Conserved Protein Domain Family
ALDH_SSADH1_GabD1

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cd07100: ALDH_SSADH1_GabD1 
Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like
Succinate-semialdehyde dehydrogenase 1 (SSADH1, GabD1, EC=1.2.1.16) catalyzes the NADP(+)-dependent oxidation of succinate semialdehyde (SSA) to succinate. SSADH activity in Mycobacterium tuberculosis (Mtb) is encoded by both gabD1 (Rv0234c) and gabD2 (Rv1731). The Mtb GabD1 SSADH1 reportedly is an enzyme of the gamma-aminobutyrate shunt, which forms a functional link between two TCA half-cycles by converting alpha-ketoglutarate to succinate.
Statistics
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PSSM-Id: 143418
View PSSM: cd07100
Aligned: 99 rows
Threshold Bit Score: 607.535
Threshold Setting Gi: 118357582
Created: 12-Oct-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:catalytic residues [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
P71989        25 VDAAIARAHRRFADYRqtSFAQRARWANATADLLEAEADQAAAMMTLEMGKtlaAAKAEALKCAKGFRYYAENAEALlAD 104 Mycobacterium t...
YP_002028212  30 LEAILDRGQAGFAAWSarSLEQRAEVLRAMAAVLRRDREKLAALATAEMGKvqaESLAEIEKCAVLCDWYADNGAQFlRD 109 Stenotrophomona...
ZP_02885731   34 VERMLEDNAAAYRLWRgtPMAVRVATYRRLAATLRERSEALAALITQEMGKtlaAARAEIAKCASAIDWIAEHGPAFlAD 113 Burkholderia gr...
ZP_01907287   28 LEGRVARAHAQQRDWAarPLAERADALRALGAHLRTIRGEAAATMTAEMGKplaQAQGELDKCAWLCEWLAEHGPAMlAD 107 Plesiocystis pa...
YP_001821117  25 AFAIVARAERAAQPWRstALAERARTLRAVGRELRRRRDDLAALLTAEVGKpirQSRAEIEKCAAGCEYFAAHAARAlRP 104 Opitutus terrae...
NP_857615     73 VDSALALTNGAFQYWRhsAMSDRVQLLRNVAGALRQQARELAEMMTSEMGKpvdQGLAEVEKSARLCEWYAEQGPAFlQR 152 Erwinia sp. Ejp...
YP_581119     26 VNNIVEASHQAFLEWRktSHKERAKVINSIGETLMKYKEELSRLMTEERGKlysQSLQEIDLCKAICDYTAEKGVAAlAD 105 Psychrobacter c...
ZP_01038744   26 ACAKVDACHEAFESWKlkSLEERAEVLRGLGQALRDNKEELAQLMTDEVGKligDSRDEVELCASICDYTAENGPSElAD 105 Erythrobacter s...
YP_860999     29 MNSAVKACHEAFLEWKnkSAEERGKVIANIGKKLDEHKDELVKLMTSEMGKllkQGEQEVELCSGICDYTAKNGPESlKD 108 Gramella forset...
EDZ47317      26 AIQKLESAQEAFLDWRklSHAERAPYLTKIAERLRASADELAVLMTRETGKllkDGKREVEICAAILEYTAKHGPDVlAD 105 Rhodobacterales...
Feature 1                                      #                                                 
P71989       105 EPADaak-vgaSAAYGRYQPLGVILAVMPWNFPLWQAVRFAAPALMAGNVGLLKHASNVPQCALYLADVIArgGFPDGCF 183 Mycobacterium t...
YP_002028212 110 EPTQvp----dDKAYVSYLPLGVVLGIMPWNFPYWQVMRAAVPILMGGNGFLLKPAENIVGTAQLLDAAWRdaGLPDGTF 185 Stenotrophomona...
ZP_02885731  114 EPAPve---gdDQVHVSYLPIGSILAVMPWNFPLWQVIRASGPIMLSGNGFILKHAANVMGSAYALQDAYEaaGFPVGLF 190 Burkholderia gr...
ZP_01907287  108 EPRSrvavegsQRSYVAHRPMGLLLAIMPWNFPWWQALRFAAPALLAGNTALLKHAPNTTGCALAIEAALLaaGFPEGCL 187 Plesiocystis pa...
YP_001821117 105 QHPIga----pRHARVVFEPLGIVLGIMPWNFPFWQTFRAAAPALMAGNVLLFKPAPSTAGCALAIEAVFDa-VAPKGLL 179 Opitutus terrae...
NP_857615    153 EPTLve----gNKAFVDYLPLGPVLSVMPWNFPVWQVLRGAVPILLAGNSYLLKPAPNVMGCALLLQQILSrvGVPEGLF 228 Erwinia sp. Ejp...
