2J6L,2JG7


Conserved Protein Domain Family
ALDH_F7_AASADH-like

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cd07086: ALDH_F7_AASADH-like 
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NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase and related proteins
ALDH subfamily which includes the NAD+-dependent, alpha-aminoadipic semialdehyde dehydrogenase (AASADH, EC=1.2.1.31), also known as Antiquitin-1, ALDH7A1, ALDH7B or delta-1-piperideine-6-carboxylate dehydrogenase (P6CDH), and other similar sequences, such as the uncharacterized aldehyde dehydrogenase of Candidatus kuenenia AldH (locus CAJ73105).
Statistics
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PSSM-Id: 143405
View PSSM: cd07086
Aligned: 42 rows
Threshold Bit Score: 575.667
Threshold Setting Gi: 108805710
Created: 30-Oct-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
NAD bindingcatalytic
Conserved site includes 21 residues -Click on image for an interactive view with Cn3D
Feature 1:NAD binding site [chemical binding site]
Evidence:
  • Structure:2JG7: Acanthopagrus schlegelii Seabream antiquitin (alpha-aminoadipic semialdehyde dehydrogenase) in complex with cofactor NAD+, defined using 3.5 A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
2J6L_A        26 GVYNGSWGGRg--EVITTYCPANNEPIARVRQas-vaDYEETVKKAREAWKIWAdiPAPKRGEIVRQIGDALREKIQVLG 102 human
2JG7_A        24 GVYNGSWGGSg--EVITSYCPANNEPIARVTQat-laEYEETVQKTREAWKMWAdiPAPKRGEIVRQIGDALRKKIKVLG 100 black porgy
CAJ73105       5 NYINGAFVDSassEVFESRNPAYCDEVLGTFPlssadDVNNAVLAAKTAYDTWRkiSRIRRGEYLDELAQLLKKDREAIS 84  Candidatus Kuen...
NP_487811      9 NYINGQWLNAateTTLNSHNPADKSEIVATFPrsqadDVDRAVAAARQAYGSWRkvPAPARAEYIFRVGELLLQHKEELA 88  Nostoc sp. PCC ...
YP_445899     41 NYIGGRWTGAasqATFDNRNPADPDDHIGDFPdsapaDVDAAVQAAQDAFSDWGstPAPDRGKILKASGDLLAERKDEIA 120 Salinibacter ru...
YP_001635373   9 NLIGGEFVPAqsgKTFERRNPADTRDVVGIFAdsderDVHAAVEAAKAAFPQWSkvPAPKRGEILLRAAELLQARKEQYS 88  Chloroflexus au...
YP_590535     16 NLIDGEWVESksgQTFENLNPADTREVVGIFQrsgkeDVEHAIDAASEAYKKWRlvPAPRRAELLFKAAAILEQRKEKYS 95  Acidobacteria b...
YP_356912      6 NFIGGQWVPPstgEYGQSVNPAHDMEVVARYPlsaksDVDRAVQAAVDAFPGWRamPAPRRAEILFRAAEILCRRKDELG 85  Pelobacter carb...
NP_617759     18 LHIGGESRDSatgETFDNINPATLENLATVQVag-seDVDRAVEAAEEGFRVWSevPAPRRAEVLFRTARILQERKEDLA 96  Methanosarcina ...
NP_279763      5 HYINGEWVDGdgtETFDSRNPANGETLGTFQRgt-ttDVEAAIAAADDAEDEWQslSRIDRAEYLWDIYHELKDRHQELG 83  Halobacterium s...
Feature 1                                                                      ####              
2J6L_A       103 SLVSLEMGKiLVEGVGEVQEYVDICDYAVGLSRMIGGPILPSERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAM 182 human
2JG7_A       101 SLVSLEMGKiYVEGVGEVQEYVDVCDYAVGLSRMIGGPVLPSERPGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAL 180 black porgy
CAJ73105      85 QLVSKECGKgIAEGRADVTEGIHMVQYIFGTTRMPHGDIIDSEIVEKDSFMRRRPKGVVAAITPWNFPFAIPLWLICPSV 164 Candidatus Kuen...
