1BPW


Conserved Protein Domain Family
ALDH_F9_TMBADH

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cd07090: ALDH_F9_TMBADH 
Click on image for an interactive view with Cn3D
NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1
NAD+-dependent, 4-trimethylaminobutyraldehyde dehydrogenase (TMABADH, EC=1.2.1.47), also known as aldehyde dehydrogenase family 9 member A1 (ALDH9A1) in humans, is a cytosolic tetramer which catalyzes the oxidation of gamma-aminobutyraldehyde involved in 4-aminobutyric acid (GABA) biosynthesis and also oxidizes betaine aldehyde (gamma-trimethylaminobutyraldehyde) which is involved in carnitine biosynthesis.
Statistics
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PSSM-Id: 143409
View PSSM: cd07090
Aligned: 16 rows
Threshold Bit Score: 732.569
Threshold Setting Gi: 167535615
Created: 14-Dec-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:NAD binding site [chemical binding site]
Evidence:
  • Structure:1BPWL: Cod Liver Betaine Aldehyde Dehydrogenase with bound NAD+, defined using 3.5 A.
    View structure with Cn3D
  • Citation:PMID 9792097

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
1BPW_A        40 VFEPATGRVLCQMVPcgaeEVDQAVQSAQAAYLKWSkmAGIERSRVMLEAARIIRERRDNIAKLEVINNGKti-tEAEYD 118 Baltic cod
XP_001749481  52 WIEPATKQAHVRVEAaamaDLDEALQGAQAAQQQWAltSGMERARALMDVAHYLRTHTTACESIECLDTGRpfreMALAD 131 Monosiga brevic...
EDP48899      28 TINPADNTPLAEIHVasnsDTDAAIAAADRAFPLWSqtPHIARARILQKAAALLRERNDELARLETLDSGKayseTSTVD 107 Aspergillus fum...
Q0B712        26 TFDPATGELLAQVQQasaaDVDRAVASAREGQREWAamTAMQRSRILRRAVDLLRERNDELAAIETRDTGKpigeTLAVD 105 Burkholderia am...
Q0TKW0        26 TINPANGNVLATVQAagreDVDRAVKSAQQGQKIWAamTAMERSRILRRAVDILRERNDELAKLETLDTGKayseTSTVD 105 Escherichia col...
Q985M6        26 VIYPATGETIAMLRSatpnVLELAIEAARAAQPAWArlKPVERGRILRRAADILRARNADLARIETLDTGKaiqeTLVAD 105 Mesorhizobium l...
ZP_01718489   22 NYNPATGEITHVVTGasqeDFEKAVQSAKKGFQVWSamSPTERGRILHKASALLREKNDELALLETQDVGKpikeSIAVD 101 Algoriphagus sp...
XP_002109396  62 IREPATNKLIGNLSSsgpkTVNDGVKSALSAFPEWSaqTSIDRGRALLRISKLLRQRNEEIARLEVRDTGKpi-sEARCD 140 Trichoplax adha...
XP_002128370  58 VIEPATGKVMCQMHEcgatDVNNAVNAAKQAQLEWGklSGFERGKILSKSSVLLKQKQEEIARMEVYDTGKpi-qEARVD 136 Ciona intestinalis
NP_001022930  31 VIEPRIGQVVAKCPKatadIVDQYVKAAADAQSAWGetTALDRGKVLHKVADLIREHAEEIAIWEVKTNGKpi-yEARCD 109 nematode
Feature 1                                                        ## ##                      #    
1BPW_A       119 IDAAWQCIEYYAGLapt--lsGQHIQLpg---gAFAYTRREPLGVCAGILAWNYPFMIAAWKCAPALACGNAVVFKPSPm 193 Baltic cod
XP_001749481 132 LPSVIDSFEYFAGVaqr--vsGEHYDMgg---gSFAYTRREPLGICAGIGAWNYPMQGAAWKAAPAMATGNALVFKPSEh 206 Monosiga brevic...
EDP48899     108 IVTGADVLEYYANLvgggglnGETTHLre---dAWVFTKKAPLGVCVGIGAWNYPLQIALWKSAPCLAAGNTMVYKPSEy 184 Aspergillus fum...
Q0B712       106 IVTGADVIEYYAGLata--ieGLQVPLra---eSFVYTRREPLGVCAGIGAWNYPIQIACWKTAPALAAGNAMVFKPSEv 180 Burkholderia am...
Q0TKW0       106 IVTGADVLEYYAGLips--leGSQIPLre---tSFVYTRREPLGVVAGIGAWNYPIQIALWKSAPALAAGNAMIFKPSEv 180 Escherichia col...
Q985M6       106 APSAADCLEYFGGAvaa--ynGEAVDLg----gPFAYTRREALGVCVGIGAWNYPIQIAGWKSAPALAMGNAMVFKPSEn 179 Mesorhizobium l...
ZP_01718489  102 VISGADCLEYYAGLaps--lhGEHFELg----gDFAYTKREPLGICAGIGAWNYPIQIACWKAAPALACGNVMIFKPAEl 175 Algoriphagus sp...
