-ddgYRYANSLLYVAgnsflanpqALSHEVFGPVSLIVECAdQAEVLRVLDCLEGNLTGSIYSSSngadE 425 Herpetosiphon a...
YP_587224    348 IEVVLEGne---agAGPAPRLFQTTgaaf-iadaSLHEEMFGPAAVVVMVPsVDAIPDVLSAVKGSLTVTIWGGDq--dN 421 Ralstonia metal...
YP_549119    340 QPLLQEAgs----aEAPRPFLAQVDavnf-iaktELREEVFGPSSLIVRADsIAQVLDVLHAVGGSLTVTLWGAEd--dN 412 Polaromonas sp....
Feature 1                                                                          
1EYY_A       417 PQVSQLIPRLeEIAGRLVFNGWPTGVEVGyaMVHGGPYPASThsaSTSV-GAEAIHRWLRPVAYQA 481 Vibrio harveyi
NP_864635    419 DFAIDWLKVSeRFAGRIILNGWPTGMEIGaaTQHGGPFPASLdgrSTSV-GHASLDRFVRPICYQN 483 Rhodopirellula baltica SH 1
NP_868633    457 DAYSQIAFELePKVGRMLNDKMPTGVAVSaaMNHGGPYPATGhpgFTAVgVPGSLIRFGKLTSFDN 522 Rhodopirellula baltica SH 1
ZP_01092234  429 AAYAQLEPHLrVKVGRLLNDKMPTGVAVSpaMNHGGPFPATGhpaFTAVgIPASLIRFAVLQCFDN 494 Blastopirellula marina DSM 3645
ZP_01855737  428 GLYEQLAPALrQKVGRLLNDKMPTGVAVSpaMNHGGPFPSTGhpvFTSVgIPAAIHRFSMLQCYDN 493 Planctomyces maris DSM 8797
EDY81838     429 ANYPTLAKQLrVKVGRLLNDKVPTGVAVCpaMNHGGPYPSTGhpgFTAVgFPASVVRFSALHSYDN 494 Verrucomicrobiae bacterium DG...
YP_921274    442 DLVRQLLPALvEKAGRVLWNGYPTGVSVTgaMMHGGPYPSSTfpaHTSV-GWTAIRRFLRPVTFQN 506 Nocardioides sp. JS614
YP_001545270 426 TFYQIVAERLrSKVGRLLNDKMPTGVAVSsaMNHGGPYPATGhagWTAVgFPATIRRFAALHCYDN 491 Herpetosiphon aurantiacus ATC...
YP_587224    422 HENREIVRVAqNIGGRVLFSGVPTGVAVTraQQHGGPWPASTdpkTTSV-GYAALQRFLRPVALQD 486 Ralstonia metallidurans CH34
YP_549119    413 ADTRALVRGAtAIAGRVLFAGVPTGVAVTaaQQHGGPWPSSTqpmTTSV-GDAAMERFLRPVALQD 477 Polaromonas sp. JS666

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