Conserved Protein Domain Family
ALDH_KGSADH-YcbD

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cd07097: ALDH_KGSADH-YcbD 
Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like
Kinetic studies of the Bacillus subtilis ALDH-like ycbD protein, which is involved in d-glucarate/d-galactarate utilization, reveal that it is a NADP+-dependent, alpha-ketoglutaric semialdehyde dehydrogenase (KGSADH). KGSADHs (EC 1.2.1.26) catalyze the NAD(P)+-dependent conversion of KGSA to alpha-ketoglutarate. Interestingly, the NADP+-dependent, tetrameric, 2,5-dioxopentanoate dehydrogenase (EC=1.2.1.26), an enzyme involved in the catabolic pathway for D-arabinose in Sulfolobus solfataricus, also clusters in this group. This CD shows a distant phylogenetic relationship to the Azospirillum brasilense KGSADH-II (-III) group.
Statistics
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PSSM-Id: 143415
View PSSM: cd07097
Aligned: 21 rows
Threshold Bit Score: 690.142
Threshold Setting Gi: 33598663
Created: 30-Dec-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:catalytic residues [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
P42236        10 YLNFINGEWVKSQSgdmvkvENPADVNDIVGYVQnstaeDVERAVTAANEAKTAWRklTGAERGQYLYKTADIMEQRLEE 89  Bacillus subtil...
YP_177302      5 YLNYIDGEWKPSISgnvfygRNPANYEEILGAYQastaeDARLAIKSAAAAFPNWKnkSAIERADVLYQLMPLLAAEKEK 84  Bacillus clausi...
YP_643330      8 SRNYIGGEWVPADSgeveevRNPARPSEVLGTAPrsdrgEMERAVAAAQEALPGWRsaLPAARGQILLRAADIIDSRSEE 87  Rubrobacter xyl...
YP_256299      2 EKGVYIGKLVKPVDrewyevRNPADYREIVSKFPrlhrkDVVDAIKIAKESYEKWReyTAYERAKILFKTADILESRMQE 81  Sulfolobus acid...
YP_137466      5 YENYIDGEWTGSGEtq--evTNPADETDVVSTVPvasaaDADEAVAAAAAATDEWGemPGPERGAILRETGEILKSRKDE 82  Haloarcula mari...
YP_822252      2 FANYINGEWIAAGAtf--enRNPANTDEVVAVMAkgsaaDIAAAADAAGAAFPAWSamSGPARGNILYKAADILDKTFDS 79  Solibacter usit...
YP_001541592   3 ERGVFIGKLIIPRDrefyeiRNPADTRQVVAKFPrlrrdDAREAIGVAKEAFAKWGktLPVERARILYKVADIIESRADE 82  Caldivirga maqu...
Q97UA1         8 ADKWIKGSGEEYLD------INPADKDHVLAKIRlytkdDVKEAINKAVAKFDEWSrtPAPKRGSILLKAGELMEQEAQE 81  Sulfolobus solf...
NP_885014      4 ITSLIDGQWAGGAGds--enINPSDLSAPVCLVAqasaqQAAQAVEAARRAQPGWAatGLAARAQILKDIGRGIVANSQQ 81  Bordetella para...
NP_887762      5 YRSFVAGQWQDGGEpv--alYNPSDLQEEAGVYMhapveMVNQAVRAAEEALDAWRglHAMARSRLLDGIADGLVRRRDE 82  Bordetella bron...
Feature 1                                                                           #            
P42236        90 IAACATREMGKTLpEAKGETARGIAILRYYAGEGMRKTGDVIPStDKDALMFTTRVPLGVVGVISPWNFPVAIPIWKMAP 169 Bacillus subtil...
YP_177302     85 LAAIITKEVGKTMaAARKEVDASIQALKHFSGAANRLAGETVPAgNPETFAYTIKEPLGPVGVITPFNFPLGIGIYKIAP 164 Bacillus clausi...
YP_643330     88 LARLMALEAGKPLgESRAEVSRAAAIFRYYGSEGWRLYGVEAPStRPGVRITSTREPLGVVGLITPWNFPLAIPSWKMAP 167 Rubrobacter xyl...