YP_581119    106 DERDie---glKKGIVTYQPIGVIYGMQPWNFPAYQVFRYTIANLMAGNSILLKHAANVTGSGLLIEKIFHesDLPNDLF 182 Psychrobacter c...
ZP_01038744  106 EQRDps---naGRGIVTYSPIGVVYGIQPWNFPAYQVIRYAIANLMTGNGVLLKHASNCTGSGLKIAEIFEkgGLPADLF 182 Erythrobacter s...
YP_860999    109 EERElp---egGKGYISYSPIGVIYGIQPWNFPAYQVVRYSIANLMAGNGVLLKHAENVTGSALLLEKIYIeaGLPENLF 185 Gramella forset...
EDZ47317     106 EDRThgt--dgARGIISYQPIGVIYSIQPWNFPLYQPVRVLAANLMAGNACVLKHASICTGSGLRLRELCIeaGLPEDLF 183 Rhodobacterales...
Feature 1                                                       #                              # 
P71989       184 QTLLVSSGaVEAILRDPrVAAATLTGSEPAGQSVGAIAGneIKPTVLELGGSDPFIVMPSaDLDAAVSTAVTGRVQNnGQ 263 Mycobacterium t...
YP_002028212 186 IAANISREgTSRAIADDrIAAVTLTGSVAAGRSIAAQAGqaLKKVVLELGGSDPFIVLADaDLDAAVEAAVASRFQNtGQ 265 Stenotrophomona...
ZP_02885731  191 ANLNADNEtVAHVIEDPrVAAVTLTGSMRAGSAVASTAGraLKKTLLELGGADAFIVLADaNIDLAVKAAIEARFQNaGQ 270 Burkholderia gr...
ZP_01907287  188 ETLVASHGqVAGLIADRrVRGVTLTGSTRAGRSVAALAGqhLKKTVLELGGSDPYLILPDaDLDHAAAVCAKARLFNsGQ 267 Plesiocystis pa...
YP_001821117 180 RTLLVETDaVATLIADArVRGVTLTGSTRAGRAVAALAGgaMKPGVFELGGSDAYLVLDDaDLDHAAAVCAQARLVNsGQ 259 Opitutus terrae...
NP_857615    229 AVVNADNDgVAQAINDRrIAAVTVTGSVRAGAAIAALSGaaIKKCVLELGGSDAFIVLADaDIDAAVKGAIAGRFMNnGQ 308 Erwinia sp. Ejp...
YP_581119    183 RTILIDHDqSEKLIGNDkVRGVTLTGSDGAGSIVGQQAAkaIKKAVLELGSNDAFIVLEDaDLELAVQTCTLARLINnGE 262 Psychrobacter c...
ZP_01038744  183 TVLVIDHDtSDAIIAHDkVRGVTLTGSDGGGKHVAEEAGkvLKPLVLELGSNDAYLVLEDaDIDKAAEVCARARLYNnGQ 262 Erythrobacter s...
YP_860999    186 KVLLISHDqSDSVIENKlVRGVTLTGSPDAGKIIGKKAGenLKKTVLELGSNDAYIVLEDaDIDLAVKTCVEGRLYNnGE 265 Gramella forset...
EDZ47317     184 QVVLIDHGtSDTLIAHPlVRGVTLTGSDGAGRHVGSVASkaLKKTVLELGSNDAYLVLEDaDIETAVKYSVIGRLYNnGE 263 Rhodobacterales...
Feature 1         #                                                                              
P71989       264 SCIAAKRFIVHadiYDDFVDKFVARMAALrvgdptdpdtDVGPLATEQGRNEVAKQVEDAAaaGAVIRCGGKRLdrpgWF 343 Mycobacterium t...
YP_002028212 266 VCIAGKRIIVEdavYDRFVAQFCQKVQALaigdgreagnRIGPMARQDLLEQLDAQVRASVdaGAKLLVGGHQLdrpgAF 345 Stenotrophomona...
ZP_02885731  271 VCLAAKRFIVErpvAEEFTRKFVAAARQVvagdphdpasTIGPMARADLRDELHGQVQRTIeaGATLLLGGSKVegagNY 350 Burkholderia gr...
ZP_01907287  268 TCVAAKRFLVCepvAEAFTEAFLAQLRAAvvgdptdpttTVGPLARADLRAGLEDQVERSVaaGARVLHRSEVPd--sPG 345 Plesiocystis pa...
YP_001821117 260 SCIAAKRFIVLaavRGEFERRFVAHMTAAkvgdptdpatDVGPLARADLCDQLHRQVKRSVqrGARVLLGGAPApgagFY 339 Opitutus terrae...
NP_857615    309 LCISAKRIIVEapvFDAFRDKFVSAVKEMkigdpresgtWIGPMARYDLRDELDSQVQATLkeGATLLLGGHVLpgegNY 388 Erwinia sp. Ejp...