NP_487811     89 QLISREMGKpLTEARGDVQEGVDCAFYSAGEGRRLFGQTTPSEMPNKFAMTMRMPIGVCALITPWNFPVAIPCWKAMPAL 168 Nostoc sp. PCC ...
YP_445899    121 RSMTREMGKpFFETKGDVQEAIDTAYYAASETRRLFGTTVPSELPDKMNMAIRRPLGVCGIITAWNFPVAVPSWKIFPAL 200 Salinibacter ru...
YP_001635373  89 RDLTREMGKpLFEAGGDIVEAIGMAQYAGSEGRRMHGVTTPSELPNKFQMSIRQPIGVVGLITPWNFPMAIASWKMLPAI 168 Chloroflexus au...
YP_590535     96 QEMTREMGKvIKETRGDVQEAIDAGYYNAGEGRRMFGPTTPSELPNKFAMAVRQPLGVCAMITPWNFPMAIPSWKLFPAL 175 Acidobacteria b...
YP_356912     86 QLVTREMGKvLSEGLGDVQEAIDMAYFMAGEGRRLQGETVPCELPNKDAKSFRVPWGVFALITPWNFPIAIPSWKIFASL 165 Pelobacter carb...
NP_617759     97 RLMTEEMGKvLPETRGDVQEAIDIAIYAAGEGRRMFGETTTSELKDKFCMTVLRPIGVVGMITPWNFPLAIPGWKIMPAL 176 Methanosarcina ...
NP_279763     84 EVVTKECGKeISEGKADVTEAWQMVEWAAGDARHPKGDVVPSEIPEKDAYMRRQPRGVVGCITPWNFPVAIPFWHMAVAL 163 Halobacterium s...
Feature 1                # ##                                      ##            ####  #  #      
2J6L_A       183 ICGNVCLWKGAPtTSLISVAVTKIIAKvlednKLPGAICSLTCGGAd--iGTAMAKDErVNLLSFTGSTQVGKQVGLMVQ 260 human
2JG7_A       181 TCGNVCLWKGAPtTPLTSVAVTKIVAEvleqnNLPGAICSMTCGGAd--iGTAMAKDErVDLLSFTGSTHVGKMVAMMVQ 258 black porgy
CAJ73105     165 VEGNTVVLKPSReTPCVANKIAEYVHAa----GFPPGVINVIHGGCg---DALVRHSD-TQVILFTGSCEVGEGIKKIAA 236 Candidatus Kuen...
NP_487811    169 VCGNTVILKPAEdTPACATKLIEIFAAa----GLPPGVINLVHGVGeevgKALVEHPN-IDLVSFTGSSATGAYVGETCG 243 Nostoc sp. PCC ...
YP_445899    201 AAGNTIVFKPSEdAPHSGLRFVQTLIDa----GIPDGVINVVHGADea-gQALVEHPE-VDAIGFTGSYEVGTAIAETCG 274 Salinibacter ru...
YP_001635373 169 VCGNTVVIKPGEdASVSTYNLVQCLMEa----GLPPGVVNIVTGYGpragQPLVEHPD-VPVISFTGSTETGRLVYELGA 243 Chloroflexus au...
YP_590535    176 VCGNTAVIKPAQdTPLSTFNFVQALNDa----GVPKGVINIVTGYGgevgTPMTEHPE-VKAVSLTGSTAVGRIVGQAAA 250 Acidobacteria b...
YP_356912    166 ICGNTVVFKPSSdSPLCATRLVEVLEEa----GMPPGVVNMITGAGetvgETLAMHPD-VQGVSFTGSCSVGEALACSVA 240 Pelobacter carb...
NP_617759    177 IAGNAIVFKPASdTPLLAIKLVEILMEa----GLPPGVVNLVTGPGgstgKAIVQHPR-IKAISFTGSLETGKWIMEECA 251 Methanosarcina ...
NP_279763    164 VEGNTVVWKPAEqTPWCGQIIAEMFADa----GIPDGVFNMVQGFGda-gARIVDHDD-IDTVLFTGSAEVGEEVARTVA 237 Halobacterium s...
