3FG0


Conserved Protein Domain Family
ALDH_BADH-GbsA

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cd07119: ALDH_BADH-GbsA 
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Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like
Included in this CD is the NAD+-dependent, betaine aldehyde dehydrogenase (BADH, GbsA, EC=1.2.1.8) of Bacillus subtilis involved in the synthesis of the osmoprotectant glycine betaine from choline or glycine betaine aldehyde.
Statistics
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PSSM-Id: 143437
View PSSM: cd07119
Aligned: 13 rows
Threshold Bit Score: 808.46
Threshold Setting Gi: 78061385
Created: 14-Dec-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:NAD(P) binding site [chemical binding site]
Evidence:
  • Structure:3FG0: Staphylococcus aureus Betb binds NAD, contacts determined at 3.5A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
3FG0_A        36 YIDGEWvesankntRDIINPYNQEVIFTVSEGtkeDAERAILAARRAFESGEWsq-eTAETRGKKVRAIADKIKEHREAL 114 Staphylococcus ...
XP_001731583  12 FIDGKWcasserktRATYNPYDASVIMHVDEAtadDAKRAVTSAKTFFNTSDWph-kTYEERCALLDRMADTLQQHKAEL 90  Malassezia glob...
NP_822798      5 FIDGEWvrgatgttREVVNPFDATVVRSVDEGdatDVDRAVTAARRAFHAADWaa-aPTQRRADVLFRVAEYLLRDIEEI 83  Streptomyces av...
ZP_01696957   14 YINGEWidadnretRAIKNPANGETIAIAPEGttrDAHEAVDAARKAFESGIWsg-iPAQERAAYLFQVADKIDENAKAL 92  Bacillus coagul...
YP_001669252   7 FIAGQWrephsgryREILNPANESLLALAPEAgaqDVDAAIDAARHAFDHGPWpq-lPPSERSAWLLRIAAAIEADAAQL 85  Pseudomonas put...
YP_300022      7 YIDGRWqsplegstRDILSPADESVIAQAAEGtraDARIAIAAARRAFDGPWRq--tTIRDRARLLNRIAALIDRDAEEL 84  Ralstonia eutro...
YP_371293      7 YIDGAWqpaaaggqRAIIDPATGEAIARVAYGsaaDAGHAIRAARAAFDAGEWph-lPAEERAACLRRLANALRDEAPAL 85  Burkholderia sp...
YP_701848     15 FVDGQWirsssgetRDCINPADGSVVATVDEAspeDATRAVAAARAAFDQGTWpc-tPVAERTALVARIADLLERDKETL 93  Rhodococcus sp....
YP_001311998   7 YINGEWveaiskktRDVINPANGQVIAKTTEGgieDTKLAIAAAKESFYGKGEwrrmNAQARADILLQIADKIAEKRDKF 86  Clostridium bei...
YP_001645980   6 FVDGKWvaalsgarRNIINPATGEVIATSAHGsadDAKIAIKAARKAFDSGIWsg-lSADERADYLYKIADRLEENTAEI 84  Bacillus weihen...
YP_001249655   7 YIDGKFtlaksgttRDIFDPANGELIARVPESakeDAILAIKAARKAFDEGEWrk-sLALDRGKLLFKLADLIRANAKML 85  Legionella pneu...
YP_590611     15 YIDGKFvesatgklFPVYDPSTEEVIAECPAGnaaDVDRAVAAARTAFDDGPWna-tTAQERGRVLFRIAEKIRQHTAEL 93  Acidobacteria b...
P71016         6 FIDGEWisaekeqiRSIINPFNQEEIATVSEGgreDAIKAIAAARRAFDKGEWss-lSGLERGKIVLKIAELIRRDLEEL 84  Bacillus subtil...
Feature 1                                                                          #####         
3FG0_A       115 ARLETLDTGKTLe-ESYADMDDIHNVFMYFAGLAdk-dgGEMIDspi--pdTESKIVKEPVGVVTQITPWNYPLLQASWK 190 Staphylococcus ...
