Conserved Protein Domain Family
ALDH_PAD-PaaZ

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cd07127: ALDH_PAD-PaaZ 
Phenylacetic acid degradation proteins PaaZ (Escherichia coli) and PaaN (Pseudomonas putida)-like
Phenylacetic acid degradation (PAD) proteins PaaZ (Escherichia coli) and PaaN (Pseudomonas putida) are putative aromatic ring cleavage enzymes of the aerobic PA catabolic pathway. PaaZ mutants were defective for growth with PA as a sole carbon source due to interruption of the putative ring opening system. This CD is limited to bacterial monofunctional enzymes.
Statistics
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PSSM-Id: 143445
View PSSM: cd07127
Aligned: 7 rows
Threshold Bit Score: 910.705
Threshold Setting Gi: 88703308
Created: 29-Oct-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
NADP bindingcatalytic
Feature 1:NADP binding site [chemical binding site]
Evidence:
  • Comment:based on similarity to structure 2VRO: Aldehyde dehydrogenase from Burkholderia xenovorans Lb400 in complex with NADPH, defined using 3.5 A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
AAG28964     12 QLFDKHHATLEAAVQaihaRGYWTPYPe-mPSPKVYGETAQDDGRRAVEAcFGQDFDLGQPGRSGWMASERSPYGVE-LG 89  Azoarcus evansii
CAD76913     11 ELFDHHRDTLERAVQaiaeRGYWSPFP---ESLRQYPEEAVMGAQAEFEAlLGRHFALAGPQPIGRSGAERSPYGFE-LG 86  Pseudomonas sp. Y2
YP_925677     8 ALFDRHRARLDAAVAacasREYYSAFDe-sPSPRVYGETAAAEGKAAFEAwLGSPFPLPTPGAQGSVATERSPYGVD-LG 85  Nocardioides sp....
ZP_01126525   4 EFFTKHRATLEQAIEitrcRDYWSPYPe-vPSGKIYGEAAAAAGQAAFEGrLHQRFVLQQPGSVADVGDEVSPYGFG-LG 81  Nitrococcus mobi...
NP_628023     9 QLIARHRPTLDLALEtirtRAYWSPHPehpKAYGENGSLDTAAGKAAFDAlHGTRLDLGQPGTDGWVGGEVSPYGVE-LG 87  Streptomyces coe...
NP_883954     4 DFFERHQPMLQKALEaaaqRGYWSPFPe-sPSPRNYGETAAQDGQAAFEAlRGKPFALDLPQASGAVGGEVSPFGFE-LG 81  Bordetella parap...
ZP_01101024  12 ALVEKHAATLDAAMDavmsRKSWSPFKd-sPSSKIHGEEKPPAGKAAFEArLNQRFDIDLPGITGWSGEEVSPFTREpLG 90  Congregibacter l...
Feature 1                                                                                       
AAG28964     90 VRYPvc-dGQALIDAAHAAMPGWQRIGAQGRAGVCLEILERLNKRSFEIAHAVMLTTGQgWMMAFQAGGPHAQDRGLEAV 168 Azoarcus evansii
CAD76913     87 VTYDqy-dTDELLERQQKALPGWRDAGARARVGACLEILQRLNALSPALAHAVMHTTGQaFMMAFQAGGAHAQDRGLEAL 165 Pseudomonas sp. Y2
YP_925677    86 VSYPravdVDALLSAARAGMKGWRDAGPDGRTGVCLEILARLHARIFELANAVQHTSGQaFVMAFQAGGAHALDRALEAI 165 Nocardioides sp....
ZP_01126525  82 VRYPkt-eLDQLLPAMQASLPAWRDAGAEARAGVCLEILARLNKRSFEMAQAVMHTTGQgFVMAFQAGATHAQDRGLEAI 160 Nitrococcus mobi...
NP_628023    88 VEYPha-dLDVLLPAMRAGQKAWRDAGAELRAMVCLEILQRIAARTMEFAQAVMHTSGQaFMMAFQAGGPHAQDRGMEAV 166 Streptomyces coe...
NP_883954    82 ITYPqv-aPEALVAASSKALEQWRRAGPRAWVGVSLEILQRLNRRSFEMAHAVQHTTGQaFMMAFQAGGPHAQDCGVEAV 160 Bordetella parap...
