Conserved Protein Domain Family
ALDH_ACDHII-AcoD

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cd07116: ALDH_ACDHII-AcoD 
Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like
Included in this CD is the NAD+-dependent, acetaldehyde dehydrogenase II (AcDHII, AcoD, EC=1.2.1.3) from Ralstonia (Alcaligenes) eutrophus H16 involved in the catabolism of acetoin and ethanol, and similar proteins, such as, the dimeric dihydrolipoamide dehydrogenase of the acetoin dehydrogenase enzyme system of Klebsiella pneumonia. Also included are sequences similar to the NAD+-dependent chloroacetaldehyde dehydrogenases (AldA and AldB) of Xanthobacter autotrophicus GJ10 which are involved in the degradation of 1,2-dichloroethane. These proteins apparently require RpoN factors for expression.
Statistics
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PSSM-Id: 143434
View PSSM: cd07116
Aligned: 10 rows
Threshold Bit Score: 942.651
Threshold Setting Gi: 21238945
Created: 14-Dec-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:catalytic residues [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
P46368        19 YENYIGGAWVPPaggeYFESTTPITGKPFTRVPRSgqqDVDAALDAAHAAKAAWArTSTTERANILNRIADRIEANLKLL 98  Ralstonia eutro...
NP_241547     19 YDNYVNGEWTPPvkgqYFENVTPVTGEVFCEVARStaeDIDLALDAAHAAKEQWGkTSPAERANLLNKIADRMEENLEKL 98  Bacillus halodu...
Q9ZA11        19 YDNFIDGTWQPPvrgeYFDNVTPITGKVFCKAARSteeDITLALDAAHAAADRWGrTTAAERALILNRIADRLQDNLETL 98  Rhodospirillum ...
P63938        20 YQNFIGGQWVAPvhgrYFENPTPVTGQPFCEVPRSdaaDIDKALDAAHAAAPGWGkTAPAERAAILNMIADRIDKNAAAL 99  Mycobacterium t...
YP_001543935  19 YGNYINGEFVEPvkgmYFENISPVNGKPFCEIPRStaeDIEKALDAAHAAKAAWGaTSPAQRANILNKIADRMEANLEML 98  Herpetosiphon a...
P37685        25 YDNFIGGEWVAPadgeYYQNLTPVTGQLLCEVASSgkrDIDLALDAAHKVKDKWAhTSVQDRAAILFKIADRMEQNLELL 104 Escherichia col...
NP_924450     24 YDNFIGGQWRAPlkgqYTDNITPVNGRVLCQVPRStveDIELALDAAHAARESWGaLSAAERSNILLKIADRMEANLHKL 103 Gloeobacter vio...
BAB96577      14 YDNYINGKFTAPvkgeYFDVLSPIDGKVFTKAAHSgkeDLELAVDAAYEAFKTWGkTSVTERSILLNKIAQKIEDNLEYI 93  Flavobacterium ...
YP_001489322  12 YENFIGGEWIAPvsgeYFDNISPVDGKLLTKIPRSnekDVELAIQAAKKAFESYKhTSVVQRSTMLNKVADLIEKNLEML 91  Arcobacter butz...
Q9RYG9        29 YDNFIGGQWVPPvkgqYFDNASPVDGKVFTQAARStaeDVELALDAAHRAAPAWGrTSVTERSNILLKIADRMEQNLEML 108 Deinococcus rad...
Feature 1                                                                          #             
P46368        99 AVAESIDNGKPVRETTAADLPLAVDHFRYFAGCIRAQEGGISEIDadTIAYHFHEPLGVVGQIIPWNFPLLMATWKLAPA 178 Ralstonia eutro...
NP_241547     99 AVAETWENGKPVRETLNADIPLAIDHFRYFAGAIRAQEGTLSQIDndTVAYHFHEPLGVVGQIIPWNFPILMATWKLAPA 178 Bacillus halodu...
Q9ZA11        99 AYVESIDNGKPIRETLAADIPLAIDHFRYFAACIRAQEGSLSQIDetTIAYHFNEPLGVVGQIIPWNFPILMATWKLAPA 178 Rhodospirillum ...
