2IMP


Conserved Protein Domain Family
ALDH_LactADH-AldA

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cd07088: ALDH_LactADH-AldA 
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Escherichia coli lactaldehyde dehydrogenase AldA-like
Lactaldehyde dehydrogenase from Escherichia coli (AldA, LactADH, EC=1.2.1.22), an NAD(+)-dependent enzyme involved in the metabolism of L-fucose and L-rhamnose, and other similar sequences are present in this CD.
Statistics
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PSSM-Id: 143407
View PSSM: cd07088
Aligned: 18 rows
Threshold Bit Score: 674.365
Threshold Setting Gi: 21221910
Created: 12-Dec-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:NAD binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
2IMP_A        10 YIDGQFVtwrgdawidVVNPATEAVISRIPDgqaeDARKAIDAAERAQPEWeaLPAIERASWLRKISAGIRERASEISAL 89  Escherichia coli
ZP_02693250    7 LVDGKLVsaadgavikVTSSYDGSLVGTVPSfskeDARVSLEAAQAAKDAWasLTFVKRAEYVSELADIIDRHSDELVKL 86  Epulopiscium sp...
ZP_01889911    7 FINGKFVkststevteILNPCTEEVLSTIPYgsvkDANDALEAAQNAQHSWksLPAIQRAGYLNKMATVIRENRVFLAKT 86  unidentified eu...
YP_001988519  12 YINGKFMdsasgdvetVIDPSTGKKLWTAPAatieEARAAVDAAWAAKNAWrrVPAPTRGAYLRKLATLVREHEDELVKI 91  Lactobacillus c...
ZP_01076640    7 FINNAFVpsitskampVYSPVNEAQVAQVALasaeDALGAVDIAAKAQKGWrqLTSIERAGFLHKLADALLARKDAIGQA 86  Marinomonas sp....
YP_373590      7 YVNGRFVapesdtfivVHNPATEAPFARVPAatpaDALAAVDAAAAAQKAWrkLPSAERATYLHRFADALTARASEIGAA 86  Burkholderia sp...
NP_765622     11 FINNEFIesqsketmdVINPATGEAFDTITLateeEVNDAIEKSQQAQLEWerVPQPTRAEHVKLLIPLLEKNRDEIAQL 90  Staphylococcus ...
NP_627689     19 FVAGEYEldsshgtlpVINPANGQLVAEVPSssssTVDRAVTAAVAAQREWgrRSHVARAAVLEAVRDAIAVHADELARI 98  Streptomyces co...
NP_116831     12 YIDGEWIdattgesqeILSPTDETVVGTVQMgveaDAQIALEAAERAQKQWkkVPARKRADLLRTFAAEIKANKNQLAEL 91  Microscilla sp....
YP_528117      9 FINGEYIasqadgaidVLSPSTGKKVGDIPAgcveDAQLALDTANAAQKLWakKTNRERAKILRVFAANIRAAADDLAKL 88  Saccharophagus ...
Feature 1                                                                   ####                 
2IMP_A        90 IVEEGGKiqqLAEVEVAFTADYIDYMAEWaRRYEGEIIQSDrpgENILLFKRALGVTTGILPWNFPFFLIARKMAPALLT 169 Escherichia coli
ZP_02693250   87 LTNEHGKtlaQAQGEVAVSAKFLRYAVESaRRVEGEVITSElenEHAFITRVPYGVVVGIVAWNFPLALAARKIGNALVC 166 Epulopiscium sp...
ZP_01889911   87 LAAEQAKvmgLAQVEIDVTADYFDYYAGFaRRIEGEIIQSDrakEHIFLHKSPIGVAVGILPWNFPFFVMARKVAASLIT 166 unidentified eu...
YP_001988519  92 LMLEQGKihaLAKTEIEFSADYFDYMANAaRVYSGDVMQSDnenENIIIARQPIGVAVGIIAWNFPFFLIARKMGPALVT 171 Lactobacillus c...
ZP_01076640   87 LALESGKsleDATNEAVYAADITRYHAEWaRRIEGEIIPSDspsENLLLQREPIGVVACLIPFNYPVYTLLRKIAPALIT 166 Marinomonas sp....
YP_373590     87 LAQESGKsveDASNEAVYAGQITRYHAEWaRRIEGEIIPSDtpdENLFLQREPIGVVACLIPFNYPVYTLLRKVAPALIA 166 Burkholderia sp...
NP_765622     91 YVKEQGKtltQAYGEIDKSISFIDYMTSLsMSDKGRVLQNSianETIQIINKPIGVTAGIVPWNAPILVLMRKVIPAIVT 170 Staphylococcus ...
NP_627689     99 VSVEQGKplsDARGETEGACAFFDFAISQkYRAVGSMMASEp-gRSLGVREEPIGVVAAILPWNFPVAIFARKVAPALMA 177 Streptomyces co...
NP_116831     92 LVREQGKllaVAKMEVEVTASFIEYACDGaRSIEGDIIPSDnpaEHIMIHKIPRGVVVAITAWNFPLALAGRKLGPALVA 171 Microscilla sp....
