2VRO,1EYY


Conserved Protein Domain Family
ALDH_KGSADH-like
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cd07084: ALDH_KGSADH-like 
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ALDH subfamily: NAD(P)+-dependent alpha-ketoglutaric semialdehyde dehydrogenases and plant delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH family 12-like
ALDH subfamily which includes the NAD(P)+-dependent, alpha-ketoglutaric semialdehyde dehydrogenases (KGSADH, EC 1.2.1.26); plant delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH, EC=1.5.1.12 ), ALDH family 12; the N-terminal domain of the MaoC (monoamine oxidase C) dehydratase regulatory protein; and orthologs of MaoC, PaaZ and PaaN, which are putative ring-opening enzymes of the aerobic phenylacetic acid catabolic pathway.
Links
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Statistics
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PSSM-Id: 143403
Aligned: 4 rows
Threshold Bit Score: 468.256
Threshold Setting Gi: 185177635
Created: 14-Jan-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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NADP bindingcatalytic
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:NADP binding site [chemical binding site]
Evidence:
  • Structure:2VRO; Aldehyde dehydrogenase from Burkholderia xenovorans Lb400 with NADPH bound in the cofactor-binding pocket, defined using 3.5 A.
    - View structure with Cn3D
  • Structure:1EYY; Aldehyde dehydrogenase from Vibrio harveyi with NADP+ bound, defined using 3.5 A.
    - View structure with Cn3D
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
2VRO_B     43 LARAFSFAREDGGaalrALTYAQRAARLADIVKLLQAKRGDYYAIATANSGTtrndSAVDIDGGIFTLSYYAKLgaslge 122 Burkholderia xenov...
Q8VZC3    112 PERYLLYGDISTKaa-hMLALPKVADFFARLIQRVAPKSYQQAAGEVFVTRK----FLENFCGDQVRFLARSFAi----- 181 thale cress
AAG28964   97 GQALIDAAHAAMPgw-qRIGAQGRAGVCLEILERLNKRSFEIAHAVMLTTGQgw-mMAFQAGGPHAQDRGLEAVayayre 174 Azoarcus evansii
1EYY_A     32 VNQAATAAAKVARdf-rRLNNSKRASLLRTIASELEARSDDIIARAHLETALpevrLTGEIARTANQLRLFADVvnsgs- 109 Vibrio harveyi

Feature 1                                          ## #                         # ##          
2VRO_B    123 vhalrdgSAESLskd----rsFSAQHVLSPTrGVALFINAFNFPs--WGLWEKAAPALLSGVPVIVKPATataWLTQRMV 196 Burkholderia xenov...
Q8VZC3    182 -------PGNHLg--------QQSHGYRWPY-GPVTIVTPFNFPl--EIPLLQLMGALYMGNKPLLKVDSkvsIVMEQMM 243 thale cress
AAG28964  175 mkfipheTVWEKpqgknpplkMKKHFEIVGR-GVALVIGCGTFPt--WNTYPGLFAALATGNPVIVKPHQnaiLPAAITV 251 Azoarcus evansii
1EYY_A    110 ---yhqaILDTPnptraplpkPDIRRQQIAL-GPVAVFGASNFPlafSAAGGDTASALAAGCPVIVKGHTahpGTSQIVA 185 Vibrio harveyi

Feature 1                                               ####  #                               
2VRO_B    197 ADVVDagi---lppGALSIICgs----saGLLDQirsfdVVSFTGSADTAATLRAHpafvqrgarLNVEADSLNSAILCA 269 Burkholderia xenov...
Q8VZC3    244 RLLHYcgl----paEDVDFINsdgk-tmnKILLEan-prMTLFTGSSRVAEKLALDlk-----grIRLEDAGFDWKVLGP 312 thale cress
AAG28964  252 RIAREvlaeagldpNLVTLAAfdkheatqALATHpa-vkSIDFTGGNAFGQWLISNakq----aqVYAELAGVNNVVIES 326 Azoarcus evansii
1EYY_A    186 ECIEQalkqeqlpqAIFTLLQgnqralgqALVSHpe-ikAVGFTGSVGGGRALFNLaherpepipFYGELGAINPTFIFP 264 Vibrio harveyi

Feature 1                                                                                     
2VRO_B    270 datpdtpAFDLFIKEVVREMTVkSGQKCTAIRRAFVPea-----aLEPVLEALKAKLAKITVgnprndavrmgSLVSREQ 344 Burkholderia xenov...
Q8VZC3    313 dv----qEVDYVAWQCDQDAYAcSGQKCSAQSMLFVHen----wsKTPLVSKLKELAERRKLe---------dLTIGPVL 375 thale cress
AAG28964  327 t-----dQYKAMLRNLAFTLCLySGQMCTTTQAILVPadgidtdqGRKSYDEVCADLATSIDkflad-pavatAVLGAIQ 400 Azoarcus evansii
1EYY_A    265 sa---mrAKADLADQFVASMTMgCGQFCTKPGVVFALnt----peTQAFIETAQSLIRQQSPs----------TLLTPGI 327 Vibrio harveyi

Feature 1                                                                                     
2VRO_B    345 YENVLAGIAALREe-----aVLAYDssavplidadaniaaCVAPHLFVvndpdna----tllhdvEVFGPVASVAPYRvt 415 Burkholderia xenov...
Q8VZC3    376 TFTTEAMLEHMENllqipgsKLLFGgkelknhsipsiygaLEPTAVYVpieeilkdnktyelvtkEIFGPFQIVTEYKkd 455 thale cress
AAG28964  401 SPDTLARIAEAPAhg----rVVRAStkieha----efpgaEVRSPLLLacdaad-----ekaymeERFGPIAFVVKVAdg 467 Azoarcus evansii
1EYY_A    328 RDSYQSQVVSRGSdd---giDVTFSqae----------spCVASALFVtssenwr---khpaweeEIFGPQSLIVVCEn- 390 Vibrio harveyi

Feature 1                                                                                     
2VRO_B    416 tdtnalpeAHAVALARRGqgsLVASIYSNd--DAHLGRLALELadSHGRVHAIspsvqhsqtghGNVMPm------SLHG 487 Burkholderia xenov...
Q8VZC3    456 ------qlPLVLEALERMhahLTAAVVSNd--PIFLQEVIGNS--VNGTTYAGlr-------grTTGAP-------QNHW 511 thale cress
AAG28964  468 a-----aaVTLSERIVREhgaLTVGLYTTk--PEVVDAMTEATw-RAGVALSInl--------tGGVFVnqsagfsDYHG 531 Azoarcus evansii
1EYY_A    391 -------vADMLSLSEMLagsLTATIHATeedYPQVSQLIPRLeeIAGRLVFNgw--------pTGVEVgy----aMVHG 451 Vibrio harveyi

Feature 1                                    
2VRO_B    488 GPGRAGg---GEELgGLRALAFYHRRSAIQA 515 Burkholderia xenovorans
Q8VZC3    512 FGPAGDp--rGAGIgTPEAIKLVWSCHREVI 540 thale cress
AAG28964  532 VGMNPA----ANAS-LSDSAFVANRFRVVQR 557 Azoarcus evansii
1EYY_A    452 GPYPASthsaSTSV-GAEAIHRWLRPVAYQA 481 Vibrio harveyi

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