Conserved Protein Domain Family
ALDH_F15-22

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cd07098: ALDH_F15-22 
Aldehyde dehydrogenase family 15A1 and 22A1-like
Aldehyde dehydrogenase family members ALDH15A1 (Saccharomyces cerevisiae YHR039C) and ALDH22A1 (Arabidopsis thaliana, EC=1.2.1.3), and similar sequences, are in this CD. Significant improvement of stress tolerance in tobacco plants was observed by overexpressing the ALDH22A1 gene from maize (Zea mays) and was accompanied by a reduction of malondialdehyde derived from cellular lipid peroxidation.
Statistics
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PSSM-Id: 143416
View PSSM: cd07098
Aligned: 14 rows
Threshold Bit Score: 727.557
Threshold Setting Gi: 149925140
Created: 1-Jan-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:catalytic residues [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
Q0WSF1        69 YEPATMKYLGYFPalsp--tevEERVTLSRKAQKTWaqsSFKLRRQFLRILLKYIIEHQELICEVSSRDTGKTmvDASLG 146 thale cress
XP_001396713 116 YCPADGRVLGNGIkpat-pddvDRAVLAAKSAQLEWantSFAERRKVLRTLLKYVLDHQDELVTACCLDSGKTkvDAAFG 194 Aspergillus nig...
XP_964629     87 YAPATGQFLGFVNpstp--egiDRAIDQAHAAQVEWaktTFRQRRAVLRSLLQYVLDNQEEICRVACLDSGKTmvDAQLG 164 Neurospora cras...
XP_503815    108 YCPATGQFLGATPastl--ldiDAAIECAAAAQCQWn-pSFSARNKVLKTIRKFLLENQEVVARVACRDTGKTmiDASMG 184 Yarrowia lipoly...
XP_001646740 104 HCPATGQHLSSYLpkyn--ediDEMVTIAQNAQEEWakaDLDRRLKVLHTLHEYIINNQEIIARVTCRDTGKTmlDASLG 181 Vanderwaltozyma...
Q9P7K9         8 YCPGDGSLLGEVKlfnk--sdiDQSIILAEEAQKEWkstSFAERRNFLKALKENIIRNQDKYAEIACKDTGKTlvDAAFG 85  fission yeast
P38694       115 HCPATGQYLGSFPskte--adiDEMVSKAGKAQSTWgnsDFSRRLRVLASLHDYILNNQDLIARVACRDSGKTmlDASMG 192 baker's yeast
XP_001690075  12 YDPSTMQLLGHLPamsa--sevRSRIARCKAAQKEWrtsSFAQRRKLLRILLKFIIENVETICRVSARDSGKPmlDAILG 89  Chlamydomonas r...
XP_001747510  98 YDKFTHAVLGSGAvpvcspadvREAVAKARVAQRQWaqtNFEERREVLRYMQDYITAHQREICVIASRDTGKTlvDGAFG 177 Monosiga brevic...
XP_845539     82 YDKGTNTQIGLVTvnsp--aevQEAVARARVAQREWaktSFSTRRQLLYSLMEYILENQALICETTSVECGKTmmDGSLG 159 Trypanosoma bru...
Feature 1                                                               #                        
Q0WSF1       147 EIMTTCEKITWLLSEGERWLKPESRssgra---mlhkVSRVEFHPLGVIGAIVPWNYPFHNIFNPMLAAVFSGNGIVIKV 223 thale cress
XP_001396713 195 EILVTAEKLKWTLDHGEKALAPESRptnfl---mmykKNMVTYEPLGVVSACVSWNYPFHNFISPVISAIFAGNGVVVKP 271 Aspergillus nig...
XP_964629    165 EILVTAEKLQWTIKHGEKALRPESRptnll---maykRNTVHYEPLGVVAALVSWNYPFHNLIGPVISALFAGNGIVVKV 241 Neurospora cras...
