Conserved Protein Domain Family
ALDH_HMSADH_HapE

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cd07115: ALDH_HMSADH_HapE 
Pseudomonas fluorescens 4-hydroxymuconic semialdehyde dehydrogenase-like
4-hydroxymuconic semialdehyde dehydrogenase (HapE, EC=1.2.1.61) of Pseudomonas fluorescens ACB involved in 4-hydroxyacetophenone degradation, and putative hydroxycaproate semialdehyde dehydrogenase (ChnE) of Brachymonas petroleovorans involved in cyclohexane metabolism, and other similar sequences, are present in this CD.
Statistics
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PSSM-Id: 143433
View PSSM: cd07115
Aligned: 7 rows
Threshold Bit Score: 743.489
Threshold Setting Gi: 41058919
Created: 14-Dec-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:catalytic residues [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
ACA50459      22 VVNPASGELITRIAAakaeDVDRAVAAAKRAFPAwa---aMPGAERGRLLLKLADRIEACTDELARLESLDTGHPLrdSR 98  Pseudomonas flu...
YP_827935      8 ICSPATGELLGKVPDfdaeAVDCAVAAARASFENktw-rgLDPSKRERILWNIGELLLKYRDELSRLISQETGKTLreAA 86  Solibacter usit...
YP_001619842  28 TANPATGGALARLARgrreDVDAAVTSARAAFPRwa---aMDPNERARILWKAGELILARCEELARLEALDTGKPItaAR 104 Sorangium cellu...
NP_770416     40 SLNPATGQVIATVAEgneaDVDHAVAAARRAFEGpw--rtMRASERGQILLRWAELLKANAEEIIELESIDAGKPIsaTL 117 Bradyrhizobium ...
AAR99065      30 NENPAKRETICRVAQasaaDVDAAVRGAQQALEPgspwaqMTPAARARLLWRVAERIREQVEELAWLESLDTGKPYgeAL 109 Brachymonas pet...
YP_001860855  29 NLNPATEEPIALVAQgsaqDVDTAVKAARAALKVwn---aMRAAERGRILMRFCEVLREHQDEIVALESLDAGKPLaaVK 105 Burkholderia ph...
AAS87583      22 TLNPHDNSEIAQVSMagreDVDRAVQAAKKAFPAws---aMAAADRGRLLLKLADAIEANADELARLESMDTGHPIrdTR 98  Ralstonia sp. SJ98
Feature 1                                                          #                             
ACA50459      99 ILDVPRTAACFRYFGGIadkieGKVIPVDagFLNYVQRKPIGVVGQIVPWNFPLMFTSWKMGPALAAGNTVVLKPSEltP 178 Pseudomonas flu...
YP_827935     87 GADVAPAADCFHYYAGWvrkqyGETIPVDgpYLNYTLREPVGVVGAIVPWNFPLQTAAWKVAPALACGCSVVLKPSEltP 166 Solibacter usit...
YP_001619842 105 AIDVPRTADTFFYFSGWatklgGETIPVRgpFLNYTVREPLGVIGAIIPWNFPLLLAARKVAPALAVGNVVVVKPPEeaS 184 Sorangium cellu...
NP_770416    118 RQDFPAAVDTLIYYAGWadkisGDVVPVRddALTYTVREPVGVVAAIVPWNFPLMIGMWKLAPALACGCTIVMKPAEltS 197 Bradyrhizobium ...
AAR99065     110 HGDIPHAAGAFEYYAGWcsklaGSVLPVSprYLDYTRLEPVGVVGAIIPWNFPLQMAAMKVAPALAAGNAVLLKPAEqtP 189 Brachymonas pet...
YP_001860855 106 RQDVPAAIDTLAYYAGWcdkinGQVVPVRpdALTYTIREPVGVVGAIVPWNFPLMIGMWKIAPALACGCTMVVKPAEitP 185 Burkholderia ph...
AAS87583      99 NLDVPRTAATFRYFGGMadkfeGSVIPVEasFLNYLTREPVGIVGQVVPWNFPLMFTSWKMAPALAAGNCVVMKPAEltP 178 Ralstonia sp. SJ98
Feature 1                                                                             #          
ACA50459     179 LSTLRIAELMKevGFPNGVVNIVPGYGhtaGQRLAEHPdVGKIAFTGSTATGRRIVEASQg-nLKRVQLELGGKGANIVF 257 Pseudomonas flu...
YP_827935    167 LSALRFGEICAeaGLPAGVLVVATGYGettGEALALHEdVDKISFTGSVTTARKLLQNSAvsnLKRLSLELGGKSPNIVF 246 Solibacter usit...
YP_001619842 185 LTTLELARILAeaGVPPGVVNVVTGHGeeaGAALVEHPgVAKISFTGGTETGRTIMRAAAg-tLKKVSLELGGKSPNIVF 263 Sorangium cellu...
NP_770416    198 LSALRIAELALqaGLPAGVFNVVTGPGrvvGDALVNHPdVDKVTFTGSPGVGRGIMKGAAg-nFKRVSLELGGKSANVIF 276 Bradyrhizobium ...
AAR99065     190 LTAFALARIFEelEFPPGVLSVLPGFGa-tGAALVAHPgIDKITFTGSTAVGKTIMRGAAd-tLKRVSLELGGKSPNIVF 267 Brachymonas pet...
