3EK1


Conserved Protein Domain Family
ALDH_F5_SSADH_GabD

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cd07103: ALDH_F5_SSADH_GabD 
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Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like
Succinate-semialdehyde dehydrogenase, mitochondrial (SSADH, GabD, EC=1.2.1.24) catalyzes the NAD+-dependent oxidation of succinate semialdehyde (SSA) to succinate. This group includes the human aldehyde dehydrogenase family 5 member A1 (ALDH5A1) which is a mitochondrial homotetramer that converts SSA to succinate in the last step of 4-aminobutyric acid (GABA) catabolism. This CD also includes the Arabidopsis SSADH gene product ALDH5F1. Mutations in this gene result in the accumulation of H2O2, suggesting a role in plant defense against the environmental stress of elevated reactive oxygen species.
Statistics
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PSSM-Id: 143421
View PSSM: cd07103
Aligned: 140 rows
Threshold Bit Score: 553.579
Threshold Setting Gi: 168334179
Created: 12-Dec-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:catalytic residues [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
3EK1_A        52 VTNPADGSVIGTVPSlsvaTIKEAIDASAKALSGWaakTAKERAGILRKWFDLIIANADDIALIMTSEQGKPLaEARGEV 131 Brucella melite...
NP_541847     30 CLTDPADGRELTIAPragrAEALQAAAAEKGFAEWsalSALERSKIMRRAADIMRERADAAARIMSMEQGKPLsEARGEW 109 Brucella melite...
YP_676299     28 VIDPSNEEVLGSYRSaapeDLQELLDSAAAGFEKWrrtSAYERCEILHKVAAALRENAQEIGSLLTLETGKILsESITEV 107 Mesorhizobium s...
EDZ60380      24 VINPATEEVLGHASKassaDVQRALQSAEQGLKVWrkiPPWQRSYVLRKIADKMREKKDLLAKWMTLENGKPLaEGIGET 103 Candidatus Pela...
YP_001833889  24 VLDPATGASLGEVASadtaDVEEAIAVASVALKSWratPAWTRADLLHAVADVMRDRLEEAARIITLESGKPLaQARREW 103 Beijerinckia in...
EDY77306      22 VISPVTETPLGDVTTataaDSKRAINAAASALAPLramGGFARADAMHRIADEMTARGDEAALMISTETGKPLaQAGREW 101 Octadecabacter ...
CAD31583      26 VINPATEKVVASVASatvsDLDEALASAERSRKAWcsrPAKERGEILVAAARVLATQIEPAARDLSAEQGKTIaEATGEY 105 Mesorhizobium loti
ZP_02418849   20 VINPADNTVVDSFCSatkeQAEEALETAQETFKTWgktSVMERCRLLSKFADLVEEHQDEISRLNSLETGKPYgEAYGDT 99  Anaerostipes ca...
YP_660476     22 IINPANDKVVAEVSVadgaLALKALEAADAAYDSWsstSISERVEWMMKLKTALKENETHLRECIHLEMGKSWaSTQGDF 101 Pseudoalteromon...
ZP_02692386   20 VYNPATGEVLAEFKSvsseQCEEALVAADAAFKIWskaSIAEREKVILAFRSDLISVQDELVALLMLETGKPLnNATYDY 99  Epulopiscium sp...
Feature 1                                                          #                             
3EK1_A       132 LYAASFIEWFAEEaKRVYGDTIPapq---ngQRLTVIRQPVGVTAAITPWNFPAAMITRKAAPALAAGCTMIVRPADlTP 208 Brucella melite...
NP_541847    110 LGSADLLDWFAEEgRRVYGRIVPsra---pnIQIQVLKHPIGPVAAFTPWNFPAWNTMQKVAPALGAGCSVVIKPASdTP 186 Brucella melite...
YP_676299    108 RGAADHFDWSGEEgRRLYGYTVParr---aeSRLRVELEPLGIVFALIPWNFPLGTSARKVAPALAAGCSVILRPPEeAP 184 Mesorhizobium s...
EDZ60380     104 NGAADIFEWNAEEtKRIFGQTIEsrf---edTRVHVYYQPVGVVAALSPWNFPLILAARKISTALAAGCSVIIKPDTiTP 180 Candidatus Pela...
YP_001833889 104 NLSIDQFRWFAEEtRRIYGRIVEsra---pgGRIEILHEPVGIVAAFTAWNFPAVLVARKIAPALAAGCSVIVRPSDeCP 180 Beijerinckia in...
EDY77306     102 VLSVDQFRWYAEEaRRIYGRVVEsrv---pgGRFEITKEAVGIVGAFTAWNFPASLPARKIAPALAAGCPVVLRPSSqTP 178 Octadecabacter ...
CAD31583     106 ARAVETLEWNGTH-AEELSATIPl------gPNRMIVPEPLGVVAAFTPWNYPAVLITRKLAPALAAGCPVILKGAEeTP 178 Mesorhizobium loti
ZP_02418849  100 GFCLNVLRFHAEEaKRVYGTTLNdynsqrgsVYHMVEKRPVGVVVGHLAWNYPMYNAALKIGPVIGSGCTAVLKPSSqTP 179 Anaerostipes ca...
