Conserved Protein Domain Family
ALDH_SSADH2_GabD2

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cd07101: ALDH_SSADH2_GabD2 
Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like
Succinate-semialdehyde dehydrogenase 2 (SSADH2) and similar proteins are in this CD. SSADH1 (GabD1, EC=1.2.1.16) catalyzes the NADP(+)-dependent oxidation of succinate semialdehyde to succinate. SSADH activity in Mycobacterium tuberculosis is encoded by both gabD1 (Rv0234c) and gabD2 (Rv1731), however ,the Vmax of GabD1 was shown to be much higher than that of GabD2, and GabD2 (SSADH2) is likely to serve physiologically as a dehydrogenase for a different aldehyde(s).
Statistics
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PSSM-Id: 143419
View PSSM: cd07101
Aligned: 17 rows
Threshold Bit Score: 716.781
Threshold Setting Gi: 88856152
Created: 1-Jan-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:catalytic residues [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
P96417       30 DEVFTGKPLTTIPvgtaaDVEAAFAEARAAQTDWakrPVIERAAVIRRYRDLVIENREFLMDLLQAEAGKArwaAQEEIV 109 Mycobacterium tu...
ZP_00380643  45 PDPFTGLELPRFAkntpaDIEKAYATARIAADAWaarSPEHRARVLLRLHSALRRHEDLLLDIIQYETGKArihAYDEIL 124 Brevibacterium l...
ZP_01130813  33 IAPFSGQPLHELPqssisDVQDAAASARLAQRAWqtaGFAHRRTVLLRAHDLLLERRDELLDLLQTETGKTrgqAFEEIF 112 marine actinobac...
YP_251264    46 EAPFLGETIGWVAsgdadDVTEAFRFARRAQQSWvhvPFAERKRIFRRFHDLVLKNADLLCDMVQLETGKNrasSFDEVM 125 Corynebacterium ...
NP_737213    37 EAPFDATTIGHVPeggqsCVDKAFSLAREAQRGWedtPHATRRSIVRTFHSLVLKHRELLMDMVQLETGKNraaAFDEVM 116 Corynebacterium ...
NP_601908    34 IAPFTGETLGFVFdgdeqDVEHAFALSRAAQKKWvhtTAVERKKIFLKFHDLVLKNRELLMDIVQLETGKNrasAADEVL 113 Corynebacterium ...
YP_120879    41 IEVYTGARIGELPqsrptDVAAAFATARAAQRDWaatPLRRRLAVFARAHELILTERETIADLIQIGCGKTrrmAFEESC 120 Nocardia farcini...
YP_823061    38 HAPFTGEVIGAIPagmpaDLDLAVQRARSAQLAWsrlTFADRARIFLRFHDLLLERQNQVLDLIQWETGKArrhAFEEIL 117 Solibacter usita...
ZP_00996715  42 HTPMTGAPLASLPvstpeDVAVAIGTARAAQRAWgrlSIERRGQVLLRFHDLVLERQVELLDLIQLESGKArshAFEEVA 121 Janibacter sp. H...
YP_326500    37 EAPFTGDEIGRLPacvsaDVEAAFDRAAEAQTDWrdrDVSDRAAVFIRYHDRIIDNREELLDLIQYETGKArrhAYEELL 116 Natronomonas pha...
Feature 1                                                       #                               
P96417      110 DLIANANYYARVcvdlLKPRKAqpllpgigKTTVCYQPKGVVGVISPWNYPMTLTVSDSVPALVAGNAVVLKPDSqtPYC 189 Mycobacterium tu...
ZP_00380643 125 DTYNVCRHYGVTaparLRPERRrgavpvltRTEVTRTPLGVVGFITPWNYPLTLGATDLLAALVAGNAVVHKPDSqtTLT 204 Brevibacterium l...
ZP_01130813 113 QAASVSRYYAVSaqrvLATRRRrsgipvlmTTRVSYSPKQLIGVVTPWNYPIALGVMDIVPALAAGSAVIQKIDNqgALS 192 marine actinobac...
YP_251264   126 DVANNSRYYSNNvekfMKPRKRasamsvmaKSVEYRHPLGVVGQISPWNYPLSLGIGDAIPALLAGNAVVAKPDSatPFT 205 Corynebacterium ...
NP_737213   117 DVASTARYYAARaeklLTPRRRqgtipvlsSTVEHRYPLGVIGQISPWNYPLTLAISDAIPALLAGNAVVSKPDErtPFT 196 Corynebacterium ...
NP_601908   114 DVAITTRFYANNagkfLNDKKRpgalpiitKNTQQYVPKGVVGQITPWNYPLTLGVSDAVPALLAGNAVVAKPDLatPFS 193 Corynebacterium ...
YP_120879   121 DVPMVISHYLRTarrvLKPRRHggpmpllsTSIEEHRPKGVVGVISPWNFPFALALSDAVAALVAGNGIVLKPDNktALC 200 Nocardia farcini...