P63938       100 AVAEVWDNGKPVREALAADIPLAVDHFRYFAAAIRAQEGALSQIDedTVAYHFHEPLGVVGQIIPWNFPILMAAWKLAPA 179 Mycobacterium t...
YP_001543935  99 AVAETWENGKPVRETLAADLPLAIDHFRYFAGVIRAQEGSAATIDenTIAYHFYEPLGVVGQIIPWNFPLLMATWKLAPA 178 Herpetosiphon a...
P37685       105 ATAETWDNGKPIRETSAADVPLAIDHFRYFASCIRAQEGGISEVDseTVAYHFHEPLGVVGQIIPWNFPLLMASWKMAPA 184 Escherichia col...
NP_924450    104 AVAETWDNGKPIRETTGADVPLAVDHFRYFAGCIRAQEGSISEIDgnTIAYHFPEPLGVVGQIIPWNFPILMAAWKLAPA 183 Gloeobacter vio...
BAB96577      94 ATVETIDNGKPIRETLAADIPLAIDHFRYFAGVIRAEESSIAELDsqTVSIALSEPLGVVAQIIPWNFPILMAVWKIAPA 173 Flavobacterium ...
YP_001489322  92 AIAETLDNGKAVRETLNADIPLVVDHFRYFASVIRAESGTVSDLDenTISQEIYEPYGVVAQIIPWNFPLLMAAWKLAPA 171 Arcobacter butz...
Q9RYG9       109 AVAETWDNGKPVRETLAADLPLAIDHFRYFAGCIRAQEGGLSQIDdsTVAYHFHEPLGVVGQIIPWNFPLLMGVWKLAPA 188 Deinococcus rad...
Feature 1                                                                                        
P46368       179 LAAGNCVVLKPAEqTPASILVLMEVIGdLLPPGVVNVINGFGleaGKPLASSPrISKVAFTGETTTGRLIMQYASqNLIP 258 Ralstonia eutro...
NP_241547    179 LAAGNCVILKPAEqTPASIFVLLELIEdLLPKGVVNIVNGFGveaGKPLASSSrVAKVAFTGETTTGRLIMQYASeNLIP 258 Bacillus halodu...
Q9ZA11       179 LAAGNCIVLKPAEqTPISILVLTELIAdLLPPGVLNVVNGFGleaGKPLASSKrIAKIAFTGETATGRLIMQYASqNLIP 258 Rhodospirillum ...
P63938       180 LAAGNTAVLKPAEqTPASVLYLMSLIGdLLPPGVVNVVNGFGaeaGKPLASSDrIAKVAFTGETTTGRLIMQYAShNLIP 259 Mycobacterium t...
YP_001543935 179 LAAGNCVVLKPAEqTPSTILVLMELIGdLIPAGVVNVVNGFGieaGKPLASSNrIAKIAFTGETTTGRLIMQYASeNIIP 258 Herpetosiphon a...
P37685       185 LAAGNCVVLKPARlTPLSVLLLMEIVGdLLPPGVVNVVNGAGgviGEYLATSKrIAKVAFTGSTEVGQQIMQYATqNIIP 264 Escherichia col...
NP_924450    184 LAAGNCVVLKPAGpTPASILVWLEVVGdLLPAGVLNVVIGPGpevGKALAASKrVAKVAFTGETETGRQIMQYAAqNIVP 263 Gloeobacter vio...
BAB96577     174 LAAGNTIVLKPAEsTPISILVLMELIGdILPPGVLNIVNGFGaelGRPLVTNKkVAKAAFTGSTTTGRLVMQYATeNIIP 253 Flavobacterium ...
YP_001489322 172 LAAGNCVVLKPASaTPMSILLLMEIIQeALPKGVINIINGAGgkiGKYLATHPdIKKVAFTGETTTGQLIMQYATeNIIP 251 Arcobacter butz...
Q9RYG9       189 LAAGNAVVLKPAEqTPASIMVLMELIAdLLPEGVVNVVNGFGleaGKPLASSPrIAKIAFTGETNTGRLIMGYAAdNLIP 268 Deinococcus rad...
