2O2Q,1BXS,1CW3


Conserved Protein Domain Family
ALDH_F1-2_Ald2-like

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cd07091: ALDH_F1-2_Ald2-like 
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ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins
ALDH subfamily which includes the NAD+-dependent retinal dehydrogenase 1 (RALDH 1, ALDH1, EC=1.2.1.36), also known as aldehyde dehydrogenase family 1 member A1 (ALDH1A1), in humans, a homotetrameric, cytosolic enzyme that catalyzes the oxidation of retinaldehyde to retinoic acid. Human ALDH1B1 and ALDH2 are also in this cluster; both are mitochrondrial homotetramers which play important roles in acetaldehyde oxidation; ALDH1B1 in response to UV light exposure and ALDH2 during ethanol metabolism. 10-formyltetrahydrofolate dehydrogenase (FTHFDH, EC=1.5.1.6), also known as aldehyde dehydrogenase family 1 member L1 (ALDH1L1), in humans, a multi-domain homotetramer with an N-terminal formyl transferase domain and a C-terminal ALDH domain. FTHFDH catalyzes an NADP+-dependent dehydrogenase reaction resulting in the conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO2. Also included in this subfamily is the Arabidosis aldehyde dehydrogenase family 2 members B4 and B7 (EC=1.2.1.3), which are mitochondrial, homotetramers that oxidize acetaldehyde and glycolaldehyde, as well as, the Arabidosis cytosolic, homotetramer ALDH2C4 (EC=1.2.1.3), an enzyme involved in the oxidation of sinapalehyde and coniferaldehyde. Also included is the AldA aldehyde dehydrogenase of Aspergillus nidulans (locus AN0554), the aldehyde dehydrogenase 2 (YMR170c, ALD5, EC=1.2.1.5) of Saccharomyces cerevisiae, and other similar sequences.
Statistics
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PSSM-Id: 143410
View PSSM: cd07091
Aligned: 25 rows
Threshold Bit Score: 742.489
Threshold Setting Gi: 46122907
Created: 14-Dec-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
NAD(P) bindingcatalytic
Conserved site includes 25 residues -Click on image for an interactive view with Cn3D
Feature 1:NAD(P) binding site [chemical binding site]
Evidence:
  • Structure:2O2Q: rat 10'formyltetrahydrofolate dehydrogenase in complex with NADP+, defined using 3.5 A.
    View structure with Cn3D
  • Structure:1CW3; Human mitochondrial aldehyde dehydrogenase (ALDH2) complexed with NAD+ and Mn2+, defined using 3.5 A.
    View structure with Cn3D
  • Structure:1BXS; Sheep liver cytosolic aldehyde dehydrogenase (ALDH1) complexed with NAD+, defined using 3.5 A.
    View structure with Cn3D
  • Citation:PMID 9195888
  • Citation:PMID 9862807

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
2O2Q_A        34 QMPYQLFIGGEFVDAEGSKTy-nTINPTDGSVICQVSLaqvsDVDKAVAAAKEAFENglwgkiNARDRGRLLYRLADVME 112 Norway rat
XP_635635      6 LPNTKLFINNEWVESVSGKKl-kTFNPTNGKLICEVSEggkeDVDVAVKAARNALDNgpwgkmTAEDRGKLILKLADLVD 84  Dictyostelium d...
XP_001014129  10 KFQTKLFINGKFVDGALKKTi-pVINPATEELICEIAEateqDVELAIDAAEASFPIws--klPQRDRTEYLLKLASLLE 86  Tetrahymena the...
XP_001386665  18 TQPTGLFINNEFVKSVSGKTl-dSINPSTSEVNGTVYCaeeeDVDIAVKAARAAFKDwk--kvTGVDRGILLNKVADAFE 94  Pichia stipitis...
P54115        23 EQPTGLFINNKFMKAQDGKTy-pVEDPSTENTVCEVSSatteDVEYAIECADRAFHDtewatqDPRERGRLLSKLADELE 101 baker's yeast
XP_503366     37 EQPVGLFINGEFVKSQSGKRf-eTENPTTETPIISVYEageaDANAAVEAAKNAFKNwgf-ktAPSERGVLLNKLADLIE 114 Yarrowia lipoly...
XP_636686     14 TIPTKIFINNEWVDSIDCNEnfsLINPTNEECLGIIGLggrkDVDRAVEAARSAIRGkws-tmAPLDRGILLNKLADKLE 92  Dictyostelium d...
