Conserved Protein Domain Family
ALDH_F16

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cd07111: ALDH_F16 
Aldehyde dehydrogenase family 16A1-like
Uncharacterized aldehyde dehydrogenase family 16 member A1 (ALDH16A1) and other related sequences are present in this CD. The active site cysteine and glutamate residues are not conserved in the human ALDH16A1 protein sequence.
Statistics
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PSSM-Id: 143429
View PSSM: cd07111
Aligned: 12 rows
Threshold Bit Score: 766.173
Threshold Setting Gi: 74728442
Created: 14-Dec-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:catalytic residues [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
Q8IZ83        19 YGPVPESHacalaWLDTQDRCLGHYVNGKWLkpehrnsVPCQDPITGENLASCLQaqaeDVAAAVEAARMAFKGws-aHP 97  human
NP_001095339  19 YGPAPESHacalaWLDTQDRHLGHYVNGQWLkpehrssVPCQDPITGENLASCLQaqseDVAAAVEAARASLENws-tQP 97  cattle
YP_924716      7 YAPAPESR-----AVVDIKPSYGLFVNGAFVdgh-gasFKTISPATEEVLAEISEadesDVDAAVKAARTAYDKvwsrMP 80  Nocardioides sp...
XP_002111625  42 YGPAPESPdvayaWLDDHHRSFGHFIDGKWLnpedrkrYDSRCPATGEKLASTVQgnqeDVEVAVSAARKAFVKws-aLP 120 Trichoplax adha...
XP_001630371  40 YGPAPEASnavnaWLTSHGRTFGHFINGKWVkpegrkvYESKNPATGEVLASTTQgetqDIEDAVKAARTAFQSws-kLP 118 starlet sea ane...
XP_797815     27 YGPNPEAPssaqaWLESHDRKLGHFINNKWVrpenrktYTTRGPAAGEPLATTVQgeeeDVELAVSSAEKAYESws-kLP 105 purple urchin
YP_445353     22 YAPAPQSA-----DHVRLDDRYGPFIDGEFRevd--eyFPSINPATEEPLAEVGLadeaVVDEAVGAARTAYEShwrdLP 94  Salinibacter ru...
XP_002128052  18 YGPAPESAdvakkWLSQHKDSLGHFINGEWVkpenrktYTTCSPATGEALADTIQgeeeDVNLAVSCAKTAFQSws-qLP 96  Ciona intestinalis
YP_997449     13 YGPCLEAAapvhsWLDAHAHSFRHFIHGEFVapaqneyFEVFNPATEERLARVAHgsdaDIDQAVAAARQALPAws-gLS 91  Verminephrobact...
YP_001546558   3 YGPAPEAAapaheWLDAHSRRFGLYINGTWTevanerlFDSINPANRSVLAQVTQassdEVNAAVAAAKAAFPAws-qTS 81  Herpetosiphon a...
NP_105575      3 YGPAPEARneadaWLAARDFGKALFIDGAWKaasggktFDTSEPSSGKLLAKVSDasaaDIDAAVAAATKALPKws-aSS 81  Mesorhizobium l...
NP_001089655   3 YGPAPEAAniaqaWLDSHQRSFGHFIDGKWLkpegrktYTTKNPATGEALATTIQgedeDVETAVKAARKAFESws-kLP 81  African clawed ...
Feature 1                                                                                        
Q8IZ83        98 GVVRAQHLTRLAEVIQKHQRLLWTLESLVTGRavreVRDGDVQLAQQLLHYHAIQASTQEEALAGWEPM---GVIGLILP 174 human
NP_001095339  98 GAIRAQHLTRLAKVIQKHQRLLWTLESLVTGRavreVRDRDVPLAQQLLQYHAVQAHTQEEALAGWEPM---GVIGLILS 174 cattle
YP_924716     81 GRERAKYLYRIARIIQERSRELAVLESLDNGKpikeSRDVDVPIAAAHFFYYAGWADKLEYAGHGRDPQp-lGVAAQVIP 159 Nocardioides sp...
XP_002111625 121 AHVRARHLYSVARHVQKHMRLFAVIESLDNGKpireTRDCDIPIVIRHIYHHAGWAQLADTEMRGWKPV---GVVGAITP 197 Trichoplax adha...
XP_001630371 119 GHARARHLYSIARHVQKHARLIAVLESMDNGKsvreTRDCDIPNVARHLYHHAGWAQLMDTEMQGWKPV---GVVGGIVP 195 starlet sea ane...