Feature 1           #                                   #  #                                     
P46368       259 VTLELGGKSPNIFFEDVLaaDDAFFDKALEGFAMFALNQGEVCTCPSRALIQesIYDRFMERALKRVAAIrqGHPLDtgT 338 Ralstonia eutro...
NP_241547    259 VTLELGGKSPNIFFDDVMakDDAFLNKAIEGFVLFALNQGEVCTCPSRALIQesIYDTFMERALARVQAIkqGNPLDpnT 338 Bacillus halodu...
Q9ZA11       259 VTLELGGKSPNVFFDDIAsaDDSFFDKAVEGFVMFALNQGEICTCPSRALIHesLYDRFIERALARVAVIkqGSPLDteT 338 Rhodospirillum ...
P63938       260 VTLELGGKSPNIFFADVLaaHDDFCDKALEGFTMFALNQGEVCTCPSRSLIQadIYDEFLELAAIRTKAVrqGDPLDteT 339 Mycobacterium t...
YP_001543935 259 VTLELGGKSPNIFFEDVLskQDSFVDKALEGFTMFALNQGEVCTCPSRALIQksIYGEFLERAVERTKRCiqGNPLDpaT 338 Herpetosiphon a...
P37685       265 VTLELGGKSPNIFFADVMdeEDAFFDKALEGFALFAFNQGEVCTCPSRALVQesIYERFMERAIRRVESIrsGNPLDsvT 344 Escherichia col...
NP_924450    264 VTLELGGKSPNLFFADVMnaDDDFLDKAVEGFVMFAFNQGEVCTCPSRALVHesIYEKFIDRAVRRVASIkqGNPLDpeT 343 Gloeobacter vio...
BAB96577     254 VTLELGGKSPNIFFPSVAdhDDDFFDKAIEGAVLFALNQGEICTCPSRLLIHedIYEKFIARVIERTEAIiaGNPLDksT 333 Flavobacterium ...
YP_001489322 252 STLELGGKSPNVFFESIMdeDDEFFDKAIEGLVLFAFNSGEVCTCPSRALIQesIYEPFMKRVLERVKAIklGNPLDteC 331 Arcobacter butz...
Q9RYG9       269 VTLELGGKSPNIFFDDVMmeDDAFLDKAVEGMVMFALNQGEVCTCPSRALIQesIYDRFMERAVQRVEAItmGHPLDpgT 348 Deinococcus rad...
Feature 1                                                                                        
P46368       339 MIGAQASAEQLEKILSYIDLGrkEGAQCLTGGERnvld--gdlaGGYYVKPTVFAghnkMRIFQEEIFGPVVSVTTFKdE 416 Ralstonia eutro...
NP_241547    339 MIGAQASQEQLEKILSYLAIGkeEGAEVLAGGERnhlpg-elanGYYVSPTVFKGtn-dMRVFQEEIFGPVVSVTTFKdA 416 Bacillus halodu...
Q9ZA11       339 MIGAQASTEQMDKILSYMDIGreEGATVLAGGARaelg--geldGGYYVQPTVFKgnnsMRIFQEEIFGPVVAVTTFKdE 416 Rhodospirillum ...
P63938       340 MLGSQASNDQLEKVLSYIEIGkqEGAVIIAGGERaelg--gdlsGGYYMQPTIFTgtnnMRIFKEEIFGPVVAVTSFTdY 417 Mycobacterium t...
YP_001543935 339 MVGAQASNDQFEKILSYLAIGrdEGAKVLVGGAKaelsg-dlaeGYYVQPTIFAGnn-rMRIFQEEIFGPVVSVTSFDdF 416 Herpetosiphon a...
P37685       345 QMGAQVSHGQLETILNYIDIGkkEGADVLTGGRRklle--gelkDGYYLEPTILFgqnnMRVFQEEIFGPVLAVTTFKtM 422 Escherichia col...
NP_924450    344 MLGAQVSQAQMEKIARYVELGkqEGAEVLIGGERnsepgeglagGYYYKPTVMKGhn-qMRIFQEEIFGPVLAVTTFKdA 422 Gloeobacter vio...