ZP_01101024  91 ITYPlc-ePEALIASAKTAMADWSKASPGLRIALCLEVAEQLYDNNFEMAHAVMHVAGQsYTQAFSGSGPNALDRGIEAL 169 Congregibacter l...
Feature 1                                                 ## #                       # ##       
AAG28964    169 AYAYREMKFIPHETVWEKPQGknpPLKMKKHFEIVGRGVALVIGCGTFPTWNTYPGLFAALATGNPVIVKPHQnAILPAA 248 Azoarcus evansii
CAD76913    166 AYAWRAMAEVPETACWIKPQGkqdPLLLDKRWHIVPRGLSLVIACSTFPTWNTYPGLFASLATGNPVLVKAHPgAILPVA 245 Pseudomonas sp. Y2
YP_925677   166 AYAWTEMTRTPATAIWEKPGRg-gPLRMEKTFTVVPRGVALVIGCNTFPTWNSWPGLFASLVTGNPVVVKPHPaAVLPLA 244 Nocardioides sp....
ZP_01126525 161 AYAYEAMSRIPPHSRWIKPQGkhePLRMDKTFHVVPRGLALLIGVSTFPTWNGYPGLFASLVTGNPVMVKPHPaTVLPLA 240 Nitrococcus mobi...
NP_628023   167 AYAYVEQSRTPETAEWTKPQGkrdPLALTKRFTPVPRGIGLVVGCNTFPTWNGYPGLFASLATGNAVLVKPHPrAVLPLA 246 Streptomyces coe...
NP_883954   161 TYAWQEMSRIPGVALWEKPQGkhdPIKMEKRFTVVPRGIALVIGCSTFPTWNGYPGLFASLATGNTVIVKPHPgAILPLA 240 Bordetella parap...
ZP_01101024 170 AYAAMAMDKVTPAAEYHRQFGr-dQVALEKTYTLVPRGVGLVICCASFPTWNAYPAMFASLATGNPVIVKPHPiAILPMA 248 Congregibacter l...
Feature 1                                                    ####  #                            
AAG28964    249 ITVRIAREVLAEAGLDPNLVTLAAfdk-heATQALATHPaVKSIDFTGGNAFGQWLISNAkQAQVYAELAGVNNVVIEST 327 Azoarcus evansii
CAD76913    246 MSVKVAQEVLGELGFDPALVSLVVdtpeapVAQRLALDPrVRLVDFTGSNAFGEWLEQHArQAQVFTEKAGINTLIIDST 325 Pseudomonas sp. Y2
YP_925677   245 ISVQVCREVLAEAGFDPDLVLLAAeepedrLAATLAVRPeVRLIDFTGGNAFGDWLEANAgQAVVFTEKAGVNTVVVDST 324 Nocardioides sp....
ZP_01126525 241 LTVEVAQEVLAEAGFDPWLVALVAdsreapVTKELARRPeIRLIDYTGSTAFGNWLEEHCrQAQLYTEKAGVNSVIVDST 320 Nitrococcus mobi...
NP_628023   247 LTVQVARHVLTEAGFDPNLVALAAerpgegIAKTLATRPeIRIIDYTGSTAFGDWLEANArQAQVYTEKAGVNTVIVEST 326 Streptomyces coe...
NP_883954   241 LTVQVAREVLGEAGFDPDVVLLAAhpagddTAQRLALDPaVRIVDFTGSSANGNWLEQNArQALVYTEKAGVNQVLIDST 320 Bordetella parap...
ZP_01101024 249 IVVERCRAVLSAFGFDPNLVTLAAdtiaepIAGHYVDHPdVQIIDFTGSPRYGSHLEKTVtGKQLFTETAGVNSVVVESV 328 Congregibacter l...
Feature 1                                                                                       
AAG28964    328 dQYKAMLRNLAFTLCLYSGQMCTTTQAILVPaDGIDTDQGRKSYDEVCADLATSIDKFLADPAVATAVLGAIQSPDTLAR 407 Azoarcus evansii
CAD76913    326 hDLKAVAKNLAFSLSLYSGQMCTTTQAIYVPrDGIRNGDEQLSFDQVADTLASAINGLLSDNDRACAVLGAIQSEATAAR 405 Pseudomonas sp. Y2
YP_925677   325 sDFAAMCQNLAFSFALYSGQMCTAPQNVYVPaAGIATEDGVRSPAEVGAGIGAALQGLLGDDARAVELLGGIVNDGVLAR 404 Nocardioides sp....