XP_001731583  91 ARIETIDTGKTLg-ESEIDIDDVTQVFRFYAKEAiklaqDKQVTgplipesVKSRIVHEPVGVCVLITPWNYPILQLCWK 169 Malassezia glob...
NP_822798     84 ARDETLNTGKTLa-EARIDVKDVSNAFRYFAEMAgk-daGRVVDag---pdVLSRVVHEPVGVCALIAPWNYPLLQASWK 158 Streptomyces av...
ZP_01696957   93 TRLETLDNGKPLr-EASYDIADAAACFRYYAGLItk-pdGFTYHva---dpMQAMVVREPVGVCGLIVPWNYPLLMSVWK 167 Bacillus coagul...
YP_001669252  86 ARLETLNTGKTLc-ESEADMACVVATFRYYAGLLea-rtDRAHPhap--dhVISVTRHEPVGVCALIVPWNYPLLQTAWK 161 Pseudomonas put...
YP_300022     85 ARFESLNTGKTLt-ESRTDMGDIAATFRYFAGLVas-esGAVNEap---hhVISRTLREPVGVCGLITPWNYPLLQAAWK 159 Ralstonia eutro...
YP_371293     86 ARIETANTGKTLa-ESSSDVHDAASAFDYFASLAvt-etGSMNAak---phVISVTLREPVGVCGLITPWNYPLLQAAWK 160 Burkholderia sp...
YP_701848     94 ARIETLDTGKTLe-ESRIDIDDVVSVFRYYAQLAav-eaDALVDvgr--peVISRVVREPIGVCVLIAPWNYPLLQISWK 169 Rhodococcus sp....
YP_001311998  87 AMLDTIDNGKPLr-EAEGDIDDGIHCFRYYAGLItk-pyGGVYDvndgfgqMHSYTVHEPVGVCGQITPWNYPFLMAVWK 164 Clostridium bei...
YP_001645980  85 ARLETANNGKVIraTTYIDIPVSIQCFRYYADLIkg-mkKESYTrd---daSETIIIHEPIGVCGLIVPWNFPLMLAVWQ 160 Bacillus weihen...
YP_001249655  86 AELETRNCGKPLp-EAEFDVTDAANCFEFYGGLAtk-ihGETMSvp---anSFSYVVREPIGVCGQIIPWNFPLLMAAWK 160 Legionella pneu...
YP_590611     94 AEIECRNSGKPIv-EAEYDIADCATCFEYYGGLAtk-itGQVNPvp---dnAVSLSLKEPIGVAGQIIPWNYPLAMAAWK 168 Acidobacteria b...
P71016        85 AELESLDTGKTLe-ESKADMDDIANVFQYYAGLAdk-dgGEIISspi--pdSESKIIREPIGVCGQITPWNYPLLQASWK 160 Bacillus subtil...
Feature 1                     #  #                             #   #             # ##  #  #      
3FG0_A       191 IAPALATGCSLVMKPSEITPLTTIRVFELMEevGFPKGTINLILGAGseVGDVMSGHKeVDLVSFTGGIETGKHIMKNAA 270 Staphylococcus ...
XP_001731583 170 LAPALATGNVVIIKPSEVTPLSSVYLVKLLLeaGFPPHSVQILTASGasVGPVLTESAdVDLVSFTGGLSTGRSIIRSCA 249 Malassezia glob...
NP_822798    159 VAPALAAGNTFVLKPSEITPLTTIAMMRLIEeaGAPPGVANLVLGAGatVGSAMTVHPeVDLVSFTGGLGTGRRIMESAA 238 Streptomyces av...
ZP_01696957  168 IAPALAAGNTIVFKPSEVTPVTAMKLFEIFEeiGLPKGVANMVMGAGpvVGEEIVTHPeVDMISFTGGTKTGKHLMRQAA 247 Bacillus coagul...
YP_001669252 162 LAPALAAGNTVILKPSELTPLSALHLTALLAalALPAGVFNLVCGDGt-VGHHMALSDrVDMVSFTGGAQAGAKVMQAAS 240 Pseudomonas put...
YP_300022    160 IAPALGAGNTVIIKPSNLTPLTTHHFTKLIAelDLPAGVFNLVTGGAe-VGAELAESRdVDLVSFTGGAFAGESIMKAAT 238 Ralstonia eutro...
