2VRO


Conserved Protein Domain Family
ALDH_MaoC-N

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cd07128: ALDH_MaoC-N 
Click on image for an interactive view with Cn3D
N-terminal domain of the monoamine oxidase C dehydratase
The N-terminal domain of the MaoC dehydratase, a monoamine oxidase regulatory protein. Orthologs of MaoC include PaaZ (Escherichia coli) and PaaN (Pseudomonas putida), which are putative ring-opening enzymes of the aerobic phenylacetic acid (PA) catabolic pathway. The C-terminal domain of MaoC has sequence similarity to enoyl-CoA hydratase. Also included in this CD is a novel Burkholderia xenovorans LB400 ALDH of the aerobic benzoate oxidation (box) pathway. This pathway involves first the synthesis of a CoA thio-esterified aromatic acid, with subsequent dihydroxylation and cleavage steps, yielding the CoA thio-esterified aliphatic aldehyde, 3,4-dehydroadipyl-CoA semialdehyde, which is further converted into its corresponding CoA acid by the Burkholderia LB400 ALDH.
Statistics
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PSSM-Id: 143446
View PSSM: cd07128
Aligned: 20 rows
Threshold Bit Score: 678.607
Threshold Setting Gi: 162451893
Created: 29-Oct-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:NADP binding site [chemical binding site]
Evidence:
  • Structure:2VRO; Aldehyde dehydrogenase from Burkholderia xenovorans Lb400 with NADPH bound in the cofactor-binding pocket, contacts determined at 3.5A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
2VRO_B         6 LKNHVAGQWIAGtg---aGITLTDPvTGVALVRVSseGLDLARAFSFAREDGGAALrALTYAQRAARLADIVKLLQAKRG 82  Burkholderia xe...
ZP_01909140    5 LDSYLQGSWKAGeg---dPRSLINPtTEATVATIRsvTRSLADAVAYGRETGGKSLrAMSFAERGAMLKGMAKALHEARE 81  Plesiocystis pa...
ZP_00056528    4 LQSYLAGRWQDGag---sGAQLKDPvSGEVLATASgdGLDMAEALAHARTKGGPVLrALSFAARAGLINAVAGVLAENRE 80  Magnetospirillu...
BAC17487      23 VPSYLSGQWVTPdnp-trIAEVADAsTGEIVARVStdGLDIGAAVAYARDMGQKNLrELTLHERALKLKELALYLSEHKQ 101 Corynebacterium...
ZP_00380748    5 LSSYVAGDWHAPsgspegARAVHDAtNGQLTHHVSssGIDFAAVDEYARTTGVAELqKLTFHQRGVILKKLGAYLMERAK 84  Brevibacterium ...
YP_001105742   4 LRSFVNGDWHVPse---dGAPLHDAvTGEEVARISsaGIDIAGALEYGRARGGPVLgELTFHQRAALLKVLASHLLEHRE 80  Saccharopolyspo...
NP_296102     11 PASYVYGQWHANk----dGQTLLDAvYGRPVAVISseGVDFAQALAYGREAGAGLR-KLTFHTRARMLKALGNYLMERKE 85  Deinococcus rad...
CAD76942       7 LQSFIGGRWIGQq----gAQALRSAlDGHTVARTHeeTLDFTEAVEHGRRHGIAALmAMDFQQRAARLKALGKYLSERKE 82  Pseudomonas sp. Y2
YP_001792587   6 LQSHIGGRWIGTq----aAQTLRSAiNGQPVAATHadAIDFGEAVAYARRTGLPGLlALDFQQRAQRLKALAKYLNEHKE 81  Leptothrix chol...
CAA66089       4 LASFLSGTWQSGrg---rSRLIHHAiSGEALWEVTseGLDMAAARQFAIEKGAPALrAMTFIERAAMLKAVAKHLLSEKE 80  Escherichia coli
Feature 1                                                                                       #
2VRO_B        83 DYYAIATANSGTtRNDSAVDIDGGIFTLSYYAKLGASLge------vhALRDGSAESLsKDRSFSAQHVLSPTrGVALFI 156 Burkholderia xe...
ZP_01909140   82 ELIDIAIQNGGNtRGDAKFDIDGGISVLSHYAYLAKELgkdskgndkpWLIEDEPVEVyRGSKIRAEHILLPRhGLAVHI 161 Plesiocystis pa...