YP_581119    263 TCVAAKRFIVVdslYDEFRKRIVEEFASKkagdpmddssDLGPLARKDLQEKLHAQVEESVskGATISVGGKLPegkgSF 342 Psychrobacter c...
ZP_01038744  263 TCINGKRFIVTdavYDEFVDKFVAKFEAIkigdpnsddsDMGPMARTDLREDVQGQVDKSVenGATIACGGKIPdgpgAY 342 Erythrobacter s...
YP_860999    266 TCVAAKRFIVVdkvYDKFKEAFVEQMSQIkagdptkedsDIGPMARKDLRDELHEQVEESVkkGAKILCGGKKPdgdgFF 345 Gramella forset...
EDZ47317     264 TCVSAKRFIVAdkvYDAFVSAFVDQMKTVkmgdptdedtQLGPLSSDAQFETVKEQVDESVakGAKALCGGKAPdrtgAF 343 Rhodobacterales...
Feature 1                                                                                        
P71989       344 YPPTVITDIsk--dmALYTEEVFGPVASVFRAAnIDEAVEIANATTFGLGSNAWTRdeTEQRRFIDd-IVAGQVFINGMt 420 Mycobacterium t...
YP_002028212 346 YAPTVLADVep--gmQAFDTETFGPVASISRARdADHAVELANQSEFGLSGNLWSGdrARAMQLARr-LQTGGVFVNGFs 422 Stenotrophomona...
ZP_02885731  351 YEPTVLADVap--gmAAFDEETFGPVAAITVADdAEHAIELANTSDYGLGGSLWTSdvARAQRIARr-LETGGVFINGFs 427 Burkholderia gr...
ZP_01907287  346 AYHPVVALGsvdetnPAAREELFGPVAAIMTVRdEAHAVAVANRSDYGLGAAVFSRdvERAEAIARdqLDAGACFVNGMv 425 Plesiocystis pa...
YP_001821117 340 YEPTVLSRVrp--gmPAFDEELFGPVAAVISARdETEAIALANRSIYGLGAAVFTRdrRRARRIAEq-LEAGFIVTNDFv 416 Opitutus terrae...
NP_857615    389 YAPTVLSDVkp--gmTSFAQELFGPVASLIQADnAEHAVVMANDSEFGLGGSLWSRdlAVAQKLASr-IETGGVFINSPs 465 Erwinia sp. Ejp...
YP_581119    343 YPATILENVek--gqPAYDDELFGPVASLIRAKdQDDALRIANDSRYGLGGAIFSKdeEKAIRLANeqFDTGMVYINGYg 420 Psychrobacter c...
ZP_01038744  343 YPATVLTDVap--gqPAYDDEIFGPVASVIRAKdDEDAMRLANDSRYGLGGGILSGdtDRAIEMAKkhFDTGMIFINTYg 420 Erythrobacter s...
YP_860999    346 YPATILDELkp--gmPAYDDELFGPVASLIKAKdAKDAMDIANSSRFGLGGGIFSKdeEKARELAKyhFDTGMVFINSFg 423 Gramella forset...
EDZ47317     344 YPATVLVDVap--gmPAYDDEIFGPVAAVIRAKdNEDAMRIANDSRYGLGGGIFSQdeERALRLARdhFDTGMIRINSFg 421 Rhodobacterales...
Feature 1                                            
P71989       421 vSYPELPFGGVKRSGYGRELSAHGIREFCNIKTVWI 456 Mycobacterium tuberculosis
YP_002028212 423 aSDPRVPIGGVKKSGFGRELSHFGIREFVNAQTVWF 458 Stenotrophomonas maltophilia R551-3
ZP_02885731  428 aSNPRIPVGGVKKSGYGRELSHFGLREFTNAQAVWA 463 Burkholderia graminis C4D1M
ZP_01907287  426 rSDPRVPFGGVKDSGYGRELGRHGMLEWVNAKTVWV 461 Plesiocystis pacifica SIR-1
YP_001821117 417 rSDPTLPFGGVKQSGYGRELGDWGVTSFVNVKTVIG 452 Opitutus terrae PB90-1
NP_857615    466 fSDPRVPIGGVKKSGFGRELSHFGLREFTNTQTVWM 501 Erwinia sp. Ejp 556
YP_581119    421 lANPALPFGGVKNSGHGREHGGFGIKEFVNIKGVHV 456 Psychrobacter cryohalolentis K5
ZP_01038744  421 vADPSMPFGGVKNSGYGREHGGFGVKEFANAKSIFV 456 Erythrobacter sp. NAP1
YP_860999    424 lAKPNMPFGGVKDSGYGREHGGFGLHEFVNVKAIML 459 Gramella forsetii KT0803
EDZ47317     422 aADPNMPFGGVKDSGYGREHGGFGMKEFVNVKAIYL 457 Rhodobacterales bacterium Y4I

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