YP_256299     82 IAKTLTMEEGKTLgESAYEVERVTSLLRYYGGLTLNSHGKTLQSsMKNSMHLTVREPIGVVGIITPWNFPFLIPGWKIAP 161 Sulfolobus acid...
YP_137466     83 LAETLTREEGKPLgEAEGEVQRAIDIFYYYAEKARDFGGTVKQPsGGRAGLQTKKEPMGVAALITPWNYPIAIPAWKIAP 162 Haloarcula mari...
YP_822252     80 VAADMTREEGKTLpEAKGEVRRAINILRYFAGEGSRLPGMLVPSeRDRVHMFALRKPVGVVGLITPWNFPSAIPAWKLAP 159 Solibacter usit...
YP_001541592  83 MARTLTLEEGKTLpDSMFEVVRTVNLLRFYAGLITRGQGKVISSqDRNTIIMTTREPLGVISVITPWNFPLSLPAWKIIP 162 Caldivirga maqu...
Q97UA1        82 FALLMTLEEGKTLkDSMFEVTRSYNLLKFYGALAFKISGKTLPSaDPNTRIFTVKEPLGVVALITPWNFPLSIPVWKLAP 161 Sulfolobus solf...
NP_885014     82 LAHILASEQGKTLpEARGEVQRAADIFDYYAGEVFRLGGEMFPSiRAGVEVEISREPLGVVALITPWNFPIAIPAWKTAP 161 Bordetella para...
NP_887762     83 LAMAIAREQGKPLrDALAEATRAADIFRYFASETIRQKGYTYASiRPGVRVEVQRNPVGVVALVTPWNFPVVIPAWKAAA 162 Bordetella bron...
Feature 1                                                                                        
P42236       170 ALVYGNTVVIKPATETAVTCAKIIACFEeaGLPAGVINLVTGPGSvVGQGLAEHdgVNAVTFTGSNQVGKIIGQAALa-- 247 Bacillus subtil...
YP_177302    165 ALIAGNTVVYKPHNDTVQIAARLVELFIeaGTPKGVLNLVTGDGDkVGQELGENrtLKAISFTGSSDVGLRLGRSVTn-- 242 Bacillus clausi...
YP_643330    168 ALICGNTVVIKPAANAVLNAAELVRILEeaGLPGGVVNLVMGPGGsSGDALVRDerVRAISFTGSTAVGLSIQERAA--- 244 Rubrobacter xyl...
YP_256299    162 ALATGNTVVFKPASNTPTVAFELVNALYeaGLPEGVVNLVTGSGReVGDEIVTNkeIKAVSFTGSLEVGREVNSKIGn-- 239 Sulfolobus acid...
YP_137466    163 ALAVGNTVVIKPAMQAPTVGAMIVEALDeaGIPDGAINLVCGPGSeVGEQLTTHddVDVVSFTGSASVGEHVYEQATs-- 240 Haloarcula mari...
YP_822252    160 ALICGNTVVIKPASAAPLSAWRIVEALHqaGIPKGVVNFIAGSGGeLGQALVNAapLKAVSFTGSCEIGDWLHAEASk-- 237 Solibacter usit...
YP_001541592 163 AIATGNTVVWKPASITPTIAYELVKAFYdaGLPEGVLNLVTGSASeVGDELVTNkdVDAITFTGSLQTGKEINEKVGrmn 242 Caldivirga maqu...
Q97UA1       162 ALAAGNTAVIKPATKTPLMVAKLVEVLSkaGLPEGVVNLVVGKGSeVGDTIVSDdnIAAVSFTGSTEVGKRIYKLVGnkn 241 Sulfolobus solf...
NP_885014    162 ALACGNAVVLKPSEFTPATAVMLAEIIRaaGVPDGVFNLVLGTGAdVGQVLTGHpaVAGVSFTGSSATGRKIAASAVa-- 239 Bordetella para...
NP_887762    163 ALAYGNTVVMKPSEIAPCGAWILADVMReaGLPAGVFNLVLGAGQ-AGAALVAHeaVAAVSFTGSVATGKRIAAAAA--- 238 Bordetella bron...
