Conserved Protein Domain Family
ALDH_F20_ACDH_EutE-like

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cd07081: ALDH_F20_ACDH_EutE-like 
Coenzyme A acylating aldehyde dehydrogenase (ACDH), Ethanolamine utilization protein EutE, and related proteins
Coenzyme A acylating aldehyde dehydrogenase (ACDH), an NAD+ and CoA-dependent acetaldehyde dehydrogenase, acetylating (EC=1.2.1.10), functions as a single enzyme (such as the Ethanolamine utilization protein, EutE, in Salmonella typhimurium) or as part of a multifunctional enzyme to convert acetaldehyde into acetyl-CoA. The E. coli aldehyde-alcohol dehydrogenase includes the functional domains, alcohol dehydrogenase (ADH), ACDH, and pyruvate-formate-lyase deactivase; and the Entamoeba histolytica aldehyde-alcohol dehydrogenase 2 (ALDH20A1) includes the functional domains ADH and ACDH, and may be critical enzymes in the fermentative pathway.
Statistics
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PSSM-Id: 143400
View PSSM: cd07081
Aligned: 3 rows
Threshold Bit Score: 580.376
Threshold Setting Gi: 2498347
Created: 10-Oct-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative catalytic cysteine [active site]
Evidence:
  • Comment:conserved cysteine that aligns with the catalytic cysteine of the ALDH superfamily

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
P0A9Q7      9 LNALVERVKKAQReyasfTQEQVDKIFRAAALAAADARIPLAKMAVAESGmGIVEDKVIKNHFASEyIYNAykdekTCGV 88  Escherichia coli K-12
P77445     36 LDDAVAAAKVAQQgl--kSVAMRQLAIAAIREAGEKHARDLAELAVSETGmGRVEDKFAKNVAQARgTPGVec--lSPQV 111 Escherichia coli K-12
P33744      9 LDEKLKVIKEAQKkfscySQEMVDEIFRNAAMAAIDARIELAKAAVLETGmGLVEDKVIKNHFAGEyIYNKykdekTCGI 88  Clostridium acetob...
Feature 1                                                                                     
P0A9Q7     89 LSeddtFGTITIAEPiGIICGIVPTTNPTSTAIFKSLISLKTRNAIIFSPHPraKDATNKAADIVLQAAIAAGapkDLIG 168 Escherichia coli K-12
P77445    112 LTgd-nGLTLIENAPwGVVASVTPSTNPAATVINNAISLIAAGNSVIFAPHPaaKKVSQRAITLLNQAIVAAGgpeNLLV 190 Escherichia coli K-12
P33744     89 IErnepYGITKIAEPiGVVAAIIPVTNPTSTTIFKSLISLKTRNGIFFSPHPraKKSTILAAKTILDAAVKSGapeNIIG 168 Clostridium acetob...
Feature 1                                                                                   # 
P0A9Q7    169 WIDQPsvelsnALMHHpdinLILATGGPGMVKAAYSSGk-PAIGVGAGNTPVVIDETADIKRAVASVLMSKTFDNGVICA 247 Escherichia coli K-12
P77445    191 TVANPdietaqRLFKFpgigLLVVTGGEAVVEAARKHTnkRLIAAGAGNPPVVVDETADLARAAQSIVKGASFDNNIICA 270 Escherichia coli K-12
P33744    169 WIDEPsieltqYLMQKa--dITLATGGPSLVKSAYSSGk-PAIGVGPGNTPVIIDESAHIKMAVSSIILSKTYDNGVICA 245 Clostridium acetob...
Feature 1                                                                                     
P0A9Q7    248 SEQSVVVVdsVYDAVRERFATHGGYLLQGkeLKAVQDVILknga------lnaAIVGQPAYKIAELAGFSVPENTKILIg 321 Escherichia coli K-12
P77445    271 DEKVLIVVdsVADELMRLMEGQHAVKLTAeqAQQLQPVLLknidergkgtvsrDWVGRDAGKIAAAIGLKVPQETRLLFv 350 Escherichia coli K-12
P33744    246 SEQSVIVLksIYNKVKDEFQERGAYIIKKneLDKVREVIFkdgs------vnpKIVGQSAYTIAAMAGIKVPKTTRILIg 319 Clostridium acetob...
Feature 1                                                                                     
P0A9Q7    322 evtvvdesePFAHEKLSPTLAMYRAKDFedavEKAEKLVAMGgIGHTSCLYTDqdnqpARVSYFGQKMkTARILINtpas 401 Escherichia coli K-12
P77445    351 ett--aehpFAVTELMMPVLPVVRVANVa--dAIALAVKLEGgCHHTAAMHSRn---iENMNQMANAIdTSIFVKNgpc- 422 Escherichia coli K-12
P33744    320 evtslgeeePFAHEKLSPVLAMYEADNFddalKKAVTLINLGgLGHTSGIYADeikarDKIDRFSSAMkTVRTFVNipts 399 Clostridium acetob...
Feature 1                                                   
P0A9Q7    402 qgGIGDLYnfkLAPSLTLGCGSwgGNSISenvgPKHLINKKTVAKR 447 Escherichia coli K-12
P77445    423 iaGLGLGGe--GWTTMTITTPT--GEGVTs---ARTFVRLRRCVLV 461 Escherichia coli K-12
P33744    400 qgASGDLYnfrIPPSFTLGCGFwgGNSVSenvgPKHLLNIKTVAER 445 Clostridium acetobutylicum

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