YP_823061   118 DTVTVTRYYARRahslLRPHRRkgalplltRTREFKAPLGVVGFIVPWNYPLNLAVTDAIPALMAGNAAVLKPDVqtSFT 197 Solibacter usita...
ZP_00996715 122 DCAIVSRHYARAaaayLKDTRVrggipvlsQTVVSHRPKGVVGIVSPWNYPLSLAITDALPALMAGNAVVLRPDQqsSLT 201 Janibacter sp. H...
YP_326500   117 DVAITARYYAYRaesfLETEPRagalpgmtETTVNYRPVGTVGIISPWNYPLSLSVSDAIPALLAGNAVVLKPDEqtSYT 196 Natronomonas pha...
Feature 1                                                                       #               
P96417      190 ALACAELLYRAGlpraLYAIVPGPGsvVGTAITDNCDYLMFTGSSATGSRLAEHAgrRLIGFSAELGGKNPMIVARGANL 269 Mycobacterium tu...
ZP_00380643 205 AIIMRRLAIACGlpaeVWQLVPGPSseVGPALMAGADGISFTGSTAAGRSIAAEAasRLLPTALELGGKNPMLILSDADL 284 Brevibacterium l...
ZP_01130813 193 MLATREAYIDAGvpaeLWPIVAGPGseVGNAVVDSCDYVCFTGSTPTGTRVGERAasRLIGASLELGGKNPLIVLGDVDP 272 marine actinobac...
YP_251264   206 SLLVFKFLFDAGlprdLVQLVTGSGrvVGSAIADQCDFLMFTGSTATGKVLGEQVgrRLIGYSAELGGKNPLIIANDADI 285 Corynebacterium ...
NP_737213   197 ALLVTSLLYDAGlprdIFHTVTGPGpvVGGAIAEHCDYLMFTGSTNTGRILGETAgrRLIGFSAELGGKNPLIIAEDADL 276 Corynebacterium ...
NP_601908   194 CLIMVHLLIEAGlprdLMQVVTGPGdiVGGAIAAQCDFLMFTGSTATGRILGRTMgeRLVGFSAELGGKNPLIVAKDADL 273 Corynebacterium ...
YP_120879   201 ALFGVELLHRAGlpegLFQVVCGEGpdIGGDLIDHSDFVMFTGSTATGRVVGERAgrNLIGCSLELGGKNPMLVLDDADL 280 Nocardia farcini...
YP_823061   198 ALWAVALLREAGlprdIFSVVTGEGplLGPALGERVDYVMFTGSTRTGRLVAHQAaeRLIGCSLELGGKNPMIVLEDADI 277 Solibacter usita...
ZP_00996715 202 ALAGHELLLEAGlpegVFQVVLGPGssTGQAIVDQADYVCYTGSTPTGRIVAQAAakRLVGCSLELGGKNSMYVAADADI 281 Janibacter sp. H...
YP_326500   197 ALKAFELLLEAGlpddLVQIVTGDGptIGEPLVANADYVCFTGSTETGRAVASQAgrHLTDCSLELGGKNPAIVRADADI 276 Natronomonas pha...
Feature 1                      #  #                                                             
P96417      270 DKVAKAATRACFSNAGQLCISIERIYVEKdIAEEFTRKFGDAVRNMKLGTAYDFs--vDMGSLISEAQLKTVSGHVDDAT 347 Mycobacterium tu...
ZP_00380643 285 PSAVDGAVRGCFSSAGQLCLSIERIYVHEdLYPEFCAHFAEATRNLELSPDYSYg--pGMGSLAGPKQLARVSEHVEQAR 362 Brevibacterium l...
ZP_01130813 273 AKAAADAVYACFSTMGQLCVSIERIYVHEsIAAEFTREFAARVDALIQTAALDYs--gDVGSLTSAAQLERIQAHVDDAV 350 marine actinobac...
YP_251264   286 SYAARGAIDACFSNSGQLCVSIERIYVERaSYEDFVGAFTSRVQSMSLGSGFEWe--tQMGSLASASQLETVEKYVEDAR 363 Corynebacterium ...
NP_737213   277 DKAVDGAVHGTISNSGQLCVSIERIFVVGsMYPRFVDAYVQRLQSIRMEAGFDWd--vEMGSLASQQQLDTVTRMVDEAV 354 Corynebacterium ...
NP_601908   274 DKVEAELPQACFSNSGQLCVSTERIYVEEdVYEEVIARFSKAAKAMSIGAGFEWk--yEMGSLINQAQLDRVSTFVDQAK 351 Corynebacterium ...
YP_120879   281 DAVLPSALFAVFANSGQACMHIERIYVHErLHDEFLRRFTEAAAELGAKAGARYdytpEFGSLVSPEHLARVAAHVDEAR 360 Nocardia farcini...
YP_823061   278 DAAVYGAIQGCFPSSGQVCVSIERLYLHEsIAERYLAAFVERTSALKLGAAFDYs--vDVGSLTTERQLARVEQHVRDAV 355 Solibacter usita...