XP_002109396 141 VESAAECFEYFGGIaat--lsGQHFEFan---gSFAYTKREPLGVCVGIGAWNFPIQIVSWKTAPALACGNTIVYKPSQm 215 Trichoplax adha...
XP_002128370 137 VQTAIDSIEYFSGIast--lcGQHFSLpn---gSFGYTRREPLGVVAAIGAWNYPIQIAAWKAAPALATGNAVVCKPSQf 211 Ciona intestinalis
NP_001022930 110 IASSADTFDFFGGIata-vlqGDSLELpggpsqRIAYTRREPYGVVGCIGAWNYPFQTCVWKVAPALAAGNAVVYKPSPf 188 nematode
Feature 1                                    #                  # ##  #                  ###     
1BPW_A       194 tPVTGVILAEIFHe-AGVPVGLVNVVQGGAe-TGSLLCHHPnVAKVSFTGSVPTGKKVMEMSAk-tVKHVTLELGGKSPL 270 Baltic cod
XP_001749481 207 tPLSALLLAEAVQqvEAIPTGLFNVVLGDGa-LGATFATNPsFAKVSFTGSRATGLKITSAAAg-dLKRVTMELGGKSPL 284 Monosiga brevic...
EDP48899     185 tPLHAQMLAEIYRe-AGLPPGVFNVVYGAGd-VGAYLTAHPlVAKVSFTGQVSTGMKVAGSAAg-qMKYVTMELGGKSPL 261 Aspergillus fum...
Q0B712       181 tPLTALKLAEIYTe-AGVPAGVFNVVQGDGs-VGALLTGHPdIAKVSFTGGVETGKKVMSLAGassLKEVTMELGGKSPL 258 Burkholderia am...
Q0TKW0       181 tPLTALKLAEIYSe-AGLPDGVFNVLPGVGaeTGQYLTEHPgIAKVSFTGGVASGKKVMANSAassLKEVTMELGGKSPL 259 Escherichia col...
Q985M6       180 tPLSALALAEIYSe-AGLPDGLFNVVQGYGd-VGAGLVGHDvVAKVSVTGSVPTGRKVLSLAGs-kMKHATMELGGKSPL 256 Mesorhizobium l...
ZP_01718489  176 tPLTAYKLAEVFRe-AGMPDGVFNVVQGDAe-VGQMMTAHPdIAKVSITGEVGTGKKVMAASAn-tLKHVTLELGGKSPI 252 Algoriphagus sp...
XP_002109396 216 tPMSSSLLGDIITe-AGLPLGCYNVVQGGSq-TGRLLCEHPsVAKVSFTGSVPVGKKIMSYCSs-gVKHSTIELGGKSPL 292 Trichoplax adha...
XP_002128370 212 tPLTAVALAEVFIe-GGLPSGLFNVVQGAGe-TGNHLTRHPdVAKVTFTGSIETGSKVMQNCAa-dIRHVTLELGGKSPL 288 Ciona intestinalis
NP_001022930 189 aPASPVLLGEILTa-AGVPKGVYNVIQGEQe-AGVALCEHNlVAKVSFTGSVASGEAVQRQAAtknVKPVTLELGGKSEI 266 nematode
Feature 1                                  #                                                     
1BPW_A       271 LIFKDcELENAVRGALMANFLTqGQVCTNGTRVFVQreiMPQFLEEVVKRTKAIv-VGDPllteTRMGGLISKPQLDKVL 349 Baltic cod
XP_001749481 285 IICADaDLEQACRGAIMANFFSnGQVCSNGTRVFVArevYQPFTQRLVELTAQLr-AGDSfdeqVAVTPVIHNDHAARVR 363 Monosiga brevic...
EDP48899     262 LILPDaDLENAVNGAMMANFFStGQVCTNGTRVFVPrgmKSAFEKALLDKMQYIr-PGPLfdnaTNFGPLSSALHLEKVT 340 Aspergillus fum...
Q0B712       259 IVFEDaDLDRAADIAVTANFFSsGQVCTNGTRVFVHrsvKDAFTQRVLERVKRIr-VGKPtdaaTNFGPLVSAAQLDKVL 337 Burkholderia am...
Q0TKW0       260 IVFDDaDLELAADIAMMANFFSsGQVCTNGTRVFVPakcKAAFEQKILARVERIr-ADDVfdpqTNFGPLVSFPHRDNVL 338 Escherichia col...
Q985M6       257 IVFDDaDIENAIGGAMLGNFYStGQICSNGTRVFVQsgiHDRFVERLVERTKKIr-IGNPldpeTQMGPLVSKAQHEKVV 335 Mesorhizobium l...
ZP_01718489  253 IIFEDaAIDEAVYGAMLGNFYTqGEICSNGTRVFVHesiKEKFIERLIEKTKELk-IGNPadseTQIGALINKTHFEKVM 331 Algoriphagus sp...
XP_002109396 293 IVFPDsDIDNAVSGTLMANFLSqGQVCSNAARVYIHdsiIDDFVTRLMERTKKMi-IGDPfkqeTQVGALISEEHYHRVK 371 Trichoplax adha...