XP_797815    106 CHVRARHIYSIARHVQKHHRLIAVVEALDNGKpireTRDADIPIVIRHLYHHAGWAELMDTEMANWKPV---GVVGAIVP 182 purple urchin
YP_445353     95 GKERAKYIYRIGRMIKEKSREFAVLESMDGGKpireSRDMDIPLVAAHFFHYAGWADKLEYALPGPGRPrslGVCGQIIP 174 Salinibacter ru...
XP_002128052  97 AHTRARHLYAVARNVQKHHRLIAVIEALDNGKsireTRDCDIPLVARHFYHYAGWAQFSDTEMREWKPV---GVVGAIVP 173 Ciona intestinalis
YP_997449     92 GHQRARYLYAIARHLQKHARFFAVLETMDNGKtireSRDIDIPLVVRHFYHHAGWAQLLDSEFPAHQAV---GVCGQIVP 168 Verminephrobact...
YP_001546558  82 GHVRARYLYALARQIQKHSRRFAVLETLDNGKpireTRDIDIPLVARHFYYHAGWAQLQESDLAGYEPL---GVVGQIIP 158 Herpetosiphon a...
NP_105575     82 GYARAKVLYAIGRAMQRHQRLFAVLESIDNGKpireSRDIDVPLAIRHFIHHAGWAQALDRDFPGHKGV---GVVGQIIP 158 Mesorhizobium l...
NP_001089655  82 CHVRARYLYSIARTVQKHQRLLSVIESMDNGKpireSRDCDVPLVVRHFYHHAGWAQLRDTEMNGWKPL---GVIAAIVP 158 African clawed ...
Feature 1         #                                                                              
Q8IZ83       175 PTFSFLEMMWRICPALAVGCTVVALVPPa-SPAPLLLAQLAGelGPFPGILNVVSGPAslVPILASQPgIRKVAFCGAPE 253 human
NP_001095339 175 PTFPFLDMMWRICPALAVGCTVVVLVPPa-SPTPLLLAQLAGelGPFPGILNVISGPAslGPVLAAQPgVQKVAFCGAIE 253 cattle
YP_924716    160 WNFPLLMLSWKIAPALACGNTVVLKPAEttPLSALLFAEICQqaDLPPGVVNIVTGAGgtGQALVGHPgVDKVAFTGSTE 239 Nocardioides sp...
XP_002111625 198 WNFPLMLLIWKVCPALAMGNTVVLKPATytRLSALLLAEVCAeaGLPPGVFNVVTGNGafGHNLATHPdVDKVGFTGSTE 277 Trichoplax adha...
XP_001630371 196 WNFPLMLLCWKVCPALAMGNTVVLKPATytRLSALLFAEICAeaGLPPGVFNVVTGNGafGSQLAGHPdVDKVAFTGSTE 275 starlet sea ane...
XP_797815    183 WNFPLMLLIWKVCPALAMGNTVVLKPATytRLSALLFAQICAeaGLPPGVLNIVTGNGafGSKLALHPrVDKVAFTGSTE 262 purple urchin
YP_445353    175 WNFPLLMAAWKLAPALATGNTVVLKPAEttPLTALKLAEVIQeaGLPPGVVNIVQGAGevGSALVEHPdVDKIAFTGSTG 254 Salinibacter ru...
XP_002128052 174 WNFPLMLLTWKVCPALAMGNTVVLKPATftRLSALLFAEICHeaGLPPGVFNVVTGNGsfGSKLALHPdVDKVAFTGSTP 253 Ciona intestinalis
YP_997449    169 WNFPLLMLAWKVAPALAAGNTVVLKPAEftPLTALAFAELCVevGLPAGVLNIVTGDGhtGASLVNHAgVDKIAFTGSTA 248 Verminephrobact...
YP_001546558 159 WNFPLLMLAWKIAPALAMGNTVVLKPAEwtSLTALAFAEICHeiGLPKGVVNIVTGDGkvGEQIVKHPdIAKIAFTGSTE 238 Herpetosiphon a...
NP_105575    159 WNFPLLMLAWKIAPALAAGCTVVLKPAEftPLTAILFAEICEraGVPKGVVNIVQGGPeaGAAIVNHPgIQKIAFTGSSE 238 Mesorhizobium l...
NP_001089655 159 WNFPLMLLTWKICPALAMGNTVVLKPATytRLTALLLAEICAeaGLPPGVFNVVTGNGafGGKLADHPdVDKVAFTGSTE 238 African clawed ...
