1AD3


Conserved Protein Domain Family
ALDH_F3-13-14_CALDH-like

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cd07087: ALDH_F3-13-14_CALDH-like 
Click on image for an interactive view with Cn3D
ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins
ALDH subfamily which includes NAD(P)+-dependent, aldehyde dehydrogenase, family 3 member A1 and B1 (ALDH3A1, ALDH3B1, EC=1.2.1.5) and fatty aldehyde dehydrogenase, family 3 member A2 (ALDH3A2, EC=1.2.1.3), and also plant ALDH family members ALDH3F1, ALDH3H1, and ALDH3I1, fungal ALDH14 (YMR110C) and the protozoan family 13 member (ALDH13), as well as coniferyl aldehyde dehydrogenases (CALDH, EC=1.2.1.68), and other similar sequences, such as the Pseudomonas putida benzaldehyde dehydrogenase I that is involved in the metabolism of mandelate.
Statistics
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PSSM-Id: 143406
View PSSM: cd07087
Aligned: 50 rows
Threshold Bit Score: 488.574
Threshold Setting Gi: 2494079
Created: 12-Oct-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
NAD(P) bindingcatalytic
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:NAD(P) binding site [chemical binding site]
Evidence:
  • Structure:1AD3; ALDH3A1, class 3 rat liver aldehyde dehydrogenase complex with nicotinamide-adenine-dinucleotide, defined using 3.5 A.
    View structure with Cn3D
  • Citation:PMID 9095201

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
1AD3_A         4 SDTVKRAREAFNSGkt----------rSLQFRIQQLEALQRMINENLKSISGALASDLGKne-wTSYYEEVAHVLEELDT 72  Norway rat
ZP_02007759    5 QTLLDRQREFFLTDat----------kSAAWRLDQLDRMERLLRENQEAFCNALYQDFRKp--pFEQLFEITVPLGVIDY 72  Ralstonia picke...
ZP_01169746   10 KSLPERQREDLFSAgs----------pSLEARKKQLSKLKTMIVDHEEAFTRALHADLGKpa-fESFSSEIAVLLNEIDH 78  Bacillus sp. NR...
Q04458        18 DEIVEISRNFFFEKqlklshennprkkDLEFRQLQLKKLYYAVKDHEEELIDAMYKDFHRnk-iESVLNETTKLMNDILH 96  baker's yeast
ZP_02184017   15 SIIQQRQKRRVSETsl----------sDIRYRKQQLVTFQLMLEENQTELLNTLYEDLGKpp-eEAYASEIAVLLQEIDF 83  Carnobacterium ...
XP_001032736  10 DPILNNLKKTFRTGkt----------rDLAFRKQQLRNLLTGIKEMEDEISEAVQKDLGYqdpkVAKFLNLLPTIGDIEY 79  Tetrahymena the...
XP_001310607  12 PTIVKELREHFKTRvs----------fDFKWREDQLNGLLKCLDEHKDDWVKAMYDDMGSh--hFEAELLIENVKTDISH 79  Trichomonas vag...
XP_001021898  14 EPTFQELRQTFLSQkt----------kSLAYRKTQLRNLLRGLTEMEQEFHKALELDLKCsp-fISFMTSYKITVSEIEH 82  Tetrahymena the...
XP_001444312  10 APTLKELKANFLTKks----------rPIPFRLQQLHNLLRGLKELRNEFYEAFQKDLGYkdqyFCELVQYQAVLTHIEC 79  Paramecium tetr...
P30840        68 QTICKTLKESYSTNal----------rHLDARKEVLYCLYRMVLDNKQAISNAIREDLHRd--vGMCVAEVNSVIHEINF 135 Entamoeba histo...
Feature 1                                                 ###                         #          
1AD3_A        73 TIKELPDWaEDEPVAktrq--tqqDDLYIHSEPLGVVLVIGAWNYPfNLTIQPMVGAVAAGNAVILKPSEvSGHMADLLA 150 Norway rat
ZP_02007759   73 YRRHLVDLmAPQQVEippgleaegYRGMIYKEPYGPTLVIGPFNAPvLLLLDPAIAALAAGNPVTLKPANtTPTVAALLQ 152 Ralstonia picke...
ZP_01169746   79 ICKHIAKWnRQSRSRylkm--gyiESIKRKRHPYGSVLIIGSWNYPlQLSLMPAIGAIAAGNRCVIKPSEhAPATAELLK 156 Bacillus sp. NR...
Q04458        97 LIEILPKLiKPRRVSdssp-pfmfGKTIVEKISRGSVLIIAPFNFPlLLAFAPLAAALAAGNTIVLKPSElTPHTAVVME 175 baker's yeast
ZP_02184017   84 LKRKLNQWqRTKKKHhvrl--ssvSKTSIQHHPYGSVLVISPWNYPlHLALLPAIGAMAAGNSCFIKPSEyAPATANLIA 161 Carnobacterium ...
XP_001032736  80 ILNNFESWaQKRSVDvslv--vgpGSGYIIPEPYGVTLVIGAWNYPfNTTVAPAANAIAAGNCVALKPSEmSPHNSNVMK 157 Tetrahymena the...
