Conserved Protein Domain Family
ALDH_SNDH

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cd07118: ALDH_SNDH 
Gluconobacter oxydans L-sorbosone dehydrogenase-like
Included in this CD is the L-sorbosone dehydrogenase (SNDH) from Gluconobacter oxydans UV10. In G. oxydans, D-sorbitol is converted to 2-keto-L-gulonate (a precursor of L-ascorbic acid) in sequential oxidation steps catalyzed by a FAD-dependent, L-sorbose dehydrogenase and an NAD(P)+-dependent, L-sorbosone dehydrogenase.
Statistics
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PSSM-Id: 143436
View PSSM: cd07118
Aligned: 11 rows
Threshold Bit Score: 742.617
Threshold Setting Gi: 69937957
Created: 14-Dec-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:catalytic residues [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
BAA13144      34 RSSPAHDVPVTRIPRct-reDLDEAVAAARRAFENgswaglAAADRAAVLLKAAGLLRERRDDIAYWEVLENGKPIsQAK 112 Gluconobacter o...
NP_104246     60 RKSPGHGFTVSRYAQag-eaEVEAAVQAAHKAFETgpwprmKAGERAAILFRAADLIEARLEDIARLDALESGKPIaQAR 138 Mesorhizobium l...
YP_998308     41 RRSPAHGQLVAVYAEag-vpDAQRAIGAARQAFDKgpwpllKGAERARILRHVADGILARRHALARMESLENGKPLaQSL 119 Verminephrobact...
ZP_01549363   40 RLSPSHGSVVTQAAKgg-vrDVDAAVSAARLAFDKgrwsrtSGKERATLLLKIADLIDRERERIAYWETLESGKPIsQAM 118 Labrenzia aggre...
YP_831343     35 RLSPAHEVEVTSFPEgg-heDVNRAVTAARKALDRgwr-qsTGSERSKLLLKVADLVRRDAEALSLAETLETGKPItQSR 112 Arthrobacter sp...
EDY88057      34 RESPAHSRVVSIYAAat-kdDTDVAISAARCSFDSgnwayaYAGDRAAVLRAVAQKIRDNVEELALVETLESSKPIgVSR 112 Octadecabacter ...
YP_001887934  39 RKSPGHGVPVTATPRac-vdDLNAAVASARRAFDDgrwsrlSGEQRATVLLKTARLIRDKVETLAYLETLESGKPIgQSR 117 Burkholderia ph...
YP_001907190  38 RIGPAHGIVVANYPEgs-keDAGLAISAAHRALDKewa-tlTASERAKLLLKVAEGIAARVDEMAMIECLETGKPLsQAH 115 Erwinia tasmani...
NP_102698     31 RRSPATGDLVARYADgt-peDVDLAVEAARIAFEDgpwprmSGMERAEVLNRLADLIRTNRDRLVRIEVEEVGKPVrFAR 109 Mesorhizobium l...
ZP_00632525   25 RHSPAHGAALADFAAgt-aeDLDAAVRAAREAFEHgpwrqmPATQKAAILNAWGDLIAADLERLAVIEAEESGKPIrFAR 103 Paracoccus deni...
NP_435363     40 RVSPGHAGEVVGTWPeasadDVRKAVAAARKAFDAgpwprmSGAERSRLMFKVADLILARQEELALIESLEVGKPIaQAR 119 Sinorhizobium m...
Feature 1                                                          #                             
BAA13144     113 GEIDHCIACFEMAAGAARmLHGDTFNnLGEGLFGMVLREPIGVVGLITPWNFPFMILCERAPFILASGCTLVVKPAEvTS 192 Gluconobacter o...
NP_104246    139 GEIGGAVDIWRYGASLARtLHGESYAnLGDAMLGVVLREPIGVVSIITPWNFPFLIVSQKLPFALAAGCTAVVKPSEmTS 218 Mesorhizobium l...
YP_998308    120 AEIEGAADLWQYAASLARnLHGDSYNtLGAATLALVLREPIGVVGIITPWNFPFLIVSQKLPFALAAGCTAVVKPAEvTS 199 Verminephrobact...
