Conserved Protein Domain Family
ALDH_F21_LactADH-like

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cd07094: ALDH_F21_LactADH-like 
ALDH subfamily: NAD+-dependent, lactaldehyde dehydrogenase, ALDH family 21 A1, and related proteins
ALDH subfamily which includes Tortula ruralis aldehyde dehydrogenase ALDH21A1 (RNP123), and NAD+-dependent, lactaldehyde dehydrogenase (EC=1.2.1.22) and like sequences.
Statistics
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PSSM-Id: 143413
View PSSM: cd07094
Aligned: 6 rows
Threshold Bit Score: 625.227
Threshold Setting Gi: 51317969
Created: 29-Oct-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:catalytic residues [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
Q58806     13 MDVINPYSLEVIKkipalsreEAKEAIDTAEKYKEVMKn-lPITKRYNILMNIAKQIKeKKEELAKILAIDAGKpikQAR 91  Methanocaldococcus...
Q8RYB8     24 LDVTNKYTGEVGAkvqlathdDVDKAIDAAVAAAPAMAa-lGAFERKAILEKTVAELKkRAEEIAQILTMESGKpikDAR 102 Tortula ruralis
AAU00094   14 TTVHDRWTGEPVGtvp---rdGAEEAAAAVAALAAGRRa-tTPQQRSAVLTRAADMLTaRAEEFSTLITAESGVcrkETL 89  Streptomyces virid...
NP_614391  18 IVVENPYDGSEVGrvla-pevDVEALLKDAREGQRRWRe-rPTYEVREALAEAAHLLKkHEDELAELIALEGGKpirDAR 95  Methanopyrus kandl...
YP_765919   2 LEVVQAFDRKHIAdlptddaaALESKLETARARFLNRNdwlAPHERMAVLRRLADLVGlQREVFAKRIACEGGKpytDAL 81  Rhizobium legumino...
Q53197     58 IAVHSPYDGSLLGsveatdpaDIDRLLATARRGAEISRn-lPRHKRASILEGAAQMVEsRHDAFAEIIVREAGKtivQAR 136 Rhizobium sp. NGR234
Feature 1                                                           #                         
Q58806     92 VEVERSIGTFKLAAFYVkehRDEVIPSd------dRLIFTRREPVGIVGAITPFNFPLNLSAHKIAPAIATGNVIVHHPS 165 Methanocaldococcus...
Q8RYB8    103 GEVARTIDTFQVAAEESvriYGEHMPLdisarnkgPQGIVKKFPIGPVSMVSPWNFPLNLVAHKVAPALAVGCPFVLKPA 182 Tortula ruralis
AAU00094   90 REVSRAAGNLRVAAAEAeriRGESIPLpd----gtRLAVTLPEPVGVVLGITPFNRPLNQVVVKAAPALAAGCPLLLKPS 165 Streptomyces virid...
NP_614391  96 YEVYRTREVLRLSAAEAerlYGETLPGdaqrgrtaELILTVREPVGVVLSITPYNFPLLLPTHKLGPALAARCSVVHKPA 175 Methanopyrus kandl...
YP_765919  82 VETDRAIDGIRNAADVLrtrGGVEIPMgltqasdnRRAWTIQEPIGVVAAISAFNHPLNLIVHQMAPAIATGCPVIIKPA 161 Rhizobium legumino...
Q53197    137 KEVLRCVNTLKLSAEEAkrnAGEIVPFdaytgseqRQGWFTRDPLGIITAITPYNDPLNLVAHKLGPAIAGGNAVMLKPS 216 Rhizobium sp. NGR234
Feature 1                                                                                #    
Q58806    166 SkaPLVCIELAKIIENalkkyNVPLGVYNLLTGAGEvvGDEIVVNEkVNMISFTGSSKVGELITKKa-gFKKIALELGGV 244 Methanocaldococcus...
Q8RYB8    183 SrtPLSALILGDILVPd---rGAAKGAFSVLPVSRAd-ADMFTVDErFKLLTFTGSGPVGWDMKARa-gKKKVVMELGGN 257 Tortula ruralis
AAU00094  166 EktPLTALAFAELLVEa----GCAKDMLAVVTGEPGevGPPLAAHPdVAMVTFTGSVATGHAVAAQa-aGKRQLLELGGN 240 Streptomyces virid...
NP_614391 176 TvtPLSSLRLAEILLDa----GVEPLALQVVVGPGAelGEELARAD-FDALSFTGSRSVGEHLREIs-pIPRITLELGGN 249 Methanopyrus kandl...
