1WNB


Conserved Protein Domain Family
ALDH_ABALDH-YdcW

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cd07092: ALDH_ABALDH-YdcW 
Click on image for an interactive view with Cn3D
Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like
NAD+-dependent, tetrameric, gamma-aminobutyraldehyde dehydrogenase (ABALDH), YdcW of Escherichia coli K12, catalyzes the oxidation of gamma-aminobutyraldehyde to gamma-aminobutyric acid. ABALDH can also oxidize n-alkyl medium-chain aldehydes, but with a lower catalytic efficiency.
Statistics
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PSSM-Id: 143411
View PSSM: cd07092
Aligned: 16 rows
Threshold Bit Score: 671.73
Threshold Setting Gi: 111019883
Created: 14-Dec-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:NAD binding site [chemical binding site]
Evidence:
  • Structure:1WNB; Escherichia coli YdcW gamma-aminobutyraldehyde dehydrogenase complexed with NADH, defined using 3.5 A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
1WNB_B        42 VYNPATGDVLLEIAEasaeQVDAAVRAADAAFAEWgq--tTPKVRAECLLKLADVIEENGQVFAELESRNCGKPlh-sAF 118 Escherichia coli
YP_001840011  23 IEDPATGKKIATVVDasatDVDKAAKAAHKAFYDGrwsglTPSERSKAIWKLADLLEEKTKEFAKWESLNAGKPyknlSL 102 Leptospira bifl...
YP_476962     22 IENPATGEKLAEAVDaspaDVDRAVQAAQTAFYDGrwsklTPGERSLALWKLADLIEARAPELARVESENTGKPyeflSL 101 Synechococcus s...
NP_823768     36 VVDPATGEEVYRYELagtaDVDAAVAAARAAFPGWaa--tTPGDRSDALHRFAAVLADRAEEFARAESLQCGKPlk-lTR 112 Streptomyces av...
ZP_00958887   21 VLDPATGTQVAEVAEatpeQIAAATRAAHEAFESYrl--sTPSERAAHLLAVADVIEANIEELAELETLDVGKPwp-mAR 97  Roseovarius nub...
YP_001105972  43 LVDPSTGEEFGISPLtrwmDVDAVMGVAAAAFESWsq--tTPRRRQQLLLRIADAMEERSEELVAAECRNTGKPra-vVR 119 Saccharopolyspo...
NP_629787     27 VVNPATGEAYATAPLsgqaDVDAAMAAAAAAFPAWrd--lVPAERQKALLKIADAFEERAEELIAAEVENTGKPig-lTR 103 Streptomyces co...
NP_929595     25 LISPVTGETYARSPNatiaDVNEAYASAKEAFKIWgr--sTPSARQQALLALADAVEKNSERLIEAQSRNTGQLkh-lIA 101 Photorhabdus lu...
YP_946547     21 FFDPATGQQIGTAPDsdaaAVDAAFQAAAAAFKRYkr--tTPGTRQSLLLQLADLIEANVDRLLEAEVACTGKPsa-lTK 97  Arthrobacter au...
YP_001701565  12 IVDPRTGEGYEFQPDsthgEVDAAFSAAHEGWRNWrg--tTPAERQIALIAFADAIESQSDQLVAIEQRNTGKTr--eQA 87  Mycobacterium a...
Feature 1                                                       ## #                       # ##  
1WNB_B       119 NDEIPAIVDVFRFFAGAARclnGLAAGEYLEgHTSMIRRDPLGVVASIAPWNYPLMMAAWKLAPALAAGNCVVLKPSEiT 198 Escherichia coli
YP_001840011 103 AGDIPFAIDNIRFFATAARdvhGSRANEYQPgYTSILRREPVGVVGQIAPWNYPLLMAVWKFGPALAAGCTVILKPAPgT 182 Leptospira bifl...
YP_476962    102 GGDLPFAVDNLRFFAAAARdihGFSAGEYAKgYTSLFRKEPVGVCAQITPWNYPLMMAVWKIGPALAAGCTVVLKPAPaT 181 Synechococcus s...
NP_823768    113 EFDVPGTIDNTSFFAGAARhlqGQSAGEYSGdHTSYIRREPIGVVGSIAPWNYPLQMAAWKVLPAIAAGNTIVLKPAEiT 192 Streptomyces av...
ZP_00958887   98 DEEMPLTIDTFRFLAGAARtmgGSAAGEYVAgHTSMIRRDPIGPVASIAPWNYPLMMAAWKIAAPLAAGCTMVLKPSEiT 177 Roseovarius nub...
YP_001105972 120 DDELPTAVDLIRFYAAAARvqeTGAATEYQPsRTSFARREPIGVCAQVTSWTHPLLLAAAKFAPALAAGNTVVLKPAEtT 199 Saccharopolyspo...
NP_629787    104 SEEIPPMVDQIRFFAGAARmleGRGAGEYMEgLTSFVRREPIGVCAQVAPWNYPMMMAVWKFAPALAAGNTVVLKPSDtT 183 Streptomyces co...