Feature 1                 ###                               #                                    
2J6L_A       261 e-RFGRSLLELGGNNAIIAFEDaDLSLVVPSALFAAVGTaGQRCTTARRLFIHesiHDEVVNRLKKAYAQIRVGNPWDPn 339 human
2JG7_A       259 e-RFGRKLLELGGNNAIIVFEDaDLNLVVPSAVFASVGTaGQRCTTTRRLMLHesvHDAVVERIAKAYKQVRIGDPWDPs 337 black porgy
CAJ73105     237 esYNKMCACEMGGKNAIIVLDGaNMEIAVNASILSAFKTsGQRCTSAGRLILHvnmLEEFEKRFVELAKRIKIGNPLDEe 316 Candidatus Kuen...
NP_487811    244 r-THKRVCLEMGGKNAQVVMEDaDLELALDGALWGAFGTtGQRCTATSRLILHrdiKEKFTTMLRERTSQLRLGAGTEPe 322 Nostoc sp. PCC ...
YP_445899    275 r-LNTPVSLEMGGKNPMIVMDDaDLDLALEGAIWGAYGTtGQRCTATSRLICHesvHDELVAMIRDEAEALVLGDGNDAd 353 Salinibacter ru...
YP_001635373 244 r-RIKRVSLEMGGKNPLIVMPDaDLDLALDGVLWAAFGTtGQRCTATSRLIVHravAKELVERIVARAQSLRVGNGLDPa 322 Chloroflexus au...
YP_590535    251 k-SFKHCSLELGGKNPMIVLDDaNLDLALEGALWGSFGTtGQRCTATSRIILQkgiYKKFADELVARARKLKVGNGLDEt 329 Acidobacteria b...
YP_356912    241 q-LHRPIAMEMGGKNAILIMDDaDLDLALEGVLWGAFGTtGQRCTAASRIIVHekvYDEFLDRLVRAANAMRLGDGLEKd 319 Pelobacter carb...
NP_617759    252 k-TMKRVSLELGGKNPVIIMDDaDLELALEGVLWGAFGTtGQRCTATSRLILHekiKDEFTARLLAKTKLLRVGNGLLPe 330 Methanosarcina ...
NP_279763    238 ddPGKLAACEMGGKNGIVVTEKaDLDIAVHAAVMSSFKTtGQRCVSSERLIVHedlYDEFKQRFVEIAESVAVDDPLDEe 317 Halobacterium s...
Feature 1                                                                               #        
2J6L_A       340 VLYGPLHTKQAVSMFLGAVEEak------keGGTVVYGGKVMdr----pGNYVEPTIVTGLgh-daSIAHTETFAPILYV 408 human
2JG7_A       338 TLYGPLHTKQAVDQYLAAIEQak------qqGGTLVCGGKVMdr----pGNYVEPTIITGLah-daPIVHTETFVPILYV 406 black porgy
CAJ73105     317 VFMGPVINQAATEKILRYNDFak------neGAEVLLDGSRLtgggydkGYFMSPFVYRMKnnpksRVLHEEVFGPHVAI 390 Candidatus Kuen...
NP_487811    323 TDIGPIINNRQLQRVHEYMNIar------eeGAKILIGGEIAtegqlqqGYFFQPTILDNVtp-qmRVAREEIFGPVVAL 395 Nostoc sp. PCC ...
YP_445899    354 TDVGPLINQAAAETVHRYVEIgq------eeGATLEMGGAPAsvd-gldGHFYEPTLFTDVtp-dmTIAQEEIFGPVLAT 425 Salinibacter ru...
YP_001635373 323 TEMGPLVNEKQLQRVLNYIDIgk------qeGATLLCGGYRLtggdydyGYFIAPTVFTNVts-qmRIAREEIFGPVLSV 395 Chloroflexus au...
YP_590535    330 VDMGPAVNENQMNTDLKYIEIgk------geGAKLAHGGHRLdkgdyahGWFLEPTIFTDVnh-kmRIAQEEIFGPVVAL 402 Acidobacteria b...