ZP_00996715 282 SRAVAGAVRACFSSAGQLCISAERLLVHRdVFGEFVTKFVEAVESMKLGTDLAYg--yDMGSLVGQSQLDTVTQHVEDAR 359 Janibacter sp. H...
YP_326500   277 DRAAEGLVRGCFTNAGQLCLSIERLYVHEaIYDRFLDAFVAAVESMPLGTDYSYd--iEMGSLISGSHLEAVEQYVEDAV 354 Natronomonas pha...
Feature 1                                                                                       
P96417      348 aKGAKVIAGGkarPDIGPLFYEPTVLTNVAPeMECAANETFGPVVSIYPVAdvDEAVEKANDTDYGLNASVWAGstAEGQ 427 Mycobacterium tu...
ZP_00380643 363 aSGAQVIAGGspvPKLGPYFYLPTVLTDVTEeAELFAEETFGPVVAVYPVAsdAEAIKRANASEYGLNASVYSQ--SRGR 440 Brevibacterium l...
ZP_01130813 351 aKGATVLAGGtarPDLGPFFFAPTALTDVTAdMECFANETFGPVVAITTVAsdDEAIDRANDSEFGLNASIFSGsiLHAR 430 marine actinobac...
YP_251264   364 eKGANILCGGkkrPDLGPYFYEPTVMVDVPEdALLRTEEVFGPVVYIEPVEdlYDAIELANDTDYGLNASVFAAd-DTAW 442 Corynebacterium ...
NP_737213   355 sKGAEVLTGGrarPDLGPYFYEPTVLTGVTKkMELYRHEVFGPVVYVEAVAdlAEAIVYANDTDYGLNAGIFAAr-DTAL 433 Corynebacterium ...
NP_601908   352 aAGATVLCGGksrPDIGPFFYEPTVLADVPEgTPLLTEEVFGPVVFIEKVAtlEEAVDKANGTPYGLNASVFGSs-ETGN 430 Corynebacterium ...
YP_120879   361 aKGATVHTGGrarPDLGPAFYEPTVLTGVTPdMALARSETFGPVVSVYRFSteQEAVAAANDTDYGLNASVWSRdrARAL 440 Nocardia farcini...
YP_823061   356 eKGAVVLAGGrrrPDVGPLFYEPTILANVTDrMQLFAEETFGPVVSVYTFArdQEAVDLANATRYGLNASVWTRntARGA 435 Solibacter usita...
ZP_00996715 360 aQGAIVLTGGrprPDLGPFVHEPTVLTGVTEtMLCRDGETFGPVVSLYEVGsdDEAIALANDTEYGLNSSVWTRdvRRGR 439 Janibacter sp. H...
YP_326500   355 aGGATVLTGGsprPDIGPYFYEPTVLEDVDEsMALCAEETFGPVVAVSAYSddADAIERANDTDYGLNAAVWTDdlDAGR 434 Natronomonas pha...
Feature 1                                                               
P96417      428 RIAArLRSGTVNVDEGYafAWGSLsAPMGGMGLSGVGRRHGPEGLLKYTESQTIAT 483 Mycobacterium tuberculosis
ZP_00380643 441 ETARqLESGMVNVNEAYvaAWGSIdSPAGGVKASGMGHRHGVEGLYQFMHTHNIAE 496 Brevibacterium linens BL2
ZP_01130813 431 RLADrLNAGSVNINEGYraSFSSVdAPMGGMKNSGLGRRNGPEGILRFVQSRTVSQ 486 marine actinobacterium PHSC20C1
YP_251264   443 KIGPkIESGSVALNDGYtsSWAAIdNPMGGMKESGVSHRHGAEGLQKYTATQNVTS 498 Corynebacterium jeikeium K411
NP_737213   434 AAAPlIRVGGVNINDSYsaTWGNIdTPLGGAKDSGLSARHGEEGLLKYTQTQNISE 489 Corynebacterium efficiens YS-314
NP_601908   431 LVAGqLEAGGIGINDGYaaTWASVsTPLGGMKQSGLGHRHGAEGITKYAEIRNIAE 486 Corynebacterium glutamicum ATCC 13032
YP_120879   441 RIAErLAAGNINVNDGFvtSYAAKaTPSGGVKQSGIGARHGDQGLLKYTDTVNVGV 496 Nocardia farcinica IFM 10152
YP_823061   436 HIARqIRAGNVNVNESYaaAWGSVdAPCGGLKDSGMHARHGAEGILKFTETQTVAV 491 Solibacter usitatus Ellin6076
ZP_00996715 440 RIAAqISTGTVNVNDGYaaAWASVgAPMGGMKASGIGRRHGREGIVKYTESQNVTA 495 Janibacter sp. HTCC2649
YP_326500   435 QLAErIDAGTVNVNESYaaAWASLdAPMGGMKDSGVGRRHGEVGLSRYTEAQTVAV 490 Natronomonas pharaonis DSM 2160

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