Conserved Protein Domain Family
ALDH_BenzADH-like

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cd07104: ALDH_BenzADH-like 
ALDH subfamily: NAD(P)+-dependent benzaldehyde dehydrogenase II, vanillin dehydrogenase, p-hydroxybenzaldehyde dehydrogenase and related proteins
ALDH subfamily which includes the NAD(P)+-dependent, benzaldehyde dehydrogenase II (XylC, BenzADH, EC=1.2.1.28) involved in the oxidation of benzyl alcohol to benzoate; p-hydroxybenzaldehyde dehydrogenase (PchA, HBenzADH) which catalyzes the oxidation of p-hydroxybenzaldehyde to p-hydroxybenzoic acid; vanillin dehydrogenase (Vdh, VaniDH) involved in the metabolism of ferulic acid as seen in Pseudomonas putida KT2440; and other related sequences.
Statistics
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PSSM-Id: 143422
View PSSM: cd07104
Aligned: 47 rows
Threshold Bit Score: 577.56
Threshold Setting Gi: 197783435
Created: 12-Oct-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:catalytic residues [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
P43503        48 DVDAAVNAAKRAQKEWAaiPFSERAAIVRKAAEKLKEREYEFADWNVRecgairPKGLWEAGIAYEQMHQAAGLASlpnG 127 Pseudomonas putida
YP_256456     43 DAKRAIDSAYEAFKGWSslTAMKRSEYLLKLEETIRANEGDLINTLIVegggtyKKAWGEVVFTERLVRNAAEMARhfkG 122 Sulfolobus acid...
YP_663449     42 DATDAIASAHQAFQTWKdvLPSVREKILLDIADAFERRADEFKDLLIDeagssmLKAGYETHHAPSFLRGMAGECRrvkG 121 Pseudoalteromon...
ZP_02037901   56 DAEKALAAAYAARGKWAatAPDVRERILLRAANEMEARAEGLTQLMIAesgsarYKAWGEVMGSAGILRVAAGECRrlhG 135 Bacteroides cap...
ZP_02085683   41 EVEEAIAAAQRAWRPWAdtPAAQKEQILLKAADWMQEHIDEVADVLMGesgsafGKAYFEAGFAVDILRTAAGECRrvfG 120 Clostridium bol...
NP_560043     40 DAKAAIDAAYDALKAWSqlPAIKRAEYLYKLYEIIKSREEELINILMVegggiyKKAWGEVVFTERLVRNAAELARhygG 119 Pyrobaculum aer...
NP_049221     42 DVNRAVENAHQAYLQHRdlPAAVREGWIAKAAEIMERDTAKFADVLVDeigspiAKAGFETRFAVSFLRAAIGVPRrirG 121 Novosphingobium...
EDZ44270      48 DVRQAVAAAKAAFTSFKetTPTERERWLLRVAEIMEVRQKDLVDCLIDeigspvQKAMFEFTKGLTMIRAAAGMCRnvrG 127 Rhodobacterales...
YP_001951155  43 DALLAVNAAADAFPDWAavAPSQKRLLFLKAADLLEKRKDELIDLLARetgaarPFAAYQAAAGPNYLREAGSQAHrvtG 122 Geobacter lovle...
YP_160079     42 DLERAIAAAYRARESWGntLANEREAILLRAADALQKRIPDVAAVLIDeagstyGKAMFEASFVVNLLRSAAGECRritG 121 Azoarcus sp. EbN1
Feature 1                                    #                                                   
P43503       128 TLFPSavpGRMNLCQRVPVGVVGVIAPWNFPLFLAMRSVAPALALGNAVILKPDLQtAVTGGALIAEIFSDaGMPDGVLH 207 Pseudomonas putida
YP_256456    123 ETIPSdseGIISMTFRKPKGVVGAITPWNYPLSISMKKVAHSLAIGNTVVLKLSSE-TPIIGVKIAELVQRaGLPKGVVN 201 Sulfolobus acid...
YP_663449    122 ETYQSdypGLKSYSIRRPLGVVLSIAPFNFPLLLAIRKIGWALAAGNTVVLKPSEV-TPVIALKLAEVMTEgGLPKGVLN 200 Pseudoalteromon...
ZP_02037901  136 EVLQPggaGQMSMAVRSPLGVVLGITPFNYPMILAIKKLAYALAAGNTFILKPSPL-TPATGLAIAGVFEAaGLPSGVLN 214 Bacteroides cap...
ZP_02085683  121 QVQQQe-aGEISMIRRLPLGVVAGIAPFNFPLLLALKKVAFALAAGNTFVLKPASA-TPVSGVMIAKALDGaGIPKGVFN 198 Clostridium bol...
NP_560043    120 KTLQSdaeGVVSMVFKRPKGVVGVITPWNYPLSISMKKIAHALATGNTIVYKPASE-TPVTGFKIAEMIHQaGFPKGVFN 198 Pyrobaculum aer...