XP_001240016  17 EIPTGLFINNEFVPSLTGTTl-dTTNPANGDLLATIAAaseeDINAAVQSAKDAFYTtwk-atPPTTRQSLILKLADLIE 94  Coccidioides im...
XP_386007     15 QIPTGLFINNRFIPSTTSETl-tTENPTTNTPLGQVSAaqpsDVDAAVSSSKEALKTwk--tsQPAERRRLLNRLADLIE 91  Gibberella zeae...
P46367        42 EQPTGLFINNKFVPSKQNKTf-eVINPSTEEEICHIYEgredDVEEAVQAADRAFSNgswngiDPIDRGKALYRLAELIE 120 baker's yeast
Feature 1                                                                                     ## 
2O2Q_A       113 QHQEELATIEALDAGAvytlALKTHVGMSIQTFRYFAGWcdkiqGATIPinqa-----rpnrNLTLTKKEPVGVCGIVIP 187 Norway rat
XP_635635     85 QHREHLSDLETLDNGKpltaSSGFDITEAARALRYFGGWadkiqGKTIPis---------seFTAMTKHEPIGVVGLIVA 155 Dictyostelium d...
XP_001014129  87 ANKEEFIALESLDNGKpl-eGATFDINDVIGHLRYYAGWadkitGKSFSsl---------dqQIFYTRREPYGVVGLISP 156 Tetrahymena the...
XP_001386665  95 AQRDLIGAIEAWDSGKtkeqNAVYDIDECISCFRYFAGWadkiqGKVIQnd---------pkKLAYTIHEPLGVCGQIIP 165 Pichia stipitis...
P54115       102 SQIDLVSSIEALDNGKtl-aLARGDVTIAINCLRDAAAYadkvnGRTINtg---------dgYMNFTTLEPIGVCGQIIP 171 baker's yeast
XP_503366    115 RDLDLISAIETTDNGKvf-aQAQGDVALVVKVLRYYAGFadkigGDLVQtn---------dgFFNYTRKEPLGVCGQIIP 184 Yarrowia lipoly...
XP_636686     93 EKREQMATIESINVGKpigeSLVYDLKQSITFLRYFAGWadkitGRTIPissssdtstptrqVLAYTKQVPLGVCALILP 172 Dictyostelium d...
XP_001240016  95 RDVDEFANLEALDGGIllsgSKGMHVPHSVETLRYFAGWadkidGKSIAip----------sGIAYTHREPLGVCAAIVP 164 Coccidioides im...
XP_386007     92 RDARELASIEAIDAGMlfnmSLGFCIVQAVETLRYFAGWadkidGQSLEfd----------qGLAYTKREPIGVCAAVVP 161 Gibberella zeae...
P46367       121 QDKDVIASIETLDNGKai-sSSRGDVDLVINYLKSSAGFadkidGRMIDtg---------rtHFSYTKRQPLGVCGQIIP 190 baker's yeast
Feature 1        ##                      #  #                            ##   ##            #### 
2O2Q_A       188 WNYPLMMLSWKTAACLAAGNTVVIKPAQvtPLTALKFAELTLkAGIPKGVVNILPGSGslvGQRLSDHPdVRKIGFTGST 267 Norway rat
XP_635635    156 WNFPLLLLSWKLGPSLAAGCTIVAKPSEftPLTALYFCELVKeAGFPPGVINIVNGVGdvvGDALSHHMdVDKISFTGST 235 Dictyostelium d...
XP_001014129 157 WNFPLMMAEWKYAPALAAGNCIVLKPSEvtPLTVLRLCELVNeAGFPPGVFNVVPGYGhvaGVAITHSKrISKISFTGSS 236 Tetrahymena the...
XP_001386665 166 WNYPLAMAAWKLAPALAAGNVVVLKTSEitPLSLLYVARLFKdAGFPAGVVNIISGFGavaGKALSSHLdVDKIAFTGST 245 Pichia stipitis...
P54115       172 WNFPIMMLAWKIAPALAMGNVCILKPAAvtPLNALYFASLCKkVGIPAGVVNIVPGPGrtvGAALTNDPrIRKLAFTGST 251 baker's yeast
XP_503366    185 WNFPLLMWAWKIAPALTTGNTVVLKTAEstPLSALYACKLSQeAGFPKGVLNVVSGYGp-vGGVLSAHPdIKKIAFTGST 263 Yarrowia lipoly...
