Conserved Protein Domain Family
ALDH_F20_ACDH

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cd07122: ALDH_F20_ACDH 
Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like
Coenzyme A acylating aldehyde dehydrogenase (ACDH, EC=1.2.1.10), an NAD+ and CoA-dependent acetaldehyde dehydrogenase, functions as a single enzyme (such as the Ethanolamine utilization protein, EutE, in Salmonella typhimurium) or as part of a multifunctional enzyme to convert acetaldehyde into acetyl-CoA . The E. coli aldehyde-alcohol dehydrogenase includes the functional domains, alcohol dehydrogenase (ADH), ACDH, and pyruvate-formate-lyase deactivase; and the Entamoeba histolytica aldehyde-alcohol dehydrogenase 2 (ALDH20A1) includes the functional domains ADH and ACDH and may be critical enzymes in the fermentative pathway.
Statistics
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PSSM-Id: 143440
View PSSM: cd07122
Aligned: 68 rows
Threshold Bit Score: 517.815
Threshold Setting Gi: 108797177
Created: 1-Jan-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative catalytic cysteine [active site]
Evidence:
  • Comment:conserved cysteine that aligns with the catalytic cysteine of the ALDH superfamily

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
P0A9Q7         9 LNALVERVKKAQReya-sfTQEQVDKIFRAAALAAA--DARIPLAKMAVAESGMGIVEDKVIKNHFASEyIYNAykdeKT 85  Escherichia col...
YP_295090     30 VAEVVARARHAQRefa-raDQATIDTAVAAAAWAIMepARNRRLAECAVADTGLGNVEDKIRKNYRKTLgLLRDlhgrKT 108 Ralstonia eutro...
YP_001088857  16 INGYIERARKAQRefe-cyTQEQVDKIVKIVGKVVY--YNAEYLAKLAVEETGMGVYEDKVAKNKSKAKvIYNNlkdkKS 92  Clostridium dif...
NP_904963      3 IKEMVSLARKAQKeyqathNQEAVDNICRAAAKVIY--ENAAILAREAVDETGMGVYEHKVAKNQGKSKgVWYNlhnkKS 80  Porphyromonas g...
YP_001865685 155 VEVMLDKALLAQKeiq-twSEERIDALLLVIASSIA--QHAESLATATVKATRVGDILDKVTKNKIASLgIYRSlvgkSG 231 Nostoc punctifo...
ZP_01112926  138 VDAMVARSVVAQNsiq-tlPEDQIDAMIGDIADAVN--RESWNLAEAAILETGMGVVNHRVQKILLGTMeVAASlmgqTG 214 Reinekea sp. ME...
YP_708761     12 LDTVLDRAQVAATafe-ayDRSQVDRIVRAVANVAL--QNARQLAEKAADETGFGVAEDKVAKNEAVSSgFVREygdlDF 88  Rhodococcus sp....
YP_637374     17 AGHMLERARWAARaya-dyDQAAVSAITTAVADAAY--GAADRFAAEAVAETGMGVVADKVLKNQACSRgILDYyreqDF 93  Mycobacterium s...
YP_995461     25 GLLQLDRAEWAARdfa-qfDREQVLRVAEAVAKAAH--DNAAFYAEWAVRETGYGVVEHKQKKNESVAYpLLDFyrdlDL 101 Verminephrobact...
YP_001953105  16 EGNMLEQAQVAARefa-kfSPQAVDKIVEAVAAVAA--ERSAFYAEWIVRETGYGVVEHKTIKNEGSSAgLVNFykgqNF 92  Geobacter lovle...
Feature 1                                                                                        
P0A9Q7        86 CGVLSeddtFGTITIAEPIGIICGIVPTTNPTSTAIFKSLISLKTRNAIIFSPHPraKDATNKAADIVLQAAIAAGAPkD 165 Escherichia col...
YP_295090    109 VGVILqdaeTGITEIARPVGVVAAITPSTNPGATPANKIINALKCGNSVIVAPSPkgQGTCELLLSFIHAEFAKAGLPaD 188 Ralstonia eutro...
YP_001088857  93 VGIIDidreTGITKVAKPVGVVAAITPCTNPIVTPMSNAMFALKGRNAIIITPHHkaIGCSTKTVEMINEELEKIGAPeN 172 Clostridium dif...
NP_904963     81 IGILNiderTGMIEIAKPIGVVGAVTPTTNPIVTPMSNIIFALKTCNAIIIAPHPrsKKCSAHAVRLIKEAIAPFNVPeG 160 Porphyromonas g...
YP_001865685 232 CGFISnnkiNNVCEIASPMGIIFGMIPMTNPVATAVFKALICIKSRNALILSFPLstKNVGTLVCEIIQEALIRQDAPvE 311 Nostoc punctifo...
ZP_01112926  215 SGALQie-sPMVDAMSVPMGVILGLIPVTNPVETLVFKTLISLKSRNAIILSSHRkaRQVSDRTVSIIRSVLSRYQVNpD 293 Reinekea sp. ME...