NP_929595    102 SEEVAASVDHIRFFAGAARfleGKATAEYLPdMTTSIRREPLGVVGQVTPWNYPLMMAVWKIAPALAAGNTVVLKPSDtT 181 Photorhabdus lu...
YP_946547     98 ELEILRGADQLRFFAGACRvvsGTAQTEYVEgFSSTIRREPIGVVAQITPWNYPFMMAIWKIGPALAAGNTLVLKPADtT 177 Arthrobacter au...
YP_001701565  88 SDELSGALDEMRFMAGAQRalqGPLAGSYVPgTVSTSSRESLGVCAQILPWNYPLASAISKLAPALAMGNTSVLKPAApT 167 Mycobacterium a...
Feature 1                                   #    #             ###  #  #              # #        
1WNB_B       199 PLTALKLAELAKd-IFPAGVVNILFGRGktvGDPLTGHPkVRMVSLTGSIATGEHIISHTAssIKRTHMELGGKAPVIVF 277 Escherichia coli
YP_001840011 183 PITTLMLAELTKkaGIPDGVINIVTGGNa-tGQAIVDHPlVRMVSLTGSTGTGKNIMKSASdsLKRVHLELGGKAPLVVF 261 Leptospira bifl...
YP_476962    182 PLTTLMLGELIAeaGIPPGVVNIVTGGNa-tGQALVEHPqVRMVSLTGSTATGKQVMRTAAdtLKRVHLELGGKAPFIVF 260 Synechococcus s...
NP_823768    193 PLTSLLFAEAATraGIPDGVVNIVTGAGrdaGEHLVAHPdVAMTSFTGSTAVGRRVAEIATstVKRLHLELGGKAPFVVF 272 Streptomyces av...
ZP_00958887  178 PLATLRLAELLAd-VLPRGVLNVIHGGGasvGDALINDPrMEGISITGSPATGMAAMRAASrqIRHVHLELGGKAPVIVL 256 Roseovarius nub...
YP_001105972 200 PLSSSLLAEIASe-VLPPGVFNLICGDRd-sGRAMVAHEvPGMFSITGTVRSGMEVAGSTAadLKRAHLQLGGKAPAVVF 277 Saccharopolyspo...
NP_629787    184 PASTALMADIIGs-IVPKGVFNVVCGDRd-tGRLMVEHEtPAMASITGSVRAGMSVAESASkdLKRVHLELGGKAPVVVF 261 Streptomyces co...
NP_929595    182 PESTLLLAELAAp-FFPTGAFNVVLGNAs-aGALVVSHKtPAMVSITGSVRAGLQVASSAAanLTRAHLELGGKAPVVVF 259 Photorhabdus lu...
YP_946547    178 PWSTLVLGELAQq-VYPAGVVNIVCGGRe-aGAAMVDHDiPEMVSITGSTRAGAQVMSAASktLKDVHLELGGKAPAVVF 255 Arthrobacter au...
YP_001701565 168 PCSVQALLAIASe-TLPPGVVNAVFGGRe-tGQYMVAHHiPALISLTGSVRAGHEITRAAG--LKVLHLELGGNCPVIVL 243 Mycobacterium a...
Feature 1                               #                                              #         
1WNB_B       278 DDaDIEAVVEGVRTFGYYNAGQDCTAACRIYAQkgIYDTLVEKLGAAVATLksgapddestELGPLSSLAHLERVGKAVE 357 Escherichia coli
YP_001840011 262 DDvDINVFAAKATFGATCNSGQDCTAATRIIVPkaLQKKITEAVVDAMKAVkvgdpfgdktEMGPLISAIHRERVIGFMD 341 Leptospira bifl...
YP_476962    261 EDaDVETVAAKATFAATVNTGQDCTAATRVYVHesKLAQAQEAIVEAMRKVtvgspfeagvEMGPLVSAAQRERVMGFVE 340 Synechococcus s...
NP_823768    273 DDaDLDAAVHGAVAGSLINTGQDCTAATRAYVQrpLYEEFVARTAALMETVrlgdpfahgtDLGPLVSHAQRDRVAGFVD 352 Streptomyces av...
ZP_00958887  257 GDaDIGALAETIRYGSFFNAGQDCAQPCRLMVEasVYDKVLQAVTDQVGQIrigapraegtEMGPIVSEIQRDRVAGFID 336 Roseovarius nub...
YP_001105972 278 GDaDLDRAVRSIAEAAFGNAGQSCTAASRVLVSaeVHDEVVERLCELAAAMrpgppqdldaAFGPLNSLGQLESVQAHLE 357 Saccharopolyspo...
NP_629787    262 EDtDIPKAVEGISEAGYFNAGQDCTAATRVLVHesVHDEFVSALAKAASEIktgqpddedvMYGPLNNPNQLKQVSGFIE 341 Streptomyces co...
NP_929595    260 ADaDMDKAVETIATAGYFNAGQDCTAASRVLVHesVYDTFVAKLVAAAKATrfgypedeeaLYGPLNNARQLEQVKGFIA 339 Photorhabdus lu...