YP_528117     89 LVSEQGKllsVAQMEVEATATFIEYACDNaLTIEGDILPSDnpnEKIYIHKVPRGVVVAITAWNFPLALAGRKIGPALVT 168 Saccharophagus ...
Feature 1              #  #                              #   ##            #  #  #  #            
2IMP_A       170 GNTIVIKPSEftPNNAIAFAKIVDe-iGLPRGVFNLVLGRGetVGQELAGNPkVAMVSMTGSVSAGEKIMATAAkNITKV 248 Escherichia coli
ZP_02693250  167 GNTMVVKPPSetPLTVMKFAEFIEkesSIPKGVLSFVTGSGrvCGDALVRNEiTQLVTLTGSTGAGIEVFKAAAeNVVDV 246 Epulopiscium sp...
ZP_01889911  167 GNTCVIKPSCiaPNTILEWLELIQk-iELPSGVLNVVCGSGpiVGNALCKSPtTGIISLTGSVFAGQQVMEAASqNITKV 245 unidentified eu...
YP_001988519 172 GNTIVIKPSSdtPGLALAFAKLVDe-vGLPAGVANFVSGRGsiIGDDLAKNPkVGIISLTGSTASGKKVMAAAAnHVAKM 250 Lactobacillus c...
ZP_01076640  167 GNSVVVRPSNntPSSAFEIAKAVQd-sGIPAGVVNILTMDHa-TAESVCTHPkVGMITLTGSVGAGRKVLEYSQvNIAKS 244 Marinomonas sp....
YP_373590    167 GNTVVVRPSNhtPVSAFEIAKAAGd-aGFPPGVINILTMDHa-TAEALCTHPaVGMITLTGSVNAGRKVLDYCKaNIAKP 244 Burkholderia sp...
NP_765622    171 GCSVVIKPSEetTLLTLRLAELFRa-sTIPAGLIQIVPGTGetVGTQLASHKdIQLISLTGSMRAGKSVYENAAqTVKKV 249 Staphylococcus ...
NP_627689    178 GNAVVLKPSEltPLSALALARLCRl-aGVPDGLLSVVCGEGkdTGRALVTHPgVGMVTMTGSTRGGREILAQVAdQIIPV 256 Streptomyces co...
NP_116831    172 GNSVVLKPTQetPIATLELGNIANk-vGLPKGLINILTGQGsvLGNALVANPiTKMVSMTGSTPAGQQIFRTAAeNLIHV 250 Microscilla sp....
YP_528117    169 GNAIVVKPTQetPLATLALGELANa-aGIPAGVLNIVNGRGsvVGQHLCESPiTRLITMTGSTPAGQRIYRTSAdHLTPV 247 Saccharophagus ...
Feature 1                                                                                        
2IMP_A       249 XLELGGKAPAIVMDDADLELAVKAIVDSRVINsGQVCNCAERVYVQkgIYDQFVNRLGEAMQAVqFGNPaerndiAMGPL 328 Escherichia coli
ZP_02693250  247 HLELGGKAPFIVMDDADIDKAARCAAVARYDNcGQICTCNERMYVHekVYDEFKNKFVEHSKKYiVGDPtda-ntTIGPK 325 Epulopiscium sp...
ZP_01889911  246 SLELGGKAPAIVCADANLELAVKAVVDSRIIFsGQVCNCAERVYVEesIHDQFLEMVTAKMKAIkVEDAfsdnnpDMSAL 325 unidentified eu...
YP_001988519 251 SLELGGKAPAIVAKDADIDLAVQAIFDSRIDNnGQICNNAERIYVQedVADEFIKKMTAKMAAVkVGNPntdpdaEMGPL 330 Lactobacillus c...
ZP_01076640  245 SLELGGKSPAIVEADADLEKAAREIVASKTTNcGQLCTAIERVYVHevIYDEFVALLKGQMSERqFGDRaqd-asFMGPL 323 Marinomonas sp....
YP_373590    245 SLELGGKTPAIIEPDADLERAAAALVASKTTHcGQLCTAIERVYVHdsVHDRFVALLKEKMAAVrIGDRaed-atRMGPL 323 Burkholderia sp...
NP_765622    250 NLELGGNAPVIVTSNADLDKAVNYIVTARINNaGQVCTCPERIFVHedVHDDFLNKVTSKMKSLtVGDPfde-ntDYGAI 328 Staphylococcus ...
NP_627689    257 SLELGGKAPFIVFEDADLDAAVEAAADARLWNtGQVCTCNEVTYVHadLHDEFVRRVVDRFASVtPLDPfaa-gsRLGPL 335 Streptomyces co...
NP_116831    251 QLELGGKAPCIVFDDADLEQAVEGAFHSRFDNcGQVCTSNERLYVHesIYNEFMERFMEKVKGLkLGNPmda-atTIGPK 329 Microscilla sp....