XP_001310607  80 TLKKFKSWlAPQSCSvawa--ltpGSASIVPEPYGVVCDFIPYNYPmYLGFATLCPILAAGNVCLFKPSSnTPHCAKLYQ 157 Trichomonas vag...
XP_001021898  83 TLKNLDQWvKARPLDttvl--sgpAKTYLKPEPYGVALVMSAWNYPlFTAIPPFAQALAAGNCVVLKPSElAPHTSNCIL 160 Tetrahymena the...
XP_001444312  80 DIKNIYKYtAKRSVStsim--aapGTSYLIPEPYGVVLVIGAWNYPiFTCIPQLSQAIGAGNAVVVKPSElVPHVSNILA 157 Paramecium tetr...
P30840       136 LRKNLNKYlKRKQVPtvca--qlfGKSFVEREPYGCVCVISPWNFPaNLSLIPCAGALACGNTVFLKMSKySMATSKLIA 213 Entamoeba histo...
Feature 1                           #                   #                                        
1AD3_A       151 TLIPq-yMDQNLYLVVKGGVPe-TTELLKEr-FDHIMYTGSTAVGKIVMAAAAkhLTPVTLELGGKSPCYVDKDc---DL 224 Norway rat
ZP_02007759  153 TLIPk-yFAPEAVTVVTGGREe-ISALLELp-FDFIFFTGSAAVGKVVMRAAAehLTPVILELGGQNPTVVDATa---NL 226 Ralstonia picke...
ZP_01169746  157 KIINd-aFPPEQLLVVTGDAQt-ASQLTAAp-FDLIFFTGSGQTGKAVAEQAArqLTPVILELGGKNPCIIDETg---FS 230 Bacillus sp. NR...
Q04458       176 NLLTtagFPDGLIQVVQGAIDe-TTRLLDCgkFDLIFYTGSPRVGSIVAEKAAksLTPCVLELGGKSPTFITENfkasNI 254 baker's yeast
ZP_02184017  162 RLVEq-yFSPDNLMVVTGDASv-ASELLELp-WDFIFFTGSKKVGSIVHKAAAarQIPIVLELGGKNPCIVDETn---LT 235 Carnobacterium ...
XP_001032736 158 KLFDk-yLDKDCYTVIEGQVEv-AKAICYKp-WDHIIFTGSPQKGKLVAQAASqnLIPCTLELGGKSPTIVDKTa---NL 231 Tetrahymena the...
XP_001310607 158 TLFPq-yLDPKGVRVVCGPTRi-CDVILDQr-FDFIFYTGSPAVAKNVMRHAAehLTPCLLELGGKSPVYFDKNc---SL 231 Trichomonas vag...
XP_001021898 161 KLFNn-yMDKSAYRCIEGQVQv-SINITKLp-WGLIIFTGSPEKGKLVAKAASenLVPCILELGGKSPTVVDSDa---NL 234 Tetrahymena the...
XP_001444312 158 KLITn-yLDQSLYRAIEGGVNv-AINITKQh-FDLIIFTGGTEKGKLVAKAAAenLVPCILELGGKGPCIIDSSs---DL 231 Paramecium tetr...
P30840       214 ELCDk-yIPSEYLRCEYLTGReaIQECCSAs-FDYYFFTGSTYVGKLINQAAAekMVPATLELGGKNPAIVDKSv---NL 288 Entamoeba histo...
Feature 1                                                                      # ##  #           
1AD3_A       225 DVACRRIAWGKFMNsGQTCVAPDYILCDpsiQNQIVEKLKKSLKDFyged-akqsRDYGRIINdRHFQRVKGLIDNq--- 300 Norway rat
ZP_02007759  227 DIAIDRIAWGHNAIsGQWCIAPGYVYVHhsiADDFIARIKRSLTAMyged-psrsPDFARMISaHDAQRVANYIQPe--- 302 Ralstonia picke...
ZP_01169746  231 KEAVREIVWGKFLNaGQTCIAPDTLFVHesiYEKTLNEISAAVSAFygeq-presSDYGRICTdDHFQKVIEFIGQg--- 306 Bacillus sp. NR...
Q04458       255 KIALKRIFFGAFGNsGQICVSPDYLLVHksiYPKVIKECESVLNEFypsf--deqTDFTRMIHePAYKKAVASINStngs 332 baker's yeast
ZP_02184017  236 PTVVQRIIWGKFLNaGQTCIAPDTVYIHesvYTEFLQLATDQIKAFygtq-pihhSRFGRIVHdKQVEKLKDYLEQg--- 311 Carnobacterium ...
XP_001032736 232 NVAVARIAQGKIGNsGQTCIAPDFAIVDqdiKDQFLSSLKEAMITQisnn-petsRDYNRMINeFHTKRMESMIKThg-- 308 Tetrahymena the...
XP_001310607 232 AKSVRRLIWGKIFNgGQTCVCPDYVMVHkdiMEQFKAEMVKAINELypnpdtaynDNITHIISkHHFDRLTKLIDNsg-- 309 Trichomonas vag...