YP_001860855 186 LSALRVAELALeaGVPPGVLNIVTGKGrvvGDAIVAHPdIDKVTFTGSPSVGRGILQGAAg-nFKRVTLELGGKSANVIF 264 Burkholderia ph...
AAS87583     179 LSSLAIAQLMAevGFPAGVVNVLPGFGhvaGQYIAEHPeIGKVAFTGSTAVGRKIVQASSg-nLKKVQLELGGKGANVVF 257 Ralstonia sp. SJ98
Feature 1                            #  #                                                        
ACA50459     258 EDaNLEAAVNGAAWAIFHNqGQACIAGSRLLLQesIADEFLERFVSLARSIrlGDPLDgttEMGPLTSALHRDRVLSFVD 337 Pseudomonas flu...
YP_827935    247 PDaDFDAAVRAALWGIYGNkGEMCTAGSRLLLHeeIHDRFVEELASKARKLrlGNPLDpatQMGPQISGRQLDRILDYIE 326 Solibacter usit...
YP_001619842 264 ADaDVESAAKAAVTAIFYNqGELCTAGSRLLVErsVHDRVLEVVTSGARRLvpGDPLDpstQMGPLVSEAHFTKVLGYID 343 Sorangium cellu...
NP_770416    277 DDaDLEAASKAAASGIFFNaGQVCSAGSRVLVQekAYDEVVERLAARAKSLkiGDPLDrktALGPVISEKQMKSILDYVD 356 Bradyrhizobium ...
AAR99065     268 ADaDLKRAVRGATTGIYYNqGQMCTAGSRILVQdsLYDKFLEAFTAAIADLrpGDPLDpktRMGALVSQEQFERVSHYVA 347 Brachymonas pet...
YP_001860855 265 ADaNIDNAVRAAASGIFFNtGQVCSAGSRILAHrdVYDEVVERLVARAKGIkvGDPAEretTMGPLVSAAQMKTVLDYVD 344 Burkholderia ph...
AAS87583     258 GDaNLDAVVQGSAFGIFHNqGQACIAASRLIVHesIADDLLERFTSLARSIriGDPLDpstEMGPLTSQMHRDRVLSYVD 337 Ralstonia sp. SJ98
Feature 1                                                                                        
ACA50459     338 IarqqGGRILTGGKApsdpslasGFYVEPTIVEAsp-gdRVAQEEVFGPFVTVLRFKtEEEALAIANGTDYGLGSGLWTR 416 Pseudomonas flu...
YP_827935    327 AgkteGARLVCGGERdtegdkahGFFVKPTIFAGvhpdmRIAREEIFGPVLSVMRFRdAEEAVRIANATTYGLASAVWTN 406 Solibacter usit...
YP_001619842 344 RgaaeGARRETGGRReg-----pGFFVEPTVFSAvspsmSVAREEIFGPVLAVLPFDdVEEAARVANATEFGLAAGIWTR 418 Sorangium cellu...
NP_770416    357 IgqkeGASLVTGGTRvg----erGYFISPAVFANvehemRISQEEIFGPVVSIIKFRdEADALRIANGTAYSLAAGVWSR 432 Bradyrhizobium ...
AAR99065     348 LgqedGATLLAGGQGsa----erGYFFPPTIFTDvkpehRIAQEEIFGPVVSVMRFGsEEEALRLANGVSYGLAAGVWTA 423 Brachymonas pet...
YP_001860855 345 VgrkeGASIVTGGARig----qkGFFVEPTVFANvehemRISQEEIFGPVASVVRFNdEEDAVRIANGTAYSLAAGVWSA 420 Burkholderia ph...
AAS87583     338 VareqGGRVLAGGKSpdaaglakGCYVEPTIVQAkp-tdRVAQEEVFGPFVTVSTFKsDEEGLAIANGTEYGLGAGLWTR 416 Ralstonia sp. SJ98
Feature 1                                                                     
ACA50459     417 DLQRAHRLAAqISAGMCWINCYkrVSPGSPFGGLGQSGYGREMGFDAIHDYTEARSVWVNV 477 Pseudomonas fluorescens
YP_827935    407 DLKLAHRMAAaLKAGSVWVNTYnaFDSGSPFGGYKQSGFGRDLGSYALDQYTNVKSVWIAL 467 Solibacter usitatus Ellin6076
YP_001619842 419 DVGKAHALAArLSAGTVWINTYnrFDAASPYGGTKQSGFGRENGRAVLDELTQLKSVWVSL 479 Sorangium cellulosum 'So ce 56'
NP_770416    433 DIGKLQRFAKrARAGTVWMNTYgyTDVRLPWGGERDSGLGREHGTAALDNFTEPKAVWMNL 493 Bradyrhizobium japonicum USDA 110
AAR99065     424 DVGRAHRVAHgLRAGTVWVNTYnaLWNEAPFGGYKQSGIGREGGREGIEPYTEVKNICLSL 484 Brachymonas petroleovorans
YP_001860855 421 DIGRVHRVAHaLKAGTVWINTYgyTDVRLPWGGSGDSGFGREHGDVAIENFTEPKAIWLAI 481 Burkholderia phymatum STM815
AAS87583     417 DLQRAHLFARqLKSGMVWINCYkrVNPGSPFGGVGASGYGREMGFEVMREYTQAKSVWVNV 477 Ralstonia sp. SJ98

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