XP_636686    173 WNFPLQLLMFKLAPALAAGNTVIIKPSEftPLSTFYLAELIKeVGFPPGVVNVVCGLGsvvGDAMSSHMkINKIGFTGST 252 Dictyostelium d...
XP_001240016 165 WNAPLIVTMWKLAPCIAAGNTLVLKTSEltPLYGIKLAALIKeAGFPAGVVNIVTGLGavaGRALSEHMdVRKIAFTGST 244 Coccidioides im...
XP_386007    162 WNTPLLITAWKLGPALAAGNTLIIKTPElaPLYGQKLAQLVLeAGFPPGVVNIITGLGpvaGQALADHHqVRKISFTGSL 241 Gibberella zeae...
P46367       191 WNFPLLMWAWKIAPALVTGNTVVLKTAEstPLSALYVSKYIPqAGIPPGVINIVSGFGkivGEAITNHPkIKKVAFTGST 270 baker's yeast
Feature 1         #  ##              ###                                #                        
2O2Q_A       268 EVGKHIMKSCAlsnVKKVSLELGGKSPLIIFADc-DLNKAVQMGMSSVFFNkGENCIAAGRLFVEesIHNQFVQKVVEEV 346 Norway rat
XP_635635    236 RVGRLIMEAAAksnLKPVTLELGGKSPNIIFGDc-DIEYVANAAKNYVFANsMQLCCAASRFFVHesILDAFLTIFTEKI 314 Dictyostelium d...
XP_001014129 237 FVGRKILEASSqtnLKKVVLELGGKSPVVVFPDa-DLDKAAEVAWYGCMFNmGQSCDAGTRLFVHedVYDKLLQKLKEYE 315 Tetrahymena the...
XP_001386665 246 ATGKLIQQAAAs-nLKAVTLECGGKSPLIIREDa-DLEQAVKWAAIGIMSNqGQICTSTSRVYVHesVYDKFLEEYTAHV 323 Pichia stipitis...
P54115       252 EVGKSVAVDSSesnLKKITLELGGKSAHLVFDDa-NIKKTLPNLVNGIFKNaGQICSSGSRIYVQegIYDELLAAFKAYL 330 baker's yeast
XP_503366    264 ATGKQVAKTALtsnLKKTTMELGGKSPNIIFDDa-NLEDALSAAALGIFFNsGEVCCAGSRLFVQagVYDQVVEAFKKKA 342 Yarrowia lipoly...
XP_636686    253 KVGKMVQNSATnsnLKHCSLELGGKSPIIIFNDveDLDLAVIHSFHGLFWNaGQCCSAASRIYVQsgIYDQFVEKIKKQV 332 Dictyostelium d...
XP_001240016 245 LTGRAIMKAAAssnLKKVTLELGGKGPTIIFDDa-DLQNAVFWATLGITANnGQICVAGSRIYVQegIYEKFIAAFSAAS 323 Coccidioides im...
XP_386007    242 AVGRTILVSAAksnLKRVTLELGGKGPSIIFNDa-NFENALAFATAGITMHnGQICAAGSRIYVQadVYDRFVSEFAAKT 320 Gibberella zeae...
P46367       271 ATGRHIYQSAAa-gLKKVTLELGGKSPNIVFADa-ELKKAVQNIILGIYYNsGEVCCAGSRVYVEesIYDKFIEEFKAAS 348 baker's yeast
Feature 1                                                                                      # 
2O2Q_A       347 EKMkignp-lerdtNHGPQNHEAHLRKLVEYCQRgv-keGATLVCGGNQvp----rpGFFFQPTVFTDvedhMYIAKEES 420 Norway rat
XP_635635    315 KQLkvgdp-ydsetHLGPLVSKQQHDRVLGYIQKgk-eeGATCHLGGEVhnhhadgaGYFIQPTIFTNvtddMTICKEEI 392 Dictyostelium d...
XP_001014129 316 QNVvigdsfevqnsNHGPLVSKLQFDRVMSYITHakeveKLQCFMGGERwg----nkGYFIKPTIFINvddnSKLAREEI 391 Tetrahymena the...
XP_001386665 324 KEAykqgsmfdseaVVGPQVSKVQRDKVLSYIEIgk-keGARLLLGGEKnsegelskGFYIKPTIFADikpeMRIVNEEI 402 Pichia stipitis...
P54115       331 ETEikvgnpfdkanFQGAITNRQQFDTIMNYIDIgk-keGAKILTGGEKvg----dkGYFIRPTVFYDvnedMRIVKEEI 405 baker's yeast
XP_503366    343 ESVkvgdp-fdpnsLQGPQQNKNQFKKILGYIEQgq-keGAHLLCGGSAqag--pnkGYFIQPTVFTDvnndMSIVREEI 418 Yarrowia lipoly...