Feature 1                          #                                #  #                         
Q8IZ83       254 EGRALRRSLAGeCAELGLALGTESLLLLTDTADVDSAVEGVVDAAWSD---RGPGGLRLLIQESvWDEAMRRLQERMGRL 330 human
NP_001095339 254 EGRALRRTLAGwVPELGLALGAESLLLLTEVADVDSAVEGIVDAAWSD---RSPGGLRLLIQEAvWDETMRRLQERMGRL 330 cattle
YP_924716    240 VGKAIARSVAGtSKRVTLELGGKAANIVFDDAPIDQAVEGIVDGIFFNqghVCCAGSRLLVQESiAEDLLERLKARMSTL 319 Nocardioides sp...
XP_002111625 278 VGRILRQATAGsGKKISLELGGKSPFVVFDSADLDSAVEGVVDAIYFNqgqVCSAGSRLIVQEScAELLIKKIKERMTHL 357 Trichoplax adha...
XP_001630371 276 VGKLLRQLTAGsGKKLSLELGGKSPFVVFDSADLDSAVEGVVDAIWFNqgqVCSAGSRLLVQETcAQRMIKKIKERMTHL 355 starlet sea ane...
XP_797815    263 VGQILRRATAGtGKKLSLELGGKSPFVVFESADLDSAVEGIVDAIWFNqgqVCSAGSRLIVQETvMSKMVAKLRERLMHL 342 purple urchin
YP_445353    255 VGKHIQKQLAGtKKRLTLELGGKGANIVFEDAPIDQAVEGIVDGIYFNqghVCCAGSRLLVQESvAEEVTRKLRDRIATL 334 Salinibacter ru...
XP_002128052 254 VGQTLRRLTAGtGKKLSLELGGKSPVIVMDTADIDSAVEGIVDAIYFNqgqVCSAGSRLLVQENiFDDVIQRVKERLKHF 333 Ciona intestinalis
YP_997449    249 VGRLIRRATAGtDKKLSLELGGKSPFIVFDDADLDAAVEGVVDSIWFNqgqVCCAGSRILVQESvAARFGDKLRARMRKL 328 Verminephrobact...
YP_001546558 239 VGKIIRSATAGsGKKLSLELGGKSPFIVFDNADLDSVVEGVVDAIWFNqgqVCCAGSRLLVQENiADKLIGKLRTRMEQL 318 Herpetosiphon a...
NP_105575    239 VGKIIRKATAGsGKKLSLELGGKSAFIVFEDADLDSAVEGLVDGIWFNqgqVCCAGSRLLVQEGiAEALIAKVKTRMSRL 318 Mesorhizobium l...
NP_001089655 239 VGRTLRKATAGtGKKLSLELGGKSPFIVFDTSDLDSAVEGIVDAIWFNqgqVCSAGSRLLMQESiSEDLVRRLKQRMSHL 318 African clawed ...
Feature 1                                                                                        
Q8IZ83       331 RSGRgLDGAVDMGARGAAACDLVQRFVREAq-sQGAQVFQAGDVps-eRPFYPPTLVSNLppasPCAQVEVPWPVVVASP 408 human
NP_001095339 331 RCGHgLDGAVDMGARGAAARDLAQRYVSEAq-sQGAQVFQAGSEps-dSPFFPPTLVSDLppasPCTQAEVPWPLVVASP 408 cattle
YP_924716    320 RMGDpLDKNTDIGAINSGEQLKRIRELSEVgdaEGAERWEVACDlptkGFWFPPTIFTGVsqahRIAREEIFGPVLSVLT 399 Nocardioides sp...
XP_002111625 358 RLGDsLDKAIDMGAIVDPSQRKSVDMMVQEakaDGAHVYQACACmpstGCYYPPTLITNVqtvsKIVQEEVFGPVLVVLT 437 Trichoplax adha...
XP_001630371 356 RLGDpLDKSIDMGAIVDPSQQKSVAKMVEEaraEGAEVYQKCASlp-sGCYYPPTLITNVqpvsKIVMEEVFGPVLVVLT 434 starlet sea ane...
XP_797815    343 RVGDsLDKSVDMGAMVDPSHLKTVTEYVEDarrEGAEIIQNPDCipkkGCFYPPTLITNVqtssRVVMEEIFGPVLVVLP 422 purple urchin
YP_445353    335 RVGDpLDKNTDIGAINSKPQLEKIRRLVDVgerEGADKFQPECNlpddGFWFPPTFFTNVtqshRIAQEEIFGPVLSVTT 414 Salinibacter ru...
XP_002128052 334 RIGHsLDKAIDMGAIVSQAQYNTIKEYVDDaraTGADVFQPDIPlpakGLFYPPTLITNVqtvsRVVREEIFGPVLVALP 413 Ciona intestinalis
YP_997449    329 RIGNpLDKSNDVGAIVDRVQLQRIRQMVESgraDGLSCWQTALDapssGHFFAPTFFEDVpaahALAQEEIFGPVVISMG 408 Verminephrobact...