YP_371293    161 LAPALVAGNTVVVKPASLTPLSTHRLVELAHdaGLPRGVLNLVTGGAd-VGDALAASPqVDLISLTGSNAAGASVMRAAA 239 Burkholderia sp...
YP_701848    170 VAPALAAGCTMVLKPSEVTPLSTIAFTALIAeaGVPAGVVNLVQGSGavLGAALTGTPdVDFISFTGGLATGRVILETAA 249 Rhodococcus sp....
YP_001311998 165 LAPAIAAGNSVVFKPSSNTPLSTIALFEIFDeiGLPKGSVNLVLGSGgtVGQEIAESNdIDMVTFTGSTEVGQSIARAAV 244 Clostridium bei...
YP_001645980 161 IAPALAAGNTIVIKPADVTPVSVFKLFEIIEevGLPDGVANLVLGPGskVGNELAESHdVDKIAFTGGTKTGQSIMRAAA 240 Bacillus weihen...
YP_001249655 161 LAPALAAGNTVVLKPSELTPITALELFKLIDqcGFPAGVVNLITGPGmgVGEELASNSmVDKVAFTGGSATGRKIMQAAT 240 Legionella pneu...
YP_590611    169 LAPAIAAGCTVVIKPAEQTPLTLLELAKHFEevGLPNGVVNVVTGYGeeAGAPIVAHKdVDKIAFTGSGSVGKLIMREAS 248 Acidobacteria b...
P71016       161 IAPALAAGNTIVMKPSEITPLTTIKVFKLMEeaGVPKGVANLVLGPGatVGDELAVNKdVDLISFTGGIETGKKIMRAAS 240 Bacillus subtil...
Feature 1                # #                               #                                     
3FG0_A       271 nnVTNIALELGGKNPNIIFDDaDFELAVDQALNGGYFHaGQVCSAGSRILVQnsIKDKFEQALIDRVKKIkLGNGFdadt 350 Staphylococcus ...
XP_001731583 250 etVKRCTVELGGKNPNVVFADcDLDWAIDNVLTAVFVHsGQVCSAGARLIVEesIADKLVDGVVKRAQNIvMGNGLdass 329 Malassezia glob...
NP_822798    239 reVKNIALELGGKNPNVVFDDaDFEAAVDHTLDASFLHsGQVCSAGSRLLVQdsWHDRFVRELADRASRIrLGNGLdpht 318 Streptomyces av...
ZP_01696957  248 dtLKKVSLELGGKSPNIIFADaDFETAVDYALYGIFSGaGQVCSAGSRILVEesLYERFVSHFVERAAKIkVGPGDdpdt 327 Bacillus coagul...
YP_001669252 241 gnFKRLALELGGKNPNIVFADaDLDVALDQALNAVFFNaGQVCSAGSRLLLQasVHDRFVARLVERIDAIvLGDGFdsrt 320 Pseudomonas put...
YP_300022    239 gnFKRIGLELGGKNPNIVFADaDLDVAVDYALNAAFFHaGQVCSAGSRLMIEdsIYDAFVAKLAERLPRIaIGNGFhaet 318 Ralstonia eutro...
YP_371293    240 gnFKRVSLELGGKNPNLVFADaDVDTALDYALNAAFFNaGQMCSAGSRLLVErtLHDAFVDALAARIAAIrVGRGDddat 319 Burkholderia sp...
YP_701848    250 knVTKVAVELGGKNPHIVFADaDGDDSVDQVLTGVFLHsGQVCSAGTRLIIEesIADRFVAALAARAEKIrMGNGLdpts 329 Rhodococcus sp....
YP_001311998 245 gnLKKVGLELGGKSPNIIFADaDFEGAVEWAMVGIFFNqGEVCSAGSRIIIEesIKDKFVARLAEKANAMtIGNPVnn-p 323 Clostridium bei...
YP_001645980 241 gnMKKITLELGGKSPLIVFDDvDFETAVDNAMFGIFHNaGQVCSAASRLLVQetIYDKFVERLAERANKIvVGNGEseni 320 Bacillus weihen...