XP_636686    333 ESRvlgdp-lskdtHQGPQVNKFQFESILRYIETgk-reGATLVCGGKRfg----nkGYYIEPTVFSNvtdvMTIAREEI 406 Dictyostelium d...
XP_001240016 324 TKAvagdp-llsntTKGPIVSADQHSKIMGYIKKgq-deGARLLHGGGQp------aPGYIENTAFVDvnedMTIMREEI 395 Coccidioides im...
XP_386007    321 RDAvmgdp-llddtVKGPVISSTQKNRIMEYITKak-seGIELLHGSAEpd----skGNFVPNTAFINvsptATIMREEV 394 Gibberella zeae...
P46367       349 ESIkvgdp-fdestFQGAQTSQMQLNKILKYVDIgk-neGATLITGGERlg----skGYFIKPTVFGDvkedMRIVKEEI 422 baker's yeast
Feature 1        #                           #                                     #             
2O2Q_A       421 FGPIMIISRFAdgdVDAVLSRANATEFGLASGVFTRdINKALYVSDkLQAGTVFINTYnkTDVAAPFGGFKQSGFGKDLG 500 Norway rat
XP_635635    393 FGPVVVILPFKt--VDEVIKRANDTTYGLAAGVWTKdISLALNVSNkLKSGSVWVNGFniLKSQIPFGGFKQSGFGRDLS 470 Dictyostelium d...
XP_001014129 392 FGPVLVVLKPWk-tFDEVIKRANDTNYGLAAYAVTQnAGNVEKFVReVKAGSFYINQGalSAHQMPFGGYKESGFGKDNG 470 Tetrahymena the...
XP_001386665 403 FGPVVVVGKFSs--DEEVITYANQTQYGLGAAIFTKdITVAHTMAAeIQAGMVWINSSndSDVHIPFGGVKMSGVGRELG 480 Pichia stipitis...
P54115       406 FGPVVTVAKFKt--LEEGVEMANSSEFGLGSGIETEsLSTGLKVAKmLKAGTVWINTYndFDSRVPFGGVKQSGYGREMG 483 baker's yeast
XP_503366    419 FGPVLTITKFNt--VDEVIDMANDSEYGLAAGIHTTdINKAHYVAEnIASGTIWVNCYnaFHEAVPFGGYKQSGFGKEMG 496 Yarrowia lipoly...
XP_636686    407 FGPVMSILRFEt--VQEAIDRANDSEFGLVGAVFTKdINKSIIVSDqVQSGLVWVNSFniIDPSIPWGGFKSSGKGRDAS 484 Dictyostelium d...
XP_001240016 396 FGPVAAISKFKt--ESEAIQKANNTEYGLSSAIFTNnVSRADRVSRaLESGQVTVNSWgmVHANVPFGGIKMSGFGKDMG 473 Coccidioides im...
XP_386007    395 FGPVASFAKFKt--EEEVISLANDNEYGLAAAVFTNdISRAVRVSDqIEVGIVFVNTWgsISANSPFGGIKQSGFGRENG 472 Gibberella zeae...
P46367       423 FGPVVTVTKFKs--ADEVINMANDSEYGLAAGIHTSnINTALKVADrVNAGTVWINTYndFHHAVPFGGFNASGLGREMS 500 baker's yeast
Feature 1                       
2O2Q_A       501 EAALNEYLRIKTVTF 515 Norway rat
XP_635635    471 EYAIQGYLSVKAVTI 485 Dictyostelium discoideum AX4
XP_001014129 471 EEGLLEYTQLKSVYY 485 Tetrahymena thermophila SB210
XP_001386665 481 EYGLSIYTQAKAIHV 495 Pichia stipitis CBS 6054
P54115       484 EEVYHAYTEVKAVRI 498 baker's yeast
XP_503366    497 RDGLENYLQTKAVRV 511 Yarrowia lipolytica CLIB122
XP_636686    485 EYCLSVWTETKTTVL 499 Dictyostelium discoideum AX4
XP_001240016 474 EESLDGWTGTKTIKY 488 Coccidioides immitis RS
XP_386007    473 TDALNDWTQVKCVKI 487 Gibberella zeae PH-1
P46367       501 VDALQNYLQVKAVRA 515 baker's yeast

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