XP_503815    185 EIMVTLEKINWLIKNGERALQPSSRpgssnp-lmfykAAKVVYEPLGVVAALVSWNYPLHNLMGPILASLYAGNAVIIKC 263 Yarrowia lipoly...
XP_001646740 182 EIMATIDKLNWIIRYGPKHLQPSARsgttnyfmewyrGTEVHYEPLGVVSSIISWNYPFYNVISPIISAIFTGNAIIVKC 261 Vanderwaltozyma...
Q9P7K9        86 EILVTLEKINWTLANGEQSLRPTKRpnsll---tsykGGYVKYEPLGVIAALVSWNYPLHNALGPIISALFAGNAIVVKG 162 fission yeast
P38694       193 EILVTLEKIQWTIKHGQRALQPSRRpgptnffmkwykGAEIRYEPLGVISSIVSWNYPFHNLLGPIIAALFTGNAIVVKC 272 baker's yeast
XP_001690075  90 EVVVTCEKIHWLSREGEAVLRPERRsagil---sfykSARVEFHPVGVVGAIVPWNYPFHNVLNPLTAALFAGDGLVIKV 166 Chlamydomonas r...
XP_001747510 178 EVLVTCEKISWTLQHGEQALRTEYRktgmi---mshkTARVEYIPLGVMGAIIPWNYPFHNLFGQIISAIFAGNAIVVKA 254 Monosiga brevic...
XP_845539    160 EILTTLEKLRWTAAHGEEALAEEVRdvgli---tfhkRAAVNYVPFGVMGAIVSWNYPFHNIYGPMISALFAGNAFVGKI 236 Trypanosoma bru...
Feature 1                                                                                        
Q0WSF1       224 SEhaSWSGCFYFRIIQAALaavGAPENLVDVITGfa-----etGEALVSSv--dKMIFVGSTAVGKMIMRNAAeTLTPVT 296 thale cress
XP_001396713 272 SEqtAWSSAFFLEIIRGALsscGHSRDLVQSIVClp-----nvADHLTSHpdisQLTFIGSKPVAHKVCESAAkSLTPVT 346 Aspergillus nig...
XP_964629    242 SEqtAWSSQWFTSVIRGALvahGHNPALVLCWPQt--------ANHITSHpkisHITFIGSQPVCKKVAESASkALIPVL 313 Neurospora cras...
XP_503815    264 SEsvVWSSQYFVQIAREALqacGHSPDLVQLVCCwp-----etANHLTSHpqisHVTFIGSKPVAHKVAAAAAeSLVPLV 338 Yarrowia lipoly...
XP_001646740 262 SEqvIWSSEFFISIVRKCLevcNEDPDLVQLCYClpksdkynaTNYFISHpgfkHITFIGRKTVANKILNCAAeSLTPVV 341 Vanderwaltozyma...
Q9P7K9       163 SEltAWSTHQYCEMVRSLLqsmGHSPELVQCITClp-----dvADHLTSHsgikHITFIGSQPIAKLVAASAAkQLTPLC 237 fission yeast
P38694       273 SEqvVWSSEFFVELIRKCLeacDEDPDLVQLCYClpptenddsANYFTSHpgfkHITFIGSQPVAHYILKCAAkSLTPVV 352 baker's yeast
XP_001690075 167 SEhaSWSTGYYGRMISAALaaaGAPADLVQIVTGyg-----eaGSALVTGgv-dKVIFVGSTQVGKMVMRAAAdTLTPVV 240 Chlamydomonas r...
XP_001747510 255 SEyaTWSSLAYLRIVHTILdhfGIDRNLVQIVTGfg-----ptGAALVESgv-dKLVFIGSPGVGKLVMKAASnNLTPVV 328 Monosiga brevic...
XP_845539    237 SEysSYYASYYLSIVQEGIkelGYSPHLVSFVVGfa-----etGEALVNSv--dKLTFIGSPAVGKIVMRSAAqTLTPVV 309 Trypanosoma bru...