BAB96577     334 MIGAQTSLVQKEKIMSYIKLGkeEGAELLTGGDEnhlgg-dlegGYYIKPTLFKGhn-kMRIFQEEIFGPVLAVTTFKtT 411 Flavobacterium ...
YP_001489322 332 MMGAQCSLNQKEKILSYLKVGkeEGAELLVGGDAynss--vnpdGFYIQPTLFKGhn-kMRIFQEEIFGPVLAVTTFKdE 408 Arcobacter butz...
Q9RYG9       349 MIGAQASTEQLDKILSYLDIGraEGAEVLTGGERgqre---gleEGFYVKPTIFKghnkMRIFQEEIFGPVLAAATFKdE 425 Deinococcus rad...
Feature 1                                                                                        
P46368       417 EEALAIANDTLYGLGAGVWTRdGARAFRMGRgIQAGRVWTNCYHaYPAHAAFGGYKQSGIGRENHRMMLDHYQQTKNLLV 496 Ralstonia eutro...
NP_241547    417 EEALAIANDTLYGLGAGVWTRdMNKAYRFGReIQAGRVWTNCYHaYPAHAAFGGYKKSGIGRETHLMMLSHYQQTKNLLV 496 Bacillus halodu...
Q9ZA11       417 DEALHLANDTHYGLGSGVWTRdGNRAFRFGRgIKAGRVWTNCYHlYPAHAAFGGYKQSGIGRENHHMMLDHYQQTKNLLV 496 Rhodospirillum ...
P63938       418 DDAIGIANDTLYGLGAGVWSRdGNTAYRAGRdIQAGRVWVNCYHlYPAHAAFGGYKQSGIGREGHQMMLQHYQHTKNLLV 497 Mycobacterium t...
YP_001543935 417 DDALSIANDTLYGLGAGLWTRdMNTAYRMGRaIQAGRVWTNCYHlYPAHAAFGGYKHSGIGRENHKMMLNHYQQVKNLLV 496 Herpetosiphon a...
P37685       423 EEALELANDTQYGLGAGVWSRnGNLAYKMGRgIQAGRVWTNCYHaYPAHAAFGGYKQSGIGRETHKMMLEHYQQTKCLLV 502 Escherichia col...
NP_924450    423 EEAVRIANDTPYGLGAGVWSRdINTAYRVGRgIQAGRVWVNCYHvYPAHAAFGGYKASGVGRETHKMMLSHYQQTKNLLV 502 Gloeobacter vio...
BAB96577     412 EEAIEIANDTMYGLGAGVWTRdAHEIYQVPRaIQSGRVWINQYHsYPAGAPFGGYKQSGIGRENHKMMLGQYRQTKNMLI 491 Flavobacterium ...
YP_001489322 409 KEALEIANDTIYGLGSGVWSRdAHQLHRMSRgIQAGRVWVNCYHmYPSHASFGGYKKSGIGRETHMMMLNNYRHTKNILT 488 Arcobacter butz...
Q9RYG9       426 AEALELANDTLYGLGAGLWTRdISRAYRMGRgIQAGRVWTNCYHvYPAHAAFGGYKQSGIGRENHRMMLDHYQQTKNLLV 505 Deinococcus rad...
Feature 1          
P46368       497 SY 498 Ralstonia eutropha H16
NP_241547    497 SY 498 Bacillus halodurans C-125
Q9ZA11       497 SY 498 Rhodospirillum rubrum ATCC 11170
P63938       498 SY 499 Mycobacterium tuberculosis C
YP_001543935 497 SY 498 Herpetosiphon aurantiacus ATCC 23779
P37685       503 SY 504 Escherichia coli str. K12 substr. DH10B
NP_924450    503 SY 504 Gloeobacter violaceus PCC 7421
BAB96577     492 SY 493 Flavobacterium frigidimaris
YP_001489322 489 SY 490 Arcobacter butzleri RM4018
Q9RYG9       506 SY 507 Deinococcus radiodurans R1

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