ZP_01549363  119 AEIEGASDIWRFAASLARtMHGESYNsLGSDMLGLVLKEPVGVVSIITPWNFPFLIVSQKLPFALAAGCTAVIKPSEmTP 198 Labrenzia aggre...
YP_831343    113 NEVSGTAELWEYAASLARnTHGDAHNaLGQDTLAMVVHEPIGVVGMITPWNFPLLIISQKLPFALAAGNTAVIKPSEsTS 192 Arthrobacter sp...
EDY88057     113 GEVMFAAELWDYAAGQARgLHGDSHNnLGPDMMGMVLREPIGVVGIITPWNFPLLILSERLPFALGAGCSVVVKPSEfTS 192 Octadecabacter ...
YP_001887934 118 GEINAAAGIWEYAAGLARvVHGDSHDtLGADLFGLTVRQPIGVVGIVTPWNFPFFILSERLPFVLAAGCTAVVKPAElTS 197 Burkholderia ph...
YP_001907190 116 GEVSGCVDLWRYAASLARtLHGESYNnLGDSMLGVVVRQPVGVVTMITPWNFPIWILSQKLPFALAAGCTVVIKPSEfTN 195 Erwinia tasmani...
NP_102698    110 GDIDGAAGLTRYAASLAMqMAGLTYTnIGDGKTALISREAVGVVALVTPWNFPALILSQKVPFALAAGCTVVLKPSEfTP 189 Mesorhizobium l...
ZP_00632525  104 GEIEHSVSMLRYAAALGMqLHGEAFEnVGPQALGLVSREPRGVVGMIVPWNFPMVTLFQKLPYALAAGCSVVVKPSElTS 183 Paracoccus deni...
NP_435363    120 GEIGFCADLWSYAAGQARaLEGQTHNnIGDDRLGLVLREPVGVVGIITPWNFPFIIASERVPWAIGSGCTVVLKPSEfTS 199 Sinorhizobium m...
Feature 1                                                                             #          
BAA13144     193 ATTLLLAEILAdAGLPKGVFNVVTGTGrtvGQAMTEHQdIDMLSFTGSTGVGKSCIHAAAdsnLKKLGLELGGKNPIVVF 272 Gluconobacter o...
NP_104246    219 ASTFVLGDILLeAGLPAGVVNILAGLGadvGAPMVSHPlVEMVSFTGSTRVGKMTMASAAq-sLKKVSMELGGKNGQIVF 297 Mesorhizobium l...
YP_998308    200 GTTVMLGEILLeAGIPAGVVNILVGQGavvGEAMVSHPdVDMLSFTGSTAVGKQAVARSAa-tLKKVALELGGKNPQIVF 278 Verminephrobact...
ZP_01549363  199 ATTVILGELCIeAGIPAGVVNIVLGYGdpvGTAMTADKrVDMVTFTGSTGVGKAIVKAAAg-tLKKVSLELGGKNPQVIF 277 Labrenzia aggre...
YP_831343    193 ATTVMLGQLIReAGFPAGVVNIVTGGRv-vGAAIAEHPgIDMISFTGSTGVGKGIASAAGr-dLKKVELELGGKNPQIIT 270 Arthrobacter sp...
EDY88057     193 GTSLMLAQYLVdAGLPKGVCNILAGDGaivGQTIIDSHdVDMVAFTGSSRVGKMAIKASAg-nIKKLSLELGGKSPSVVF 271 Octadecabacter ...
YP_001887934 198 TTTLKLAALLTeAGLPDGVVNVVTGLGavvGQALAEHMdVDMMSFTGSTPVGRSVLAAAGg-nMKKVGLELGGKNPQIVF 276 Burkholderia ph...
YP_001907190 196 GTTLMLGEILIeAGLPRGVVNIVTGLGeevGAPLSTHElVDMVSFTGSTRVGTLIAAEAGr-rLKKVSLELGGKNPQIIF 274 Erwinia tasmani...
NP_102698    190 GSAFEIAALAAeAGVPAGAFNVVSGYGataGDHLTGHMgIDFVSFTGSTRTGSRVVGNTSr-hLVKSSVELGGKSANIVF 268 Mesorhizobium l...