ZP_00056528   81 RYNSIALANSGNtALDAALDVDGGIGTLKYYASIGRKLge------ahLLAEATDDQLtKDEAFRGRHIWTTIqGVAVHI 154 Magnetospirillu...
BAC17487     102 ELYEIAYCTGAT-KRDNGVDIDGGISTLFTYSSKGRRElpn-----adVIIDGPTEVLsKDSSFQGTHIYTPLpGVAVQI 175 Corynebacterium...
ZP_00380748   85 DYHEISFTTGTT-KRDGFVDIEGGIGTLFTYSGVARRQmpn-----stVHLDGGIERLsKNGTFVGRHILTSRqGLALQI 158 Brevibacterium ...
YP_001105742  81 ELYALSARTGAT-LGDSKFDIDGGIGVLFGYSGKGRREmpn-----akVYVDGAVEPLgKGGTFVGQHICTPLrGVAVQI 154 Saccharopolyspo...
NP_296102     86 DYYALNLLTGAT-RRDGWVDIEGGIGTLFSYSSMARRElpd-----erFLPDGKVEVLgKGGTFMARHLLVPReGVAVQI 159 Deinococcus rad...
CAD76942      83 QLYAISHHSGAT-RADSWVDIEGGAGTLFAYASLGARElps-----gnVVHEGPAIPLgKTNKFAGSHILVPRgGVAVHI 156 Pseudomonas sp. Y2
YP_001792587  82 QLYAVSAHTGAT-RTDSWIDIEGGTGTLFAYASAGSNElps-----gnLLHEGPVLNLsKKGGFAATHILVPRgGLAVHI 155 Leptothrix chol...
CAA66089      81 RFYALSAQTGAT-RADSWVDIEGGIGTLFTYASLGSRElpd-----dtLWPEDELIPLsKEGGFAARHVLTSKsGVAVHI 154 Escherichia coli
Feature 1        # #                       # ##                                             #### 
2VRO_B       157 NAFNFPSWGLWEKAAPALLSGVPVIVKPATaTAWLTQRMVADVVDAGILPPGALSIICGssaGLLDQIrsfDVVSFTGSA 236 Burkholderia xe...
ZP_01909140  162 NAFNFPAWGMMGKAAVALLAGMPVLCKPATsTAWLAHRMVQILVDAGLVPEGAFQLLMGsagDLLDHLgpqDVVAFTGSQ 241 Plesiocystis pa...
ZP_00056528  155 NAFNFPSWGLWEKAAVSLLAGVPFLAKPATaTCLLAYEMVKDVVEAGVLPEGALSLLCGggrDLMDHLqpgDVVAFTGSA 234 Magnetospirillu...
BAC17487     176 NAFNFPVWGMLEKFAPSFIAGVPSLVKPATpTGYVTQACVRLMVESGILPEGSIQLISGsarDLLDHLdyrDHVAFTGSA 255 Corynebacterium...
ZP_00380748  159 NAFNFPVWGMLEKFGPMFVAGVPVIVKPATdTAHLTRAVVADMVESGLLPDGAIQLIAGdvtPLFDHLaeqDAIAFTGSA 238 Brevibacterium ...
YP_001105742 155 NAFNFPVWGPLEKFAPAFLAGVPTLVKPASqTAYLTHRLVELIVESGVLPEGSLQLVCGgvgDLLDHLtdqDLVSFTGSA 234 Saccharopolyspo...
NP_296102    160 NAYNFPVWGMLEKLAPAFIAGMPSLVKPAPqTAYLTERVVRDIIASGILPEGSLQLVTGdpgDLLDHLleqDMVAFTGSA 239 Deinococcus rad...
CAD76942     157 NAFNFPIWGMLEKFAPSFLAGMPCIVKPATaTSYITEAAVRLMHESGLLPAGSLQLIIGgtgDLLDRLqgqDVVTFTGSA 236 Pseudomonas sp. Y2
YP_001792587 156 NAFNFPIWGLLEKFAPSFLAGMPCIGKPATaTSYLTEALVRLIDASGLLPAGALQLVIGgtgDLLDRLdgsDVVTFTGSA 235 Leptothrix chol...
CAA66089     155 NAFNFPCWGMLEKLAPTWLGGMPAIIKPATaTAQLTQAMVKSIVDSGLVPEGAISLICGsagDLLDHLdsqDVVTFTGSA 234 Escherichia coli
Feature 1         #                                                                              
2VRO_B       237 DTAATLRAHpafvqrgARLNVEADSLNSAILCADatpdtpAFDLFIKEVVREMTVKSGQKCTAIRRAFVPea-aLEPVLE 315 Burkholderia xe...