YP_708761     89 VSHRAdn-eKKLLLSPKPAGVIFAVTPSTSPVANLYFKVLSSLLTRNAVVISPHPaaVQTSLEAAQLLSRAATEAGAPeG 167 Rhodococcus sp....
YP_637374     94 VSPRVdp-dSKIVEIPRPAGVVLALTPTTNPVSTVYFKVLLALMTRNAVVVAPHPraKRCSADAARLLADAAIAAGAPdG 172 Mycobacterium s...
YP_995461    102 VHPRVde-aRKMVEIPKPAGIVLALTPATNPVATVYYKVMLALLSRNAIVISPHPaaSRCCNDAARKLDAAAHAAGAPpG 180 Verminephrobact...
YP_001953105  93 CGYEIdt-eKKVVKIARPAGVVLALVPSTNPVATTYYKILLSLMSRNAVILCPHPaaKGCIVGSADELTAVAEKAGLPkG 171 Geobacter lovle...
Feature 1                                                                                        
P0A9Q7       166 LIGWIDQPsve-lsnALMHHpdinLILATGGPGMVKAAYSSGkPAIGVGAGNTPVVIDETADIKRAVASVLMSKTFDNGV 244 Escherichia col...
YP_295090    189 LVQMLRSPvskaataELMRQa--dLIVATGSQANVHMAYTSGtPAFGVGAGNVASIIDASATLDDAAAKIVRSKTFDNAT 266 Ralstonia eutro...
YP_001088857 173 LIQILDQQsre-ntrNLISSa--dVVIATGGMGMVKAAYSSGkPALGVGAGNVQCIIDRDVDIKEAVPKIIAGRIFDNGI 249 Clostridium dif...
NP_904963    161 MVQIIEEPsie-ktqELMGAv--dVVVATGGMGMVKSAYSSGkPSFGVGAGNVQVIVDSNIDFEAAAEKIITGRAFDNGI 237 Porphyromonas g...
YP_001865685 312 LIQWLKHRssreqteILMKHknvsLILATGGASMVKAAYSSGtPAIGVGPANTPTLICADANIQHAARTIIVSKSFDNGL 391 Nostoc punctifo...
ZP_01112926  294 LVQIPSQAprreltsLLMSHpdiaFILATGGPGMVRSAYQSGtPSIGVGKGNAPVWVCDDADVKTAAKQIVDSKSFDNGI 373 Reinekea sp. ME...
YP_708761    168 AIQILNKPsvp-lieAAMGDarvnLILATGGSAVVRAAYRSGtPAIGVGPGNAAVVVDETADLERAADQISASKAFDNSV 246 Rhodococcus sp....
YP_637374    173 IVQVVEEPsip-lveALMADertdVIVATGGTGVVRAAYSSGtPALGVGPGNVPVLVDASADITAAAKRIVDSKAFDNSV 251 Mycobacterium s...
YP_995461    181 LIQCIERPsip-lvdTLMRSpqvaVVMATGGGPMVRAAYSSGnPAIGVGPGNAPAYIDTSADMRKAARMIVSSKSFDNSV 259 Verminephrobact...
YP_001953105 172 VIQVVREPsia-lleTMMKSdqvnLILATGGPGVVRAAYSSGnPAIGVGPGNVGHYVDGTGSLDKAALDIAISSGFDNNL 250 Geobacter lovle...
Feature 1         #                                                                              
P0A9Q7       245 ICASEQSVVVVdsVYDAVRERFATHGGYLLQGk-eLKAVQDVILknga--lnaAIVGQPAYKIAELAGFSVPE---NTKI 318 Escherichia col...
YP_295090    267 SCSSENSLVVLdaVYKPMLRALAAVGGVLLTSt-eKARLQALMWqngk--lvgEATGQSARRIAELAGLERVRdqqPTML 343 Ralstonia eutro...
YP_001088857 250 ICSGEQSVIVAeeMFDKIMDEFKNNKGFIVRDkvqKEAFRNAMFvnks--mnkDAVGQSVHTIAKIAGVEIPE---DTKI 324 Clostridium dif...
NP_904963    238 ICSGEQSIIYNeaDKEAVFTAFRNHGAYFCDEa-eGDRARAAIFenga--iakDVVGQSVAFIAKKANINIPE---GTRI 311 Porphyromonas g...
YP_001865685 392 ICGSEHNLIVDarVRKNFIKVLEQEGAAILTHe-eKSYFSTVAFedksnrlqaKIIGQSAAKIAVMANIKRDY---HIKL 467 Nostoc punctifo...
ZP_01112926  374 VCGSENNLIADrsVYDDLRRALEAQGAAVLEAk-eVVRLNNAVLeggk--lcgDWMGKGASLICQQAGIERPY---PIRL 447 Reinekea sp. ME...
YP_708761    247 LCTAESVLIMVesIASRMNELLVRRGAHLCRPd-eTRRLRNYMYpkgk--fntEVVGRPAREIAKKAGITVAE---GTQL 320 Rhodococcus sp....