ZP_01126525 321 dNLQGLVHNLAFSLSLYSGQMCTTPQNIYVPrDGIETEQGWLGADEFAQAIAEGITRLLADGERAAELLGALQSENTARR 400 Nitrococcus mobi...
NP_628023   327 dDYQGMLANLAFSLSLYSGQMCTTPQNLLIPrDGIRTDQGAKSYDEVTADLARAVDGLLGDDARANALLGAIVNPDVKAR 406 Streptomyces coe...
NP_883954   321 dDLKGVARNLAFSLALYSGQMCTAPQNIYVPrDGIQTAEGRVGFDEVAAALGAALDKLAGDPAKAVELTGAVQNDATVAR 400 Bordetella parap...
ZP_01101024 329 dDLVASMRAIARASSLFSAQMCTSPQVVFVPkDGIQTRDGHASFDAVAQCIVDEIDALAANPKVAAGIMGAVQAQLSLDV 408 Congregibacter l...
Feature 1                                                                                       
AAG28964    408 IAEAPAHGr-----VVRASTKIEHAEFPGAEVRSPLLLACDaad---ekAYMEERFGPIAFVVKVAdgaaAVTLSERIVR 479 Azoarcus evansii
CAD76913    406 IADCRALGe-----VLLDSEVREHPQFPGARVRTPLLLKVDasd---raAYAQERFGPIAFVIATDdsahSLRVAREVIA 477 Pseudomonas sp. Y2
YP_925677   405 LEKAGRGH------VLVPSREVAHPAYADATVRTPMLVGLTaed---sdVYESECFGPVAYLIETEgtdqSIDLFRHTVL 475 Nocardioides sp....
ZP_01126525 401 IAEAARLGe-----VVLASEPRGHPRFADARVHTPLLLKVGaep---sdRYDREWFGPIAFVVATEstdeSIERSRGSAL 472 Nitrococcus mobi...
NP_628023   407 LEAAAGLGe-----VALASREVTNPEFPDAVVRTPVIVKLDgakpedeaAYTSECFGPVSFAVAVDsadhAVELLRRSVR 481 Streptomyces coe...
NP_883954   401 IGKARQLGl----pVLADSKALAHPQFEQARVHTPLLLRADag----ndALGQEWFGPIAFVVATDstahSIELAGASVR 472 Bordetella parap...
ZP_01101024 409 VTEASQMAggeglrILREGEAYAHPDFPKALTRTMMVIAGDssh---qaMYAEERFGPVLFVVATDsadaAAQEATELAR 485 Congregibacter l...
Feature 1                                                                                       
AAG28964    480 EHGALTVGLYTTkPEVVDAMTEATWRAGVALSINLTGGVFVNQSAGFSDYHGVGMNPAANASLSDSAFVANRFRVVQRRH 559 Azoarcus evansii
CAD76913    478 EKGAMTLGVYSTdAAFLYQAESLARDVAVALSVNFDGGVFVNQSAAFSDFHATGGNPAANASITDGAFVSRRFVTVQSRR 557 Pseudomonas sp. Y2
YP_925677   476 AHGAMTAAVYSTsPEVVEQVREAALEAGVALSENLLGGVFVNQSAAYSDFHGTGANPAANAAYTDGAYVASRFRVVQSRR 555 Nocardioides sp....
ZP_01126525 473 AHGAITWSVYATeAAVLERTQHAALEAGVALSCNLTDGVYVNQSAAFSDFHATGANPAANACLCDAAFVANRFRVVQTRR 552 Nitrococcus mobi...
NP_628023   482 EKGAMTVGAYTTdPEVEEAVQEVCLDEAAQLSLNLTGGVYVNQTAAFSDFHGSGGNPAANAALCDGAFVANRFRVVEVRR 561 Streptomyces coe...
NP_883954   473 QHGALSLSAYTTdEAVASRVQDMAEHSGVSLSLNLTGGVFVNQTAAFSDFHGTGANPAANAALSDSAFVANRFRVVQTRR 552 Bordetella parap...
ZP_01101024 486 TRGTISCYMYSTdEDFIDRWVDVYAAVGANLSINLTGAMWINFAAAYSDYHVTGLNPAGNACLADLSFVASRFRIAQRRR 565 Congregibacter l...

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