ZP_01909140  242 AVGLQIKTHanviargVRVNLEADSLNSVVIGPDveegteLFDLVIRDLAVEMTQKAGQKCTATRRVFVPeg-aVDSIKE 320 Plesiocystis pa...
ZP_00056528  235 DTAAQLRSNpnviaanIRFAVEADSLNLCALGPDakpdgaEFAAFIKEVSREMTVKAGQKCTAIRRILVPrd-rMDAVVD 313 Magnetospirillu...
BAC17487     256 TTAATLRAHdnvqhagLRFSAEADSVNAAILGEDatpdtpEFDAYVKTLFNELTSKAGQKCTAVRRAIVPtgliDDVAFA 335 Corynebacterium...
ZP_00380748  239 NTAKHLGGLdcvrdrgTRFFAEADSLNFSLLGPDaapgteEFDLFISGVVAEMTIKAGQKCTAIRRTFVPeq-hKEAVAE 317 Brevibacterium ...
YP_001105742 235 ATGQRLRAHpnvaarsVRFNVEADSLNCSVLGPDaapgtdEFDLFVKQLVTEMTVKAGQKCTAIRRALVPag-rVDDVVQ 313 Saccharopolyspo...
NP_296102    240 ATANKLKVHpnivarsIPFNAEADSLNAAVLGVTvrpkdpEFALFVKEVAREMTGKAGQKCTAIRRPLVPch-lVDPVVE 318 Deinococcus rad...
CAD76942     237 DTAARLRVNanlvrnsIPFNAEADSLNCAILAPEitpddpEFDLFVKEVAREMTTKAGQKCTAIRRAIVPar-yIDAVAE 315 Pseudomonas sp. Y2
YP_001792587 236 DTAAKLRVHpnivrhsIPFNAEADSLNCAILAPDvspddeEFELFVKEVAREMTVKAGQKCTAIRRAIVPrq-hLDAVAE 314 Leptothrix chol...
CAA66089     235 ATGQMLRVQpnivaksIPFTMEADSLNCCVLGEDvtpdqpEFALFIREVVREMTTKAGQKCTAIRRIIVPqa-lVNAVSD 313 Escherichia coli
Feature 1                                                                                        
2VRO_B       316 ALKAKLAKITVGNPrndaVRMGSLVSREQYENVLAGIAALREeaVLAYDSsavpli---dadaniAACVAPHLFVvndp- 391 Burkholderia xe...
ZP_01909140  321 ALFDRLDQIKIGDPsdkaNRMGPLTSKRQLEDARAGVKTLSAd-AEILRGnpersegfagveagtGYFLEPIVLLgkpdk 399 Plesiocystis pa...
ZP_00056528  314 GLKAALAKALMGDPrtegVRMGPLVSRAQAMAAWGGLETLKAetQVVAGGgnd----------dgGCFVPPTLLLcnnp- 382 Magnetospirillu...
BAC17487     336 LADRITAKIVVGDPrdekTTMGPVVSVEQRDDVAAAVDKLIAagGTVRLGgpe---------eldGAFFAPTILTfdna- 405 Corynebacterium...
ZP_00380748  318 ALLAKLETQGVGDPreksTRLGPVVSDKQRNDVLDAIDEITSagAHVLTGgreasde--laqnlgGAYVAATVLQaddp- 394 Brevibacterium ...
YP_001105742 314 AASERLSKVVVGNPaspeVRMGALASLEQREEVRRSLKALLAa-GTLVHGdpervev-agadaerGAFLPPMLVRcddp- 390 Saccharopolyspo...
NP_296102    319 ALRAELAKVTVGDParddVRMGALVSVEQRERVRETLEKLGQd-AEVVIGggagell--ggdrekGAFLDPTVLLcrnp- 394 Deinococcus rad...
CAD76942     316 RLHARLAKVVVGDPsvegVKMGALASHAQQADVAARVETLLAg-SDLLFGardgfap-lgegvaeGAFFAPTLLRsrdp- 392 Pseudomonas sp. Y2
YP_001792587 315 KLRARLAKTTVGDPslegVRMGPLASHAQQADVAERVALLLQg-CEQVYGakdgaap-qgtgvaeGAFFSPTLLLsrqp- 391 Leptothrix chol...