ZP_00632525  184 GTALEVAKLAIrAGLPKGVYNVVTGTGgavGEAMTRHPeVDMISFTGSTKVGKAIARTCAd-sVKRVALELGGKAANVVF 262 Paracoccus deni...
NP_435363    200 GTSIRLAELAReAGIPDGVFNVVTGYGdpaGQVLAEDPnVDMVAFTGSVRVGTKLGEIAAr-tVKRVGLELGGKGPQIVF 278 Sinorhizobium m...
Feature 1                            #  #                                                        
BAA13144     273 ADsNLEDAADAVAFGISFNtGQCCVSSSRLIVErsvAEKFERLVVPKMEKIrVGDPFDpetQIGAITTEAQNKTILDYIA 352 Gluconobacter o...
NP_104246    298 PDaDLEAAADAAVFGGFFNaGECCNAGSRLIVHeaiADDFLSAVKALTARVtVGDPLDdqtKVGAMISSDHLAKVTDYVT 377 Mesorhizobium l...
YP_998308    279 ADcDWEAAVDAAVYGIFFNaGQCCNSGSRILVQdavADKFAEAVIARSRQVrVGDPFDertQVGAITTERQLHTILAHVE 358 Verminephrobact...
ZP_01549363  278 PDaDLESAVDAVVFGVYFNaGECCNSGSRIIVHediAEAFLKATVELSRKVpFGDPLDpstKVGAIITPDHQSKIDKYVR 357 Labrenzia aggre...
YP_831343    271 ANaDFTAAVDAGVFGGYFNvGQCCNSGSRLIVHrsiADEFASAVVERAQHMrVGDPLKaetLVGSLVNDAQLAVVERYVA 350 Arthrobacter sp...
EDY88057     272 ADcDIDAAIDGVLKAANVNmGECCIAGSRLLIQdsiADAFQAKLAARLKDLkMGDPFDptsRIGAIINDRQYAQISSYVD 351 Octadecabacter ...
YP_001887934 277 ADaDLDDAADAIAFGICFNaGQCCVSGSRLVVHrsvEEELVARVKAVFEKVrVGDPLDasnHVGAIVEARQFDKIRGFID 356 Burkholderia ph...
YP_001907190 275 PDcDWDAAVDAVVFGVYFNaGECCNSGSRILVHkdiADKFTRAVVEKSRLVrVGDPLNpevKIGAIINENQMITIEKAIQ 354 Erwinia tasmani...
NP_102698    269 ADaDLEAAADGALMGVFFNnGECCVSGSRLFVQssiADDFIAKVIARSRKMkVGDPFDddtDVGALIDRNHLAKVTGFVK 348 Mesorhizobium l...
ZP_00632525  263 ADaDLDAAVDGVLFGYVLNqGEECVCGARLLIEesvADAFVSRLVERTRKIrTGLPLDedaDQAAMIHEAQFDQVMDYLE 342 Paracoccus deni...
NP_435363    279 ADaDLDAAADGIAYGVYHNaGQCCISGSRLLVQegiRDALMERLLDISRKVaFGDPLNertKIGAMISEAHAEKVHSYVT 358 Sinorhizobium m...
Feature 1                                                                                        
BAA13144     353 KgkaeGAKLLCGGGIvdf---gkGQYIQPTLFTDVkpsMGIARDEIFGPVLASFHFDtVDEAIAIANDTVYGLAASVWSK 429 Gluconobacter o...
NP_104246    378 AaageGSNVYSGGKQlas---naGQYLDPTIIRGVtedMAIAREEVFGPVLSVLTFEsIEKALHIANNTPYGLSAGVWSA 454 Mesorhizobium l...
YP_998308    359 GarqaGATVALGGARld----rpGLYMEPTVLTGVtrdMAIARQEVFGPVLSMLRFGtLDEAVDLANSTLYGLSAAVWSQ 434 Verminephrobact...