Feature 1               #                              #  #                                      
P42236       248 rGAKYQLEMGGKNPVIVADDADLEAAAEAVITGAFRSTGQKCTATSRVIVQsgIYERFKEKLLQRTKDItIGDSLKEdVW 327 Bacillus subtil...
YP_177302    243 rGGKMQAEMGGKNATVILEDADLDKAVSGIVISGLLNNGQSCTGTSRVIVPknIAKTVTSKLVEKATAIrVGDGFNEnVE 322 Bacillus clausi...
YP_643330    245 -GKKVQLEMGGKNPYVVMEDADLEDAAAKVAYGAFGYAGQKCTASSRAVVVeeVYEAFLEQVVEATRALkLGEPLDEeAV 323 Rubrobacter xyl...
YP_256299    240 rFTRLQLELGGKNATVLTKNGDFNLAIEHVTWSVMVNTGQVCLATSRFLVPkeLHDKAVNAMTESFKSLvVGNALKQpVH 319 Sulfolobus acid...
YP_137466    241 nGKRAQAEMGGKNPTVVMPSADVDKAADIVGAGAFGGTGQACTATSRAIVHedVYDEFLDAIVDYAESLeIGDGLDR-AG 319 Haloarcula mari...
YP_822252    238 rRLRIQLEMGGKNPTIVLADADFGSAVENVVNAAFFSTGQKCTATSRAIVEdaIYDKFVAAVVARTRKLkVGDGMQPgID 317 Solibacter usit...
YP_001541592 243 rFIRVQLELGGKNATVLSKNGDINLAVELTARSAFGLTGQACTATSRFLVPedMHDEVLSKLIERTKKIvVGNGLKSgVD 322 Caldivirga maqu...
Q97UA1       242 rMTRIQLELGGKNALYVDKSADLTLAAELAVRGGFGLTGQSCTATSRLIINkdVYTQFKQRLLERVKKWrVGPGTED-VD 320 Sulfolobus solf...
NP_885014    240 gHKKLQMEMGGKNPLVVLDDADLEIALACALDGAFHATGQRCTASSRLIVTpgIHDRFVQELAQRVMALnVGHALDErSQ 319 Bordetella para...
NP_887762    239 -GKRIQLEMGGKNPLIVLDDADLDTAVACAIDGAFLYAGQRCTASSRIIVTegIHAAFVKRLLAQTASLaVGHALDEaTV 317 Bordetella bron...
Feature 1                                                                                        
P42236       328 MGPIASKNQLDNCLSYIEKgkqeGASLLIGGEKLengk-yqnGYYVQPAIFDNVtseMTIAQEEIFGPVIALIKVDsIEE 406 Bacillus subtil...
YP_177302    323 NGPVANEAQLQKYLHYVDIavkeGAKLECGGKRLfgeg-kdkGYFVAPTVLSGVtpeMTIAQEEVFAPVVAIMEVDsFDE 401 Bacillus clausi...
YP_643330    324 IGPVINESQYESILGAIEQaredGRVVLDGGATGpr----eeGYYISPVIVADVdngSKTAREEIFGPVLAVIKARdFDH 399 Rubrobacter xyl...
YP_256299    320 MGPLSSRDQYEKVLGYVEIgkdeGAKLVYGGEPIkged-ydyGYFVKPTIFDNVtkdMRIAKEEIFGPVLAIMTYEsLDE 398 Sulfolobus acid...
YP_137466    320 MGPHVSEDELAGSLEYIDVaqseGATLETGGEELtsge-ydgGNFISPAVFSDVepdMRIAQEEVFGPVLAVMSVSdFDE 398 Haloarcula mari...
YP_822252    318 IGPCVDQSQMETVLRYIEIgrkeCGEPACGGKRLtega-lakGYFVEPTVFAGVtpdQTIAREEIFGPVLAIMRARdFED 396 Solibacter usit...