YP_765919 162 AatPLCCLELVKLVHEa----GMPEGWVQAFLPESRvlSSAFASDArIAFLSFIGSAEVGWRLRANlapGTRCALEHGGV 237 Rhizobium legumino...
Q53197    217 NltPFSAIKLVGALREa----GLPEEVITISHGDREl-VTAMIAAReVRMVSFTGGFATGEAISRAa-gLKKLAMELGGN 290 Rhizobium sp. NGR234
Feature 1                                #  #                                                 
Q58806    245 NPNIVLKDa-DLNKAVNALIKGSFIYaGQVCISVGMILVDesiADKFIEMFVNKAKVLnVGNPLDEkTDVGPLISVEHAE 323 Methanocaldococcus...
Q8RYB8    258 APCIVDDYvpDLDYTIQRLINGGFYQgGQSCIHMQRLYVHerlYDEVKAEFLAQVKKLkVGNPFEDdTFIGPMISEKDAT 337 Tortula ruralis
AAU00094  241 DPLFVLPDa-DLRRAAKLAADGSCATaGQSCRGIKRVFVWeevADEFTALLEPAVAAKrAGDPRREdTDLGPLVSEEAAL 319 Streptomyces virid...
NP_614391 250 DPVIVDETa-DVEAAAEAAVRGACYHaGQVCIAVERAIVVedvYEEFLEAAVEVAESLkVGDPLDEdTDVGPLIDDGAVE 328 Methanopyrus kandl...
YP_765919 238 APVIVDRSa-DLDAIIEPLAKGGYYHaGQVCVSVQRIYVHaelKEAFIERFAARVEQLrVGDPTHAeTEVGPLITPAEAT 316 Rhizobium legumino...
Q53197    291 APVIVMNDc-DFDKAVEGCVSGAFWAaGQNCIGAQRILIQselYGRFRDAFVAATKKLkAGDPLQEdTDVGPMISKQVAE 369 Rhizobium sp. NGR234
Feature 1                                                                                     
Q58806    324 WVEKVVEKaideGGKLLLGGKRdkALFYPTILEVDr-dNILCKTETFAPVIPIIRTN-EEEMIDIANSTEYGLHSAIFTN 401 Methanocaldococcus...
Q8RYB8    338 RVEDWVKEavekGGKLLCGGSRkgAVMQPTVLEDVpmdAMARKEEIFGPVVLFYKYSdFKEAVKECNNTHYGLQSGIFTK 417 Tortula ruralis
AAU00094  320 VVERRIARavrdGARLVTGGERdgALVRPAVLDHVppdTELVTEETFGPVAPVIRVRdADEAVRLSNGTAYGLQAGVLTR 399 Streptomyces virid...
NP_614391 329 KVRRHVEDaverGAEILTGGEPegRLFPPTVLADVpedALVAREETFGPVLPVIRAKdFEEAIRIANSTDYGLHAAVFTE 408 Methanopyrus kandl...
YP_765919 317 RVETWIDEaataGARRIGGGRLsdTTLKPAILVDPprdTKVSTHEIFGPVTCIYGYDeVEDAIAAANSLPVAFQASIFTR 396 Rhizobium legumino...
Q53197    370 RTEAAVNEaikaGATLLCGNYRegSLYHPTVLEGTpltCRLWHEEVFAPVVMLAPFDtLDKGIEMANDPDYSLHAGIFTN 449 Rhizobium sp. NGR234
Feature 1                                                                 
Q58806    402 diNKSLKFAEnLEFGGVVINDSslFRQDNMPFGGVKKSGLGREGVKYAMEEMSNIKTIII 461 Methanocaldococcus jannaschii
Q8RYB8    418 dlNKAFYAFEhMEVGGVILNDSpaLRVDSQPYGGLKDSGIQREGVKYAMEDYLETKVLVM 477 Tortula ruralis
AAU00094  400 dsAAFWDIAArLRVGAVNLGEGphFDSPHIPFGGVKSSGVGREGIRYAIAEMTVTKTVTL 459 Streptomyces viridochromogenes
NP_614391 409 rlDRAVKATRkLEAGGVIVNEStiYRADYMPFGGVKASGVGREGVPQAVREFTEEKTVVI 468 Methanopyrus kandleri AV19
YP_765919 397 dlDVAFNAAEkLDASAVMVNDHsaFRTDWMPFAGRRESGYGVGGIPFTAREMTAEKMIVF 456 Rhizobium leguminosarum bv. viciae 3841
Q53197    450 dlNVALEAANrIEVGGVMINDSsdYRFDAMPFGGFKYGSMGREGVRFAYEDMTQPKVVCI 509 Rhizobium sp. NGR234

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