Feature 1         #                                  #  #                                        
Q0WSF1       297 LELGGKDAFIICED----ADVSHVAQVAVRGTLQSSGQNCAGAERFYVHKdIYTAFIGQVTKIVKSVSAGpplt------ 366 thale cress
XP_001396713 347 VELGGKDPALVLDDsrtvSEIPAIASILMRGVFQSAGQNCIGVERIIALPnAYDKLVETVSTRIARLRLGsilldsqtsa 426 Aspergillus nig...
XP_964629    314 AELGGKDASIILASap-kSDLPRIVNTLMRGTFQASGQNCIGIERIVVAPqHYDTLLSMLTPRVRALRLGpt-------- 384 Neurospora cras...
XP_503815    339 VELGGKDPCVVFDDd--gLDLKTIAHTILRGTFQAAGQNCIGFERVIAQPsAYKTLLDIFRETIPKLRVGagidq----q 412 Yarrowia lipoly...
XP_001646740 342 VELCGKDSYIVLESq---KDVSSVSSLILRTTFQSSGQSCIGIERIIVSSkRYKQTVQLLKDRLTTQPLRlgsdmd--hl 416 Vanderwaltozyma...
Q9P7K9       238 LELGGKDPCILTDD----HRLEEILSIVMRGVFQSAGQNCIGIERIIALDgVYDTIITKLYNRISTMRLGmytq------ 307 fission yeast
P38694       353 VELGGKDAFIVLDSa---KNLDALSSIIMRGTFQSSGQNCIGIERVIVSKeNYDDLVKILNDRMTANPLRqgsdid--hl 427 baker's yeast
XP_001690075 241 LELGGKDAVIVTED----ADLDNLVQVVLKAAFLNCGQNCAGGERFFVHEkIYDKFLERLTPLVAGLRQGnplg-----d 311 Chlamydomonas r...
XP_001747510 329 LELGGKDAAIICED----CDFDQAVNLALRGTFQNCGQNCIGLERLIVHEgVYDKMVATLAPKVQALVQGcpad------ 398 Monosiga brevic...
XP_845539    310 LELGGKDPAIVCDD----ADLEHVVPIIMRGTFQNCGQNCVGLERVIVQEsIHDRLLTILEKRVRALTQGpasv------ 379 Trypanosoma bru...
Feature 1                                                                                        
Q0WSF1       367 gryDMGAICLQEHSEHLQSLVNDALd-kGAEIAVRGsfghlgedavdQYFPPTVLINVNHnMKIMKEEAFGPIMPIMQFS 445 thale cress
XP_001396713 427 gtpDVGAMISPASFDRLESLIADAVk-qGARLICGGkrfqhpehplgHYFTPTLLVDVTPtMKIAQQELFAPVFLVMRAS 505 Aspergillus nig...
XP_964629    385 --aDVGAMISDNAFARLEGLVADAVk-qGARLLAGGkryahpeypsgHYFVPTLLVDVTPdMAIAQEECFGPIMVVMRAA 461 Neurospora cras...
XP_503815    413 ddvDVGACISNMHFDRLEELIADAVa-qGAELVAGGhryphpkypqgHYFQPTLLVGVTAdMEIAQTEVFGPVLTMMQAE 491 Yarrowia lipoly...
XP_001646740 417 eniDVGAMISPKTFDSLEELIKDAVe-sGATLICGGsrynhpnypqgHYFQPTLLVDVTSdMKIANSDLFGPILLVMKAN 495 Vanderwaltozyma...
Q9P7K9       308 ndvDMGAMVSNNRFDHLESLIQDAVs-kGARLVYGGhrfqhpkypkgNYFLPTLLVDATNeMKIAQEECFAPIALVFRAK 386 fission yeast
P38694       428 envDMGAMISDNRFDELEALVKDAVa-kGARLLQGGsrfkhpkypqgHYFQPTLLVDVTPeMKIAQNEVFGPILVMMKAK 506 baker's yeast
XP_001690075 312 apvDCGAMCMPGLAEKVHGLVTEAVs-rGARLLAGGvlvps-gerggQFYPPTLLADVRPgMKIWEEEVFGPVMSVIKWS 389 Chlamydomonas r...