YP_001546558 319 RIGDpLDKAIDIGAIVAPAQLQKIEQLVAEgenEGSIKWQPSWAcptdGYFYPPTLFTNVapasTLAQVEIFGPVLVTMT 398 Herpetosiphon a...
NP_105575    319 RVGSpLDKNTDIGPLVDLTQLDRVKGLVAEgakQGAVCWQPDAAlpssGYYHLPTLATGVspanILAQEEVFGPVLATMT 398 Mesorhizobium l...
NP_001089655 319 RLGDsLDKTIDMGALVDETQKKTIEEFVEEaraEGADVFQSPGPipkkGLFYPPTLITGVnttsRCVREEIFGPVLVAMT 398 African clawed ...
Feature 1                                                                                        
Q8IZ83       409 FRTAKEALLVANGTPRGGSASVWSERLGQALELGYgLQVGTVWINAHgLRDPSVPTGGCKESGCSWHGGPDGLYEYLRPS 488 human
NP_001095339 409 FRTAKEALAVANGTPRGGSASVWSERLGQALELAYgLQVGTVWINAHgLRDPAVPTGGCKESGSSWHGGQDGLYEYLRPS 488 cattle
YP_924716    400 FRTPAEALEKANNTPYGLSAGVWTDKGSLILKMAAsLRAGVVWANTFnKFDPTSPFGGYKESGYGREGGRHGLEAYLRSP 479 Nocardioides sp...
XP_002111625 438 FRTPKEAIALSNNTVFGLGASVWTENLSLALEVALsIRAGSVWVNGHnLFDAAAGFGGMRESGFGRDGGKEGLYEYSVPA 517 Trichoplax adha...
XP_001630371 435 FRTAKEAVAIANNTNFGLGASVWTENLSLAMEVGLsMKAGAVWINGHnLFDAAAGFGGYRESGYGRDGGKEGLYEYVCPT 514 starlet sea ane...
XP_797815    423 FRTAKEAVALANNSNYGLAGSVWTENVSLGLEVALsIKAGAIWINAHnMFDAAAGFGGYRHSGYGRDGGKEGLYEYVVPS 502 purple urchin
YP_445353    415 FRTPEEAVERANNTEYGLASGIWSDKGSKLFSISQaLKSGVVWGNTYnKFDPASPFGGYKESGFGREGGMHGLLPYLERP 494 Salinibacter ru...
XP_002128052 414 FRTAKEAGNLGNNTNYGLAASVWSENLPTALELAItLKAGTVWVNCHnLFDAAAGFGGYRESGFGRDGGKEGLYEYVMPK 493 Ciona intestinalis
YP_997449    409 FRTLDEAVALANHSRYGLAASLWSENIDVCLTVAAqLAAGVVWVNGAnMFDAAAGFGGYRESGFGREGGREGMHEYLVPK 488 Verminephrobact...
YP_001546558 399 FRTPDEAIAIANNTRFGLAASIWSEDINVALHAAArVKAGVVWINSTnLFDAAAGFGGYRESGYGREGGKEGLYEYLKKS 478 Herpetosiphon a...
NP_105575    399 FRNTEEAIELANNTRYGLAASVWSENVNLALHVAPqLKAGVVWVNGTnMFDAACGFGGYRESGFGREGGREGMFEYLTAK 478 Mesorhizobium l...
NP_001089655 399 FRTAKEAIALGNNTPYGLAASVWTENLPLALEVALsIKAGTVWVNGHnMFDAAAGFGGYKESGFGRDGGKEGLYEYVRPS 478 African clawed ...
Feature 1            
Q8IZ83       489 GTPA 492 human
NP_001095339 489 GTPA 492 cattle
YP_924716    480 HEGA 483 Nocardioides sp. JS614
XP_002111625 518 WLTR 521 Trichoplax adhaerens
XP_001630371 515 WQER 518 starlet sea anemone
XP_797815    503 WMEK 506 purple urchin
YP_445353    495 SQSW 498 Salinibacter ruber DSM 13855
XP_002128052 494 WERT 497 Ciona intestinalis
YP_997449    489 WLHA 492 Verminephrobacter eiseniae EF01-2
YP_001546558 479 EVKK 482 Herpetosiphon aurantiacus ATCC 23779
NP_105575    479 LPLG 482 Mesorhizobium loti MAFF303099
NP_001089655 479 WESR 482 African clawed frog

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