NP_049221    122 ETIPSdtpGRFSMSLRQPVGVVAGITPFNVPLIKGIKQSAMALATGNAFVLLPSEA-APMIADLLAKLWKEaGVPDGLFN 200 Novosphingobium...
EDZ44270     128 ETIPSdrpGTFSMSIREPLGVVAVITPFNVPLIKTTRLVANALAVGNTVVHLPSEM-APHLSLIFAEIVAEaGIPEGVYN 206 Rhodobacterales...
YP_001951155 123 TILPSe-tTKVSMVMRHPVGVVAGISPWNCPVVLSLRAVCFAMAYGNTVVLKPSEEsPVSGGILLAELFEEaGFPKGVFN 201 Geobacter lovle...
YP_160079    122 ETMPSdspGVFSMSVRRPLGVIAGIAPFNFPFLLATKKVALALAAGNTFILKPASY-TPVTGLKIAEIFEAaGLPKGVLN 200 Azoarcus sp. EbN1
Feature 1                                                          #                             
P43503       208 VLPGGAd----VGESMVANSgINMISFTGSTQVGRLIGEKCGrMLKKVALELGGNNVHIVLPDaDLEGAVSCAAWGTFLH 283 Pseudomonas putida
YP_256456    202 VVTGPGs---aVGDEIVTNKrVSHVTFTGETNTGREIASKAGhSLKTVTLELGGSDPLIVLDDaDVNLAVKIAVFGAFFH 278 Sulfolobus acid...
YP_663449    201 VIPANGa---eLGDVLIADErVRKVTFTGSTRVGKSIALACAkYHKPITLEMGGKNPFIVLADaDVDYAVDAATFSNFMH 277 Pseudoalteromon...
ZP_02037901  215 VVPGRSe---vIGDMLVDDPrVRMVTFTGSSAVGRSIAVRAArDLKKVAMELGGKNPLIVLKDfDPVQAADIAAYGAFCH 291 Bacteroides cap...
ZP_02085683  199 LVPGSGe---eVGNKLIEDErIRMVAFTGSTAVGRGIASKASvLFKKYSLEMGGKNPLILLKDfDVEQAVRIAGFGAFFH 275 Clostridium bol...
NP_560043    199 LVVGPGs---tVGDEIVVNKkVSHVTFTGESATGREIASKAGgALKTVTLELGGSDPLIILDDaDLNLAVRIAVFGAFFH 275 Pyrobaculum aer...
NP_049221    201 VVYGNGa---eIGDVLTGHPkVASITFTGSSRVGKHIAEIAArNLKKYTLELGGKSPLVICADaDLDKAVNAALFSIFMY 277 Novosphingobium...
EDZ44270     207 VVTGMGa---eIGDDLTSHKdIDFVTFTGSTVVGQHINEICAkNKTPNTLELGGKSPTIVLADaDLDKVMPLAARSVFMF 283 Rhodobacterales...
YP_001951155 202 IVTHGYgrsseVGDLFIQDRrVKRISFTGSTRVGRELAEKCGrHLKRIALELGGNDPLIVLNDaDMDHAVNAAIFGRFLH 281 Geobacter lovle...
YP_160079    201 VVPVQGs---vLGNTFVADPrVRMITFTGSTEVGRELSAEAGrHFKRITLELGGKSPMIVLKDaDVDYAVNAAAFGIFLH 277 Azoarcus sp. EbN1
Feature 1         #  #                                                                           
P43503       284 qGQVCMAAGRHLVHrdvAQQYAEKLALRAKNLvvgdpnsdqvHLGPLINEKQVVRVHALVESAQraGAQVLAGGTYqDRY 363 Pseudomonas putida
YP_256456    279 qGQICTSSKRIIVSekvYEAFVKKFVERVSQLkvgdprdrtiEQGPLISKRQVESMIEFYEDSVkrGGKIMTGGKWdGNY 358 Sulfolobus acid...
YP_663449    278 qGQVCMTGSRVIVEdavYDEFVRKFTAKVSALgygnprdpgvIVGPLIRPTQTEFIKKQVEKAVeqGAKINVGGHYeGNV 357 Pseudoalteromon...
ZP_02037901  292 qGQVCMATSRIIVEgdgYQPFCDALVCRAEGLkvgdpreedtIIGPLIQPEKWKFIDGQIEDALskGAKLLTGGRHeGPW 371 Bacteroides cap...
ZP_02085683  276 qGEICMCTSRLIVEepvYDPFCEAFAAYARTMkvgdphqkdtIIGPLIKQEQCQIIDSQIQDAVskGAVLMTGGTHeGNF 355 Clostridium bol...
NP_560043    276 qGQICTSSKRIIVHervYDVFVKKFVERVSQLkvgdprdrtvEQGPLISPRQADEMERFYQDAVsrGGRALTGGKRaGAY 355 Pyrobaculum aer...