YP_001541592 323 MGPLASKEQYDKILSYIEIgrneGAKLVYGGQPIkgseefdhGYFVMPTIFDGVtpdMRIAKEEIFGPVLAVMTYRtLDE 402 Caldivirga maqu...
Q97UA1       321 MGPVVDEGQFKKDLEYIEYgknvGAKLIYGGNIIpg-----kGYFLEPTIFEGVtsdMRLFKEEIFGPVLSVTEAKdLDE 395 Sulfolobus solf...
NP_885014    320 IGPVSNGAQFDKDLSYIALar-dEAQRVIGGAALqra---qrGYYLQPCLALDVsldARIAREEVFGPLACVLRAQdYEH 395 Bordetella para...
NP_887762    318 IGPVVNAEQFEKNRRYADLar-qEGGTVAGGRALsrp---trGHYFEPCLVTGLdnsATVCREEVFGPFACVLTARdYEH 393 Bordetella bron...
Feature 1                                                                                        
P42236       407 ALNIANDVKFGLSASIFTEnIGRMLSFIDeIDAGLVRINAeSAGVELQAPFGGMKQSs-SHSREQGEAAKDFFTAIKTVF 485 Bacillus subtil...
YP_177302    402 AIAVANQTDFGLSSAIYTTnLQKAHEFVRrVETGVTHINIpSNHYENQLPFGGKKNSs-IGPREQGSTALDFWVDTKAVY 480 Bacillus clausi...
YP_643330    400 AVEIANDTRYGLTAGIATRsLRYAEEFIErSQTGLVNVNLpTAGVEFQVPFGGSKQSg-VGGREQGMAAIEFYTGWKTAS 478 Rubrobacter xyl...
YP_256299    399 AIEIVNSTDYGLTAEIVTNnLNEAMKFSEgVEAGVVKVNRpTVELDQWVPYGGFKGSgnDVYKELGEEALDFYTKIKAVH 478 Sulfolobus acid...
YP_137466    399 GVEVANDIDYGLSASIVTDrIKEENEFIErSESGVVKVNEkTTGLELHVPFGGLKRSstNTYREQGDAGLEFFSYIKTVY 478 Haloarcula mari...
YP_822252    397 AMSIANSIPFGLSSSIQTTnLSRAFEYIYrAEAGLLTVNLpSAGVEYQLPFGGTKDSs-FGPKEQGPAALEFYSDYKTVY 475 Solibacter usit...
YP_001541592 403 AIDIVNSTEYGLIAGIVTRdISEAAKFTEgVKVGVVKVNKpTIGLEPWVPYGGVKGSgnDMYKEMGEEAVEFFTRIKAIY 482 Caldivirga maqu...
Q97UA1       396 AIRLVNAVDYGHTAGIVASdIKAINEFVSrVEAGVIKVNKpTVGLELQAPFGGFKNSgaTTWKEMGEDALEFYLKEKTVY 475 Sulfolobus solf...
NP_885014    396 ALAIANDTEYGLSAGICTQsLKHATHFRRhVQSGLAMVNMpTSGVDFHVPFGGRGASs-YGSSEQGHYAREFFTSLKTSY 474 Bordetella para...
NP_887762    394 ALAIANDTPFGLSSGLCTTsMKHAQHFKAhTKSGLASINTsTSGVDFHVPFGGNGASs-YGPREQGEFAIEFFTTLRTVY 472 Bordetella bron...
Feature 1         
P42236       486 V 486 Bacillus subtilis subsp. subtilis str. 168
YP_177302    481 L 481 Bacillus clausii KSM-K16
YP_643330    479 V 479 Rubrobacter xylanophilus DSM 9941
YP_256299    479 L 479 Sulfolobus acidocaldarius DSM 639
YP_137466    479 R 479 Haloarcula marismortui ATCC 43049
YP_822252    476 L 476 Solibacter usitatus Ellin6076
YP_001541592 483 V 483 Caldivirga maquilingensis IC-167
Q97UA1       476 E 476 Sulfolobus solfataricus
NP_885014    475 I 475 Bordetella parapertussis 12822
NP_887762    473 I 473 Bordetella bronchiseptica RB50

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