ZP_01549363  358 DaaeaGATVRLGGEAlsvp-glaGQFYQPTIVADVksdMPIAREEVFGPVLSVLTFKtLDEAIDLVNDADYGLSAGVWSE 436 Labrenzia aggre...
YP_831343    351 EgrdaGAHLLTGGDRldt--glnGRFYQPTVFTDVtahMTIATDEIFGPVLSVLPYDtLEEAIGIANSTSFGLSAGIWSN 428 Arthrobacter sp...
EDY88057     352 IavkeGATMVCGGDQda----ydGLFFPPTIIADVrpeMRVAREEIFGPVLVMMTFQdRDEAIKLANATDYGLAAYVWTQ 427 Octadecabacter ...
YP_001887934 357 AgrrdGAQLVHGGEStsh---geRFFIQPTLFRNVqpqSALAQEEIFGPVLSVTSFDtFEEAIQLANGVPYGLAASIWTR 433 Burkholderia ph...
YP_001907190 355 SardqGAEILLGGERips---rqGLFLEPTIVGNVtpgMDIAREEVFGPVLSILTFEdKDQAIKIANDTCYGLSASVWSK 431 Erwinia tasmani...
NP_102698    349 SgieeGAQLVLGGNVaag---avGHFHEATIFDRVephMTIFREEIFGPVLSITRFDtVDDAVRLANDTAYGLSNYIWSK 425 Mesorhizobium l...
ZP_00632525  343 IgkaeGATVAVGGGRaeegalakGYFVMPTIFTDVspdMRIFREEIFGPVLTVTTFKtVDEAVTLANDTVYGLGNGLWTK 422 Paracoccus deni...
NP_435363    359 AgitsGAELLLGGERigr---eaGLYYAPTVFAGVtpdMSIAREEIFGPVLSTLTFKtADEAVALANATEFGLSASVWST 435 Sinorhizobium m...
Feature 1                                                                   
BAA13144     430 dIDKALAVTRrVRAGRFWVNTImsGGPETPLGGFKQSGWGREAGLYGVEEYTQIKSVHI 488 Gluconobacter oxydans
NP_104246    455 sIDTCMSVARgVRSGTVWVNTFmeGYPELPFGGYKQSGLGRELGKRAVEDYTEEKTIQF 513 Mesorhizobium loti MAFF303099
YP_998308    435 dINTCITAARrIEAGTVWVNTFleGHAELPFGGYRESGIGRELGRFAAEDYTETKTVHL 493 Verminephrobacter eiseniae EF01-2
ZP_01549363  437 nVHTCLEFARrAHAGTVWTNTWmdGFAELPFGGMKESGQGRELGKYGLDEFLEAKTVTM 495 Labrenzia aggregata IAM 12614
YP_831343    429 dINEALTAARdLRAGTVWVNRWmdGYPEVPFGGYGHSGIGRELGRQALAEFSELKTIQL 487 Arthrobacter sp. FB24
EDY88057     428 dLANALYCTRhIKAGRVWVNSAldGFPEMPLGGFKQSGNGRETGRYGIEEYTELKSVHL 486 Octadecabacter antarcticus 238
YP_001887934 434 dLQGAISSFReVQAGRIWVNCTitGGPEMPIGGVKQSGIGRETGRYGVEEYTELKSVHV 492 Burkholderia phytofirmans PsJN
YP_001907190 432 dIDICLEAARkIKAGTVWVNTFldGSPELPFGGFNQSGLGRELGRHAVEDYTEQKTIQL 490 Erwinia tasmaniensis Et1/99
NP_102698    426 nIDTVLTVAKrLKSGWVQANTIidGAPQLPLTGVKGSGFGYEMGQAGFEEFTQLKTLLI 484 Mesorhizobium loti MAFF303099
ZP_00632525  423 dLDKAILVARrLRSGTVFVNTFleTSVQMPFGGFKQSGIGRENGIDGLLEYTEVKSTFI 481 Paracoccus denitrificans PD1222
NP_435363    436 nLETALQTIRrIRAGRCWINSVidGTPELPIGGYKKSGLGRELGRYGFDEYSQFKGVHV 494 Sinorhizobium meliloti 1021

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