NP_049221    278 qGQVCMGASRIYVErsiFDQFTKAFAAATGRAnsgdlrdpttMLGPIISERQRDRVRRHIDDARskGAAVLAGGEWsGNS 357 Novosphingobium...
EDZ44270     284 aGQACIASSRFYVErplYDEFVKQFSFIIGKLgmgdlrdpntVIAPAISPRQRERIKSHIDDARakGANVIGGEWE-GNR 362 Rhodobacterales...
YP_001951155 282 qGQVCMNAKRLIIEktvAQEFTARFVARTSALkvgnpldaatVIGPLINHKQYETLEGQVNRAVaeGAELLCGGYGnGLC 361 Geobacter lovle...
YP_160079    278 qGQVCMANSRLIVEapiFDVFCDKLATKIAGFkvgdprdpqtVIGPLIDRKQCAVLDRHVADAVakGAKLLHGGKSdGAF 357 Azoarcus sp. EbN1
Feature 1                                                                                        
P43503       364 YQATVIMDVKpeMEVFKSEIFGPVAPITVFDsIEEAIELANCSEYGLAASIHTRalATGLDIAKrLNTGMVHINDQpINC 443 Pseudomonas putida
YP_256456    359 FYPTVVTDVDrnFRIMKEEVFGPIRPVLRVKdDEEAIEVANDTEYGLSAAVVTRnvTRAFKFVEqIESGMVHINDVtMLE 438 Sulfolobus acid...
YP_663449    358 FQPTVISDVTsdMSIFHTECFGPVASVIKASdYLHALALANDSEYGLTSAVITNdlQMSIFFSEnLESGMVHINGPsIRD 437 Pseudoalteromon...
ZP_02037901  372 YWPTVLADVTpeMRIFHEETFGPVTSVMRAKdPEEALALCNDNEYGLSAALLTHnlELAWSMGLrMEAGMVHINDTtFLS 451 Bacteroides cap...
ZP_02085683  356 YQPTVLKDVTpdMRIFYEESFGPVTSIIKAVdAQDAVRLCNDNQYGLSSSLLTNdlSKAMSLSLdMEAGMVHINNAtVSD 435 Clostridium bol...
NP_560043    356 FWPTVFVDVDrnFRIMREEVFGPIRPVVPVKnDDEAVEVANDTEYGLSAAVVTTniNRAFKIAEaIESGMVHINDVtMLE 435 Pyrobaculum aer...
NP_049221    358 CAATILSGVTaeMTVFEEETFGPVTSLFPFDtLEEALELANNTEYGLSASIFTRdlDKALAFAQrAEAGMVHINAPtLHD 437 Novosphingobium...
EDZ44270     363 CQPTLLTDVSedMAVCRTETFGPVTAIYPIDsYEEGLEKANDTEYGLSSAIFTKdiDKAFHFARnSNAGMCHINGPtIHD 442 Rhodobacterales...
YP_001951155 362 YHPTVLGNVRedMSIFHEETFGPVAPIIVAEdADDALRLANSSAYGLSAGILTNnmQQGLALARrIESGACHVNDSpLYG 441 Geobacter lovle...
YP_160079    358 YQPTILAGVTpdMVVFREESFGPAVSVIRAAdSEDALRLANDSCYGLSSGLITNdlQKAFDLSLrLEAGMVHINDSsIMD 437 Azoarcus sp. EbN1
Feature 1                                           
P43503       444 EPHVPFGGMGASGsGGRFGgPASIEEFTQSQWISM 478 Pseudomonas putida
YP_256456    439 ESHIPFGGIKASG-IGREGgEYSFRETTYERWTTI 472 Sulfolobus acidocaldarius DSM 639
YP_663449    438 EAVVPFGGVKNSG-MGREGgTFAMDEFTELKWITV 471 Pseudoalteromonas atlantica T6c
ZP_02037901  452 GTTAPSGGVKFSG-FGREGgRYSMEDFTELKWLTM 485 Bacteroides capillosus ATCC 29799
ZP_02085683  436 NSTVAFGGVKNSG-VGREGgSYSIDEFTELKWITV 469 Clostridium bolteae ATCC BAA-613
NP_560043    436 ESHVPFGGIKASG-FGREGgEWSFHETTYDRWLTI 469 Pyrobaculum aerophilum str. IM2
NP_049221    438 EPHVPFGGTKASG-FGREGtEADLEIMTEWKWVTI 471 Novosphingobium aromaticivorans
EDZ44270     443 EAHVPFGGNGESG-VGREGtDADMEAMTELKWVTV 476 Rhodobacterales bacterium HTCC2083
YP_001951155 442 ETHAPLGGVNNSG-WGKFG-IEAMHEFTEQQWVTL 474 Geobacter lovleyi SZ
YP_160079    438 EPHVPFGGVKDSG-FGREGgHHSMDEMTELKWITV 471 Azoarcus sp. EbN1

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