XP_002128370 289 ILFGDcDITNAVNGALMANFLSqGQVCSNGTRVFIQddiYDEVVTMLVERTLGIk-HGDPhhehTKMGAMMNEEHAHKVM 367 Ciona intestinalis
NP_001022930 267 IIFDDsDVKSAVASAMLANFLNqGQVCTNATRVFVQkgiLASFTEAIVQEANDKlkVGDPlledTRVGANINEGHLQRIL 346 nematode
Feature 1                                                            # #                         
1BPW_A       350 GFVAQak-keGARVLCGGEPltpsd-pklknGYFMSPCVLDNcrddMTCVKEEIFGPVMSVLPFDtEEEVLQRANNTTFG 427 Baltic cod
XP_001749481 364 EFLERar-tqGATVLYGGEYadeevpshidrTGLIKPHILTDcsddMEIVREEVFGPVMAVLPFDtVDEAVRRANDTPYG 442 Monosiga brevic...
EDP48899     341 SYIRHgietdKATLLYGGLGkpslp-kdlenGFWVRPTVFTDctdsMRIVQEEIFGPVMSILYYDtVEEAVRRANNTELG 419 Aspergillus fum...
Q0B712       338 GFIDSgk-aeGAKLLAGGTRltdg---hfasGQYVAPTVFGDcrddMKIVREEIFGPVMSILDFEsEDEVIARANDTHYG 413 Burkholderia am...
Q0TKW0       339 RYIAKgk-eeGARVLCGGDVlkgd---gfdnGAWVAPTVFTDcsddMTIVREEIFGPVMSILIYEsEDEVIRRANDTDYG 414 Escherichia col...
Q985M6       336 GYIGIgk-qdGAVLACGGNVpslq---gfdgGFFVEPTVFTGvtdtMRIAREEIFGPVMSVLKFDgEDEVIDRANDTEFG 411 Mesorhizobium l...
ZP_01718489  332 SYIALgk-eqGAELRYGGNSiavd---gcegGYFVEPTIFVSndeeDRIVKEEIFGPVMTILTFQeEEDVIRRANDTPFG 407 Algoriphagus sp...
XP_002109396 372 AYIDQav-teGARIRCGGERvvfdn-selagGFYMSPCVLDSchddMTIVKEEVFGPVVSILSFKdEEEVLERANNTVFG 449 Trichoplax adha...
XP_002128370 368 GFIERak-keGAEVLCGGELvqmed-pvlrgGSYISPCIIRPsd-sMEISREELFGPVMNVYSFKtEDEVIRRANDSKYG 444 Ciona intestinalis
NP_001022930 347 GYVESak-qeGGVVLRGGVRvhpt---gvegGAYFEPAIITGlsdeARAVREEIFGAVMLILPFEtEEEVIARANNTTYG 422 nematode
Feature 1                                              #                               
1BPW_A       428 LASGVFTRDISRAHRVAAnLEAGTCYINTYsiSPVEVPFGGYKMSGFGRENGQATVDYYSQLKTVIVEMG 497 Baltic cod
XP_001749481 443 LSAGVFTQDLKQAHRVIAeLKAGTTWINDYnlAPTQLPWGGYKQSGVGRENGTDAINHWTQLKRIGSRER 512 Monosiga brevicollis MX1
EDP48899     420 LAAGVFTRDLNMAHRIIDqLQAGITWINSWgeSPAEMAVGGWKKSGVGVENGRRGIEAWVRNKSTLVDMN 489 Aspergillus fumigatus A1163
Q0B712       414 LAAGVVTENLSRAHRTIHrLEAGICWINTWgeSPAEMPVGGYKQSGVGRENGITTLEHYTRIKSVQVELG 483 Burkholderia ambifaria AMMD
Q0TKW0       415 LAAGIVTADLNRAHRVIHqLEAGICWINTWgeSPAEMPVGGYKHSGIGRENGVMTLQSYTQVKSIQVEMA 484 Escherichia coli F11
Q985M6       412 LAAGVFTRDLPRAHRVIAeLQAGTCWINAYnlTPVEIPFGGFKQSGIGRENSLAALALYSQLKSIYVETG 481 Mesorhizobium loti MAFF30...
ZP_01718489  408 LAAGVYTNDMRRAHRSVAsLQAGMCWINTYniNPVEIPFGGNKQSGIGRENGLAAIEHYSQLKTVYVAMK 477 Algoriphagus sp. PR1
XP_002109396 450 LSAGVFTKDIQRAHRVIAkLQAGSCWINNYniYPTGFPFGGYKESGIGRENCAQTLNHYSQLKTVYVEMG 519 Trichoplax adhaerens
XP_002128370 445 LASGVFTKDIQRAHRVAAsMQAGSCYINNYniFPIEMPFGGYKKSGLGRENGTVTVDYFTQLKTVYVEMN 514 Ciona intestinalis
NP_001022930 423 LAAGVFSGNLARGHRVAArLQAGTVFINTYndTEVNVPFGGFKNSGHGRENCIDTLRAHTQTKAIYVNVQ 492 nematode

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