YP_637374    252 LCTNESVLIVEdsVADALRSAMTRAGAHILDAd-aTERLRAYMFadgh--lntDVVGRDAAWIAGQAGIRVTP---KTRV 325 Mycobacterium s...
YP_995461    260 LCTSESVLLVQqkDAQRFERELRAAGAHLCQEr-eVERLRAYLFpdgd--lnpAAIGKSAVWIAREAGLKVLP---ATQV 333 Verminephrobact...
YP_001953105 251 GCTSDSVALVErdVADAMLEALSRNGVLKLEDkddIEKVRNVLYpdgg--fnpAAIGKSAAWIANEAGISINE---DIKI 325 Geobacter lovle...
Feature 1                                                                                        
P0A9Q7       319 LIgevtvvdesePFAHEKLSPTLAMYRAKDFedavEKAEKLVAMGgIGHTSCLYTDqdnqpARVSYFGQKMkTARILINT 398 Escherichia col...
YP_295090    344 LVeesgv-gsdfPFSGEKLSPVLTLYRAADFaaavDTVSRLYDYMgAGHSVSLHTSn---pRQAQQLGLELpVARVIVNQ 419 Ralstonia eutro...
YP_001088857 325 IVieadgpgeedIIAKEKMCPVISAYKYKSFeegvAIAKANLNVEgKGHSVSIHSNt---vKNIEYAGENIeVSRFVINQ 401 Clostridium dif...
NP_904963    312 LVveargvgaedVICKEKMCPVMCALSYKHFeegvEIARTNLANEgNGHTCAIHSNn---qAHIILAGSELtVSRIVVNA 388 Porphyromonas g...
YP_001865685 468 IIvpneflsldnPYAYEKMAPILSLFTVQNEiegiDLCRSILQIEgKGHTAIIHTKn---kAVVRRFGLEMpASRILVNS 544 Nostoc punctifo...
ZP_01112926  448 IAvpqsvfdqnsPWLREKLAPIVSLMGVESEaealSVARRVLALEgRGHTAIVHTQd---aERIERYAKACdVCRVLVNS 524 Reinekea sp. ME...
YP_708761    321 LLapidsirddePLTHEKLSPVLAVMTVSNFdqalAAAASLVDIVgVGHSAVIHSEd---pQHVLDYSHRLpVHRVAVNI 397 Rhodococcus sp....
YP_637374    326 LVapfdhviseeMLAHEKLSPVIGMTTVPDAargiRAARAVVRIGgAGHSAAIHSEn---aSVITEFATQVpVLRVSVNV 402 Mycobacterium s...
YP_995461    334 LVanvqhigvdePLTKEKLCPVLALYAVDSFeratRSAQMILRLSgAGHSAAFHGNd---pQKALDFAARLnVYRVVVNA 410 Verminephrobact...
YP_001953105 326 LCvevdkiddkdIYTREKLFPVLGFLRIDGLdaayRAAEAMIAMGgAGHTAAIHSKd---sDKIVAWSQLP-VYRIATNG 401 Geobacter lovle...
Feature 1                                                         
P0A9Q7       399 PasqGGIGDLYNfkLAPSLTLGCGSWGGNSISenVGPKHLINKKTVAKR 447 Escherichia coli K-12
YP_295090    420 AhcfATGGNFDNg-LPFSLSMGCGTWGGNNFSdnLGWRQYLNITRIAEP 467 Ralstonia eutropha JMP134
YP_001088857 402 CcatSAGGSFFNg-LAPTNTLGCGSWGNNSISenLDYKHLINISRIAYY 449 Clostridium difficile 630
NP_904963    389 PsatTAGGHIQNg-LAVTNTLGCGSWGNNSISenFTYKHLLNISRIAPL 436 Porphyromonas gingivalis W83
YP_001865685 545 PgvhGIIGLTSA--LDPSFTLGCGTFGGNSTTdnVTYSNLLNLKRVAYY 591 Nostoc punctiforme PCC 73102
ZP_01112926  525 PgtqGCIGACNG--LELSWTLGCGTAGGSSTSdnVTYRHLQNTKRIARA 571 Reinekea sp. MED297
YP_708761    398 GgslGNAGIGTG--LPLTMSIGTGFAGGSSLGenLAPEHLVQWKRAAYP 444 Rhodococcus sp. RHA1
YP_637374    403 GnstGSSGLETN--LAPSMTIGTGFVGRSSIGenLRPDNLMNWARIAYN 449 Mycobacterium sp. MCS
YP_995461    411 PcaqGASGFATH--LPPTFMIGTGYFGRSCVGenVGPQHLVHWTRLAYN 457 Verminephrobacter eiseniae EF01-2
YP_001953105 402 PaplVASGFASG--LAPTMTVGTGFFGRSSVCenVGPQHLIHWTQIAYS 448 Geobacter lovleyi SZ

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