CAA66089     314 ALVARLQKVVVGDPaqegVKMGALVNAEQRADVQEKVNILLAagCEIRLGgqad-------lsaaGAFFPPTLLYcpqp- 385 Escherichia coli
Feature 1                                                                                        
2VRO_B       392 --dnatLLHDVEVFGPVASVAPYRvttdtnalpeAHAVALARRGQGSLVASIYSNDDAHLGRLALELadSHGRVHAISPs 469 Burkholderia xe...
ZP_01909140  400 vadpqaAFHQHEVFAPVSTLLPYDge-------lATAAKLIAMGNGSLVTTVYTDDRKWLAQAVAEMgpYLGRIVVANEk 472 Plesiocystis pa...
ZP_00056528  383 --laatAVHEVEVFGPVATLMPYDs--------vEQAVELARRGGGSLAASVFSGDCAFLADFVPAIatSHGRVLVVDGs 452 Magnetospirillu...
BAC17487     406 ---dadAVHDTEAFGPVVSIIGYSd--------tADAIRLAARGQGSLVASVITHDPALANQFAMGIaaHHGRLHFLDRd 474 Corynebacterium...
ZP_00380748  395 ---wvdAVHDVEAFGPVTSLITYSs--------tAEAVRLAARGRGSLVGSVVTHDAEFATEFVRQVapWHGRILVLDRd 463 Brevibacterium ...
YP_001105742 391 ---draEPHEVEAFGPVSTIMPYDs--------aAHAVELARRGLGSLAGSVVSADADFAREVVLGAasRHGRLLVLNRh 459 Saccharopolyspo...
NP_296102    395 --leakGPHELEAFGPVATLMPYDt--------lDDAITLAKMGRGSLAASVVTFNRHEATELVLGIasTHGRVLVLNRa 464 Deinococcus rad...
CAD76942     393 --haegGAHDIEAFGPVSTLMAYDd--------lDEAIALAARGKGSLVASLVTKDPQVAAKVVPAAaaLHGRLHILDRe 462 Pseudomonas sp. Y2
YP_001792587 392 --lqhdAVHDVEAFGPVSTLMAYDg--------iDEALALAARGRGSLVGTLVTKSPAIAARVIPVAaaLHGRLLVLDRe 461 Leptothrix chol...
CAA66089     386 --detpAVHATEAFGPVATLMPAQn--------qRHALQLACAGGGSLAGTLVTADPQIARQFITDAarTHGRIQILNEe 455 Escherichia coli
Feature 1                                                                
2VRO_B       470 vqHSQTGHGNVMPmSLHGGPGRAGGGEELGGLRALAFYHRRSAIQAASAAIGTLTQ 525 Burkholderia xenovorans
ZP_01909140  473 haGASMAPGCVFPvANHGGPGRAGGGAELGGVHGMSLYMQRVAVQGGASQLARLLG 528 Plesiocystis pacifica SIR-1
ZP_00056528  453 vaASHSGHGVVMPhCTHGGPSRAGGGEELGGLRGLRFYMQRSAVQGSRAMLDAMTQ 508 Magnetospirillum magnetotacticum MS-1
BAC17487     475 daRTSTGHGSPLPhLIHGGPGRAGGGEELGGIRGVKHYMQRTAIQGTPDHLTAITG 530 Corynebacterium efficiens YS-314
ZP_00380748  464 daEESTGHGSPLPnLIHGGPGRAGGGEEMGGLRGVEHFMQRTAIQASPDMLTAIGG 519 Brevibacterium linens BL2
YP_001105742 460 naRESTGHGSPLPaLVHGGPGRAGGGEEMGGVRGVLHHMQRTAVQADPDTLTAVTG 515 Saccharopolyspora erythraea NRRL 2338
NP_296102    465 daKESTGHGSPLPqLLHGGPGRAGGGAEMAGLAGVKHHMNKVAVQADPTTLAAITK 520 Deinococcus radiodurans R1
CAD76942     463 saAESTGHGSPLPqLKHGGPGRAGGGEELGGLRAVKHYLQRAAVQGSPSMLMAVTG 518 Pseudomonas sp. Y2
YP_001792587 462 aaVESTGHGSPLPmLKHGGPGRAGGGEELGGMRAVKHYLQRTAVQGSPTMLAAITG 517 Leptothrix cholodnii SP-6
CAA66089     456 saKESTGHGSPLPqLVHGGPGRAGGGEELGGLRAVKHYMQRTAVQGSPTMLAAISK 511 Escherichia coli

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