YP_528117    248 MLELGGKAPFIVMEDANLESAVEAAFTTRYANcGQVCTCAERLYVHesIYPAFMDKLLEKVKAIkVGDPmaa-dtDMGPK 326 Saccharophagus ...
Feature 1           #   #                                                                        
2IMP_A       329 INAAALERVEQKVARAveeGARVAFGGKAve----gkGYYYPPTLLLDvrqemSIMHEETFGPVLPVVAFDtLEDAISMA 404 Escherichia coli
ZP_02693250  326 VSKAEVAKLKEMKEKSieqGGKVVYEMTAdnvp-taeGNWFYPTVLEVsdnknILMQEEIFGPMVAMMKISsLEEAIKYA 404 Epulopiscium sp...
ZP_01889911  326 VSKAQLDKVSEMVEFAkkeGAEIVLGGSRssq--fdkGYFYQPTLVSNvkqdmQIMQEEVFGPVLPVMKFStLDEAIALA 403 unidentified eu...
YP_001988519 331 INQGALDKVDGLVQRAveaGGQIQTGGHPadi---dgGFFYEPTVITNvaqdsEIVQNEIFGPVLPILTFKtIPEAIEMA 407 Lactobacillus c...
ZP_01076640  324 INENARLNIHQMVERAiddGASLEVGGYIpe----gkGHFYPPTLLTNcrqdmEIVQEEIFGPVLPVLKYTdADQALELA 399 Marinomonas sp....
YP_373590    324 VSASARAHIHGMVERAiaaGATLETGGAIpa----gpGFFYPATLLTGvrqdmEIVQEETFGPIMPVLRYStIDEAIAQA 399 Burkholderia sp...
NP_765622    329 INQKQLDSIHEKVQDAiknGATLMTGGHQlk----rhGFFYAPTVLDNvrkddNVFKDEIFGPVLAITTYRdFEQVIEDA 404 Staphylococcus ...
NP_627689    336 VAERERTRVQGMVDAAvaaGARVRTGGGRpdgeqyqsGAWFAPTVLTNvrpemDIARREVFGPVLPIIPFDaEAEVVSAA 415 Streptomyces co...
NP_116831    330 VNAKEVAHMEHLVTKSveeGATVAIGGKKpqgkafekGHWFEPTILTDvkqnmTIVHEESFGPILPVIKFSeFNEVIGYA 409 Microscilla sp....
YP_528117    327 VNQSEIENIDALVKKGieqGATLLHGGKRahvpgfegGNWYEPTLLGDvqqsnILVHEETFGPILPVVKINsIEQAIEYT 406 Saccharophagus ...
Feature 1                                                                                 
2IMP_A       405 NDSDYGLTSSIYTQnLNVAMKAIKgLKFGETYINREnFEAMQGFHAGWRKSGIGGADGKHGLHEYLQTQVVYL 477 Escherichia coli
ZP_02693250  405 NDCEYGLSAYLFSDsVKNAMIATQkLEFGELYINREnGELLNGFHNGYKKSGLGGEDGKYGLEGYLQKKMVYL 477 Epulopiscium sp. 'N.t....
ZP_01889911  404 NDSEYGLTSSIFSEnFNKVMHAAEeLQYGETYINREhFEAIQGFHAGWKKSGLGGADGKHGMEEYLQTKVVYA 476 unidentified eubacteri...
YP_001988519 408 NDTVYGLTSSVYTRdLETASYVANeIEFGETYINRFnFEGIQGFHAGWKQSGVGGADGIHGVEEFTNTHVIYL 480 Lactobacillus casei BL23
ZP_01076640  400 NDHQFGLASVIYTEnYRTAMKVANnIEAGEIYINRTpADPYQGFHAGWKRSGLGGDDGKHGMLEYTQTRLVVL 472 Marinomonas sp. MED121
YP_373590    400 NDHQFGLSSVLYTEhYRTAMTVANaIEAGELYVNRTpADPYQGFHAGWKRSGLGGDDGKHGMLEFTQTRLVVM 472 Burkholderia sp. 383
NP_765622    405 NDTNAGLSSYIFSEnLTEVMTATErLKFGEVYANCEaEEVVNGYHAGWRESGLGGADGIHGFEEYYNTTVSYI 477 Staphylococcus epiderm...
NP_627689    416 NSTAYGLTAYVYTRdLSRAMRMIDaLEFGEVYVNQAgPEQVQGFHTGWKSSGLGGDDGPHGYEKYLRRKTVYV 488 Streptomyces coelicolo...
NP_116831    410 NDCEYGLAAMVFTNdMNKIMRLNDeLEFGEIYINRGhGEQHQGFHNGYKLSGTGGEDSKYGFEQYMEKKTFYI 482 Microscilla sp. PRE1
YP_528117    407 NDSEYGLSTYLFTQnLKYIHQYIAeVEAGEVYVNRGiGEQHQGFHNGWKLSGAGGEDGRYGLEQYLEKKTVYF 479 Saccharophagus degrada...

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