2H5G


Conserved Protein Domain Family
ALDH-like

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cd07077: ALDH-like 
Click on image for an interactive view with Cn3D
NAD(P)+-dependent aldehyde dehydrogenase-like (ALDH-like) family
The aldehyde dehydrogenase-like (ALDH-like) group of the ALDH superfamily of NAD(P)+-dependent enzymes which, in general, oxidize a wide range of endogenous and exogenous aliphatic and aromatic aldehydes to their corresponding carboxylic acids and play an important role in detoxification. This group includes families ALDH18, ALDH19, and ALDH20 and represents such proteins as gamma-glutamyl phosphate reductase, LuxC-like acyl-CoA reductase, and coenzyme A acylating aldehyde dehydrogenase. All of these proteins have a conserved cysteine that aligns with the catalytic cysteine of the ALDH group.
Statistics
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PSSM-Id: 143396
View PSSM: cd07077
Aligned: 4 rows
Threshold Bit Score: 427.795
Threshold Setting Gi: 2498347
Created: 31-Dec-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:putative catalytic cysteine [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
2H5G_A     36 EXARSGGRxlatlEPEQRAEIIHHLADLLTdQRDEILLANKKdleeaegrla-------------apllkrlslSTSKLN 102 human
P0A9Q7     14 ERVKKAQReyasfTQEQVDKIFRAAALAAAdARIPLAKMAVAesg--------------------------mgiVEDKVI 67  Escherichia coli 1...
P08639     33 DSFNNLHLtqmvnHDYLNDLNINNIINFLYtTGQRWKSEEYSrrrayirslitylgyspqmakleanwiamilcSKSALY 112 Vibrio harveyi
P77445     41 AAAKVAQQgl--kSVAMRQLAIAAIREAGEkHARDLAELAVSetg--------------------------mgrVEDKFA 92  Escherichia coli s...
Feature 1                                                                                     
2H5G_A    103 SLAIGLRqiaassqdsvgrvLRRTriaknleLEQVtvpiGVLLVIFESRPDcl--pQVAALAIASGNGLLLKGGKea-aH 179 human
P0A9Q7     68 KNHFASEyiynay--kdektCGVLseddtfgTITIaepiGIICGIVPTTNPtstaiFKSLISLKTRNAIIFSPHPrakdA 145 Escherichia coli 1...
P08639    113 DIIDTELgst--------hiQDEWlpq--geCYVRafpkGRTMHLLAGNVPls-gvTSILRGILTRNQCIVRMSAsd-pF 180 Vibrio harveyi
P77445     93 KNVAQARgtpgv----eclsPQVLtgd-nglTLIEnapwGVVASVTPSTNPaatviNNAISLIAAGNSVIFAPHPaakkV 167 Escherichia coli s...
Feature 1                                                                                     
2H5G_A    180 SNRILHLLTQEALsihg--vkeAVQLVNtre---eveDLCRLdkxidLIIPRGSSQLVRDIQKAak-giPVXGHSEGICH 253 human
P0A9Q7    146 TNKAADIVLQAAIaaga--pkdLIGWIDqpsv-elsnALMHHpd-inLILATGGPGMVKAAYSSg---kPAIGVGAGNTP 218 Escherichia coli 1...
P08639    181 TAHALAMSFIDVDpnhpisrsiSVLYWPhasdttlaeELLSHm---dAVVAWGGRDAIDWAVKHspshiDVLKFGPKKSF 257 Vibrio harveyi
P77445    168 SQRAITLLNQAIVaagg--penLLVTVAnpdi-etaqRLFKFpg-igLLVVTGGEAVVEAARKHtn--kRLIAAGAGNPP 241 Escherichia coli s...
Feature 1                                 #                                                   
2H5G_A    254 XYVDSe-aSVDKVTRLVRDSKCEY-PAACNALETLLIHrdllrtplFDQIIDXLRv------------------------ 307 human
P0A9Q7    219 VVIDEt-aDIKRAVASVLMSKTFDnGVICASEQSVVVVdsvy-davRERFATHGGyllqgkelkavqdvilkng------ 290 Escherichia coli 1...
P08639    258 TVLDHpadLEEAASGVAHDICFYD-QNACFSTQNIYFSgd-----kYEEFKLKLVe------------------------ 307 Vibrio harveyi
P77445    242 VVVDEt-aDLARAAQSIVKGASFDnNIICADEKVLIVVdsva-delMRLMEGQHAvkltaeqaqqlqpvllknidergkg 319 Escherichia coli s...
Feature 1                                                                                     
2H5G_A    308 -----------------eQVKIHAgpkfasyltf-spsevkslrtEYGDLELCIEVVdn---vQDAIDHIHKYgs----- 361 human
P0A9Q7    291 alnaaivgqpaykiaelaGFSVPEntkiligevtvvdesepfaheKLSPTLAMYRAKdfedavEKAEKLVAMGgi----- 365 Escherichia coli 1...
P08639    308 ------------------KLNLYQevlpkskq-----sfddealfSMTRLECQFSGLkvisepENNWMIIESEpgveynh 364 Vibrio harveyi
P77445    320 tvsrdwvgrdagkiaaaiGLKVPQetrllfvett--aehpfavteLMMPVLPVVRVAnv--adAIALAVKLEGgc----- 390 Escherichia coli s...
Feature 1                                                                                     
2H5G_A    362 sHTDVIVTEd---eNTAEFFLQHVd-----sACVFWNastrfsd-gyrfglgAEVGISTsriharg-----pvglegLLT 427 human
P0A9Q7    366 gHTSCLYTDqdnqpARVSYFGQKMk-----tARILINtpasqggigdlynfkLAPSLTLgcgswggnsisenvgpkhLIN 440 Escherichia coli 1...
P08639    365 pLSRCVYVHk---iNKVDDVVQYIekhqtqtISFYPWesskkyr-dafaakgVERIVESgmnnifr----aggahdaMRP 436 Vibrio harveyi
P77445    391 hHTAAMHSRn---iENMNQMANAId-----tSIFVKNgpciag---lglggeGWTTMTIttptgeg-----vtsartFVR 454 Escherichia coli s...
Feature 1           
2H5G_A    428 TKWLLR 433 human
P0A9Q7    441 KKTVAK 446 Escherichia coli 101-1
P08639    437 LQRLVR 442 Vibrio harveyi
P77445    455 LRRCVL 460 Escherichia coli str. K12 substr. DH10B

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