XP_001747510 399 gdvDCGAMTMGVASAQKIEELVQRAvaqGARCLAGGmmhqg-qqgvaGYMTPTLLVDVTPdMDIAQHEVFGPVMTVMKAR 477 Monosiga brevic...
XP_845539    380 glyDLGAMTMGEDAVRKIQKLVDDSvdaGATLVCGGkg-------gtSFFPPTILTNVTPsVPIAREEVFGPVLVMMKFK 452 Trypanosoma bru...
Feature 1                                                                                        
Q0WSF1       446 t--dEEVIKLANDSRYALGCAVFSGs-kHRAKQIASqIQCGVAAINDFasNYMCQsLPFGGVKDSGFGRFAGIEGLRACC 522 thale cress
XP_001396713 506 s--vPHAISIANSTDYGLGASVFGYn-qTDIAKCVAnIKSGMVSVNDFg-SYYAVqLPFGGVKGSGYGRFAGEEGLRGVS 581 Aspergillus nig...
XP_964629    462 sssaEDILAVANAPDFGLGSSVFGSewdSTLHEVVRgLKAGMVAVNDFg-ATYAVqLPFGGVAGSGYGRFAGEEGLRGLC 540 Neurospora cras...
XP_503815    492 t--vDQAIDLANSTIYGLGAAVFGAn-tVTLRKAINdIKSGNIAVNDLa-AFYVCqLPFGGCKGSGYGKFGGEEGLQGLC 567 Yarrowia lipoly...
XP_001646740 496 s--dEDCITIANAAPYAVGTCVFGKn-vKQCRYVAKkLKTTDVTINDFt-TFYVRqTPFGGISGSGSGKFGSKEGLLSLC 571 Vanderwaltozyma...
Q9P7K9       387 s--pEHALEIANGTEFGLGASVFGRd-kQLCQYFTDnLETGMVAVNDFg-AFYLLqMPFGGCKKSGYGRFAGYEGLRGIC 462 fission yeast
P38694       507 n--tDHCVQLANSAPFGLGGSVFGAd-iKECNYVANsLQTGNVAINDFa-TFYVCqLPFGGINGSGYGKFGGEEGLLGLC 582 baker's yeast
XP_001690075 390 t--dDEVVALANDCDFGLGSNVFAGs-qARARSIASrLEAGMSSINDFatTYMCQsLPFGGVKHSGFDRFAGVEGLRGLC 466 Chlamydomonas r...
XP_001747510 478 d--dADAVRIANSVEYGLGSSVFSRn-yARAERIANqLTTGMCNINDFgvNYLCQaLPFGGVNISGFDRFAGVEGLRGCC 554 Monosiga brevic...
XP_845539    453 t--dAEAVELVNACEYGLGSSVFSSd-iERAKHIADqLVTGMTNVNDFgiNYLCQsLPFGGVKISGFDRFAGVEGLRGNC 529 Trypanosoma bru...
Feature 1                 
Q0WSF1       523 LVKSVVEDR 531 thale cress
XP_001396713 582 NIKAVCVDR 590 Aspergillus niger CBS 513.88
XP_964629    541 NIKAVCEDR 549 Neurospora crassa OR74A
XP_503815    568 LAKSVAFDS 576 Yarrowia lipolytica CLIB122
XP_001646740 572 YTKSISFNI 580 Vanderwaltozyma polyspora DSM 70294
Q9P7K9       463 NSKAIAYDR 471 fission yeast
P38694       583 NAKSVCFDT 591 baker's yeast
XP_001690075 467 VPKAVAEDR 475 Chlamydomonas reinhardtii
XP_001747510 555 LMRSITSDR 563 Monosiga brevicollis MX1
XP_845539    530 VVRASTTDR 538 Trypanosoma brucei TREU927

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