YP_001249655 241 gnLKKTSLELGGKNPNIVFADcDLEMAIDGALFGAFANqGEVCSAGSRLLVErsIHKKIVEGMLKKIPNIkLGHGLdagv 320 Legionella pneu...
YP_590611    249 atLKRVSLELGGKSPNIFFADaDFEAAIDGALFGVFINqGEVCSAGSRILVErpIYKKFVEAMTEKAKKIkLGAPLdrdt 328 Acidobacteria b...
P71016       241 gnVKKIALELGGKNPNIVFKDaDLEVAVDQALNAVFFHaGQVCSAGSRLLVEdaIHDQFLAELVKRAKRIkLGNGFhaet 320 Bacillus subtil...
Feature 1                    #                                                     #             
3FG0_A       351 EMGPVISTEHRNKIESYMDVAkaEGATIAVGGKRpdrd---dlkDGLFFEPTVITNcdtsMRIVQEEVFGPVVTVEGFEt 427 Staphylococcus ...
XP_001731583 330 ETGPLVSAEHLAKVESYVQLAreEGAVIRCGGRRpdpktfphlaKGYFFLPTVIDKcnrtMRIVQEESFGPILTVERFAd 409 Malassezia glob...
NP_822798    319 ESGPLSSAEHRAKVEKYIDLGrsEGARLVTGGRRpddp---dlaHGFFLLPTIFDDcdrsMRIVQEEVFGPVVTVETFRt 395 Streptomyces av...
ZP_01696957  328 EMGPLVSEEHMKKVLSYIEIGkqEGATLALGGNRllen---gldKGYFVGPAVFVDvkqnMRIVQEEIFGPVVVIQKFKd 404 Bacillus coagul...
YP_001669252 321 RMGPLISAAQRNRVLSLIQAAqgEGARLRAGGQRptda---hleKGFWLRPTLLSDvqadMRIAREEIFGPVITVERFTd 397 Pseudomonas put...
YP_300022    319 QMGPVQSAQQHEKILRMVQAGvaEGARLVYGGKRpegd---vyrKGYWLQPTLLADvtadMNIAKDEIFGPVVTAERFRs 395 Ralstonia eutro...
YP_371293    320 RMGPVISAQQRDRVLALIGEAarDGARIVCGGRApagd---afaTGFWVEPTLIAGvrttMAIAREEVFGPVLTVEAFDs 396 Burkholderia sp...
YP_701848    330 RTGPLVSEAHREKVERYVALGlsEGARLVTGGARpadp---alaDGSYYLPTIFDHcdrtMRLVQEETFGPILTVERFTt 406 Rhodococcus sp....
YP_001311998 324 DMGPLVSKEHMETVLKYIEIGknEGATLVCGGERyteg---ecaEGYYVRPTIFDNctsdMTIVKEEIFGPVVTIQTFKt 400 Clostridium bei...
YP_001645980 321 EMGALTNEFHMNEVLHYIQRGieEGAKLVCGGKRlten---gldRGFFIAPTIFADvnenMCIVKEEIFGPVLVVQKFKd 397 Bacillus weihen...
YP_001249655 321 KMGPLVSSAHREKVESYVKLGmeEGAKLLCGGKRptgs---efaKGHFFEPTIFDEvkstMRIAREEIFGPVLVVIPFDt 397 Legionella pneu...
YP_590611    329 KMGPLVSKDQYERVREYQEIGk-KEAKVASGGNRpsg-----faKGYYVEPTIFYDvdnsARIAREEIFGPVASVIPFDn 402 Acidobacteria b...
P71016       321 ESGPLISAEHRAKVEKYVEIGieEGAKLETGGKRpedp---elqNGFFYEPTIFSNcnsdMRIVQEEVFGPVLTVETFSs 397 Bacillus subtil...
Feature 1                                                                                        
3FG0_A       428 --EQEAIQLANDSIYGLAGAVFSKdIGKAQRVANKLKLGTVWINDFHpYFAQAPWGGYKQSGIGRELGKEGLEEYLVSKH 505 Staphylococcus ...
