Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like
Succinate-semialdehyde dehydrogenase, mitochondrial (SSADH, GabD, EC=184.108.40.206) catalyzes the NAD+-dependent oxidation of succinate semialdehyde (SSA) to succinate. This group includes the human aldehyde dehydrogenase family 5 member A1 (ALDH5A1) which is a mitochondrial homotetramer that converts SSA to succinate in the last step of 4-aminobutyric acid (GABA) catabolism. This CD also includes the Arabidopsis SSADH gene product ALDH5F1. Mutations in this gene result in the accumulation of H2O2, suggesting a role in plant defense against the environmental stress of elevated reactive oxygen species.