YP_660476    102 EMLLDSLDFFASDiQKQAAETLEdke---gtHSHVLVRESVGVVAAFLAWNFPLLNLAYKLGPALASGCPIVVKPSLkTP 178 Pseudoalteromon...
ZP_02692386  100 EMLIDCLYFFNEEnKRLYGKTISnrt---nsHLNIIDHVPLGVVVGYLAFNFPILNLGYKLGPILASGCTCVLKPSSlTP 176 Epulopiscium sp...
Feature 1                                                                            #           
3EK1_A       209 LTALALGVLAEkAGIPAGVLQIVTGKAreiGAELTSNDTVRKLSFTGSTEVGRLLMAQCAptIKRISLELGGNAPFIVFD 288 Brucella melite...
NP_541847    187 GTAWLIGKCLLeAGLPPKAVSVIWGTTselSDALIKAPEIRKVSLTGSTRVGRIVAAQAGeyLKKVTMELGGHGPVIVAA 266 Brucella melite...
YP_676299    185 ATVEAFVRCCQeAGLPPGVLNMVLGSPkdvVEPLMASFSVRAVTFTGSTRVGKILIQQAAdtVKHLVLELGGHAPAIVLP 264 Mesorhizobium s...
EDZ60380     181 GIVMELVDICReCGVPPGAINLLSGDPpsiASQLIQSDIIKKISITGSVRVGKLILKQAAdkVQRVTMELSGHSPFIVFD 260 Candidatus Pela...
YP_001833889 181 GTAMHLVDCLRqAGVPKGVVNLVVGPVkntYAPLVASPLVRKITLTGSTAVGQQMIRDSAatVKRVSMELGGNAPLIVFD 260 Beijerinckia in...
EDY77306     179 GVAMVMVDCIRaGGLPDGAMNLVVGSTadtYGPIMADPRVRKVSLTGSTRVGQQMIRDAAetVKKVSMELGGNAPCIIFD 258 Octadecabacter ...
CAD31583     179 SVAVHIVESLRqAGVPDGVVNLVFGVPvhiSRHLLSSPIVKVLTFTGSTAVGKQLAMLAAnnLQRCILELGGHSPVIVCE 258 Mesorhizobium loti
ZP_02418849  180 LATLFLGKLITeAGIPDGVINILAGSSselGYALNSSTIPRLIGLIGSTDTALKVMSDSAtsVKRFSFELGGNAPTIVSE 259 Anaerostipes ca...
YP_660476    179 LSALAVGEICQqIGLPAGVVNIVCGPDqeiGDAISSSPIPALLTLIGSTETGKHVMQQGAtsIKRYSMELGGNAPVLIFD 258 Pseudoalteromon...
ZP_02692386  177 LTSLKIGEIAN-KHFPAGVINIIAGKSgvvAPVMNKSAIPKMMTMIGSSRAGKSVIRDSAdyLRHYSLELGGNAPAVVCK 255 Epulopiscium sp...
Feature 1                           #  #                                                         
3EK1_A       289 DADLDAAVDGAMVSKYRNAGQTCVCANRIYVQrgVYDKFAEKLAAKVKELk--VGNGTEpgvVIGPMIEEKAITKVKAHI 366 Brucella melite...
NP_541847    267 DADLDHLIPLAVQWKFRNCGQVCVSPTRFIVEasIHDEFIRRFSEKARELk--VGKGVEegaQMGPLTSQNQLETVLSMV 344 Brucella melite...
YP_676299    265 DADPKKVGVAAARAKFRNAGQVCVSPSRFIVHekIVEPFTQAMVEETRSIk--LGSGFDagaQMGPLTTARQRERVERLV 342 Mesorhizobium s...
EDZ60380     261 DADVKKATDMAIAAKFRNNGQVCISPNRFYIHenKKNEFIDLFIEKTKKLk--IGNGMDpdtQLGPLTTQKRLNEVEALV 338 Candidatus Pela...
YP_001833889 261 DVDVDAVLDIATPTKYGNAGQICVAPDRFYVHesIHDRFIEGLAQRAKALr--LGHGLDdatQMGPLINQRRIDAMESIV 338 Beijerinckia in...
EDY77306     259 DADLGAALDACVPSKFGNAGQVCVTPDRFFVHdsLHDTFVAEFAKRAAALt--LGDGLDddvEMGPLINAGRMTEVDAIV 336 Octadecabacter ...
CAD31583     259 DADLAKAIPAISEYKFECAGQSCNAPSRILVArtLYEEFLSRMTEAARKIr--IGLPDDpatEMGPMANARRIEAMQRLT 336 Mesorhizobium loti
ZP_02418849  260 SADLAAAADTVASMKMGNSGQMCVDHNRIYIHesVYDQFCDMMLERLEKYk--VGQGADegmIIGPMINQSAQKTMEDLV 337 Anaerostipes ca...