YP_356912    320 TDVGPLINRRALNKVLNYIRIgk------deGARLCCGGNQAkhnglteGYFVEPTVFSNVtp-smRIAQEEIFGPVVCL 392 Pelobacter carb...
NP_617759    331 TDIGPIINKAQLEKIERYVRIgm------eeGATLLLGGKAIdpg--lpGYFFEPTVFTDVrp-dmRIAQEEIFGPVLSI 401 Methanosarcina ...
NP_279763    318 TFMGPAIEPAHVEKIQTYNDIareeaenvlvDRTELGDDEIPdgh--edGNWVGPFVYEVDydpdlRSITEEVFGPHVAL 395 Halobacterium s...
Feature 1                                                                     #                  
2J6L_A       409 FKFqn-eEEVFAWNNEVKQGLSSSIFTKdlGRIFRWLGpkgSDCGIVNVNIPtsGAEIGGAFGGEKHTGGGRESG---SD 484 human
2JG7_A       407 LKFkt-eEEAFAWNNEVQQGLSSSIFTKdlGRVFRWLGpkgSDCGIVNVNIPtsGAEIGGAFGGEKHTGGGRESG---SD 482 black porgy
CAJ73105     391 IPVes-iDEAINVYNDTEYGLSCAVITEdfRKARRIRDd--CEYGLGYVNLPtiGAEVHLPFGGLKKSGTGLPSA---ST 464 Candidatus Kuen...
NP_487811    396 IEVst-fEEAIAILNDTKYGLSSSVYTRdiNRAFVAMRd--IEAGITYINGPtiGAEVHLPFGGVKQTGNGHREAg--TT 470 Nostoc sp. PCC ...
YP_445899    426 FEVgs-yDEAVTVANDTQYGLSSSIYTQdvNKSFRAMRd--LEAGITYVNGPtiGAEAHMPFGGVKDTGNGQRDGg--YA 500 Salinibacter ru...
YP_001635373 396 IEVds-lDEAVAIANDVAYGLSSAIYTRdiNAAFRAMQa--LQAGIVYINAPtiGAEIHLPFGGVKATGNGHREAg--PT 470 Chloroflexus au...
YP_590535    403 IPCdd-lDEAIEIANGIEYGLSSAIYTRdvNKSFRAMRd--LHAGITYVNAPtiGAEVHMPFGGVKATGNGHREGg--IG 477 Acidobacteria b...
YP_356912    393 IKCds-yEQGIAIVNQSRFGLSTAIYTRdvNISARAEGd--LDSGLVYINAStiGAEIQLPFGGFKHSGSGHPEAggrMG 469 Pelobacter carb...
NP_617759    402 ITVsg-lEEAIEVANNTRYGLSSAIYTEnvGKAFRAVKk--IEAGITYVNAPtiGAEVHLPFGGVKGTGNGFREAg--TE 476 Methanosarcina ...
NP_279763    396 IEYsgdiERAVEIHNDTPYGLAGAVISEdyRQINYYRDn--AEVGLAYGNLPciGAEVQLPFGGMKKSGNGYPSA---RE 470 Halobacterium s...
Feature 1                        
2J6L_A       485 AWKQYMRRSTCTINYS 500 human
2JG7_A       483 SWKQYMRRSTCTINYS 498 black porgy
CAJ73105     465 LIDAVTHRTAWTVNHD 480 Candidatus Kuenenia stuttgartiensis
NP_487811    471 ALDVFTEWKSVYVDFS 486 Nostoc sp. PCC 7120
YP_445899    501 AFEFWTEHKTLYVDYS 516 Salinibacter ruber DSM 13855
YP_001635373 471 MLDVFSEWKSVYIDYS 486 Chloroflexus aurantiacus J-10-fl
YP_590535    478 ALDFYTEWKAIYVDYS 493 Acidobacteria bacterium Ellin345
YP_356912    470 ALDFFSRIKVVYRDFS 485 Pelobacter carbinolicus DSM 2380
NP_617759    477 AIKEFTEIKAVYIDYS 492 Methanosarcina acetivorans C2A
NP_279763    471 VIEAVTERTAWTLNNS 486 Halobacterium sp. NRC-1

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