XP_001731583 410 gdERTAIMLANDTKYGLAGGVQSKdQARAERVARRLRHGTVWTNTYGvYTAQSEWGGYGMSGNGRELGSKGLDEYVEVKH 489 Malassezia glob...
NP_822798    396 --EDEAVELANDTRYGLAAGVWTGeASRAQRVAARLRHGTVWINDFHpYLPQAEWGGYGQSGVGRELGPTGLREYQEIKH 473 Streptomyces av...
ZP_01696957  405 --EAEAVKLANDTVYGLAGAVFSNdGAKALRVIKKIRSGITWINSYHpTYNEAPWGGYKQSGIGRSLGTFGLEEFQEIKQ 482 Bacillus coagul...
YP_001669252 398 --EAHAVRLANDTPYGLAAGVWTGdLGCANRMARRLRVGTLWVNDYNlAFPQAPWGGFKASGIGRELSATGLEEFSELKH 475 Pseudomonas put...
YP_300022    396 --EDDALRAANDTPYGLAAAVWTRdLDKANRMSRALRFGTVWVNDYHpYFPEAPWGGYKASGIGRELARIGLDEYTELKH 473 Ralstonia eutro...
YP_371293    397 --EDEAVALANDTPFGLAGAVWTRdFARANRVMRRLRAATVWINDYNvTLPGAPWGGYKASGIGRELSRSGLDEYTELKH 474 Burkholderia sp...
YP_701848    407 --EEEALRLGNDTEYGLAAGVRTAdSARGERMVRGLRHGTVWLNDFGyYTAAAEWGGFKMSGNGRELGPTGLAEYQETKH 484 Rhodococcus sp....
YP_001311998 401 --EEEAIALANDTVYGLAGAVFTSdGTIALKVIKEIRAGITWINCYNpTFNEAPWGGYKMSGYGRELGVHGLEEYQEIKQ 478 Clostridium bei...
YP_001645980 398 --EEDAIQKANDSIYGLAGAVFTEdMDLAKRVISKLRAGITWINSYHlAYVEGPWGGYKQSGIGRALGVAGLEHFMETKQ 475 Bacillus weihen...
YP_001249655 398 --EEEAIRIANDTDYGLSGAVWTKsVTRAHRVTSQIRAGILWVNHYHpTYNEMPWGGYKQSGAGRELGLYGIESYLEVKQ 475 Legionella pneu...
YP_590611    403 --EADGLKIANDTPFGLAAAVWTRdIFKAFRMVKKIRAGIVWVNHMQpTYYEAPWGGYKQSGFGRELGPWGVEEYLETKQ 480 Acidobacteria b...
P71016       398 --EEEVIELANDTIYGLAGAVWSKdIEKCERVAARLRMGTVWINDFHpYFAQAPWGGYKQSGFGRELGKIGLEEYTEVKH 475 Bacillus subtil...
Feature 1                     
3FG0_A       506 ILTNtnpqlvNWF 518 Staphylococcus aureus subsp. aureus
XP_001731583 490 IWSEtkpakmNWF 502 Malassezia globosa CBS 7966
NP_822798    474 IYQNlspgpsGWF 486 Streptomyces avermitilis MA-4680
ZP_01696957  483 ININlqveptGWF 495 Bacillus coagulans 36D1
YP_001669252 476 VLLNcepralNWF 488 Pseudomonas putida GB-1
YP_300022    474 SYINlapkamGWF 486 Ralstonia eutropha JMP134
YP_371293    475 AYLNfeaspqRWF 487 Burkholderia sp. 383
YP_701848    485 IWHNtsptaaGWF 497 Rhodococcus sp. RHA1
YP_001311998 479 ININltpgpiGWY 491 Clostridium beijerinckii NCIMB 8052
YP_001645980 476 INIHqhanpvGWY 488 Bacillus weihenstephanensis KBAB4
YP_001249655 476 VNINldetpiGWY 488 Legionella pneumophila str. Corby
YP_590611    481 VHINlseqpiGWY 493 Acidobacteria bacterium Ellin345
P71016       476 VYRNtkpaavNWF 488 Bacillus subtilis subsp. subtilis str. 168

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