YP_946547    256 ADvDIQRTASEIALAAFFNAGQDCTAVTRVLVHqdIHTEFAAALADAASALkvgg---sdaDLGPLNSAAQLERVEGFMS 332 Arthrobacter au...
YP_001701565 244 GDvDVEAVAHEIAEAALYNAGQDCTAAARLIVAseVVDEFVAALTREFLAS----------RTVPLATREHLDRITALLA 313 Mycobacterium a...
Feature 1                                                   #                                    
1WNB_B       358 EakatgHIKVITGGEKrk--gnGYYYAPTLLAGalqddAIVQKEVFGPVVSVTPFDnEEQVVNWANDSQYGLASSVWTKD 435 Escherichia coli
YP_001840011 342 Rak-kqGAKILTGGGIpkgldkGYFFEPTVVTEvkqnfDIVQNEIFGPVLTIQTYDkEEEAVKLANDVNYGLASSIWTKD 420 Leptospira bifl...
YP_476962    341 Rak-aeGAKVLTGGRIpsqlaqGYYYEPTVIANvdqkaEIVQSEVFGPVLTLGSFReEAEALRLGNDVLYGLAASVWTQD 419 Synechococcus s...
NP_823768    353 Rar--aYARVVTGGEIpeelkdGAYYRPTLIADaaqdsEIVQSEIFGPVLVVLPFDsDDEGIRLANDTPYGLAASAWSRD 430 Streptomyces av...
ZP_00958887  337 Rar--gHAEIATGGASge--gpGYFYQPTVVANvdndaEIAASEVFGPVVTLSRIKdADEALRIANAAPYGLASSVWTRD 412 Roseovarius nub...
YP_001105972 358 Rlp--eHARIAAGGARrg--erGYFFEATVVTGveqddELVQNEVLGPLLTVQSFAsEQEALELANGVRYGLVASVWTRD 433 Saccharopolyspo...
NP_629787    342 Rlp--aHAKVEAGGHRvg--dkGYFYAPTVVSGlkqddEIIQREVFGPVITVQAFRdEDQAVEWANGVEYALASSVWTKD 417 Streptomyces co...
NP_929595    340 Rlp--aHACIETGGRQae--rsGYYFEPTVITGleqhdEAIQTEIFGPVITVQKFRdEQDAIEKANDVKYGLASSVWTRD 415 Photorhabdus lu...
YP_946547    333 Rlp--aNARVLSGGKRtg---tGFHFEPTVIDGvfqsdEVVCDEIFGPVLTVQPFAtEEEAIELANGTKYALASSVWSEN 407 Arthrobacter au...
YP_001701565 314 Rvp--kTARVECGGRRad--apGLYVEPTVVTNvaqddEIVTEEIFGPVVTVQQFEsADEAVALANDTEYGLAASIWTTE 389 Mycobacterium a...
Feature 1                                                                  
1WNB_B       436 VGRAHRVSArLQYGCTWVNTHfmLVSEMPHGGQKLSGYGKDMsLYGLEDYTVVRHVMV 493 Escherichia coli
YP_001840011 421 VARAMRVAKqLEFGTVWVNDHlpLASETPHGGFKQSGFGKDLsIESVGDYLITKHVMV 478 Leptospira biflexa serovar Patoc stra...
YP_476962    420 IGRAMRLAAdLEFGTVWINDHipIASEAPHGGFKQSGFGKDLsAEAVRDYQITKHVMI 477 Synechococcus sp. JA-2-3B'a(2-13)
NP_823768    431 VYRANRATReIKAGCVWVNDHipIISEMPHGGYKASGFGKDMsAYSFEEYTQIKHVMF 488 Streptomyces avermitilis MA-4680
ZP_00958887  413 LSAAMRLSSqLRYGMTWVNTHgvPTPEMPWAAMKGSGTGCDMsIYALDAYTSVRHVMV 470 Roseovarius nubinhibens ISM
YP_001105972 434 HSRAMRLSRkLQTGTVWINTHhpFTAEMPHSGFKHSASARDFgRYGLEEYSRIKHVMS 491 Saccharopolyspora erythraea NRRL 2338
NP_629787    418 HGRAMRMSKkLDFGCVWINTHipLVAEMPHGGFKKSGYGKDLsGYGFEDYTRIKHVMT 475 Streptomyces coelicolor A3(2)
NP_929595    416 HGRALRLSReLDFGTVWINTHipLTAEAPHGGFKSSGYGKDLsAYGFDEYTRIKHVMS 473 Photorhabdus luminescens subsp. laumo...
YP_946547    408 HGVVTRVSNeLDFGAVWINCHqvIPAEAPHGGFKHSGTGKDLsVYGLEDYTRIKSVTT 465 Arthrobacter aurescens TC1
YP_001701565 390 HSSAVALSQrIDAGTVWINTHgvYATEMPFGGFKSSGYGKDLsPLALENYSRVKHIMT 447 Mycobacterium abscessus

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