YP_660476    259 DADVDLAADIVCGLKFENAGQICVAPNRVFVHrdVAEIFYQKVLARTQAVk--VGFDRNdaiDMGPVIDQQAWQRIDALV 336 Pseudoalteromon...
ZP_02692386  256 DADVAKAAAEISDLKYGNAGQVCVSPNRVFVHknVADEFVEEVLAFVKKIklkVGDDSNe-vLMGPIASEEYAQGMVAFT 334 Epulopiscium sp...
Feature 1                                                                                        
3EK1_A       367 EDavskGAKLITGGKEl-----gGLFFEPGILTGvtsdmLVAKEETFGPLAPLFAFDtEEEVIAQANDTIFGLAAYFYTE 441 Brucella melite...
NP_541847    345 EDaltkGAKIETGGNRig---dtGNFYEPTILSGmtaemLAMNEEPFGPLALVMRVHsLDEAIAESNRLPVGLGAYLFTS 421 Brucella melite...
YP_676299    343 EDarskGARILAGGQRpsg-fnrGFFFEPTVLGDvpdtaLIFEEEPFGPVAPIIPVRsVQEAVEKANAVKWGLAGYLFTS 421 Mesorhizobium s...
EDZ60380     339 EKtkqeGAKVLLGGKRpag-fnkGFFYEPTIFDEvkddfTIMKEEPFGPLVPMLSFKsFDEVIERANNHELGLCSYVCTN 417 Candidatus Pela...
YP_001833889 339 ADaesrGGRIATGGQRpag-qnkGFFFAPTVISGlpdnaKALAEENFGPIAAVTPFSdPESVYERANASEFGLAAYVFTR 417 Beijerinckia in...
EDY77306     337 QEavaaGAKLETGGQRaag-fnvGHFYEPTVLSNvtddmRVFADENFGPIAAISRFSgDDEVWARANASTMGLSAYAFTR 415 Octadecabacter ...
CAD31583     337 KDavdrGAHIETGGTRld---gaGFYWPPTILTGvpkdaRVLHEEPFGPILTVAPFDtLDEAIGEANDTEYGLAAYFFTD 413 Mesorhizobium loti
ZP_02418849  338 EDavdkGARLVLGGKIpegmpegSAFFEPTLLLDcnrsmKVYQQEIFGPIAALSKYSdYDEILAEAADTDGGLSSYLFSH 417 Anaerostipes ca...
YP_660476    337 NDavakGAEVLIGSGRpah-lpkGAFYAPTVLKGvtrdaNIYREEVFGPVISILTFDeEAQVVKDANDTDAGLSSFIFTA 415 Pseudoalteromon...
ZP_02692386  335 EDaiakGAKLLAGGKRtg----vGYFFEPTVLLGvtnemRVYKEEVFGPIMSIIPFDdSDDIVALANDTEYGLAAYVYTK 410 Epulopiscium sp...
Feature 1                                                                    
3EK1_A       442 NFSRAIRVSEaLEYGMVGHNTGliSNEV-APFGGVKQSGLGREGSKYGIEEYLETKYICS 500 Brucella melitensis biovar Abortus ...
NP_541847    422 SMTTAHRVQNhLQAGMLGVNHFalALPE-TPFGGVRDSGFGSEGGLEGIEAYLTTMTVTT 480 Brucella melitensis 16M
YP_676299    422 SLADATKVSEaMQVGMVGLNTFaaAAPE-APFGGVKESGYGRECGLEGIREFVSSKLIHT 480 Mesorhizobium sp. BNC1
EDZ60380     418 SMETAHLASEqLETGSVAVNTGfvAIAE-APFGGIKQSGYGREGGSMAIKDYLNVKYTHL 476 Candidatus Pelagibacter sp. HTCC7211
YP_001833889 418 DPARMREAVSrIETGMVAVNSTalAAAE-APFGGIKFSGMGREGGSEGILDFLNVKLAQV 476 Beijerinckia indica subsp. indica A...
EDY77306     416 SPERARRAAAtLKAGMVGINSFalAASE-APFGGTNYSGLGREGGSEGIEDYLDTKLLQI 474 Octadecabacter antarcticus 307
CAD31583     414 AADTQRKLTNsLSAGAVSVNYLkgVSAD-APYGGVKQSGYGYEGGEQGVRSFQILKMVNG 472 Mesorhizobium loti
ZP_02418849  418 DTKEIAKAVEiFNSGEVLINVDgiGDVEfLPHCGIGNSGLGCDNSLWSLDEYFELKRVKI 477 Anaerostipes caccae DSM 14662
YP_660476    416 NEERAQRIAKrLRFGEVHVNGVk-YAIH-LPHCGVKQSGVGVDCSHLSLEEYFTVKRIST 473 Pseudoalteromonas atlantica T6c
ZP_02692386  411 DLDCALELGSaIEAGSVSINEPl-YDFN-LPHGGLKESGIGKDCSLYSLEEYYYVKRLSI 468 Epulopiscium sp. 'N.t. morphotype B'

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