XP_001021898 235 ENAALRVTQGRFLNaGQTCVACDYLFVHksiKAEFIKKLKEKIILFyged-pqksNDYNRIVNcQSTERLASLLNPedh- 312 Tetrahymena the...
XP_001444312 232 ALAGRRVVSTKLLNcGQTCVAPDYLLVEesiLDNVVNTFKQQIKDFygpe-tknsECLNRIVNeFHTNRIAELLNNhg-- 308 Paramecium tetr...
P30840       289 KVAAKRIAWAKSINaGQICVCVDHVFVPrsiKNEFCEAVKNSFIKFfged-qkksEDFGRIITkSAAKKMKEIIDQs--- 364 Entamoeba histo...
Feature 1                                             # #                                        
1AD3_A       301 -----KVAHGGTWdqssRYIAPTILVDVdpqSPVMQEEIFGPVMPIVCVRsLEEAIQFINQREKPLALYVFSNn-eKVIK 374 Norway rat
ZP_02007759  303 -----KVVHGGRFdipgRYVEPTVLYPSswdDPAMQQEIFGPVLPVLPYDdLDEVIETIKRKPKSLAAYIFSKd-qRAID 376 Ralstonia picke...
ZP_01169746  307 -----DVRHGGSYdrsdRFIAPTVLTDIepgSPILQEEIFGPVLPVIPYTdMRTLLSSGRIQRDALTGYIFSKn-kDNIQ 380 Bacillus sp. NR...
Q04458       333 kivpsKISINSDTed-lCLVPPTIVYNIgwdDPLMKQENFAPVLPIIEYEdLDETINKIIEEHDTPLVQYIFSdsqTEIN 411 baker's yeast
ZP_02184017  312 -----KIYYGGQVdtanRFIEPTLLTNIpvdSSILREEIFGPILPVIPYTdLTTLVHQLKDYPDPLAVYVFSKd-rETSQ 385 Carnobacterium ...
XP_001032736 309 ----gQIYYGGKVdvskKFVEPTIIVNPkldSECMQDEIFGPIFPVIFYKnFDEVINFINDRPKPLALYYFGEn-kTHKD 383 Tetrahymena the...
XP_001310607 310 ----gNIIIKGFQdpekLFIGPTLIENPsmeADIMTTEVFGPVIPFFPVDnEDKAIEFINEREKPLAAYVFTSd-wNVFT 384 Trichomonas vag...
XP_001021898 313 ---kgQIIIGGKFdisdKYIAPTLIDQPsleSRVMKEEIFGPILPILEFTdIQTVVQFINDRPNPLALYYFGS---KHAQ 386 Tetrahymena the...
XP_001444312 309 ----gKVVHGGQFglkeKWIEPTFVVNPdpnSELMKNEIFGPILPIITYKnIEDAINFINSRPKPLALYYFGTn-kAHKN 383 Paramecium tetr...
P30840       365 -----DVYYGGEVdienKYVQPTILQNVkidDLCMKEEIFGPILPVIEYDtLDEVFEMVKQHPNPLACYVFTEd-nDMFE 438 Entamoeba histo...
Feature 1                                                               
1AD3_A       375 KMIAeTSSGGVTANDVIVHITVPtLPFGGVGNSGMGAYHGKKSFETFSHRRSCLV 429 Norway rat
ZP_02007759  377 RFLGsVSFGGGCVNQTNLHCWIDsLPFGGVGLSGMGKYYGQAGFDALSNTKSLLI 431 Ralstonia pickettii 12D
ZP_01169746  381 LFKEhMRSSTISVNQVIHHAASPhIAFGGVGTSGYGAYHGKAGFLAFSYEKTEYK 435 Bacillus sp. NRRL B-14911
Q04458       412 RILTrLRSGDCVVGDTVIHVGITdAPFGGIGTSGYGNYGGYYGFNTFSHERTIFK 466 baker's yeast
ZP_02184017  386 FLKReLRSGAFSLNQVILHAVSShSPFGGVGASGFGRYHGMASLATFSYLKMDYE 440 Carnobacterium sp. AT7
XP_001032736 384 RLLNeTSSGHLSFNECVMHYINNtLPFGGVGNSGSGVIHGKLGFENCSHLKPVLD 438 Tetrahymena thermophila SB210
XP_001310607 385 KFQQqTSSGALMQNDVVFHVSSPySPFGGVGNSGMGQYHGEIGVKTLSHLKPILT 439 Trichomonas vaginalis G3
XP_001021898 387 LFEEqTSSGSYSINDAIFQLTNPnLPFGGVGNSGSGKYHGLAGFDSCSHLKPVFN 441 Tetrahymena thermophila SB210
XP_001444312 384 AILEsTSSGGVCINDCIFHLINQeLPFGGVGDSGYGVCGSKFGFDQCQHLKPVLE 438 Paramecium tetraurelia strain d4-2
P30840       439 HVIAnINSGAIYNNDSIVHLLNPnLPFGGNCQSGIGCYHGKYTFDTFSRPRAVCN 493 Entamoeba histolytica

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